15420

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15N spin diffusion rate in solid-state NMR of totally enriched proteins: the magic angle spinning frequency effect.

Alexey Krushelnitsky et al.

Journal of magnetic resonance (San Diego, Calif. : 1997), 182(2), 339-342 (2006-07-21)

As demonstrated by means of the one-dimensional solid-state MAS exchange experiment (CODEX), the rate of the proton driven spin diffusion between backbone (15)N nuclei in totally enriched protein depends strongly on the magic angle spinning (MAS) frequency: spin diffusion at

Substituted hippurates and hippurate analogs as substrates and inhibitors of peptidylglycine alpha-hydroxylating monooxygenase (PHM).

David J Merkler et al.

Bioorganic & medicinal chemistry, 16(23), 10061-10074 (2008-10-28)

Peptidyl alpha-hydroxylating monooxygenase (PHM) functions in vivo towards the biosynthesis of alpha-amidated peptide hormones in mammals and insects. PHM is a potential target for the development of inhibitors as drugs for the treatment of human disease and as insecticides for

N-Boc-glycine-assisted indium-mediated allylation reaction: a sustainable approach.

Vemula SR, et al.

Tetrahedron Letters, 56(23), 3322-3325 (2015)

In situ fabrication of cleavable peptide arrays on polydimethylsiloxane and applications for kinase activity assays.

Huang-Han Chen et al.

Analytica chimica acta, 865, 53-59 (2015-03-04)

Polydimethylsiloxane (PDMS) is widely used for microfabrication and bioanalysis; however, its surface functionalization is limited due to the lack of active functional groups and incompatibility with many solvents. We presented a novel approach for in situ fabrication of cleavable peptide

Efficient total synthesis of pulchellalactam, a CD45 protein tyrosine phosphatase inhibitor.

Wen-Ren Li et al.

The Journal of organic chemistry, 67(14), 4702-4706 (2002-07-06)

A new approach to a CD45 protein tyrosine phosphatase inhibitor, pulchellalactam, is described. The key step of the sequence involves addition and elimination of an enolic lactam in a single step and 70% yield, employing an organocuprate reagent. The resulting

Optimization of the Ugi reaction using parallel synthesis and automated liquid handling.

Jean-Claude Bradley et al.

Journal of visualized experiments : JoVE, (21)(21), doi:10-doi:10 (2008-12-11)

The optimization of a Ugi reaction involving the mixing of furfurylamine, benzaldehyde, boc-glycine and t-butylisocyanide is described. Triplicate runs of 48 parallel experiments are reported, varying concentration, solvent and the excess of some of the reagents. The isolation of the

Anticonvulsant activities of N-benzyloxycarbonylglycine after parenteral administration.

D M Lambert et al.

Neuroreport, 5(7), 777-780 (1994-03-21)

Although glycine does not cross easily the blood-brain barrier, it exhibits at very high doses (10-40 mmol kg-1) a modest anticonvulsant activity. In this study, carbamate derivatives--N-benzyloxycarbonylglycine (Z-glycine) and N,tert-butoxycarbonylglycine (Boc-glycine)--have been compared with glycine. Z-glycine (1 mmol kg-1), but

Metabolism of C-terminal pentapeptide of gastrin in the rat. Part IV. Catabolic pathways of the N-terminal BOC-14C-glycine fragment.

L Varga et al.

Hepato-gastroenterology, 27(2), 146-149 (1980-04-01)

The catabolism of the 14C-labelled pentagastrin was investigated in rats. The following results were found: -- the labelled BOC-glycine fragment is split off the pentagastrin in the small intestine -- it is absorbed through the intestinal wall, and -- enters

Measurements of carbon to amide-proton distances by C-H dipolar recoupling with 15N NMR detection.

Klaus Schmidt-Rohr et al.

Journal of the American Chemical Society, 125(19), 5648-5649 (2003-05-08)

A new magic-angle spinning NMR method for measuring internuclear distances between a 13C-labeled site and amide protons is described. The magnetization of the protons evolves under homonuclear decoupling and the recoupled 13C-1H dipolar interaction, which provides simple spin-pair REDOR curves

Ceric ammonium nitrate (CAN) mediated esterification of N-Boc amino acids allows either retention or removal of the N-Boc group.

Kuttan A, et al.

Tetrahedron Letters, 45(12), 2663-2665 (2004)

Analogues of the neuroprotective tripeptide Gly-Pro-Glu (GPE): synthesis and structure-activity relationships.

De Diego SAA, et al.

Bioorganic & Medicinal Chemistry Letters, 15(9), 2279-2283 (2005)

Accumulation of cell-penetrating peptides in large unilamellar vesicles: A straightforward screening assay for investigating the internalization mechanism.

Jean-Marie Swiecicki et al.

Biopolymers, 104(5), 533-543 (2015-04-08)

The internalization of cell-penetrating peptides (CPPs) into liposomes (large unilamellar vesicles, LUVs) was studied with a rapid and robust procedure based on the quenching of a small fluorescent probe, 7-nitrobenz-2-oxa-1,3-diazole (NBD). Quenching can be achieved by reduction with dithionite or

Endoplasmic reticulum stress induces Alzheimer disease-like phenotypes in the neuron derived from the induced pluripotent stem cell with D678H mutation on amyloid precursor protein.

Tania Devina et al.

Journal of neurochemistry, 163(1), 26-39 (2022-08-10)

Alzheimer disease (AD), a progressive neurodegenerative disorder, is mainly caused by the interaction of genetic and environmental factors. The impact of environmental factors on the genetic mutation in the amyloid precursor protein (APP) is not well characterized. We hypothesized that

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