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Suneela S Dhaneshwar et al.
European journal of medicinal chemistry, 44(10), 3922-3929 (2009-05-16)
Colon-specific mutual azo prodrugs of 5-aminosalicylic acid with essential amino acids were synthesized for the management of inflammatory bowel disease. The structures were confirmed by elemental and spectral analyses. 85-88% release of 5-aminosalicylic acid was achieved in rat fecal matter
Joseph I Kang et al.
Chemical research in toxicology, 17(9), 1236-1244 (2004-09-21)
Recent studies have shown that reactive chlorine species, derived from myeloperoxidase-mediated inflammation responses, can modify DNA bases, generating 5-chloropyrimidines. The chlorinated adducts could be mutagenic or perturb DNA-protein interactions; however, the biological significance of these adducts is as yet unknown.
Sanka N Atapattu et al.
Journal of chromatography. A, 1195(1-2), 136-145 (2008-05-27)
An iteration procedure is used to optimize the solute descriptors for 94 compounds suitable for characterizing the retention properties of open-tubular columns for gas chromatography in the intermediate temperature range of 160-240 degrees C. These solute descriptors are used to
Amir E Wahba et al.
ACS pharmacology & translational science, 4(2), 680-686 (2021-04-17)
DNA methylation has a major role in cancer, and its inhibitors are used therapeutically. DNA methylation depends on methyl group flux through the transmethylation pathway, which forms adenosine. We hypothesized that an adenosine kinase isoform with nuclear expression (ADK-L) determines
Jun Hang et al.
The Journal of biological chemistry, 280(25), 23675-23683 (2005-04-26)
Tissue transglutaminase belongs to the multigene transglutaminase family of Ca2+-dependent protein cross-linking enzymes. Unlike other transglutaminases, it is involved in cell-matrix interactions and serves as an adhesion co-receptor for fibronectin. Previous work established that the fibronectin-binding motif(s) is located within
Harold J Burstein et al.
Investigational new drugs, 25(2), 161-164 (2006-09-14)
Rebeccamycin analog (NSC 655649) is a synthetic antibiotic cytotoxic agent thought to inhibit topoisomerase function. We sought to determine the response rate to rebeccamycin analog among patients with refractory advanced breast cancer using two different treatment schedules. Eligible patients had
T L Peeters et al.
Naunyn-Schmiedeberg's archives of pharmacology, 343(2), 202-208 (1991-02-01)
Recent studies suggested that certain erythromycin A (EM-A) derivatives are motilin receptor agonists. As proposed by Itoh they may be called "motilides". We have investigated the Ca2(+)-dependence of contractions induced by two potent motilides, ME-34 [de(N-methyl) 8,9-anhydroeryhtromycin A 6,9-hemiacetal] and
Splice variant HE4-V3 expression is associated with favorable prognosis in pulmonary adenocarcinoma.
Keita Tokuishi et al.
Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine, 33(1), 103-109 (2011-10-22)
The human epididymis 4 (HE4) gene product, also known as whey-acidic-protein four-disulfide core domain protein 2, was identified as the transcript expressed in the epididymis and respiratory tract. HE4 is also expressed in lung adenocarcinoma. We investigated mRNA expressions of
Tianzhu Qin et al.
Journal of contaminant hydrology, 230, 103598-103598 (2020-01-04)
This study presents a pore-scale investigation of two-phase flow dynamics during nanofluid flooding in subsurface formations containing non-aqueous phase liquids (NAPLs) such as crude oils. The goal was to gain fundamental understanding of the dominant displacement mechanisms of NAPL at
Lei Cai et al.
Oncotarget, 8(23), 37646-37656 (2017-04-22)
Pancreatic ductal adenocarcinoma (PDAC) has one of the poorest prognosis among malignancies. Thus, the identification of markers useful in developing innovative diagnostic and therapeutic methods is an imperative need. Folate receptor alpha (FRα) has been associated with prognosis in several
Martina Dieber-Rotheneder et al.
Life sciences, 91(13-14), 710-715 (2012-05-15)
Preeclampsia (PE), fetal growth restriction (FGR) and gestational diabetes mellitus (GDM) are major pregnancy complications affecting maternal and fetal health. The placenta and the vasoconstrictor endothelin-1 (ET-1) have a controlling and mediating role in these conditions. This study tested the
Xiaogang Tan et al.
Clinical cancer research : an official journal of the American Association for Cancer Research, 17(21), 6802-6811 (2011-09-06)
Recent studies have suggested that microRNA biomarkers could be useful for stratifying lung cancer subtypes, but microRNA signatures varied between different populations. Squamous cell carcinoma (SCC) is one major subtype of lung cancer that urgently needs biomarkers to aid patient
Béatrice Teylaert et al.
BMC biotechnology, 11, 1-1 (2011-01-07)
The rat hybridoma cell line YB2/0 appears a good candidate for the large-scale production of low fucose recombinant mAbs due to its lower expression of fut8 gene than other commonly used rodent cell lines. However, important variations of the fucose
Ralf Biebinger et al.
The British journal of nutrition, 102(9), 1362-1369 (2009-08-06)
Adverse sensory changes prevent the addition of highly bioavailable ferrous sulfate (FeSO4) to most wheat flours. Poorly absorbable reduced Fe powders are commonly used. Encapsulation of FeSO4 can overcome these sensory changes, but the particle size of commercial compounds is
F Denoyelle et al.
Lancet (London, England), 353(9161), 1298-1303 (1999-04-28)
DFNB1, the locus of an autosomal recessive form of deafness due to mutations in the connexin-26 gene (CX26 or GJB2) is one of the most frequent hereditary defects in human beings. To date, no clinical characterisation of the DFNB1 inner-ear
Gary M Williams et al.
Regulatory toxicology and pharmacology : RTP, 53(1), 6-15 (2008-10-22)
Ethyl acrylate (EA) is an acrylic monomer used in the manufacture of a variety of polymers and copolymers as components of many commercially important products. Human exposure to EA occurs primarily in the workplace via inhalation or dermal contact. In
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