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C Le Chalony et al.
Cytogenetics and cell genetics, 88(3-4), 240-243 (2000-06-01)
We have isolated the swine homologs of human CDKN2A and CDKN2B exon 2 sequences. As in the human and mouse genomes, the exon 2 sequences of these two genes present a high level of sequence homology and are tightly linked.
Johana Musso et al.
Analytical and bioanalytical chemistry, 407(5), 1285-1294 (2014-12-20)
Detection of protein biomarkers is of major interest in proteomics. This work reports the analysis of protein biomarkers directly from a biological fluid, human saliva, by surface plasmon resonance imaging coupled to mass spectrometry (SPRi-MS), using a functionalized biochip in
Shalini Mukherjee et al.
Plant science : an international journal of experimental plant biology, 240, 143-160 (2015-10-18)
Combining physiological, molecular and biochemical approaches, this study investigated the transcriptional coordination and abscisic acid (ABA) mediated regulation of genes involved in sucrose import and its conversion to starch during grain filling in wheat. Sucrose import appears to be mediated
R E Foulger et al.
BMC microbiology, 15, 146-146 (2015-07-29)
The Gene Ontology project is a collaborative effort to provide descriptions of gene products in a consistent and computable language, and in a species-independent manner. The Gene Ontology is designed to be applicable to all organisms but up to now
Su'e Chang et al.
Oncotarget, 6(10), 7675-7685 (2015-03-13)
VitaminD3 signaling is involved in inhibiting the development and progression of gastric cancer (GC), while the active vitamin D metabolite 1-alpha,25-dihydroxyvitamin D3 (1,25(OH)2D3)-mediated gene regulatory mechanisms in GC remain unclear. We found that miR-145 is induced by 1,25(OH)2D3 in a
Olgary Figueroa-Santiago et al.
Infection and immunity, 82(12), 5005-5012 (2014-09-17)
The liver fluke Fasciola hepatica is a highly evolved parasite that uses sophisticated mechanisms to evade the host immune response. The immunosuppressive capabilities of the parasite have been associated with antigens secreted through the parasite's tegument, called excretory-secretory products (ESPs).
Judita Zozomová-Lihová et al.
American journal of botany, 102(8), 1380-1395 (2015-08-21)
• Contact zones between diploids and their autopolyploid descendants represent a unique evolutionary venue for studying polyploid establishment, cytotype coexistence, and interactions. Here, we examine cytotype coexistence in a diploid-tetraploid contact zone of a perennial herb, Cardamine amara, located north
Christian M Karsten et al.
Journal of immunology (Baltimore, Md. : 1950), 194(4), 1841-1855 (2015-01-16)
Many of the biological properties of C5a are mediated through activation of its receptor (C5aR1), the expression of which has been demonstrated convincingly on myeloid cells, such as neutrophils, monocytes, and macrophages. In contrast, conflicting results exist regarding C5aR1 expression
Shamol Saha et al.
Molecular neurodegeneration, 10, 26-26 (2015-07-15)
Autophagy is thought to play a pivotal role in the pathophysiology of Parkinson's disease, but little is known about how genes linked to PD affect autophagy in the context of aging. We generated lines of C. elegans expressing reporters for
Shiwei Wang et al.
Journal of bacteriology, 197(14), 2361-2373 (2015-05-06)
The Gram-positive spore-forming anaerobe Clostridium difficile is a leading cause of nosocomial diarrhea. Spores of C. difficile initiate infection when triggered to germinate by bile salts in the gastrointestinal tract. We analyzed germination kinetics of individual C. difficile spores using
Ajaz A Ganai et al.
Chemico-biological interactions, 214, 33-40 (2014-02-26)
Glycine propionyl l-carnitine (GPLC) is a propionyl ester of carnitine that includes an additional glycine component. The present study evaluated hepatoprotective effect of GPLC in d-Galactosamine (d-GalN) induced fulminant hepatic failure. Rats were intraperitonially administered d-GalN (700mg/kgBW). GPLC was given
Vittorio Caggiano et al.
PloS one, 9(6), e100865-e100865 (2014-06-26)
Inhibitory neurons in the adult mammalian spinal cord are known to locally modulate afferent feedback--from muscle proprioceptors and from skin receptors--to pattern motor activity for locomotion and postural control. Here, using optogenetic tools, we explored how the same population of
Zai Ahmad et al.
PloS one, 10(3), e0119834-e0119834 (2015-03-19)
Medulloblastoma (MB) is the most common malignant pediatric brain tumor. While the pathways that are deregulated in MB remain to be fully characterized, amplification and/or overexpression of the MYCN gene, which is has a critical role in cerebellar development as
Catherine Tanzer et al.
Burns : journal of the International Society for Burn Injuries, 41(5), 1114-1121 (2015-02-02)
The early and accurate assessment of burns is essential to inform patient treatment regimens; however, this first critical step in clinical practice remains a challenge for specialist burns clinicians worldwide. In this regard, protein biomarkers are a potential adjunct diagnostic
Yihang Zeng et al.
Journal of separation science, 38(12), 2053-2058 (2015-04-14)
A method was developed for quantifying 17 amino acids in tobacco leaves by using an A300 amino acid analyzer and chemometric resolution. In the method, amino acids were eluted by the buffer solution on an ion-exchange column. After reacting with
Nicholas A Dillon et al.
Antimicrobial agents and chemotherapy, 58(12), 7258-7263 (2014-09-24)
Pyrazinamide (PZA) is a first-line tuberculosis drug that inhibits the growth of Mycobacterium tuberculosis via an as yet undefined mechanism. An M. tuberculosis laboratory strain that was auxotrophic for pantothenate was found to be insensitive to PZA and to the
Francesca Isabella De-Simone et al.
PloS one, 10(6), e0129694-e0129694 (2015-06-11)
Patients undergoing immune modulatory therapies for the treatment of autoimmune diseases such as multiple sclerosis, and individuals with an impaired-immune system, most notably AIDS patients, are in the high risk group of developing progressive multifocal leukoencephalopathy (PML), an often lethal
Oana Birceanu et al.
Aquatic toxicology (Amsterdam, Netherlands), 168, 11-18 (2015-09-24)
Bisphenol A (BPA) is widespread in the aquatic environment, and early life-stage exposure to this chemical affects growth and development in fish. We tested the hypothesis that BPA accumulation in eggs, mimicking maternal transfer, impacts the development and function of
Derek Leaderer et al.
The journal of gene medicine, 17(6-7), 101-115 (2015-04-29)
A variety of disorders are associated with the activation of complement. CD46, CD55 and CD59 are the major membrane associated regulators of complement on human cells. Previously, we have found that independent expression of CD55, CD46 or CD59 through gene
Elumalai Satheeshkumar et al.
Analytica chimica acta, 879, 111-117 (2015-05-24)
A new method based on photochemical formation of silver nanoparticles (AgNPs) was developed for detection of tyrosine (Tyr). To selectively detect Tyr and to simplify the detection procedure, the photoactivity of Tyr was utilized to trigger the photochemical reduction in
Dekai Wang et al.
Journal of integrative plant biology, 57(9), 745-756 (2015-02-03)
Serine hydroxymethyltransferase (SHMT) is important for one carbon metabolism and photorespiration in higher plants for its participation in plant growth and development, and resistance to biotic and abiotic stresses. A rice serine hydroxymethyltransferase gene, OsSHM1, an ortholog of Arabidopsis SHM1
Jenna M Puccini et al.
The Journal of neuroscience : the official journal of the Society for Neuroscience, 35(13), 5271-5283 (2015-04-04)
Leucine-rich repeat kinase 2 (LRRK2) is the single most common genetic cause of both familial and sporadic Parkinson's disease (PD), both of which share pathogenetic and neurologic similarities with human immunodeficiency virus 1 (HIV-1)-associated neurocognitive disorders (HAND). Pathologic LRRK2 activity
F J Neumann et al.
Circulation, 95(10), 2387-2394 (1997-05-20)
Activated platelets tether and activate myeloid leukocytes. To investigate the potential relevance of this mechanism in acute myocardial infarction (AMI), we examined cytokine induction by leukocyte-platelet adhesion and the occurrence of leukocyte-platelet conjugates in patients with AMI. We obtained peripheral
Davide Bressanello et al.
Journal of chromatography. A, 1361, 265-276 (2014-08-28)
This study investigates the potential of a parallel dual secondary column-dual detection two-dimensional comprehensive GC platform (GC×2GC-MS/FID) for metabolic profiling and fingerprinting of mouse urine. Samples were obtained from a murine model that mimics a typical unhealthy Western diet featuring
Silvina Fernández et al.
Zoological science, 30(12), 1110-1116 (2013-12-11)
The aim of this research was to evaluate two different diluents for sperm cryopreservation and to study functional parameters in relation to the response to heparin, lysophosphatidylcholine and progesterone, in frozen-thawed semen of fallow deer (Dama dama) during the reproductive
Sheng Zhang et al.
Journal of proteomics, 126, 263-278 (2015-07-15)
Ancient trees have an important value in humanities and history, and also have an important scientific value in the investigation of the decline and senescence mechanisms. Thus, we conducted an environmental stress study using ancient trees. To evaluate age-dependent changes
Siddhesh S Kamat et al.
Nature, 497(7447), 132-136 (2013-04-26)
Methane is a potent greenhouse gas that is produced in significant quantities by aerobic marine organisms. These bacteria apparently catalyse the formation of methane through the cleavage of the highly unreactive carbon-phosphorus bond in methyl phosphonate (MPn), but the biological
Jia-Xuan Qiu et al.
Drug design, development and therapy, 9, 349-417 (2015-01-23)
Plumbagin (PLB) has exhibited a potent anticancer effect in preclinical studies, but the molecular interactome remains elusive. This study aimed to compare the quantitative proteomic responses to PLB treatment in human prostate cancer PC-3 and DU145 cells using the approach
Naomi M de Almeida et al.
Journal of bacteriology, 197(14), 2432-2441 (2015-05-13)
Anaerobic ammonium-oxidizing (anammox) bacteria oxidize ammonium with nitrite as the terminal electron acceptor to form dinitrogen gas in the absence of oxygen. Anammox bacteria have a compartmentalized cell plan with a central membrane-bound "prokaryotic organelle" called the anammoxosome. The anammoxosome
Jiandong Ren et al.
Journal of the science of food and agriculture, 95(13), 2595-2600 (2015-01-08)
Phosvitin is the principal phosphoprotein in egg yolk and has great potential for use as a functional food ingredient in improving bone health. This study reports a thermal-aided extraction method without using organic solvents or non-food-compatible chemicals. Egg yolk was
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