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Sunil K Tewary et al.
Virology, 476, 61-71 (2014-12-22)
Members of the Parvoviridae family all encode a non-structural protein 1 (NS1) that directs replication of single-stranded viral DNA, packages viral DNA into capsid, and serves as a potent transcriptional activator. Here we report the X-ray structure of the minute
Chitra Rani et al.
Tuberculosis (Edinburgh, Scotland), 95(6), 664-677 (2015-09-01)
N-acetylglucosamine-1-phosphate uridyltransferase (GlmU) is a pivotal bifunctional enzyme, its N and C terminal domains catalyzes uridyltransferase and acetyltransferase activities, respectively. Final product of GlmU catalyzed reaction, uridine-diphospho-N-acetylglucosamine (UDP-GlcNAc), acts as sugar donor providing GlcNAc residues in the synthesis of peptidoglycan
Shalene Sankhagowit et al.
Biochimica et biophysica acta, 1838(10), 2615-2624 (2014-07-08)
We have studied the dynamics of Lissamine Rhodamine B dye sensitization-induced oxidation of 1,2-dioleoyl-sn-glycero-3-phosphocholine (DOPC) giant unilamellar vesicles (GUVs), where the progression of the underlying chemical processes was followed via vesicle membrane area changes. The surface-area-to-volume ratio of our spherical
Shin Kedashiro et al.
Journal of cell science, 128(2), 385-396 (2014-11-22)
The binding of ligand to epidermal growth factor receptor (EGFR) causes the receptor to become activated and stimulates the endocytosis of EGFR. Early endosomes containing activated EGFR migrate along microtubules as they mature into late endosomes. We have recently shown
James R Kornacki et al.
ACS chemical biology, 10(1), 157-164 (2014-09-10)
Epigenetic regulation is directed, in part, by the correlated placement of histone post-translational modifications, but the mechanisms controlling correlated modifications are incompletely understood. Correlations arise from crosstalk among modifications and are frequently attributed to protein-protein interactions that recruit enzymes to
Cihad Anamur et al.
International journal of pharmaceutics, 483(1-2), 131-141 (2015-02-11)
A clear limitation of many liquid vaccines is the obligatory cold-chain distribution system. Therefore, distribution of a dried vaccine formulation may be beneficial in terms of vaccine stability, handling and transport. Collapse freeze-drying is a process which utilizes fairly aggressive
Zhanpeng Zhang et al.
Advanced functional materials, 25(3), 350-360 (2015-06-13)
Injectable microspheres are attractive stem cell carriers for minimally invasive procedures. For tissue regeneration, the microspheres need to present the critical cues to properly direct stem cell differentiation. In natural extracellular matrix (ECM), growth factors (GFs) and collagen nanofibers provide
Z Huang et al.
Thrombosis and haemostasis, 112(1), 142-150 (2014-03-19)
ATP released by activated platelets can serve as a positive feedback machinery to amplify platelet responses by activating P2X1 receptors. It has, however, not been defined how P2X1 activities influence thromboxane A2 (TXA2)-stimulated platelet functional responses. Our aim was to
Buyong Ma et al.
Growth factors (Chur, Switzerland), 32(6), 236-246 (2014-11-21)
EphB2 interacts with cell surface-bound ephrin ligands to relay bidirectional signals. Overexpression of the EphB2 receptor protein has been linked to different types of cancer. The SNEW (SNEWIQPRLPQH) peptide binds with high selectivity and moderate affinity to EphB2, inhibiting Eph-ephrin
K. Ariga et al.
The Journal of Organic Chemistry, 57, 417-417 (1992)
T M Hörer et al.
European journal of vascular and endovascular surgery : the official journal of the European Society for Vascular Surgery, 45(6), 596-606 (2013-04-02)
This study aims to evaluate intra-peritoneal (ip) microdialysis after endovascular aortic repair (EVAR) of ruptured abdominal aortic aneurysm (rAAA) in patients developing intra-abdominal hypertension (IAH), requiring abdominal decompression. Prospective study. A total of 16 patients with rAAA treated with an
Hyong Woo Choi et al.
Molecular medicine (Cambridge, Mass.), 21, 526-535 (2015-06-24)
Salicylic acid (SA) and its derivatives have been used for millennia to reduce pain, fever and inflammation. In addition, prophylactic use of acetylsalicylic acid, commonly known as aspirin, reduces the risk of heart attack, stroke and certain cancers. Because aspirin
Timothy A Vickers et al.
PloS one, 9(10), e108625-e108625 (2014-10-10)
Antisense oligonucleotides (ASOs) are most commonly designed to reduce targeted RNA via RNase H1-dependent degradation. In this paper we demonstrate that cellular proteins can compete for sites targeted by RNase H1-dependent ASOs. We further show that some ASOs designed to
A Kerdudo et al.
International journal of cosmetic science, 37(1), 31-40 (2014-09-27)
Preservation of cosmetics is a prerequisite for industrialization, and among the proposed solutions, self-preserved cosmetics are of great interest. One key influencing parameter in self-preservation is water activity; its reduction can help to fight against microbial growth in cosmetic products.
Rong Qin et al.
Environmental science and pollution research international, 21(18), 10736-10743 (2014-05-30)
Results from our previous investigation indicated that Al could affect the nucleolus and induce extrusion of silver-staining nucleolar particles containing argyrophilic proteins from the nucleolus into the cytoplasm in root tip cells of Vicia faba L. So far, the nucleolar
Shuang Liu et al.
mAbs, 7(1), 110-119 (2014-12-23)
Monoclonal antibodies (mAbs) against human proteins are the primary protein capture reagents for basic research, diagnosis, and molecular therapeutics. The 2 most important attributes of mAbs used in all of these applications are their specificity and avidity. While specificity of
Amir H Salehi et al.
Journal of liposome research, 25(1), 38-45 (2014-06-25)
Ag:Au alloy nanoparticles were successfully synthesized through the new route using co-reduction method with silver nitrate, chloroauric acid, cetyl trimethyl ammonium bromide (CTAB) and sodium borohydride at room temperature. The Ag:Au alloy nanoparticles were then loaded within the phosphatidylcholine (97%)
Maria I Tsiraki et al.
Food microbiology, 53(Pt B), 150-155 (2015-12-19)
The antimicrobial effect of citrus extract (at 1 mL/kg [TC1] and 2 mL/kg [TC2]) on the naturally occurring microflora and inoculated pathogens (Bacillus cereus and Salmonella enterica, at ca. 6 log cfu/g) in the traditional Greek yogurt-based salad Tzatziki during storage under vacuum
Devashish Rath et al.
Nucleic acids research, 43(1), 237-246 (2014-12-02)
Methods that permit controlled changes in the expression of genes are important tools for biological and medical research, and for biotechnological applications. Conventional methods are directed at individually changing each gene, its regulatory elements or its mRNA's translation rate. We
Prashant Kumar et al.
Journal of chromatography. A, 1356, 105-116 (2014-07-16)
Kafirin is a natural, hydrophobic and celiac safe prolamin protein obtained from sorghum seeds. Today kafirin is found to be useful in designing delayed delivery systems and coatings of pharmaceuticals and nutraceuticals where its purity is important and this can
Cvetan Popov et al.
BMC molecular biology, 16, 6-6 (2015-04-17)
Tendons are dense connective tissues subjected periodically to mechanical stress upon which complex responsive mechanisms are activated. These mechanisms affect not only the development of these tissues but also their healing. Despite of the acknowledged importance of the mechanical stress
Maria Campaña-Seoane et al.
International journal of pharmaceutics, 477(1-2), 495-505 (2014-12-03)
The aim of this study is to propose that mucoadhesive vaginal emulsions can be able to resist the clearance effect of vaginal fluid and to have an effective control release of progesterone. With this goal, silicon derivative, cyclomethicone pentamer, was
Yu Matsuzawa et al.
Biochemical and biophysical research communications, 456(1), 298-304 (2014-12-03)
RIPK3 is a key molecule for necroptosis, initially characterized by necrotic cell death morphology and the activation of autophagy. Cell death and autophagic signaling are believed to tightly regulate each other. However, the associated recruitment of signaling proteins remains poorly
Koichi Sato et al.
PloS one, 9(12), e114752-e114752 (2014-12-10)
FANCD2 is a product of one of the genes associated with Fanconi anemia (FA), a rare recessive disease characterized by bone marrow failure, skeletal malformations, developmental defects, and cancer predisposition. FANCD2 forms a complex with FANCI (ID complex) and is
Tara L Conforto et al.
Molecular endocrinology (Baltimore, Md.), 29(9), 1286-1302 (2015-07-29)
Hepatocyte-enriched nuclear factor (HNF)6 and CUX2 are GH and STAT5-regulated homeobox transcription factors. CUX2 shows female-specific expression and contributes to liver sex differences by repressing many male-biased genes and inducing many female-biased genes, whereas HNF6 is expressed at similar levels
Eileen Deng et al.
Molecules (Basel, Switzerland), 20(11), 20131-20145 (2015-11-17)
Macromolecules that possess three-dimensional, branched molecular structures are of great interest because they exhibit significantly differentiated application performance compared to conventional linear (straight chain) polymers. This paper reports the synthesis of 3- and 4-arm star branched polymers via ring opening
Quan Chi et al.
Luminescence : the journal of biological and chemical luminescence, 30(7), 990-995 (2015-02-03)
The chemiluminescence (CL) of lucigenin (Luc(2+)) can be enhanced by different alcohols in alkaline solution. The effect of different fatty alcohols on the CL of lucigenin was related to the carbon chain length and the number of hydroxyl groups. Glycerol
Daniel J O'Neill et al.
Epigenetics, 9(7), 942-950 (2014-04-23)
The lysine methyltransferase SETD6 modifies the histone variant H2AZ, a key component of nuclear receptor-dependent transcription. Herein, we report the identification of several factors that associate with SETD6 and are implicated in nuclear hormone receptor signaling. Specifically, SETD6 associates with
Thaisa Moro Cantu-Jungles et al.
Carbohydrate polymers, 122, 276-281 (2015-03-31)
Primary cell wall polysaccharides from aqueous extract of buriti fruit pulp (Mauritia flexuosa, an exotic tropical palm) were isolated and characterized. After freeze-thaw and α-amylase treatments, extracted polysaccharides were purified by sequential ultrafiltration through membranes. Two homogeneous fractions were obtained
Katsuhiro Hayashi et al.
International journal of clinical oncology, 19(4), 731-738 (2013-07-25)
Low-grade osteosarcoma, including low-grade central osteosarcoma and parosteal osteosarcoma, is an extremely rare variant, and the diagnosis is occasionally difficult. In this article we present cases of low-grade osteosarcomas that should be reviewed by a clinical oncologist. Nine cases of
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