14-349

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Two additive mechanisms impair the differentiation of 'substrate-selective' p38 inhibitors from classical p38 inhibitors in vitro.

Bart S Hendriks et al.

BMC systems biology, 4, 23-23 (2010-03-17)

The success of anti-TNF biologics for the treatment of rheumatoid arthritis has highlighted the importance of understanding the intracellular pathways that regulate TNF production in the quest for an orally-available small molecule inhibitor. p38 is known to strongly regulate TNF

Kinome inhibition reveals a role for polo-like kinase 1 in targeting post-transcriptional control in cancer.

Qamraa H Al-Qahtani et al.

Molecular oncology, 15(8), 2120-2139 (2021-01-08)

Dysfunctions in post-transcriptional control are observed in cancer and chronic inflammatory diseases. Here, we employed a kinome inhibitor library (n = 378) in a reporter system selective for 3'-untranslated region-AU-rich elements (ARE). Fifteen inhibitors reduced the ARE-reporter activity; among the targets is

A single autophosphorylation site confers oncogenicity to the Neu/ErbB-2 receptor and enables coupling to the MAP kinase pathway.

Ben-Levy, R, et al.

The Embo Journal, 13, 3302-3311 (1994)

Serine 727 phosphorylation and activation of cytosolic phospholipase A2 by MNK1-related protein kinases.

Y Hefner et al.

The Journal of biological chemistry, 275(48), 37542-37551 (2000-09-09)

We have previously reported that in thrombin-stimulated human platelets, cytosolic phospholipase A(2) (cPLA2) is phosphorylated on Ser-505 by p38 protein kinase and on Ser-727 by an unknown kinase. Pharmacological inhibition of p38 leads to inhibition of cPLA2 phosphorylation at both

MAPKAP kinase-2; a novel protein kinase activated by mitogen-activated protein kinase.

D Stokoe et al.

The EMBO journal, 11(11), 3985-3994 (1992-11-01)

A novel protein kinase, which was only active when phosphorylated by the mitogen-activated protein kinase (MAP kinase), has been purified 85,000-fold to homogeneity from rabbit skeletal muscle. This MAP kinase activated protein kinase, termed MAPKAP kinase-2, was distinguished from S6

The substrate specificity and structure of mitogen-activated protein (MAP) kinase-activated protein kinase-2.

D Stokoe et al.

The Biochemical journal, 296 ( Pt 3), 843-849 (1993-12-15)

The substrate specificity of mitogen-activated protein (MAP) kinase-activated protein kinase-2 (MAPKAP kinase-2) was investigated by using synthetic peptides related to the N-terminus of glycogen synthase. The minimum sequence required for efficient phosphorylation was found to be Xaa-Xaa-Hyd-Xaa-Arg-Xaa-Xaa-Ser-Xaa-Xaa, where Hyd is

Keratins as susceptibility genes for end-stage liver disease.

Nam-On Ku et al.

Gastroenterology, 129(3), 885-893 (2005-09-07)

Keratins 8 and 18 protect the liver from stress. Keratin 8 and 18 variants in 17 of 467 liver disease explants and 2 of 349 blood bank controls were previously reported in 5 analyzed exonic regions. We asked whether mutations

Mitochondrial dysfunction and free radical damage in the Huntington R6/2 transgenic mouse.

S J Tabrizi et al.

Annals of neurology, 47(1), 80-86 (2000-01-13)

Huntington's disease is a progressive neurodegenerative disease caused by an abnormally expanded (>36) CAG repeat within the ITI5 gene encoding a widely expressed 349-kd protein, huntingtin. The medium spiny neurons of the caudate preferentially degenerate in Huntington's disease, with the

Sequence of the amino-terminal 349 residues of rabbit muscle glycogen phosphorylase including the sites of covalent and allosteric control.

A Koide et al.

Biochemistry, 17(26), 5657-5672 (1978-12-26)

The sequence of the amino-terminal 349 residues of rabbit muscle glycogen phosphorylase (EC 2.4.1.1) has been determined. Limited proteolysis of native phosphorylase b (841 residues, subunit molecular weight 97 412) by subtilisin BPN', Streptomyces alkaline protease, or elastase yielded two

Methods to assess changes in the pattern of nuclear phosphoinositides.

Nullin Divecha

Methods in molecular biology (Clifton, N.J.), 645, 165-177 (2010-07-21)

Phosphatidylinositol (PtdIns) and its phosphorylated derivatives represent less than 5% of total membrane phospholipids in cells. Despite their low abundance, they form a dynamic signalling system that is regulated in response to a variety of extra and intra-cellular cues (Curr

Prion protein gene (PRNP) polymorphisms in native Chinese cattle.

Hui Zhao et al.

Genome, 53(2), 138-145 (2010-02-09)

Polymorphisms in four regions of the bovine prion protein gene (PRNP) confer susceptibility to bovine spongiform encephalopathy (BSE). These polymorphisms include a 23-bp insertion/deletion (indel) in the promoter region, a 12-bp indel in intron 1, an octapeptide repeat or 24-bp

Molecular cloning, chromosomal localization, and functional characterization of a human liver Na+/bile acid cotransporter.

B Hagenbuch et al.

The Journal of clinical investigation, 93(3), 1326-1331 (1994-03-01)

We have used a cDNA probe from a cloned rat liver Na+/taurocholate cotransporting polypeptide (Ntcp) to screen a human liver cDNA library. A 1,599-bp cDNA clone that encodes a human Na+/taurocholate cotransporting polypeptide (NTCP) was isolated. The human NTCP consists

Choline status is not a reliable indicator of moderate changes in dietary choline consumption in premenopausal women.

Christian M Abratte et al.

The Journal of nutritional biochemistry, 20(1), 62-69 (2008-05-23)

For the prevention of liver dysfunction in women, a choline adequate intake of 425 mg/day was established. To date, the relationship between dietary choline intake and plasma concentrations of choline moieties remains relatively unexplored. As an extension of our previous

The human alpha-fetoprotein gene. Sequence organization and the 5' flanking region.

M Sakai et al.

The Journal of biological chemistry, 260(8), 5055-5060 (1985-04-25)

The human alpha-fetoprotein (AFP) gene was isolated into three overlapping clones in bacteriophage lambda vectors and its sequence organization analyzed by restriction endonuclease mapping and nucleotide sequencing. The human AFP gene is about 20 kilobase pairs long and contains 15

Quantitative trait loci for clinical mastitis on chromosomes 2, 6, 14 and 20 in Norwegian Red cattle.

M Sodeland et al.

Animal genetics, 42(5), 457-465 (2011-09-13)

Mastitis is the most frequent and costly disease in dairy production and solutions leading to a reduction in the incidence of mastitis are highly demanded. Here a genome-wide association study was performed to identify polymorphisms affecting susceptibility to mastitis. Genotypes

Standardized centile curves and reference intervals of serum insulin-like growth factor-I (IGF-I) levels in a normal Japanese population using the LMS method.

Tsuyoshi Isojima et al.

Endocrine journal, 59(9), 771-780 (2012-06-08)

Measurements of insulin-like growth factor-I (IGF-I) are useful not only for diagnosis and management of patients with growth hormone (GH)-related disorders but also for assessing nutritional status. We reported population-based references of serum IGF-I in 1996. However, they did not

Characterization of mannose-binding lectin gene polymorphism among human T-cell lymphotropic virus 1 and 2-infected asymptomatic subjects.

G S Pontes et al.

Human immunology, 66(8), 892-896 (2005-10-12)

The present study investigated the association between mannose-binding lectin (MBL) gene polymorphism and the susceptibility to human T-cell lymphotropic virus (HTLV) infection in a group of 83 HTLV-infected asymptomatic subjects (62 HTLV-1 and 21 HTLV-2) and 99 healthy controls. Detection

Cloning, expression and characterization of an A6-related protein.

A Rohwer et al.

European journal of biochemistry, 263(2), 518-525 (1999-07-17)

By interaction cloning (yeast two-hybrid system) using the catalytic domain of protein kinase Czeta (PKCzeta) as bait, we cloned a human full-length cDNA with 62% nucleotide homology to the A6 protein recently cloned and characterized by Beeler et al. [Beeler

Genetic variants in phosphatidylethanolamine N-methyltransferase and methylenetetrahydrofolate dehydrogenase influence biomarkers of choline metabolism when folate intake is restricted.

Alexandre Ivanov et al.

Journal of the American Dietetic Association, 109(2), 313-318 (2009-01-27)

Choline is a required nutrient with roles in liver and brain function, lipid metabolism, and fetal development. Recent data suggest that choline requirements may be altered by polymorphisms in the phosphatidylethanolamine N-methyltransferase (PEMT) gene (ie, 5465G-->A; rs7946 and -744G-->C; rs12325817)

PSORS2 is due to mutations in CARD14.

Catherine T Jordan et al.

American journal of human genetics, 90(5), 784-795 (2012-04-24)

Psoriasis is a common, immune-mediated genetic disorder of the skin and is associated with arthritis in approximately 30% of cases. Previously, we localized PSORS2 (psoriasis susceptibility locus 2) to chromosomal region 17q25.3-qter after a genome-wide linkage scan in a family

Serum C reactive protein levels and genetic variation in the CRP gene are not associated with the prevalence, incidence or progression of osteoarthritis independent of body mass index.

Hanneke J M Kerkhof et al.

Annals of the rheumatic diseases, 69(11), 1976-1982 (2010-06-01)

To study the relationship between serum C reactive protein (CRP) levels, genetic variation in the CRP gene and the prevalence, incidence and progression of radiographic osteoarthritis (ROA) in the Rotterdam Study-I (RS-I). A systematic review of studies assessing the relationship

Identification and characterization of miRNAs involved in cold acclimation of zebrafish ZF4 cells.

Xiangqin Ji et al.

PloS one, 15(1), e0226905-e0226905 (2020-01-11)

MicroRNAs (miRNAs) play vital roles in various biological processes under multiple stress conditions by leading to mRNA cleavage or translational repression. However, the detailed roles of miRNAs in cold acclimation in fish are still unclear. In the present study, high-throughput

Genetic repeat polymorphism in the regulating region of CYP2E1: frequency and relationship with enzymatic activity in alcoholics.

E Plee-Gautier et al.

Alcoholism, clinical and experimental research, 25(6), 800-804 (2001-06-19)

Differences in the regulatory region of the CYP2E1 gene could be responsible for the interindividual variation in the cytochrome P-450 2E1 (CYP2E1) involved in ethanol oxidation. Recently, a polymorphic repeat sequence in the human gene was described between -2178 and

Hospitalization costs for acute myocardial infarction patients treated with percutaneous coronary intervention in the United States are substantially higher than Medicare payments.

Majed Afana et al.

Clinical cardiology, 38(1), 13-19 (2014-10-23)

Acute coronary syndromes account for half of all deaths secondary to cardiovascular disease and represent a significant economic burden in the United States. Therefore, assessing hospitalization costs relative to Medicare reimbursement for these patients is important in understanding the impact

Identification and characterization of insulin-like growth factors (IGFs), IGF-binding proteins (IGFBPs), and IGFBP proteases in human synovial fluid.

T Matsumoto et al.

The Journal of clinical endocrinology and metabolism, 81(1), 150-155 (1996-01-01)

The insulin-like growth factors (IGFs) and IGF-binding proteins (IGFBPs) in human synovial fluid play an important role in maintaining articular cartilage metabolism. In this study we measured the concentrations of IGF-I, IGF-II, and IGFBP-3 in normal human synovial fluid by

Reduced Carotenoid and Retinoid Concentrations and Altered Lycopene Isomer Ratio in Plasma of Atopic Dermatitis Patients.

Renata Lucas et al.

Nutrients, 10(10) (2018-10-03)

Carotenoids and retinoids are known to alter the allergic response with important physiological roles in the skin and the immune system. In the human organism various carotenoids are present, some of which are retinoid precursors. The bioactive derivatives of these

Differential effects of B2 receptor antagonists upon bradykinin-stimulated phospholipase C and D in guinea-pig cultured tracheal smooth muscle.

S Pyne et al.

British journal of pharmacology, 110(1), 477-481 (1993-09-01)

1. Guinea-pig tracheal smooth muscle cells were isolated and maintained in culture for 14-21 days prior to the study of the effect of a selective bradykinin B1 agonist and B2 antagonists upon bradykinin-stimulated phospholipase C and D activities. 2. Bradykinin-stimulated

Third-line antiretroviral therapy in low-income and middle-income countries (ACTG A5288): a prospective strategy study.

Beatriz Grinsztejn et al.

The lancet. HIV, 6(9), e588-e600 (2019-08-03)

Antiretroviral therapy (ART) management is challenging for individuals in resource-limited settings presenting for third-line treatment because of complex resistance patterns, partly due to reduced access to viral load monitoring. We aimed to evaluate use of newer antiretroviral drugs and contemporary

Bisphosphonates or RANK-ligand-inhibitors for men with prostate cancer and bone metastases: a network meta-analysis.

Tina Jakob et al.

The Cochrane database of systematic reviews, 12, CD013020-CD013020 (2020-12-04)

Different bone-modifying agents like bisphosphonates and receptor activator of nuclear factor-kappa B ligand (RANKL)-inhibitors are used as supportive treatment in men with prostate cancer and bone metastases to prevent skeletal-related events (SREs). SREs such as pathologic fractures, spinal cord compression

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