1449-70-3

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Nucleotide sequence of cloned cDNA for human sphingolipid activator protein 1 precursor.

N N Dewji et al.

Proceedings of the National Academy of Sciences of the United States of America, 84(23), 8652-8656 (1987-12-01)

Two cDNA clones encoding prepro-sphingolipid activator protein 1 (SAP-1) were isolated from a lambda gt11 human hepatoma expression library using polyclonal antibodies. These had inserts of approximately 2 kilobases (lambda-S-1.2 and lambda-S-1.3) and both were both homologous with a previously

Population pharmacokinetic analysis of istradefylline in healthy subjects and in patients with Parkinson's disease.

William Knebel et al.

Journal of clinical pharmacology, 51(1), 40-52 (2010-03-05)

This model-based analysis quantifies the population pharmacokinetics (PK) of orally administered istradefylline, a selective adenosine A(2A) receptor antagonist, in healthy subjects and patients with Parkinson's disease, including the estimation of covariate effects on istradefylline PK parameters. Istradefylline plasma concentration data

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