CN
Search Within
129935
应用筛选条件
关键词:'129935'
显示 1-9 共 9 条结果 关于 "129935" 范围 论文
David W Doo et al.
Therapeutic advances in medical oncology, 12, 1758835920913798-1758835920913798 (2020-04-22)
The Wnt/β-catenin pathway is linked to tumorigenesis in a variety of tumors and promotes T cell exclusion and resistance to checkpoint inhibitors. We sought to determine whether a small molecule inhibitor of this pathway, WNT974, would impair tumor growth, affect
Zili Zhang et al.
Autophagy, 16(8), 1482-1505 (2019-11-05)
Ferroptosis is a recently discovered form of programmed cell death, but its regulatory mechanisms remain poorly understood. Here, we show that the RNA-binding protein ZFP36/TTP (ZFP36 ring finger protein) plays a crucial role in regulating ferroptosis in hepatic stellate cells
Whitney N Goldsberry et al.
Cancers, 12(3) (2020-03-28)
In ovarian cancer, upregulation of the Wnt/β-catenin pathway leads to chemoresistance and correlates with T cell exclusion from the tumor microenvironment (TME). Our objectives were to validate these findings in an independent cohort of ovarian cancer subjects and determine whether
Yanhe Zhang et al.
Cancer cell international, 20(1), 556-556 (2020-12-10)
There is evidence that circSMYD4 is differentially expressed in hepatocellular carcinoma (HCC), but its mechanism of action remains unclear. Therefore, this study aimed to explore the role of circSMYD4 in the occurrence and development of HCC and its specific molecular
Huizhen Yang et al.
Cell biology international, 44(8), 1671-1680 (2020-04-14)
To better treat patients with non-small cell lung cancer (NSCLC), the investigations on novel molecules affecting NSCLC progression are of vital importance. Long noncoding RNAs (lncRNAs) are identified as pivotal regulators that can affect the cellular activities of carcinomas. Long
Annelise Y Mah-Som et al.
Cell reports, 35(9), 109209-109209 (2021-06-03)
Natural killer (NK) cell effector functions are dependent on metabolic regulation of cellular function; however, less is known about in vivo metabolic pathways required for NK cell antiviral function. Mice with an inducible NK-specific deletion of Cox10, which encodes a component
David W Doo et al.
Therapeutic advances in medical oncology, 12, 1758835920913798-1758835920913798 (2020-04-22)
The Wnt/β-catenin pathway is linked to tumorigenesis in a variety of tumors and promotes T cell exclusion and resistance to checkpoint inhibitors. We sought to determine whether a small molecule inhibitor of this pathway, WNT974, would impair tumor growth, affect
Xiao-Long Ma et al.
Cell death discovery, 7(1), 309-309 (2021-10-25)
Accumulating evidence has shown that circular RNA (circRNA) dysregulation is involved in various types of cancer, including osteosarcoma (OS). Nevertheless, the role and mechanism of circRNAs in OS progression and chemoresistance remain elusive. We found that a novel doxorubicin-induced circular
Huayu Zhu et al.
Science advances, 7(9) (2021-02-26)
Mechanical stimuli on cells and mechanotransduction are essential in many biological and pathological processes. Glucocorticoid is an important hormone, roles, and mechanisms of which in cellular mechanotransduction remain unknown. Here, we report that glucocorticoid counteracted cellular mechanoresponses dependently on a
1/1