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显示 1-30 共 945 条结果 关于 "130672" 范围 论文
Ching-Hsin Huang et al.
Advanced therapeutics, 3(6) (2021-03-02)
Mono- or dual-checkpoint inhibitors for immunotherapy have changed the paradigm of cancer care; however, only a minority of patients responds to such treatment. Combining small molecule immuno-stimulators can improve treatment efficacy, but they are restricted by poor pharmacokinetics. In this
Nicholas J Izzo et al.
PloS one, 9(11), e111898-e111898 (2014-11-13)
Synaptic dysfunction and loss caused by age-dependent accumulation of synaptotoxic beta amyloid (Abeta) 1-42 oligomers is proposed to underlie cognitive decline in Alzheimer's disease (AD). Alterations in membrane trafficking induced by Abeta oligomers mediates reduction in neuronal surface receptor expression
Haijun Tian et al.
Journal of cellular biochemistry, 116(4), 667-676 (2014-11-25)
Secreted phosphoprotein 24 kD (spp24) is a bone matrix protein isolated during attempts to identify osteogenic proteins. It is not osteogenic but performs other important roles in the regulation of bone metabolism, at least in part, by binding to and affecting
Yun Liu et al.
Scientific reports, 5, 12864-12864 (2015-08-11)
We demonstrate a fiber optic surface plasmon resonance (SPR) biosensor based on smart phone platforms. The light-weight optical components and sensing element are connected by optical fibers on a phone case. This SPR adaptor can be conveniently installed or removed
Denis V Yashin et al.
The Journal of biological chemistry, 290(35), 21724-21731 (2015-07-18)
Tag7 (also known as peptidoglycan recognition protein PGRP-S, PGLYRP1), an innate immunity protein, interacts with Hsp70 to form a stable Tag7-Hsp70 complex with cytotoxic activity against some tumor cell lines. In this study, we have analyzed the programmed cell death
Ji-hye Lee et al.
Drug delivery and translational research, 5(2), 146-159 (2015-03-20)
The concept of guided bone regeneration facilitated by barrier membranes has been widely considered to achieve enhanced bone healing in maxillofacial surgery. However, the currently available membranes are limited in their active regulation of cellular activities. In this study, we
In-Cheol Sun et al.
Pharmaceutical research, 31(6), 1418-1425 (2013-08-13)
The application of gold nanoparticles (AuNPs) in biomedical field was limited due to the low stability in the biological condition. Herein, to enhance stability and tumor targeting ability of AuNPs, their surface was modified with biocompatible glycol chitosan (GC) and
Pengkai Ma et al.
International journal of nanomedicine, 10, 2173-2190 (2015-04-04)
Antibody-dendrimer conjugates have the potential to improve the targeting and release of chemotherapeutic drugs at the tumor site while reducing adverse side effects caused by drug accumulation in healthy tissues. In this study, trastuzumab (TMAB), which binds to human epidermal
Ping Yang et al.
Chemistry (Weinheim an der Bergstrasse, Germany), 18(30), 9294-9299 (2012-06-30)
Multifunctional Ag@Au@ phenol formaldehyde resin (PFR) particles loaded with folic acids (FA) have been designed for killing tumor cells through photothermy conversion under the irradiation of near-infrared (NIR) light. Possessing the virtue of good fluorescence, low toxicity, and good targeting
Maike G Müller et al.
Infection and immunity, 83(4), 1257-1264 (2015-01-15)
The ability of the human bacterial pathogen Neisseria meningitidis to cause invasive disease depends on survival in the bloodstream via mechanisms to suppress complement activation. In this study, we show that prophage genes coding for T and B cell stimulating
Natasha Buwa et al.
FEBS letters, 595(4), 532-547 (2020-12-15)
Integrin-mediated adhesion regulates cellular responses to changes in the mechanical and biochemical properties of the extracellular matrix. Cell-matrix adhesion regulates caveolar endocytosis, dependent on caveolin 1 (Cav1) Tyr14 phosphorylation (pY14Cav1), to control anchorage-dependent signaling. We find that cell-matrix adhesion regulates
Huile Gao et al.
Molecular pharmaceutics, 11(8), 2755-2763 (2014-07-02)
Gliomas are hard to treat because of the two barriers involved: the blood-brain barrier and blood-tumor barrier. In this study, a dual-targeting ligand, angiopep-2, and an activatable cell-penetrating peptide (ACP) were functionalized onto nanoparticles for glioma-targeting delivery. The ACP was
Yajie Gao et al.
Pharmaceutical research, 32(8), 2649-2662 (2015-02-14)
The purpose of the present study was to design and fabricate endosomal pH-sensitive dual-ligand-modified micellar nanoparticles to achieve enhanced drug delivery to tumor cells and facilitated intracellular drug release. End-group-carboxylated poly(2-ethyl-2-oxazoline)-poly(D,L-lactide) and cyclic Arg-Gly-Asp-Tyr-Lys- and anti-prostate specific membrane antigen antibody-modified
Claire Valotteau et al.
ACS applied materials & interfaces, 7(32), 18086-18095 (2015-08-08)
Classical antibacterial surfaces usually involve antiadhesive and/or biocidal strategies. Glycosylated surfaces are usually used to prevent biofilm formation via antiadhesive mechanisms. We report here the first example of a glycosylated surface with biocidal properties created by the covalent grafting of
Adam J McShane et al.
Journal of the American Society for Mass Spectrometry, 25(10), 1694-1704 (2014-08-06)
Direct reductive methylation of peptides is a common method for quantitative proteomics. It is an active derivatization technique; with participation of the dimethylamino group, the derivatized peptides preferentially release intense a1 ions. The advantageous generation of a1 ions for quantitative
Polycyclic Aromat. Compd., 3, 781-781 (1993)
Christopher P Landowski et al.
PloS one, 10(8), e0134723-e0134723 (2015-08-27)
The filamentous fungus Trichoderma reesei has tremendous capability to secrete proteins. Therefore, it would be an excellent host for producing high levels of therapeutic proteins at low cost. Developing a filamentous fungus to produce sensitive therapeutic proteins requires that protease
Soner Donmez et al.
Applied biochemistry and biotechnology, 176(5), 1431-1444 (2015-05-08)
An electrochemical nucleic acid biosensor based on label-free DNA detection method was prepared for the first time by using electropolymerized poly(L-glutamic acid)-modified pencil graphite electrode (PGA/PGE) for detection of hepatitis C virus genotype 1a (HCV1a). Inosine-substituted 20-mer probes related to
Nopporn Sawatjui et al.
Materials science & engineering. C, Materials for biological applications, 52, 90-96 (2015-05-09)
Tissue engineering is becoming promising for cartilage repair due to the limited self-repair capacity of cartilage tissue. We previously fabricated and characterized a three-dimensional silk fibroin/gelatin-chondroitin sulfate-hyaluronic acid (SF-GCH) scaffold and showed that it could promote proliferation of human bone
Christopher J Silva
Prion, 6(2), 163-173 (2012-03-23)
PrP(Sc) is an infectious protein. The only experimentally verified difference between PrP(Sc) and its normal cellular isoform (PrP(C)) is conformational. This work describes an approach to determining the presence of surface exposed or sequestered amino acids present in the PrP(Sc)
Kara L Spiller et al.
Biomaterials, 37, 194-207 (2014-12-03)
In normal tissue repair, macrophages exhibit a pro-inflammatory phenotype (M1) at early stages and a pro-healing phenotype (M2) at later stages. We have previously shown that M1 macrophages initiate angiogenesis while M2 macrophages promote vessel maturation. Therefore, we reasoned that
Ana C M Fernandes Patta et al.
International journal of biological macromolecules, 148, 550-564 (2020-01-21)
The production of efficient micro and nanoparticles of pH-responsive and mucoadhesive properties is of high scrutiny. We produced a drug carrier bioparticle providing such structural features. Thereby, protonated chitosan bearing chemically bonded arginine was interacted with ionized alginate, leading to
Rajdeep Banerjee et al.
Proceedings of the National Academy of Sciences of the United States of America, 112(10), 3062-3067 (2015-02-26)
Several Plasmodium species exhibit a strong age-based preference for the red blood cells (RBC) they infect, which in turn is a major determinant of disease severity and pathogenesis. The molecular basis underlying this age constraint on the use of RBC
Abdul R Al-Azri et al.
Journal of oral pathology & medicine : official publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology, 44(6), 459-467 (2014-09-13)
Matrix metalloproteinases (MMPs) are involved in both maintenance of healthy mucosa and mediation of several pathologies. Recently, MMPs and their inhibitors have attracted attention as potential mediators of mucositis. We investigated tissue expression of MMP-3 and MMP-9 over time in
Shefaat Ullah Shah et al.
Expert opinion on drug delivery, 12(8), 1209-1223 (2015-03-26)
The aim of this work is to synthesize a novel stable and biodegradable nitric oxide (NO) donor polymer based on a chitosan backbone. This polymer needed to be linked to glutathione (GSH), which was nitrosated in a second step. This
Kuldeep Kumar Bansal et al.
Pharmaceutics, 12(8) (2020-08-05)
Biodegradable polymers from renewable resources have attracted much attention in recent years within the biomedical field. Lately, poly(δ-decalactone) based copolymer micelles have emerged as a potential drug delivery carrier material as a sustainable alternative to fossil-based polymers. However, their intracellular
Hisako Hikiji et al.
Journal of materials science. Materials in medicine, 25(6), 1531-1538 (2014-02-28)
Rapid and efficient animal models are needed for evaluating the effectiveness of many new candidate bone regenerative materials. We developed an in vivo model screening for calvarial bone regeneration in lipopolysaccharide (LPS)-treated mice, in which materials were overlaid on the
Leilei Li et al.
International journal of biological macromolecules, 78, 17-22 (2015-03-24)
In this current work, a novel functional ionic liquid-coated Fe3O4@chitosan@graphene oxide was synthesized and tested as adsorbents for methylene blue through batch adsorption tests. The physicochemical properties of the adsorbent were investigated using scanning electron microscopy, x-ray diffraction, and fourier
Min Li et al.
Colloids and surfaces. B, Biointerfaces, 131, 191-201 (2015-05-20)
Drug loading is a key procedure in the preparation of drug-loaded nano-carriers. In this study, the paclitaxel (PTX)-loaded polymeric complex micelles (FA-P123-PTX/PTX micelles) with double drug-loading strategies were designed and prepared to improve the drug loading percentage of carriers and
Jun Arii et al.
Journal of virology, 89(3), 1879-1888 (2014-11-28)
Nonmuscle myosin heavy chain IIA (NMHC-IIA) has been reported to function as a herpes simplex virus 1 (HSV-1) entry coreceptor by interacting with viral envelope glycoprotein B (gB). Vertebrates have three genetically distinct isoforms of the NMHC-II, designated NMHC-IIA, NMHC-IIB
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