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D Matas et al.
Cell death and differentiation, 11(4), 458-467 (2004-01-10)
While it is well accepted that p53 plays a role in apoptosis, less is known as to its involvement in cell differentiation. Here we show that wild-type p53 facilitates IL-6-dependent macrophage differentiation. Treatment of M1/2 cells expressing the temperature-sensitive p53
Masayuki Fujinaga et al.
Journal of medicinal chemistry, 58(3), 1513-1523 (2015-01-21)
Metabotropic glutamate 1 (mGlu1) receptor is found not only in the brain but also in melanomas and breast cancers. mGlu1 is a promising target for molecular imaging-based diagnosis and treatment of melanoma because its overexpression induces melanocyte carcinogenesis. Here we
Ota Fuchs et al.
Blood cells, molecules & diseases, 40(3), 401-405 (2008-01-10)
The transcription factor CCAAT/enhancer binding protein (C/EBP)alpha is a myeloid-specific transcription factor which is required for normal myeloid differentiation. C/EBPalpha is encoded by an intronless gene that is 2783 bp long and maps to human chromosome 19q13.1. C/EBPalpha is a
Min Pan et al.
Journal of investigative medicine : the official publication of the American Federation for Clinical Research, 59(2), 272-276 (2010-12-16)
Interleukin 6 (IL-6) is a cytokine involved in different physiologic and pathophysiologic processes, and circulating levels of IL-6 differ greatly between individuals, but the results have not always been concordant among diverse populations. The aim of present study was to
Xilin Wu et al.
Nature medicine, 29(1), 190-202 (2023-01-17)
Primary aldosteronism (PA) due to a unilateral aldosterone-producing adenoma is a common cause of hypertension. This can be cured, or greatly improved, by adrenal surgery. However, the invasive nature of the standard pre-surgical investigation contributes to fewer than 1% of
Faye N Hant et al.
The Journal of rheumatology, 36(4), 773-780 (2009-03-17)
To assess whether serum concentrations of surfactant protein D (SP-D) and Krebs von den Lungen-6 (KL-6), glycoproteins expressed by type II pneumocytes, correlate with the presence of "alveolitis" and measures of lung function in patients enrolled in the Scleroderma Lung
Francesco Buccisano et al.
Blood, 116(13), 2295-2303 (2010-06-16)
A total of 143 adult acute myeloid leukemia (AML) patients with available karyotype (K) and FLT3 gene mutational status were assessed for minimal residual disease (MRD) by flow cytometry. Twenty-two (16%) patients had favorable, 115 (80%) intermediate, and 6 (4%)
Suk Keun Lee et al.
Molecules and cells, 15(2), 216-225 (2003-06-14)
Ameloblastin (also designated amelin and sheathlin) is an enamel matrix protein expressed within the ameloblast lineage. In this study we analyzed the structure of the rat ameloblastin gene and characterized its subtypes. The promoter sequence contains several E-box-like elements, and
P J Kretschmer et al.
Growth factors (Chur, Switzerland), 5(2), 99-114 (1991-01-01)
This report describes the cloning, expression and characterization of two members of a novel human gene family of proteins, HBNF and MK, which exhibit neurite outgrowth-promoting activity. The HBNF cDNA gene codes for a 168-residue protein which is a precursor
Chonglin Song et al.
Chemosphere, 79(11), 1033-1039 (2010-04-27)
This paper presents an investigation of the carbonyl emissions from a direct injection heavy-duty diesel engine fueled with pure diesel fuel (DF) and blended fuel containing 15% by volume of ethanol (E/DF). The tests have been conducted under steady-state operating
Thomas D Dreesen et al.
Prostaglandins, leukotrienes, and essential fatty acids, 75(2), 97-106 (2006-07-19)
The rate limiting steps in the conversion of 18-carbon unsaturated fatty acids to 20- and 22-carbon products are catalyzed by two desaturase enzymes (Delta5-desaturase and Delta6-desaturase) found within a lipid desaturase gene cluster. Careful examination of this cluster revealed the
T T Yohe et al.
Journal of dairy science, 102(9), 8502-8512 (2019-07-08)
Diet is known to affect rumen growth and development. Calves fed an all-liquid diet have smaller and less developed rumens and a decreased ability to absorb volatile fatty acids (VFA) compared to calves fed both liquid and dry feed. However
A C Wong et al.
Neuroscience, 89(1), 221-233 (1999-03-02)
The neuromodulatory actions of dopamine in the striatum and nucleus accumbens are likely to depend on the distribution of dopamine receptors on individual postsynaptic cells. To address this, we have visualized D1- and D2-like receptors on living medium-spiny GABAergic neurons
Marianne Udd et al.
Brain and behavior, 7(7), e00737-e00737 (2017-07-22)
Continuous levodopa-carbidopa intestinal gel (LCIG) diminishes daily "off" time and dyskinesia in patients with advanced Parkinson's disease (PD). Complications are common with percutaneous endoscopic gastrostomy with a jejunal extension tube (PEG-J). To report the clinical outcome of LCIG in patients
Jesus San Miguel et al.
The Lancet. Oncology, 14(11), 1055-1066 (2013-09-07)
Few effective treatments exist for patients with refractory or relapsed and refractory multiple myeloma not responding to treatment with bortezomib and lenalidomide. Pomalidomide alone has shown limited efficacy in patients with relapsed multiple myeloma, but synergistic effects have been noted
Bjørn-Erik Bertelsen et al.
Journal of the Endocrine Society, 4(6), bvaa047-bvaa047 (2020-06-06)
Current analytical routine methods lack the sensitivity to monitor plasma estrogen levels in breast cancer patients treated with aromatase inhibitors. Such monitoring is warranted for premenopausal patients treated with an aromatase inhibitor and an LH-releasing hormone analogue in particular. Therefore
Sonnich Meier et al.
Comparative biochemistry and physiology. Toxicology & pharmacology : CBP, 145(3), 420-430 (2007-03-09)
Offshore oil production releases large amounts of lipophilic compounds in produced water into the ocean. In 2004, 143 million m(3) produced water, containing approximately 13 tons of long-chain (>C(4)) alkylphenols (AP), was discharged from installations in the Norwegian sector of
Shun-ying Yang et al.
Gene, 555(2), 305-317 (2014-12-03)
Ammonium is the main inorganic nitrogen source in paddy soil. Rice (Oryza sativa), an ammonium-preferring and -tolerant grain crop, is a valuable resource for researching ammonium-uptake mechanism and understanding the molecular networks that the plant copes with ammonium variation. To
Katharina Judith Wild et al.
Journal of animal physiology and animal nutrition, 102(5), 1306-1319 (2018-07-08)
The chemical composition of 16 microalgae products of four genera, Arthrospira (n = 2), Chlorella (n = 8), Nannochloropsis (n = 4) and Phaeodactylum (n = 2), was assayed to evaluate the intra- and inter-genera variation of nutrient profiles of commercial microalgae products. Crude protein was the main
Md Munir Hossain et al.
BMC genomics, 10, 443-443 (2009-09-22)
MicroRNAs are the major class of gene-regulating molecules playing diverse roles through sequence complementarity to target mRNAs at post-transcriptional level. Tightly regulated expression and interaction of a multitude of genes for ovarian folliculogenesis could be regulated by these miRNAs. Identification
Helen E Davies et al.
JAMA, 307(22), 2383-2389 (2012-05-23)
Malignant pleural effusion causes disabling dyspnea in patients with a short life expectancy. Palliation is achieved by fluid drainage, but the most effective first-line method has not been determined. To determine whether indwelling pleural catheters (IPCs) are more effective than
Jürgen Knapp et al.
Shock (Augusta, Ga.), 43(6), 576-581 (2015-02-24)
The immunosuppressant drug cyclosporine A (CsA) is a direct inhibitor of the mitochondrial permeability transition pore, which is the common end point of many pathways of ischemic preconditioning and postconditioning. We studied the neuroprotective and cardioprotective effect of CsA after
Tao Jiang et al.
Clinical drug investigation, 33(1), 1-9 (2012-11-28)
Citalopram is a selective serotonin reuptake inhibitor (SSRI) mainly prescribed to treat major depression. The aim of this study was to compare the pharmacokinetic characteristics of a new and a branded citalopram 20 mg formulation to support the marketing authorization
Yanjun Zhang et al.
The Lancet. Infectious diseases, 21(2), 181-192 (2020-11-21)
With the unprecedented morbidity and mortality associated with the COVID-19 pandemic, a vaccine against COVID-19 is urgently needed. We investigated CoronaVac (Sinovac Life Sciences, Beijing, China), an inactivated vaccine candidate against COVID-19, containing inactivated severe acute respiratory syndrome coronavirus 2
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