128-69-8

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Factor V Leiden in patients with venous thrombosis in Slovak population.

M Simkova et al.

General physiology and biophysics, 23(4), 435-442 (2005-04-09)

Resistance to activated protein C determined by factor V Leiden (FVL) is the most frequent inherited risk factor of venous thrombosis. The purpose of our work was to reveal the frequency of FVL in Slovak patients with venous thromboses, to

The solution structure of melanoma growth stimulating activity.

W J Fairbrother et al.

Journal of molecular biology, 242(3), 252-270 (1994-09-23)

The solution structure of melanoma growth stimulating activity (MGSA), a dimeric chemokine consisting of 73 residues per monomer, has been determined using two-dimensional homonuclear and three-dimensional heteronuclear NMR spectroscopy. Structure calculations were carried out using a hybrid distance geometry-simulated annealing

Genetic factors are associated with modic changes in endplates of lumbar vertebral bodies.

Jaro Karppinen et al.

Spine, 33(11), 1236-1241 (2008-05-13)

A cross-sectional genotype-phenotype evaluation. To evaluate the genetic background to Modic changes in an occupational cohort. Modic changes are vertebral endplate changes visible in magnetic resonance imaging. Twin studies suggest that intervertebral disc degeneration may be primarily explained by genetic

Order of Treatment Matters in Ischemic Stroke: Mechanical Thrombectomy First, Then Carotid Artery Stenting for Tandem Lesions of the Anterior Circulation.

Volker Maus et al.

Cerebrovascular diseases (Basel, Switzerland), 46(1-2), 59-65 (2018-08-10)

One endovascular treatment option of acute ischemic stroke due to tandem occlusion (TO) comprises intracranial thrombectomy and acute extracranial carotid artery stenting (CAS). In this setting, the order of treatment may impact the clinical outcome in this stroke subtype. Retrospective

Essential hypertension is associated with blunted smooth muscle cell vasodilator responsiveness and is reversed by 10-20-30 training in men.

Thomas P Gunnarsson et al.

American journal of physiology. Cell physiology, 318(6), C1252-C1263 (2020-04-09)

Essential hypertension is associated with impairments in vascular function and sympathetic nerve hyperactivity; however, the extent to which the lower limbs are affected remains unclear. We examined the leg vascular responsiveness to infusion of acetylcholine (ACh), sodium nitroprusside (SNP), and

Incidence, pattern, and etiology of elevated liver enzymes in pediatric inflammatory bowel disease.

Antoinette J Pusateri et al.

Journal of pediatric gastroenterology and nutrition, 60(5), 592-597 (2014-12-11)

Patients with inflammatory bowel disease (IBD) often develop elevated liver enzymes (ELE), which are frequently a benign, transient finding, but may be related to treatment or IBD-associated liver diseases. Distinguishing benign from pathologic ELE is crucial for focused diagnostic and

Utilization of amino acid analogues in diets of young turkeys.

C M Parsons et al.

The British journal of nutrition, 46(1), 77-86 (1981-07-01)

1. The relative potencies of three lysine, one tryptophan and six methionine analogues to their corresponding l-amino acids were determined. 2. Male poults, 9 d of age, were used in five 14 d experiments. Experimental diets were formed by adding

Neonatal Isoflurane Anesthesia or Disruption of Postsynaptic Density-95 Protein Interactions Change Dendritic Spine Densities and Cognitive Function in Juvenile Mice.

Michele L Schaefer et al.

Anesthesiology, 133(4), 812-823 (2020-08-11)

Experimental evidence shows postnatal exposure to anesthesia negatively affects brain development. The PDZ2 domain, mediating protein-protein interactions of the postsynaptic density-95 protein, serves as a molecular target for several inhaled anesthetics. The authors hypothesized that early postnatal disruption of postsynaptic

Expression of matrix metalloproteinases and endogenous inhibitors within ascending aortic aneurysms of patients with Marfan syndrome.

John S Ikonomidis et al.

Circulation, 114(1 Suppl), I365-I370 (2006-07-06)

Marfan syndrome (MFS) is known to cause ascending thoracic aortic aneurysms (ATAAs). Transforming growth factor beta (TGF-beta) has recently been implicated in this process. Imbalances between the matrix metalloproteinases (MMPs) and their endogenous inhibitors (TIMPs) have also been shown to

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