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Frances V Hundley et al.
Molecular cell, 81(6), 1319-1336 (2021-02-05)
The human ubiquitin proteasome system, composed of over 700 ubiquitin ligases (E3s) and deubiquitinases (DUBs), has been difficult to characterize systematically and phenotypically. We performed chemical-genetic CRISPR-Cas9 screens to identify E3s/DUBs whose loss renders cells sensitive or resistant to 41
Julie Schwartz et al.
The Journal of experimental biology, 222(Pt 13) (2019-06-22)
In Protostoma, the diuretic hormone 31 (DH31) signalling system was long considered as the orthologue of the chordate calcitonin (CT) signalling system. Using the Pacific oyster (Crassostrea gigas) transcriptomic database GigaTON, we characterized seven G-protein-coupled receptors (GPCRs) named Cragi-CTR1-7 and
Liu De et al.
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie, 128, 110291-110291 (2020-06-12)
The antitumor activity of atypical adamantyl retinoid ST1926 has been frequently reported in cancer studies; nevertheless, its effect on glioma has not been fully understood. Mitochondria are critical in regulating tumorigenesis and are defined as a promising target for anti-tumor
Yutao Yan et al.
Antioxidants & redox signaling, 32(7), 429-446 (2019-12-08)
Aims: Carbon monoxide (CO) confers antiproliferative effects on T cells; however, how these effects are produced remains unclear. Reactive
Shenglong Zhu et al.
Nutrition and cancer, 72(4), 696-707 (2019-07-30)
Kudingcha is implicated in alleviating metabolic disorders in traditional Chinese medicine. However, the role of Kudingcha, one of the Ligustrum robustum species, in metabolic regulations and its antitumor activity in triple-negative breast cancer (TNBC) remains to be determined. Two breast
Kohei Yamashita et al.
Antimicrobial agents and chemotherapy, 63(8) (2019-06-12)
The novel arylamidine T-2307 exhibits broad-spectrum in vitro and in vivo antifungal activities against clinically significant pathogens. Previous studies have shown that T-2307 accumulates in yeast cells via a specific polyamine transporter and disrupts yeast mitochondrial membrane potential. Further, it
Pamela Maher
Antioxidants (Basel, Switzerland), 10(1) (2021-01-21)
Although the hallmarks of Alzheimer's disease (AD) are amyloid beta plaques and neurofibrillary tangles, there is growing evidence that neuroinflammation, mitochondrial dysfunction and oxidative stress play important roles in disease development and progression. A major risk factor for the development
Sam C Nalle et al.
PloS one, 15(11), e0238484-e0238484 (2020-11-25)
Antigen cross presentation, whereby exogenous antigens are presented by MHC class I molecules to CD8+ T cells, is essential for generating adaptive immunity to pathogens and tumor cells. Following endocytosis, it is widely understood that protein antigens must be transferred
Pamela R Hall et al.
Antimicrobial agents and chemotherapy, 52(6), 2079-2088 (2008-04-09)
Viral entry into susceptible host cells typically results from multivalent interactions between viral surface proteins and host entry receptors. In the case of Sin Nombre virus (SNV), a New World hantavirus that causes hantavirus cardiopulmonary syndrome, infection involves the interaction
Rui Tang et al.
Journal of natural medicines, 74(1), 153-158 (2019-08-23)
The core of solid tumors is characterized by hypoxia and a nutrient-starved microenvironment and has gained much attention as targets of anti-cancer drugs. In the course of search for selective growth inhibitors against the cancer cells adapted to nutrient starvation
Karen Page et al.
Journal of peptide science : an official publication of the European Peptide Society, 13(12), 833-838 (2007-08-30)
Human amylin (1-37) and the (1-13) fragment were synthesized with and without pseudoproline dipeptides. Thallium (III) trifluoroacetate, a mild oxidant, was used to cyclize the peptides by forming a disulfide bridge from C(2) to C(7). On the basis of our
Cuihua Hu et al.
Molecular pharmaceutics, 16(2), 561-572 (2018-12-29)
The chimeric peptide HPRP-A1-iRGD, composed of a chemically conjugated tumor-homing/penetration domain (iRGD) and a cationic anticancer peptide domain (HPRP-A1), was used to study the effect of targeted modification to enhance the peptide's specificity, penetration, and tumor accumulation ability. The iRGD
Jianmin Chen et al.
Toxicology, 222(3), 195-201 (2006-04-06)
Particulate air pollution is associated with respiratory and cardiovascular morbidity and mortality. However, important uncertainties remain in the quantification of extrapulmonary translocation of ultrafine particles into blood circulation. Therefore, the widely used radioiodinated technique was applied to radiolabel polystyrene particles
Journal of the Chemical Society. Chemical Communications, 163-163 (1987)
Richa Bajpai et al.
Nature communications, 11(1), 1228-1228 (2020-03-08)
The BCL-2 antagonist venetoclax is highly effective in multiple myeloma (MM) patients exhibiting the 11;14 translocation, the mechanistic basis of which is unknown. In evaluating cellular energetics and metabolism of t(11;14) and non-t(11;14) MM, we determine that venetoclax-sensitive myeloma has
Baoyi Zhu et al.
Cell communication and signaling : CCS, 18(1), 19-19 (2020-02-06)
Neutrophils form the first line of innate host defense against invading microorganisms. We previously showed that F0F1 ATP synthase (F-ATPase), which is widely known as mitochondrial respiratory chain complex V, is expressed in the plasma membrane of human neutrophils and
Studies on peptides. CLVI. Synthesis of second human calcitonin gene-related peptide (beta-hCGRP) by application of a new disulfide-bonding reaction with thallium (III) trifluoroacetate.
N Fujii et al.
Chemical & pharmaceutical bulletin, 35(12), 4769-4776 (1987-12-01)
Shuna Cui et al.
mSphere, 5(2) (2020-04-17)
Candida albicans adapts to various conditions in different body niches by regulating gene expression, protein synthesis, and metabolic pathways. These adaptive reactions not only allow survival but also influence the interaction with host cells, which is governed by the composition
J Yoon et al.
Journal of physiology and pharmacology : an official journal of the Polish Physiological Society, 71(1) (2020-06-20)
Ataxia telangiectasia (A-T) is an inherited neurodegenerative disease caused by mutation in the ataxia telangiectasia mutated (ATM) gene, leading to loss of function in the encoded protein ATM. Because ATM functions to reduce oxidative stress by up-regulating antioxidant enzymes, oxidative
H Lamthanh et al.
International journal of peptide and protein research, 41(1), 85-95 (1993-01-01)
The acetamidomethyl (Acm) group is a widely used protecting group for the thiol of cysteine during the SPPS process. We prepared the amino terminal loop of the snake alpha-neurotoxin, [Cys3,Cys23, Ser17](1-24) amide, from the linear peptide [Cys(Acm)3,23,Ser17](1-24) amide obtained by
Tetrahedron, 44, 805-805 (1988)
Takako Ikeda et al.
Biochimica et biophysica acta. Bioenergetics, 1861(11), 148281-148281 (2020-08-01)
It is well known that the disruption of the mitochondrial respiratory components prolongs lifespan in many species. The mitochondrial stress response can lead to an increased survival rate through the restoration of the cellular homeostasis. Therefore, developing pharmacological interventions that
Taylor, E. C.; Katz, A. H. et al.
Tetrahedron Letters, 26, 5963-5963 (1985)
Studies on peptides. CLI. Syntheses of cystine-peptides by oxidation of S-protected cysteine-peptides with thallium(III) trifluoroacetate.
N Fujii et al.
Chemical & pharmaceutical bulletin, 35(6), 2339-2347 (1987-06-01)
Deacon, G. B.; Smith, R. N. M.
Journal of Fluorine Chemistry, 15, 85-85 (1980)
Mathieu Vernier et al.
Genes & development, 34(7-8), 544-559 (2020-02-23)
Excessive reactive oxygen species (ROS) can cause oxidative stress and consequently cell injury contributing to a wide range of diseases. Addressing the critical gaps in our understanding of the adaptive molecular events downstream ROS provocation holds promise for the identification
Rui Tang et al.
Journal of natural medicines, 74(2), 495-500 (2020-02-01)
Cancer cells adapted to the microenvironment in tumor such as hypoxic and nutrient-starved conditions are now paid much attention as the therapeutic target of cancer. In the course of search for selective cytotoxic substances against cancer cells adapted to nutrient
Luis Julià et al.
Magnetic resonance in chemistry : MRC, 49(4), 164-167 (2011-03-26)
Electron paramagnetic resonance (EPR) analysis of neutral and acidic solutions of 2,5-dimethyl-1-phenylpyrrol (1) and meta-, para-, and ortho-bis(2,5-dimethylpyrrol-1-yl)benzenes (4-6) in the presence of Tl(III) trifluoroacetate as oxidant reveals the poor stability of their generated monomeric radical cations which dimerize through
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