130-17-6

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关键词:'130-17-6'

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Characteristics of TRK-130 (Naltalimide), a novel opioid ligand, as a new therapeutic agent for overactive bladder.

Morihiro Fujimura et al.

The Journal of pharmacology and experimental therapeutics, 350(3), 543-551 (2014-06-15)

We characterized TRK-130 (N-[(5R,6R,14S)-17-(cyclopropylmethyl)-4,5-epoxy-3,14-dihydroxymorphinan-6-yl]phthalimide; naltalimide), an opioid ligand, to clarify the therapeutic potential for overactive bladder (OAB). In radioligand-binding assays with cells expressing human µ-opioid receptors (MORs), δ-opioid receptors (DORs), or κ-opioid receptors (KORs), TRK-130 showed high selectivity for MORs

Evidence for altered activity of the IL-6 pathway in chronic rhinosinusitis with nasal polyps.

Anju T Peters et al.

The Journal of allergy and clinical immunology, 125(2), 397-403 (2010-02-18)

IL-6 activates T(H)17 cells and regulates the response of B lymphocytes and regulatory T cells. The IL-6 receptor and the membrane protein, glycoprotein 130 (gp130), form an active signaling complex that signals through signal transducer and activator of transcription 3

Molecular weight and molar substitution are more important in HES-induced renal impairment than concentration after hemorrhagic and septic shock.

T P Simon et al.

Minerva anestesiologica, 81(6), 608-618 (2014-10-10)

Clinical studies have raised concerns about the safety of 6% hydroxyethylstarch (HES) 130/0.42, but the pathomechanisms of this renal impairment remain unknown. To evaluate the effects of different HES concentrations, molar substitutions and molecular weights in HES-induced renal impairment, we

The alpha-A-crystallin and cystathionine beta-synthase genes are physically very closely linked in proximal mouse chromosome 17.

L Stubbs et al.

Genomics, 7(2), 284-288 (1990-06-01)

Murine genes homologous to those contributing to the Down syndrome (DS) phenotype in man are currently of interest because of their potential for providing animal models for the study of specific DS symptoms. Most of the genes mapping to human

Enantiomerically pure 1,3-dioxanes as highly selective NMDA and σ₁ receptor ligands.

Jens Köhler et al.

Journal of medicinal chemistry, 55(20), 8953-8957 (2012-09-28)

We synthesized and investigated the NMDA and σ₁ receptor affinity of enantiomerically pure 2-(2-phenyl-1,3-dioxan-4-yl)ethanamines 17-26. The primary amines (R,R)-18-20 with an axially oriented phenyl moiety in position 2 interacted with high enantioselectivity (eudismic ratios 70-130) and high affinity (K(i)((R,R)-19) =

Cytokine expression profiles in Autism spectrum disorder: A multi-center study from Turkey.

Meryem Ozlem Kutuk et al.

Cytokine, 133, 155152-155152 (2020-06-22)

Autism Spectrum Disorder (ASD) is a complex neurodevelopmental disorder characterized by impairments in communication and social interaction as well as restricted interests and repetitive behaviors. The pathogenesis of ASD is not completely understood, but a growing body of research has

Design and synthesis of new N-(fluorenyl-9-methoxycarbonyl) (Fmoc)-dipeptides as anti-inflammatory agents.

Chiao-Ting Yen et al.

European journal of medicinal chemistry, 44(5), 1933-1940 (2008-12-27)

Twenty-four new dipeptide analogs (1-24) of aurantiamide acetate were designed, synthesized, and assayed for effects on superoxide anion generation and elastase release by human neutrophils in response to fMLP/CB. Among them, seven N-(fluorenyl-9-methoxycarbonyl) (Fmoc)-dipeptides (6, 9, 12, 14, 17, 18

Prediction of in vivo clearance and associated variability of CYP2C19 substrates by genotypes in populations utilizing a pharmacogenetics-based mechanistic model.

Boyd Steere et al.

Drug metabolism and disposition: the biological fate of chemicals, 43(6), 870-883 (2015-04-08)

It is important to examine the cytochrome P450 2C19 (CYP2C19) genetic contribution to drug disposition and responses of CYP2C19 substrates during drug development. Design of such clinical trials requires projection of genotype-dependent in vivo clearance and associated variabilities of the

Add-on therapy with montelukast in the treatment of Henoch-Schönlein purpura.

Sheng-Hua Wu et al.

Pediatrics international : official journal of the Japan Pediatric Society, 56(3), 315-322 (2013-12-05)

Previous studies suggested that leukotrienes (LT) were involved in the pathogenesis of Henoch-Schönlein purpura (HSP). This study investigated the efficacy of an add-on therapy with montelukast in the treatment of HSP. In this four-center, double-blind, placebo-controlled, parallel paired comparative study

Decreased steroidogenic enzyme 17,20-lyase and increased 17-hydroxylase activities in type 2 diabetes mellitus.

Hajime Ueshiba et al.

European journal of endocrinology, 146(3), 375-380 (2002-03-13)

To analyze activities of adrenal steroidogenic enzymes in type 2 diabetes mellitus, serum levels of 11 steroid hormones were measured simultaneously. We studied 130 patients with type 2 diabetes mellitus (74 men and 56 women between the ages of 40

Interleukin-6-dependent influence of nociceptive sensory neurons on antigen-induced arthritis.

Matthias Ebbinghaus et al.

Arthritis research & therapy, 17, 334-334 (2015-11-22)

Interleukin-6 (IL-6) is an important mediator of inflammation. In addition to cells involved in inflammation, sensory nociceptive neurons express the IL-6 signal-transducer glycoprotein 130 (gp130). These neurons are not only involved in pain generation but also produce neurogenic inflammation by

Effect of sea anemone toxin anthopleurin-Q on sodium current in guinea pig ventricular myocytes.

L Y Fu et al.

Acta pharmacologica Sinica, 22(12), 1107-1112 (2001-12-26)

To investigate the effects of a sea anemone toxin anthopleurin-Q (AP-Q) isolated from Anthopleura xanthogrammica on sodium current (INa) in isolated guinea pig ventricular myocytes. Single myocytes were dissociated by enzymatic dissociation method. INa was recorded using whole-cell patch-clamp technique.

Mutation analysis of the human NR4A2 gene, an essential gene for midbrain dopaminergic neurogenesis, in schizophrenic patients.

Y H Chen et al.

American journal of medical genetics, 105(8), 753-757 (2002-01-23)

Recent studies have revealed that an orphan receptor gene of the steroid/thyroid hormone nuclear receptor superfamily, the Nurr1 gene, is essential for the neurogenesis and differentiation of dopaminergic neurons in the midbrain of mice. Transgenic mice lacking the Nurr1 gene

Quantitation of the mRNA levels of Epo and EpoR in various tissues in the ovine fetus.

R Bruce David et al.

Molecular and cellular endocrinology, 188(1-2), 207-218 (2002-03-26)

A partial cDNA of the sheep erythropoietin receptor (EpoR) was obtained and used in real-time PCR to quantitate mRNA levels in placenta, liver and kidney throughout development (term=150 days). This was compared with Epo mRNA levels in the same tissues.

Association study of paroxetine therapeutic response with SERT gene polymorphisms in patients with major depressive disorder.

Nada Bozina et al.

The world journal of biological psychiatry : the official journal of the World Federation of Societies of Biological Psychiatry, 9(3), 190-197 (2007-09-14)

We investigated the relationships between LS promoter (SERTPR) and ls intron2 (SERTin2) genetic variants of serotonin transporter (SERT) polymorphisms with treatment response in 130 patients with major depressive disorder (MDD) treated with paroxetine (20 mg/day) for 6 weeks. To assess

Search for Higgs Boson Decays into a Z Boson and a Light Hadronically Decaying Resonance Using 13 TeV pp Collision Data from the ATLAS Detector.

G Aad et al.

Physical review letters, 125(22), 221802-221802 (2020-12-15)

A search for Higgs boson decays into a Z boson and a light resonance in two-lepton plus jet events is performed, using a pp collision dataset with an integrated luminosity of 139 fb^{-1} collected at sqrt[s]=13 TeV by the ATLAS experiment at

Association of polymorphisms in the interleukin 6 receptor complex with obesity and hyperandrogenism.

Héctor F Escobar-Morreale et al.

Obesity research, 11(8), 987-996 (2003-08-15)

Interleukin-6 (IL-6), is an inflammatory cytokine that may influence the pathogenesis of obesity and hyperandrogenism. IL-6 exerts its actions through a heterodimeric receptor consisting of two membrane-bound glycoproteins: an 80-kDa IL-6 binding unit (IL6R-alpha) and a 130-kDa IL-6 signal transducer

355 nm multiphoton dissociation and ionization of 2, 5-dihydroxyacetophenone.

Yuri A Dyakov et al.

The journal of physical chemistry. A, 113(52), 14987-14994 (2009-12-24)

Multiphoton dissociation and ionization of 2,5-dihydroxyacetophenone (DHAP), an important matrix compound in UV matrix-assisted laser desorption/ionization (MALDI), is studied in a molecular beam at 355 nm using multimass ion imaging mass spectrometer and time-of-flight mass spectrometry. For laser fluence larger

The catalytic center of glucose-6-phosphatase. HIS176 is the nucleophile forming the phosphohistidine-enzyme intermediate during catalysis.

Abhijit Ghosh et al.

The Journal of biological chemistry, 277(36), 32837-32842 (2002-07-03)

Glucose-6-phosphatase (G6Pase), a key enzyme in glucose homeostasis, is anchored to the endoplasmic reticulum by nine transmembrane helices. The amino acids comprising the catalytic center of G6Pase include Lys(76), Arg(83), His(119), Arg(170), and His(176). During catalysis, a His residue in

Histamine-releasing activity and binding to the FcepsilonRI alpha human mast cell receptor subunit of mast cell degranulating peptide analogues with alanine substitutions.

A Buku et al.

Journal of medicinal chemistry, 46(14), 3008-3012 (2003-06-27)

We have investigated the effects on mast cell binding and the histamine-releasing activity of l-alanine substitutions for the five lysine residues and the proline residue in the MCD peptide (1) sequence. All synthesized analogues Ala(2) (2), Ala(6) (3), Ala(11) (4)

Differences in the frequency and distribution of BRCA1 and BRCA2 mutations in breast/ovarian cancer cases from the Basque country with respect to the Spanish population: implications for genetic counselling.

E Beristain et al.

Breast cancer research and treatment, 106(2), 255-262 (2007-01-31)

The prevalence of unique and recurrent BRCA1 and BRCA2 pathogenic mutations and unclassified variants varies among different populations. Two hundred and thirty-six breast and/or ovarian cancer patients were analysed to clarify the role of these genes in the Basque Country.

Cytokine profile in cervical mucosa of Japanese patients with cervical intraepithelial neoplasia.

Takashi Iwata et al.

International journal of clinical oncology, 20(1), 126-133 (2014-03-01)

Immune responses in the uterine cervix are considered to play an important role in persistent human papillomavirus (HPV) infection and carcinogenesis, but many aspects of the mechanism are still unclear. The goal of this study was to measure cytokines to

Restoration of thrombolytic potential in plasminogen-deficient mice by bolus administration of plasminogen.

H R Lijnen et al.

Blood, 88(3), 870-876 (1996-08-01)

Homozygous plasminogen-deficient (Plg-/-) mice had a significantly reduced thrombolytic capacity toward intravenously injected 125I-fibrin labeled plasma clots prepared from Plg-/- murine plasma (9% +/- 3% lysis after 8 hours; (mean +/- SEM, n = 6), as compared with 82% +/-

Primary genome scan to identify putative quantitative trait loci for feedlot growth rate, feed intake, and feed efficiency of beef cattle.

J D Nkrumah et al.

Journal of animal science, 85(12), 3170-3181 (2007-08-22)

Feed intake and feed efficiency of beef cattle are economically relevant traits. The study was conducted to identify QTL for feed intake and feed efficiency of beef cattle by using genotype information from 100 microsatellite markers and 355 SNP genotyped

Endothelium modulates anion channel-dependent aortic contractions to iodide.

F S Lamb et al.

American journal of physiology. Heart and circulatory physiology, 278(5), H1527-H1536 (2000-04-25)

Anion currents contribute to vascular smooth muscle (VSM) membrane potential. The substitution of extracellular chloride (Cl) with iodide (I) or bromide (Br) initially inhibited and then potentiated isometric contractile responses of rat aortic rings to norepinephrine. Anion substitution alone produced

RIII S/J (H-2r). An inbred mouse strain with a massive deletion of T cell receptor V beta genes.

T M Haqqi et al.

The Journal of experimental medicine, 169(6), 1903-1909 (1989-06-01)

We have identified an inbred strain of mouse, RIII S/J (H-2r), that has the largest known deletion of the TCR V beta genes by screening with mAb and TCR V beta specific probes. Upon screening of PBL with mAb F23.1

ZNF280BY and ZNF280AY: autosome derived Y-chromosome gene families in Bovidae.

Yang Yang et al.

BMC genomics, 12, 13-13 (2011-01-11)

Recent progress in exploring the Y-chromosome gene content in humans, mice and cats have suggested that "autosome-to-Y" transposition of the male fertility genes is a recurrent theme during the mammalian Y-chromosome evolution. These transpositions are lineage-dependent. The purpose of this

Increased renal production of angiotensin II and thromboxane B2 in conscious diabetic rats.

Alaa S Awad et al.

American journal of hypertension, 18(4 Pt 1), 544-548 (2005-04-16)

The mechanisms involved in development of cardiovascular complications associated with diabetes mellitus are not well elucidated. Among the vasoactive factors that may play a role in development of these complications are angiotensin II and thromboxane B2 (TXB2). We hypothesized that

Composition of the ovarian fluid in 4 salmonid species: Oncorhynchus mykiss, Salmo trutta f lacustris, Salvelinus alpinus and Hucho hucho.

F Lahnsteiner et al.

Reproduction, nutrition, development, 35(5), 465-474 (1995-01-01)

The ovarian fluid of rainbow trout (Oncorhynchus mykiss), charr (Salvelinus alpinus), lake trout (Salmo trutta f lacustris) and Danube salmon (Hucho hucho) was analyzed for its inorganic and organic composition. The qualitative composition of the ovarian fluid of the investigated

Extracellular matrix disturbances in acute myocardial infarction: relation between disease severity and matrix metalloproteinase-1, and effects of magnesium pretreatment on reperfusion injury.

Kenji Ueshima et al.

Magnesium research, 16(2), 120-126 (2003-08-02)

The purpose of this paper is to clarify the relationship between cytokines, matrix metalloproteinase-1 (MMP-1) and severity of acute myocardial infarction (AMI). Additionally, to investigate whether magnesium (Mg) sulfate pretreatment inhibits myocardial damage in coronary reperfusion therapy for patients with

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