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Hector Corominas et al.
Medicina clinica, 126(11), 410-412 (2006-04-06)
Thiopurine S-methyltransferase (TPMT) metabolizes thiopurine drugs regulating their cytotoxicity and clinical response. TPMT activity is inherited as an autosomal recessive trait and several mutations in the TPMT gene have been identified which correlate with a low activity phenotype. A variable
Andreza Camilotti Dionisio et al.
Chemosphere, 151, 17-29 (2016-03-01)
Abamectin is a broad-spectrum antiparasitic agent that has been widely employed in veterinary medicine and has also been used as a pesticide in agriculture. Veterinary drugs may reach the soil and may be transported to surface and ground waters, posing
W Bender et al.
Development (Cambridge, England), 127(18), 3981-3992 (2000-08-23)
P elements containing a 7 kb DNA fragment from the middle of the Drosophila bithorax complex insert preferentially into the bithorax complex or into the adjacent chromosome regions. This 'homing' property is similar to that reported for the engrailed promoter
J F Watchko et al.
Journal of applied physiology (Bethesda, Md. : 1985), 82(5), 1416-1423 (1997-05-01)
Creatine kinase (CK) is an enzyme central to cellular high-energy phosphate metabolism in muscle. To characterize the physiological role of CK in respiratory muscle during dynamic contractions, we compared the force-velocity relationships, power, and work output characteristics of the diaphragm
C Borup et al.
Alimentary pharmacology & therapeutics, 45(11), 1433-1442 (2017-04-06)
Bile acid diarrhoea is underdiagnosed and better diagnostic tests are needed. Fasting serum fibroblast growth factor-19 (FGF19) has insufficient diagnostic value, but this may be improved by stimulation. To explore if an impaired FGF19 response identifies primary bile acid diarrhoea.
Boyd Steere et al.
Drug metabolism and disposition: the biological fate of chemicals, 43(6), 870-883 (2015-04-08)
It is important to examine the cytochrome P450 2C19 (CYP2C19) genetic contribution to drug disposition and responses of CYP2C19 substrates during drug development. Design of such clinical trials requires projection of genotype-dependent in vivo clearance and associated variabilities of the
Emilia Cantón et al.
Journal of clinical microbiology, 50(12), 3921-3926 (2012-09-28)
The Sensititre YeastOne (SYO) method is a widely used method to determine the susceptibility of Candida spp. to antifungal agents. CLSI clinical breakpoints (CBP) have been reported for antifungals, but not using this method. In the absence of CBP, epidemiological
Jefferson Pessoa Hemerly et al.
European journal of endocrinology, 163(5), 747-755 (2010-08-13)
Somatic mutations at residue R132 of isocitrate dehydrogenase 1 (IDH1) were recently discovered in gliomas and leukaemia at a high frequency. IDH1 is a metabolic gene, and the R132 mutations create a new enzymatic activity. To determine whether IDH1 had
Teguh Haryo Sasongko et al.
The Kobe journal of medical sciences, 51(3-4), 41-47 (2006-01-20)
The angiotensin converting enzyme (ACE) gene carries insertion (I) and deletion (D) polymorphism within its intron 16. The presence of D-allele in the ACE gene has been reported as a probable genetic risk factor for idiopathic nephrotic syndrome (INS), especially
Spontaneous and induced primary oncogenesis in natural killer (NK)-cell-deficient beige mutant mice.
T Haliotis et al.
International journal of cancer, 35(4), 505-513 (1985-04-15)
Spontaneous tumor development and primary oncogenesis were compared in a large number of NK4-deficient, homozygous C57Bl/6-bg/bg mice and their NK normal, heterozygous +/bg littermate controls. In a group of 167 retired breeders followed for spontaneous tumors, the probability of survival
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