153842

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Towards high-throughput identification of endocrine disrupting compounds with mass spectrometry.

Cédric Bovet et al.

Toxicology in vitro : an international journal published in association with BIBRA, 23(4), 704-709 (2009-02-24)

High-mass matrix-assisted laser desorption/ionization mass spectrometry (MALDI-MS) combined with chemical cross-linking has the ability to monitor the ligand-dependent dimerization of the human estrogen receptor alpha ligand binding domain (hERalpha LBD) in solution. Because only ER ligands enhance the homodimer abundance

Single-laboratory validation of a method for the determination of phenols and phenates in disinfectant formulations by liquid chromatography with UV detection.

Tommy Phillips et al.

Journal of AOAC International, 93(3), 1039-1045 (2010-07-16)

A single-laboratory validation study was conducted for an LC method using UV detection for the simultaneous determination of the active ingredients o-phenylphenol (OPP), p-tert-amylphenol (PTAP), and o-benzyl-p-chlorophenol (OBPCP) in disinfectant formulations. Samples were extracted, the extracts diluted with acidified methanol

Cleaning validation 1: development and validation of a chromatographic method for the detection of traces of LpHse detergent.

José Zayas et al.

Journal of pharmaceutical and biomedical analysis, 41(2), 589-593 (2006-01-13)

A high performance liquid chromatography (HPLC) method for the detection of traces of LpHse (4-tert-amylphenol and 2-phenylphenol) has been developed and validated. The method was shown to be linear in the range from 0.5 to 10.00 ppm in solution. The

Inactivation of surrogate coronaviruses on hard surfaces by health care germicides.

Rachel L Hulkower et al.

American journal of infection control, 39(5), 401-407 (2011-01-25)

In the 2003 severe acute respiratory syndrome outbreak, finding viral nucleic acids on hospital surfaces suggested surfaces could play a role in spread in health care environments. Surface disinfection may interrupt transmission, but few data exist on the effectiveness of

Ecotoxicological evaluation of the biocidal agents sodium o-phenylphenol, sodium o-benzyl-p-chlorophenol, and sodium p-tertiary amylphenol.

M Davoren et al.

Ecotoxicology and environmental safety, 60(2), 203-212 (2004-11-18)

The ecotoxicological effects of three biocidal agents frequently employed as active ingredients in phenolic-based disinfectants were evaluated using a test battery comprising of organisms representing three aquatic trophic levels. Phenolic-based disinfectants are commonly used by mushroom growers to disinfect spent

Effects of 4-tert-pentylphenol on the gene expression of P450 11beta-hydroxylase in the gonad of medaka (Oryzias latipes).

Hirofumi Yokota et al.

Aquatic toxicology (Amsterdam, Netherlands), 71(2), 121-132 (2005-01-12)

Alkylphenols including 4-tert-pentylphenol (4-PP) have been shown to alter sexual differentiation in fish due to their estrogenic properties. Medaka (Oryzias latipes) is so sensitive to these substances because morphological sex reversal and testis-ova induction are well developed in the exposed

Effects of a weak oestrogenic active chemical (4-tert-pentylphenol) on pair-breeding and F1 development in the fathead minnow (Pimephales promelas).

G H Panter et al.

Aquatic toxicology (Amsterdam, Netherlands), 97(4), 314-323 (2010-01-29)

A fish full life-cycle (FFLC) is the most comprehensive test to determine reproductive toxicity of chemicals to fish and this is likely to apply equally to endocrine active chemicals (EACs). However, FFLC tests use large numbers of animals, are expensive

Occupational vitiligo: clinical and epidemiological aspects.

C J Stevenson

The British journal of dermatology, 105 Suppl 21, 51-56 (1981-09-01)

Determination of three germicidal phenols in serum of infants with hyperbilirubinemia.

L L Needham et al.

Clinica chimica acta; international journal of clinical chemistry, 107(3), 261-266 (1980-11-06)

[Study on para-derivative of phenol as enhancers of chemiluminescence].

Zhi-wei Zhao

Guang pu xue yu guang pu fen xi = Guang pu, 22(6), 895-897 (2003-08-14)

In chemiluminescent analysis, the reaction system of luminol-hydrogen peroxide is always used under the alkaline condition, and the reaction is advantageous through the medium of catalyzing horseradish peroxidase. After being added, the enhances were found to be able to improve

Phenylphenols, biphenols, bisphenol-A and 4-tert-octylphenol exhibit alpha and beta estrogen activities and antiandrogen activity in reporter cell lines.

Françoise Paris et al.

Molecular and cellular endocrinology, 193(1-2), 43-49 (2002-08-06)

We previously demonstrated the interactions of different chemical compounds with estrogen receptors ERalpha and ERbeta and the androgen receptor (AR) using different reporter cell lines. In this study, we characterize the ERalpha, ERbeta and AR activity of different biphenyls using

Direct evidence revealing structural elements essential for the high binding ability of bisphenol A to human estrogen-related receptor-gamma.

Hiroyuki Okada et al.

Environmental health perspectives, 116(1), 32-38 (2008-01-17)

Various lines of evidence have shown that bisphenol A [BPA; HO-C6H4-C(CH3)2-C6H4-OH] acts as an endocrine disruptor when present in very low doses. We have recently demonstrated that BPA binds strongly to human estrogen-related receptor-gamma (ERR-gamma ) in a binding assay

In vitro cytotoxicity assessment of the biocidal agents sodium o-phenylphenol, sodium o-benzyl-p-chlorophenol, and sodium p-tertiary amylphenol using established fish cell lines.

Maria Davoren et al.

Toxicology in vitro : an international journal published in association with BIBRA, 20(7), 1190-1201 (2006-05-09)

The cytotoxicity of three biocidal agents frequently employed as active ingredients in phenolic-based disinfectants, were evaluated in three established fish cell lines (EPC, CHSE and RTG-2). Cell viability was assessed using two fluorescent indicator dyes, Alamar Blue for metabolism and

Feminization of male carp.

S Gimeno et al.

Nature, 384(6606), 221-222 (1996-11-21)

Fish full life-cycle testing for the weak estrogen 4-tert-pentylphenol on medaka (Oryzias latipes).

Masanori Seki et al.

Environmental toxicology and chemistry, 22(7), 1487-1496 (2003-07-03)

We studied the chronic effects of 4-tert-pentylphenol (4-PP) on reproductive status of medaka (Oryzias latipes) over two generations under continuous exposure, with the goal of verifying the applicability of the fish full life-cycle test (FFLC) for this weak estrogen with

Convenient QSAR model for predicting the complexation of structurally diverse compounds with beta-cyclodextrins.

Alfonso Pérez-Garrido et al.

Bioorganic & medicinal chemistry, 17(2), 896-904 (2008-12-06)

This paper reports a QSAR study for predicting the complexation of a large and heterogeneous variety of substances (233 organic compounds) with beta-cyclodextrins (beta-CDs). Several different theoretical molecular descriptors, calculated solely from the molecular structure of the compounds under investigation

Development of chronic tests for endocrine active chemicals. Part 1. An extended fish early-life stage test for oestrogenic active chemicals in the fathead minnow (Pimephales promelas).

G H Panter et al.

Aquatic toxicology (Amsterdam, Netherlands), 77(3), 279-290 (2006-02-18)

An extended early-life stage test (based on OECD test guideline 210) was developed to allow the evaluation of a weak environmental oestrogen, 4-tert-pentyphenol (4TPP), on sexual differentiation and gonadal development. Fathead minnow (Pimephales promelas) embryos were exposed to three concentrations

Determination of germicidal phenols in blood by capillary column gas chromatography.

R E Cline et al.

Journal of chromatography, 307(2), 420-425 (1984-05-11)

Screening estrogenic activities of chemicals or mixtures in vivo using transgenic (cyp19a1b-GFP) zebrafish embryos.

François Brion et al.

PloS one, 7(5), e36069-e36069 (2012-05-16)

The tg(cyp19a1b-GFP) transgenic zebrafish expresses GFP (green fluorescent protein) under the control of the cyp19a1b gene, encoding brain aromatase. This gene has two major characteristics: (i) it is only expressed in radial glial progenitors in the brain of fish and

Impact of induced fit on ligand binding to the androgen receptor: a multidimensional QSAR study to predict endocrine-disrupting effects of environmental chemicals.

Markus A Lill et al.

Journal of medicinal chemistry, 48(18), 5666-5674 (2005-09-02)

We investigated the influence of induced fit of the androgen receptor binding pocket on free energies of ligand binding. On the basis of a novel alignment procedure using flexible docking, molecular dynamics simulations, and linear-interaction energy analysis, we simulated the

Screening for occupational vitiligo in workers exposed to hydroquinone monomethyl ether and to paratertiary-amyl-phenol.

J J O'Sullivan et al.

British journal of industrial medicine, 38(4), 381-383 (1981-11-01)

Two men reported previously with vitiligo after occupational exposure to hydroquinone monomethyl ether (HMME) have been reviewed after eight years. Repigmentation of significant degree was found in one man and of limited degree in the other. One hundred and sixty-nine

Binding of selected phenol derivatives to human serum proteins.

J Judis

Journal of pharmaceutical sciences, 71(10), 1145-1147 (1982-10-01)

The binding of phenol and four of its derivatives to whole human serum and several human serum proteins was investigated. 14C-labeled derivatives were utilized and binding was studied by either equilibrium or dynamic dialysis. Phenol itself was bound least to

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