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Chem. Abstr., 113, 210350s-210350s (1990)
Asma Kheirollahi et al.
Naunyn-Schmiedeberg's archives of pharmacology, 387(12), 1199-1208 (2014-09-28)
With the aim of discovering potential cytotoxic agents, a series of benzochromene derivatives were screened for their cytotoxic activity against seven human cancer cell lines by standard 3-(4, 5-dimethyl thiazol)-2,5-diphenyl tetrazolium bromide (MTT) assay. Apoptosis, as the mechanism of cell
Azfar Jamal et al.
Cell cycle (Georgetown, Tex.), 14(16), 2688-2700 (2015-06-04)
E3 ubiquitin ligases have been implicated in the ubiquitination and proteasome-mediated degradation of several key regulators of cell cycle. Owing to their pleotropic behavior, E3 ubiquitin ligases are tightly regulated both at transcriptional and post-translational levels. The E3 ubiquitin ligase
Mark McDonald et al.
Biochimica et biophysica acta, 1848(7), 1451-1461 (2015-04-04)
Gad-1 and Gad-2 are antimicrobial peptide (AMP) sequences encoded by paralogous genes. They are rich in histidine, which suggests that their activity might be pH-dependent. We examined their structure-function relationships with a view to learning how to improve AMP therapeutic
Eita Sasaki et al.
Nature, 510(7505), 427-431 (2014-05-13)
Sulphur is an essential element for life and is ubiquitous in living systems. Yet how the sulphur atom is incorporated into many sulphur-containing secondary metabolites is poorly understood. For bond formation between carbon and sulphur in primary metabolites, the major
Zhiyang Jia
OncoTargets and therapy, 8, 1561-1565 (2015-07-08)
The objective of the present investigation was to investigate the role of integrin-linked kinase (ILK) in the gemcitabine-resistant lung cancer cell line A549 and explore the underlying mechanism. Gemcitabine-resistant A549 (A549/GemR) cell line was established by pulse-exposed to moderate concentration
Ranjana Mitra et al.
The Prostate, 75(5), 527-538 (2015-01-15)
The central role of androgen receptor (AR) signaling is established in prostate cancer growth and progression. We propose CYP3A5 is part of a feedback loop that modulates the sensitivity of AR to androgen exposure. The purpose of this study is
Mohammad Sayed Alam et al.
Chemical & pharmaceutical bulletin, 62(12), 1259-1268 (2014-12-03)
A novel series of 2-arylidenehydrazinyl-4-arylthiazole analogues (3a-p) was designed and synthesized in excellent yields using a rapid, simple, efficient methodology. Sixteen novel compounds were screened for in vitro antimicrobial activities against eleven bacteria, namely, Staphylococcus aureus, Listeria monocytogenes, Enterococcus faecalis
Ryan M Sheehy et al.
Cancer biology & therapy, 16(8), 1259-1268 (2015-06-06)
Schweinfurthins are intriguing natural products with anti-cancer activities and as yet incompletely understood mechanisms of action. We investigated whether inhibitors of P-glycoprotein (Pgp), in a manner analogous to other natural products, might enhance schweinfurthins' growth inhibitory actions by increasing intracellular
Maria Hayashi et al.
Journal of nutritional science and vitaminology, 61(3), 270-274 (2015-08-01)
The biosynthetic pathways of the thiazole moiety of thiamin were studied in the archaeon Halobacterium salinarum. Thiamin is generated by the union of 4-amino-5-hydroxymethyl-2-methylpyrimidine (pyrimidine) and 5-(2-hydroxyethyl)-4-methylthiazole (thiazole). The biosynthesis of thiazole is different in facultative anaerobes, aerobes and eukaryotes.
Yukiko Kiniwa et al.
PloS one, 10(5), e0124094-e0124094 (2015-05-21)
Immunotherapy has emerged as a promising strategy for the treatment of metastatic melanoma. Clinical studies have demonstrated the feasibility of cancer immunotherapy using tumor antigens recognized by CD8(+) T cells. However, the overall immune responses induced by these antigens are
Shruthi Vaidhyanathan et al.
Drug metabolism and disposition: the biological fate of chemicals, 42(8), 1292-1300 (2014-05-31)
Brain metastases are a major cause of mortality in patients with advanced melanoma. Adequate brain distribution of targeted agents for melanoma will be critical for treatment success. Recently, improvement in overall survival led to US Food and Drug Administration (FDA)
Yan Liu et al.
Microbial cell factories, 14, 50-50 (2015-04-18)
The filamentous fungus Acremonium chrysogenum is an important industrial fungus and is used in the production of the β-lactam antibiotic cephalosporin C. Little is known regarding the molecular and biological mechanisms of how this industrial strain was improved by mutagenesis
Thiazole and oxazole peptides: biosynthesis and molecular machinery.
R S Roy et al.
Natural product reports, 16(2), 249-263 (1999-05-20)
Lisa Nezvitsky et al.
American journal of physiology. Renal physiology, 307(5), F634-F647 (2014-07-25)
The unfolded protein response and endoplasmic reticulum-associated degradation (ERAD) contribute to injury in renal glomerular diseases, including those mediated by complement C5b-9. In the present study, we address the role of protein-tyrosine phosphatase 1B (PTP1B) in complement-mediated glomerular injury and
Chem. Abstr., 105, 189645q-189645q (1986)
Lebensm. Wiss. Technol., 19, 122-122 (1986)
Koryo, 165, 91-91 (1990)
Mahesh D Pawar et al.
Materials science & engineering. C, Materials for biological applications, 48, 126-137 (2015-01-13)
The rationale of this work is to develop new bioactive thermoresponsive polyblend nanofiber formulations for wound healing (topical). Various polymer compositions of thermoresponsive, poly(N-isopropylacrylamide), egg albumen and poly(ε-caprolactone) blend solutions with and without a drug [gatifloxacin hydrochloride, Gati] were prepared.
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