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关键词:'129-43-1'
显示 1-30 共 35 条结果 关于 "129-43-1" 范围 论文
Jose A Sánchez et al.
Basic research in cardiology, 108(3), 351-351 (2013-04-19)
Connexin 43 (Cx43) deficiency increases myocardial tolerance to ischemia-reperfusion injury and abolishes preconditioning protection. It is not known whether modifications in baseline signaling through protective RISK or SAFE pathways or in response to preconditioning may contribute to these effects. To
Y Kondo et al.
Carcinogenesis, 20(8), 1625-1627 (1999-07-30)
We examined the carcinogenicity of N-butyl-N-(4-hydroxybutyl)nitrosamine (BBN) in transgenic mice deficient in the metallothionein (MT) I and II genes and in control (129/Sv) mice. Both strains of mice were given BBN for 8 weeks with or without Zn treatment. All
J L Hoover-Plow et al.
Inflammation research : official journal of the European Histamine Research Society ... [et al.], 57(10), 457-463 (2008-10-02)
The objective of this study was to determine genetic differences in inflammation in these distinct inbred mouse strains. Peritoneal leukocyte recruitment, matrix metalloproteinases and cytokines were quantified in A/J, 129/svJ, C57BL/6J, using thioglycollate or biomaterial implants as inflammatory stimuli. In
Yonggang Zuo et al.
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie, 95, 922-928 (2017-09-17)
Long non-coding RNA Metastasis associated lung adenocarcinoma transcript 1(lncRNA MALAT1) play important roles in tumor progression. In the present study, we determined the regulatory function of MALAT1 in triple-negative breast cancer (TNBC). A total of 43 cases of TNBC tissues
L Xu et al.
Genomics, 27(3), 475-480 (1995-06-10)
The recently isolated gene for tuberous sclerosis 2 (TSC2) encodes a 5.5-kb transcript that is widely expressed. The TSC2 gene product, named tuberin, is a 1784-amino-acid protein that shows a small stretch of homology to the GTPase activating protein rap1GAP.
Jong-Hwan Lim et al.
Experimental animals, 61(1), 71-75 (2012-02-02)
This study was conducted to evaluate the oral absorption of enrofloxacin (ENFX) in rats when administered with orange oil or its main component, limonene. Compared with the group administered ENFX alone, the ENFX + limonene group did not show any
Rumiko Izumi et al.
Human mutation, 41(9), 1540-1554 (2020-05-14)
Dysferlinopathy is a group of autosomal recessive muscular dystrophies caused by variants in the dysferlin gene (DYSF), with variable proximal and distal muscle involvement. We performed DYSF gene analyses of 200 cases suspected of having dysferlinopathy (Cohort 1), and identified
B Kerfelec et al.
European journal of biochemistry, 190(2), 299-304 (1990-06-20)
A genomic library has been constructed in EMBL3 lambda phage using high molecular mass DNA isolated from canine spleen. A cDNA clone, shown to code for preprophospholipase A2 which is processed to the prosecretory form prior to release from secretory
Z Su et al.
International journal of obesity (2005), 32(7), 1180-1189 (2008-04-17)
To identify the genes controlling body fat, we carried out a quantitative trait locus (QTL) analysis using C57BL/6J (B6) and 129S1/SvImJ (129) mice, which differ in obesity susceptibility after consuming an atherogenic diet. Mice were fed chow until 8 weeks
Lazar M Kaluđerović et al.
Journal of environmental science and health. Part. B, Pesticides, food contaminants, and agricultural wastes, 53(8), 503-509 (2018-05-01)
The results presented in this paper show an impact of the concentration of the aromatic organic cation on the adsorption of acetochlor on the surface of the organic-modified montmorillonite. Natural montmorillonite from Bogovina (Boljevac municipality, Serbia) was used for organic
F M Hahn et al.
Archives of biochemistry and biophysics, 332(1), 30-34 (1996-08-01)
Isopentenyl diphosphate (IPP):dimethylallyl diphosphate isomerase catalyzes an essential activation step in the isoprenoid biosynthetic pathway. A human cDNA sequence [J. Xuan, J. Kowalski, A.F. Chambers, and D.T. Denhardt (1994) Genomics 20, 129-131] containing a 684-base-pair open reading frame was recently
A Ikeda et al.
Human molecular genetics, 8(9), 1761-1767 (1999-08-11)
Quantitative trait locus (QTL) analysis of genetic crosses has proven to be a useful tool for identifying loci associated with specific phenotypes and for dissecting genetic components of complex traits. Inclusion of a mutation that interacts epistatically with QTLs in
Anne Hempelmann et al.
Neuroscience letters, 402(1-2), 118-120 (2006-04-25)
Two recurrent missense mutations (c.20C>T: A7V; c.26C>T: A9V) in the gene encoding the myofibrillogenesis regulator 1 (MR-1) have been shown to cause autosomal dominant paroxysmal nonkinesigenic dyskinesia (PNKD) in 13 families of primarily European ancestry. Here we report an Omani
Preeti J Khandelwal et al.
Molecular and cellular neurosciences, 49(1), 44-53 (2011-09-29)
Neurodegeneration involves multiple pathogenic proteins, including Tau, Aβ, TDP-43 and α-Synuclein, but there is little information how these pathogenic proteins interact. We cloned human wild type 4 repeat Tau (Tau(wt)) and mutant Tau(P301L) into a lentivirus and performed stereotaxic injection
Jadwiga Skretkowicz et al.
European journal of clinical pharmacology, 65(10), 971-976 (2009-05-16)
Involvement of genetic and environmental factors in the pathogenesis of scleroderma has contributed to a number of studies whose aim is to elucidate the way in which xenobiotics exert effects on the occurrence of autoimmune processes resulting in development of
Preeti J Khandelwal et al.
Molecular and cellular neurosciences, 49(1), 44-53 (2011-09-29)
Neurodegeneration involves multiple pathogenic proteins, including Tau, Aβ, TDP-43 and α-Synuclein, but there is little information how these pathogenic proteins interact. We cloned human wild type 4 repeat Tau (Tau(wt)) and mutant Tau(P301L) into a lentivirus and performed stereotaxic injection
Jérôme Harambat et al.
Kidney international, 77(5), 443-449 (2009-12-18)
We sought to ascertain the long-term outcome and genotype-phenotype correlations available for primary hyperoxaluria type 1 in a large retrospective cohort study. We examined the clinical history of 155 patients (129 families primarily from Western Europe, North Africa, or the
H Roger Lijnen
Thrombosis and haemostasis, 93(5), 816-819 (2005-05-12)
Plasminogen activator inhibitor-1 (PAI-1) is the main physiological inhibitor of tissue-type (t-PA) and urokinase-type (u-PA) plasminogen activator. Recent studies in murine models have yielded apparently conflicting data on a potential role of PAI-1 in adipose tissue development and obesity. To
Karina Galoian et al.
Molecular and clinical oncology, 3(1), 171-178 (2014-12-04)
Disruption of cell-cell junctions and the concomitant loss of polarity, downregulation of tumor-suppressive adherens junctions and desmosomes represent hallmark phenotypes for several different cancer cells. Moreover, a variety of evidence supports the argument that these two common phenotypes of cancer
Benjamin Kest et al.
Mammalian genome : official journal of the International Mammalian Genome Society, 15(8), 610-617 (2004-10-01)
Chronic morphine exposure results in physical dependence, manifested by physical symptoms during naloxone-precipitated withdrawal. Jumping frequency is widely considered the most sensitive and reliable index of withdrawal intensity in mice. Inbred mouse strains surveyed for naloxone-precipitated withdrawal display large and
Ebymar Arismendi et al.
PloS one, 9(9), e107859-e107859 (2014-09-23)
Obesity is associated with low-grade systemic inflammation. The "inflammome" is a network layout of the inflammatory pattern. The systemic inflammome of obesity has not been described as yet. We hypothesized that it can be significantly worsened by smoking and other
Hong Xie et al.
Mutation research, 586(2), 160-172 (2005-08-23)
Hexavalent chromium (Cr(VI)) is a widespread environmental contaminant and a known human carcinogen, generally causing bronchial cancer. Recent studies have shown that the particulate forms of Cr(VI) are the potent carcinogens. Particulate Cr(VI) is known to induce a spectrum of
Daniel I Swerdlow et al.
Lancet (London, England), 385(9965), 351-361 (2014-09-30)
Statins increase the risk of new-onset type 2 diabetes mellitus. We aimed to assess whether this increase in risk is a consequence of inhibition of 3-hydroxy-3-methylglutaryl-CoA reductase (HMGCR), the intended drug target. We used single nucleotide polymorphisms in the HMGCR
Cheng-Ying Ho et al.
Neuro-oncology, 15(1), 69-82 (2012-11-20)
Pilocytic astrocytoma (PA) is a World Health Organization grade I glioma that occurs most commonly in children and young adults. Specific genetic alterations have been described in PA, but the pathogenesis remains poorly understood. We studied microRNA (miRNA) alterations in
Patrizia De Marco et al.
European journal of human genetics : EJHG, 11(3), 245-252 (2003-04-04)
Transport of folates in mammalian cells occurs by a carrier-mediated mechanism. The human folate carrier (RFC-1) gene has been isolated and characterized. Within this gene, a common polymorphism, 80A-->G, changing a histidine to an arginine in exon 2 (H27R), was
Onur Karsli et al.
Urolithiasis, 41(1), 9-13 (2013-03-28)
To describe the metabolic risk factors and investigate the effect of prophylaxis based on these factors on long-term recurrence of urolithiasis in pediatric patients with hypocitraturia. One-hundred and twenty-nine pediatric patients who underwent percutaneous nephrolithotomy between January 2008 and June
Patricia A Hingston et al.
Applied and environmental microbiology, 81(16), 5350-5362 (2015-05-31)
Listeria monocytogenes is a foodborne pathogen whose survival in food processing environments may be associated with its tolerance to desiccation. To probe the molecular mechanisms used by this bacterium to adapt to desiccation stress, a transposon library of 11,700 L.
Bardia Nourbakhsh et al.
The Lancet. Neurology, 20(1), 38-48 (2020-11-27)
Methylphenidate, modafinil, and amantadine are commonly prescribed medications for alleviating fatigue in multiple sclerosis; however, the evidence supporting their efficacy is sparse and conflicting. Our goal was to compare the efficacy of these three medications with each other and placebo
Ming-hua Yang et al.
Zhonghua er ke za zhi = Chinese journal of pediatrics, 48(3), 175-179 (2010-04-30)
Multidrug resistance (MDR) is one of the primary causes of suboptimal outcomes in chemotherapy of children with acute myeloblastic leukemia (AML). The mechanisms of drug transport resistance may chiefly contribute to MDR. Expression and/or activity of P-glycoprotein (P-gp), multiple resistance-associated
Liis Uusküla et al.
PloS one, 7(11), e49248-e49248 (2012-11-13)
Despite the importance of placenta in mediating rapid physiological changes in pregnancy, data on temporal dynamics of placental gene expression are limited. We completed the first transcriptome profiling of human placental gene expression dynamics (GeneChips, Affymetrix®; ~47,000 transcripts) from early
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