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National Cancer Institute carcinogenesis technical report series, 11, 1-88 (1977-01-01)
A bioassay of the chelating agent, trisodium ethylenediaminetetraacetate trihydrate (Na3EDTA.3H2O), for possible carcinogenicity was conducted by administering the test material in feed to Fischer 344 rats and B6C3F1 mice. The chemical was administered to 50 males and 50 females of
Jong-Pil Park et al.
Circulation journal : official journal of the Japanese Circulation Society, 74(2), 332-336 (2009-12-17)
The relationship between plasma biomarkers and vulnerable plaque is not well understood. The 188 patients who underwent 3-vessel virtual histology (VH) intravascular ultrasound (IVUS) with peripheral blood sampling were enrolled. Plasma levels of matrix metalloproteinase 2 and 9 (MMP-2, -9)
Gian Luca Vita et al.
Frontiers in molecular neuroscience, 13, 102-102 (2020-07-14)
Transthyretin variant amyloidosis (ATTRv) is a rare autosomal dominant disease characterized by the accumulation of amyloid in many organs, mostly causing a sensory-motor neuropathy, cardiomyopathy, and dysautonomia. The aim of the study was to report microRNAs (miRNAs) expression profile identified
Anne Goodeve et al.
Blood, 109(1), 112-121 (2006-09-21)
Type 1 von Willebrand disease (VWD) is characterized by a personal and family history of bleeding coincident with reduced levels of normal plasma von Willebrand factor (VWF). The molecular basis of the disorder is poorly understood. The aims of this
S De Franco et al.
International journal of immunopathology and pharmacology, 20(3), 567-576 (2007-09-21)
The Fas death receptor triggers lymphocyte apoptosis through an extrinsic and an intrinsic pathway involving caspase-8 and -9 respectively. Inherited defects of Fas function are displayed by a proportion of patients with Type 1 diabetes mellitus (T1DM) especially those with
Betul Emine Derinkuyu et al.
Brain & development, 39(3), 211-217 (2016-11-16)
Central tegmental tract is an extrapyramidal tract between red nucleus and inferior olivary nucleus which is located in the tegmentum pontis bilaterally and symmetrically. The etiology of the presence of central tegmental tract hyperintensity on MRI is unclear. In this
Atsuyuki Kurashima et al.
Kekkaku : [Tuberculosis], 85(10), 743-756 (2010-11-11)
This is a review of non-clinical and clinical study results of rifabutin (Mycobutin, RBT) which was approved as a new anti-mycobacterial agent 38 years after rifampicin (RFP) was approved in Japan. The anti-bacterial actions of RBT were similar to those
Mariella Carrieri et al.
Archives of toxicology, 81(7), 529-532 (2007-02-08)
Nonfatal acute inhalation of trichloroethylene (TRI) at work was described. The subject, male, 54 years old, was drawn unconscious by a metal-degreasing machine and immediately sheltered in intensive care unit. Other than basic life support and common laboratory indices, blood
Patrick Gladding et al.
JACC. Cardiovascular interventions, 2(11), 1095-1101 (2009-11-21)
Our aim was to assess whether a higher clopidogrel maintenance dose has a greater antiplatelet effect in CYP2C19*2 allele carriers compared with noncarriers. Clopidogrel is a prodrug that is biotransformed by the cytochrome P450 enzymes CYP2C19, 2C9, and 3A4, 2B6
Mo Yuan et al.
Renal failure, 39(1), 465-473 (2017-04-11)
Anti-pentraxin 3 (PTX3) auto-antibodies were found to be associated with the absence of renal involvement in systemic lupus erythematosus (SLE). This study is to investigate the prevalence of anti-PTX3 auto-antibodies and their clinical significance based on a large Chinese lupus
R Meatherall
Journal of analytical toxicology, 23(3), 177-186 (1999-06-16)
A procedure for the simultaneous confirmation of codeine, morphine, 6-acetylmorphine, hydrocodone, hydromorphone, oxycodone, and oxymorphone in urine specimens by gas chromatography-mass spectrometry (GC-MS) is described. After the addition of nalorphine and naltrexone as the two internal standards, the urine is
A Leyton et al.
Journal of applied microbiology, 127(4), 1069-1079 (2019-06-27)
To evaluate an aqueous extract of Macrocystis pyrifera as a nutrient source for the production of carotenoids by a marine Rhodotorula mucilaginosa isolated from seaweed samples. The effect of different culture conditions on the concentration of biomass and total pigments
Reed M Stein et al.
Nature, 579(7800), 609-614 (2020-02-11)
The neuromodulator melatonin synchronizes circadian rhythms and related physiological functions through the actions of two G-protein-coupled receptors: MT1 and MT2. Circadian release of melatonin at night from the pineal gland activates melatonin receptors in the suprachiasmatic nucleus of the hypothalamus
Silvia Casarotto et al.
Annals of neurology, 80(5), 718-729 (2016-11-03)
Validating objective, brain-based indices of consciousness in behaviorally unresponsive patients represents a challenge due to the impossibility of obtaining independent evidence through subjective reports. Here we address this problem by first validating a promising metric of consciousness-the Perturbational Complexity Index
Timothy J Jorgensen et al.
Cancer chemotherapy and pharmacology, 59(6), 725-732 (2006-09-13)
ABT-751 is an orally active antimitotic agent that is currently in Phase II clinical trials. This agent binds to the colchicine site on ss-tubulin and inhibits polymerization of microtubules. This disruption of microtubule dynamics leads to a block in the
Alejandra Nieto et al.
Experimental eye research, 116, 161-168 (2013-09-17)
Porous silicon (pSi) microparticles have been investigated for intravitreal drug delivery and demonstrated good biocompatibility. With the appropriate surface chemistry, pSi can reside in vitreous for months or longer. However, ocular distribution and clearance pathway of its degradation product, silicic
Bettina M Foidl et al.
Frontiers in aging neuroscience, 10, 113-113 (2018-05-05)
Alzheimer's disease (AD) is a progressive neurodegenerative disorder of the brain, characterized by extracellular aggregation of beta-amyloid (Aβ) and hyperphosphorylation of tau causing intraneuronal neurofibrillary tangles (NFTs). There is urgent need to study the interactions between Aβ and tau, especially
G P Frick et al.
Endocrinology, 131(6), 3083-3090 (1992-12-01)
Two mRNA transcripts that are believed to be alternately spliced products of the GH receptor gene have been reported in a variety of rat tissues. The smaller (1.2 kilobases) transcript was cloned from an adipocyte library, sequenced, and found to
D R Clemmons et al.
The Journal of clinical endocrinology and metabolism, 73(4), 727-733 (1991-10-11)
Insulin-like growth factor binding protein-2 (IGFBP-2) is one of a family of IGFBPs that are present in extracellular fluids, and binds both IGF-II and IGF-I with high affinity. These studies were conducted to determine the nutritional and hormonal variables that
Shuangjie Leow et al.
Hematological oncology, 29(4), 211-219 (2011-03-10)
FMS-like tyrosine kinase 3 (FLT3) is critical for normal haematopoiesis and have been reported to be expressed in the majority of acute myeloid and lymphoid malignancies. We correlated the impact of FLT3 mutations and its expression with age, WHO 2008
Henrik Hasseldam et al.
Journal of neuroinflammation, 13(1), 246-246 (2016-09-16)
Multiple sclerosis is widely accepted as an inflammatory disease. However, studies indicate that degenerative processes in the CNS occur prior to inflammation. In the widely used animal model experimental autoimmune encephalomyelitis (EAE), we investigated the significance of degenerative processes from
Sina Gallo et al.
JAMA, 309(17), 1785-1792 (2013-05-02)
Vitamin D supplementation in infancy is required to support healthy bone mineral accretion. A supplement of 400 IU of vitamin D per day is thought to support plasma 25-hydroxyvitamin D (25[OH]D) concentrations between 40 and 50 nmol/L; some advocate 75
Rabea Hinkel et al.
Circulation, 117(17), 2232-2240 (2008-04-23)
Prolonged myocardial ischemia results in cardiomyocyte loss despite successful revascularization. We have reported that retrograde application of embryonic endothelial progenitor cells (eEPCs) provides rapid paracrine protection against ischemia-reperfusion injury. Here, we investigated the role of thymosin beta4 (Tbeta4) as a
Maria Muravyeva et al.
Anesthesiology, 120(4), 870-879 (2013-12-19)
Diabetes alters mitochondrial bioenergetics and consequently disrupts cardioprotective signaling. The authors investigated whether mitochondrial DNA (mtDNA) modulates anesthetic preconditioning (APC) and cardiac susceptibility to ischemia-reperfusion injury by using two strains of rats, both sharing nuclear genome of type 2 diabetes
Jesus San Miguel et al.
The Lancet. Oncology, 14(11), 1055-1066 (2013-09-07)
Few effective treatments exist for patients with refractory or relapsed and refractory multiple myeloma not responding to treatment with bortezomib and lenalidomide. Pomalidomide alone has shown limited efficacy in patients with relapsed multiple myeloma, but synergistic effects have been noted
Karl B Scheidweiler et al.
Analytical and bioanalytical chemistry, 407(3), 883-897 (2014-09-17)
Clandestine laboratories constantly produce new synthetic cannabinoids to circumvent legislative scheduling efforts, challenging and complicating toxicological analysis. Sundstrom et al. (Anal Bioanal Chem 405(26):8463-8474, [9]) and Kronstrand et al. (Anal Bioanal Chem 406(15):3599-3609, [10]) published nontargeted liquid chromatography, high-resolution, quadrupole/time-of-flight
H Tinnerberg et al.
American Industrial Hygiene Association journal, 58(3), 229-235 (1997-03-01)
Comparative air measurements of toluene diisocyanate (TDI) were performed in a 5.6 m3 standard atmosphere and at a TDI flexible foam plant. Air samples were collected in midget impinger flasks containing 9-(N-methyl-amino-methyl)-anthracene (MAMA) in toluene and on 13-mm glass-fiber filters
M Robinson et al.
Cancer letters, 48(3), 197-203 (1989-12-01)
Several chlorinated acetones have been identified in drinking water and these, as well as a number of chlorinated acroleins, are produced by chlorination of humic acid solutions. Many of these chlorinated compounds and the brominated acrolein analog were positive in
Fiona Wong et al.
Environmental science & technology, 45(3), 876-881 (2011-01-05)
Shipboard measurements of organohalogen compounds in air and surface seawater were conducted in the Canadian Arctic in 2007-2008. Study areas included the Labrador Sea, Hudson Bay, and the southern Beaufort Sea. High volume air samples were collected at deck level
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