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C Le Chalony et al.
Cytogenetics and cell genetics, 88(3-4), 240-243 (2000-06-01)
We have isolated the swine homologs of human CDKN2A and CDKN2B exon 2 sequences. As in the human and mouse genomes, the exon 2 sequences of these two genes present a high level of sequence homology and are tightly linked.
Zoé Husson et al.
The Journal of neuroscience : the official journal of the Society for Neuroscience, 34(28), 9418-9431 (2014-07-11)
The principal neurons of the cerebellar nuclei (CN), the sole output of the olivo-cerebellar system, receive a massive inhibitory input from Purkinje cells (PCs) of the cerebellar cortex. Morphological evidence suggests that CN principal cells are also contacted by inhibitory
Valéria Dornelles Gindri Sinhorin et al.
Ecotoxicology and environmental safety, 106, 181-187 (2014-05-21)
The aim of this study was to investigate the effects of acute glyphosate (active ingredient) exposure on the oxidative stress biomarkers and antioxidant defenses of a hybrid surubim (Pseudoplatystoma sp). The fish were exposed to different herbicide concentrations for 96
Andrey Finegersh et al.
Alcoholism, clinical and experimental research, 38(7), 1865-1873 (2014-06-20)
Ethanol (EtOH) exposure alters gene expression in the cerebral cortex (CCx); however, mechanisms of EtOH-induced gene regulation are not well understood. We hypothesized that EtOH regulates gene expression by differentially altering histone modifications at gene promoters that are up- and
V Karamatic Crew et al.
Vox sanguinis, 106(3), 242-247 (2014-05-06)
Kell is a complex blood group system comprising 35 antigens. Kell antigens are absent from rare red cells of the Ko (null) phenotype and expressed only weakly in the Kmod phenotype. Molecular analysis of three uncommon KEL alleles elucidated the
S Ishiwata et al.
The Tohoku journal of experimental medicine, 176(1), 61-68 (1995-05-01)
To evaluate the clinical usefulness of serum 1-methyladenosine, several modifications have been made in our previously established inhibition ELISA system. Horseradish peroxidase (HRP) labeled anti-mouse IgG and 3,3',5,5'-tetramethylbenzidine (TMBZ) were used as a secondary antibody and a substrate, respectively. The
Z-W Lee et al.
British journal of pharmacology, 171(18), 4322-4336 (2014-05-16)
Many disparate studies have reported the ambiguous role of hydrogen sulfide (H2 S) in cell survival. The present study investigated the effect of H2 S on the viability of cancer and non-cancer cells. Cancer and non-cancer cells were exposed to
Wei Wang et al.
CNS neuroscience & therapeutics, 21(5), 425-434 (2015-02-04)
Anxiety disorders are characterized by a deficient extinction of fear memory. Evidence is growing that leptin influences numerous neuronal functions. The aims of this study were to investigate the effects and the mechanism of leptin on fear extinction. Leptin (1
Simon A Ramsbottom et al.
PLoS genetics, 10(12), e1004871-e1004871 (2014-12-19)
Planar cell polarity (PCP) is the mechanism by which cells orient themselves in the plane of an epithelium or during directed cell migration, and is regulated by a highly conserved signalling pathway. Mutations in the PCP gene Vangl2, as well
Junfeng Zhai et al.
PloS one, 9(11), e105417-e105417 (2014-11-05)
Leymus chinensis (Trin.) Tzvel. is a perennial rhizome grass of the Poaceae (also called Gramineae) family, which adapts well to drought, saline and alkaline conditions. However, little is known about the stress tolerance of L. chinensis at the molecular level.
Virginia Carvalhais et al.
Molecular immunology, 65(2), 429-435 (2015-03-10)
Virulence of Staphylococcus epidermidis is mainly attributed to surface colonization and biofilm formation in indwelling medical devices. Physiological heterogeneity of biofilms may influence host immune response and sensitivity to antibiotics. Dormant cells, among others, contribute to biofilm heterogeneity. The aim
Pierre-Hervé Luppi et al.
Sleep medicine, 14(8), 714-718 (2013-06-25)
Rapid eye movement sleep behavior disorder (RBD) is a parasomnia characterized by the occurrence of intense movements during rapid eye movement (REM) sleep, also named paradoxical sleep. The neuronal dysfunctions at the origin of the loss of atonia in RBD
T Bharathidasan et al.
ACS applied materials & interfaces, 7(33), 18450-18459 (2015-08-08)
We developed a single-step thermal method that enables successful inclusion of ZnO components in the porous boron-carbon-nitrogen (BCN) framework to form a new class of functional hybrid. ZnO-containing BCN hybrids were prepared by treating a mixture of B2O3, glycine, and
Black soyabean seed coat extract regulates iron metabolism by inhibiting the expression of hepcidin.
Mingdao Mu et al.
The British journal of nutrition, 111(7), 1181-1189 (2014-01-07)
Hepcidin, a key regulator of Fe homeostasis, is an ideal drug target for treating patients with Fe disorders such as haemochromatosis, anaemia of chronic inflammation and Fe-deficiency anaemia. However, whether (and how) traditional Chinese black foods (e.g., black soyabeans) target
X-X Chen et al.
Lupus, 24(9), 948-954 (2015-02-13)
The aim of this work was to develop a simple assay to distinguish between patients with rheumatoid arthritis (RA) and patients with systemic lupus erythematosus (SLE) by measuring the serum sialylated IgG (SAIgG). Using a newly established SNA-based ELISA method
Alexander Carvajal-González et al.
Brain : a journal of neurology, 137(Pt 8), 2178-2192 (2014-06-22)
The clinical associations of glycine receptor antibodies have not yet been described fully. We identified prospectively 52 antibody-positive patients and collated their clinical features, investigations and immunotherapy responses. Serum glycine receptor antibody endpoint titres ranged from 1:20 to 1:60 000.
H Yanai et al.
Oncogenesis, 3, e98-e98 (2014-04-23)
Drosophila myelodysplasia/myeloid leukemia factor (dMLF), a homolog of human MLF1, oncogene was first identified by yeast two-hybrid screen using the DNA replication-related element-binding factor (DREF) as bait. DREF is a transcription factor that regulates proliferation-related genes in Drosophila. It is
Maria Luisa Gelmi et al.
Journal of medicinal chemistry, 50(9), 2245-2248 (2007-04-07)
New 3-O-glycosyl-3-demethylthiocolchicines containing natural and unnatural sugar moieties were prepared and tested on gamma-aminobutyric acid (GABA) and strychnine-sensitive glycine receptors present in rat brain and spinal cord. Two different synthetic approaches were used with the readily available 3-O-demethylthiocolchicine (1b) and
Daiki Goto et al.
Analytical sciences : the international journal of the Japan Society for Analytical Chemistry, 31(11), 1143-1149 (2015-11-13)
It is difficult to control the electrophoretic mobility in order to obtain high resolution among saccharides in complex samples. We report herein on a new affinity capillary electrophoresis (ACE) method for an anionic monosaccharide, N-acetylneuraminic acid (Neu5Ac), which is important
Patient and tumor characteristics and BRAF and KRAS mutations in colon cancer, NCCTG/Alliance N0147.
Wilson I Gonsalves et al.
Journal of the National Cancer Institute, 106(7), doi:10-doi:10 (2014-06-14)
KRAS and BRAF (V600E) mutations are important predictive and prognostic markers, respectively, in colon cancer, but little is known about patient and clinical factors associated with them. Two thousand three hundred twenty-six of 3397 patients in the N0147 phase III
M V T Lobo et al.
American journal of physiology. Endocrinology and metabolism, 308(2), E111-E121 (2014-11-13)
The aim of the present work was to determine the effects of liver growth factor (LGF) on the regeneration process of rat testes after chemical castration induced by ethane dimethanesulfonate (EDS) by analyzing some of the most relevant proteins involved
Young Joon Song et al.
Molecules and cells, 38(4), 362-372 (2015-02-27)
Setdb1, an H3-K9 specific histone methyltransferase, is associated with transcriptional silencing of euchromatic genes through chromatin modification. Functions of Setdb1 during development have been extensively studied in embryonic and mesenchymal stem cells as well as neurogenic progenitor cells. But the
Gordon Sproul
Origins of life and evolution of the biosphere : the journal of the International Society for the Study of the Origin of Life, 45(4), 427-437 (2015-08-08)
Researchers have formed peptide bonds under a variety of presumed prebiotic conditions. Here it is proposed that these same conditions would have also formed amide bonds between fatty acids and amino acids, producing phosphate-free amphipathic lipoamino acids and lipopeptides. These
Ranran Ding et al.
Stem cell research & therapy, 6, 91-91 (2015-05-10)
Transplantation of bone marrow mesenchymal stem cells (BMSCs) can repair injured hearts. However, whether BMSC populations contain cells with cardiac stem cell characteristics is ill-defined. We report here that Notch signalling can promote differentiation of c-Kit(POS)/NKX2.5(POS) BMSCs into cardiomyocyte-like cells.
Cihad Anamur et al.
International journal of pharmaceutics, 483(1-2), 131-141 (2015-02-11)
A clear limitation of many liquid vaccines is the obligatory cold-chain distribution system. Therefore, distribution of a dried vaccine formulation may be beneficial in terms of vaccine stability, handling and transport. Collapse freeze-drying is a process which utilizes fairly aggressive
Lim Jeong et al.
International journal of molecular sciences, 15(4), 6857-6879 (2014-04-25)
Ag nanoparticles (NPs) were synthesized in formic acid aqueous solutions through chemical reduction. Formic acid was used for a reducing agent of Ag precursor and solvent of gelatin. Silver acetate, silver tetrafluoroborate, silver nitrate, and silver phosphate were used as
M Gåfvels et al.
Clinica chimica acta; international journal of clinical chemistry, 442, 87-95 (2015-01-21)
Surrogate markers for reverse cholesterol transport (RCT) efficiency such as HDL cholesterol and immune methods for apolipoprotein A-I (ApoA-I) may not fully reflect the actual efficiency of the RCT pathway. Several genetic variants and different posttranslational proteoforms of ApoA-I may
Buyong Ma et al.
Growth factors (Chur, Switzerland), 32(6), 236-246 (2014-11-21)
EphB2 interacts with cell surface-bound ephrin ligands to relay bidirectional signals. Overexpression of the EphB2 receptor protein has been linked to different types of cancer. The SNEW (SNEWIQPRLPQH) peptide binds with high selectivity and moderate affinity to EphB2, inhibiting Eph-ephrin
Venkanna Balaganur et al.
Connective tissue research, 55(5-6), 367-377 (2014-08-12)
The aim of the present study was to evaluate in vivo modulatory effect of S-methylisothiourea (SMT), a preferential inhibitor of inducible nitric oxide synthase (iNOS) on pain and pathology in the surgical model of osteoarthritis (OA) in rats. The OA
Maria Carmen Mora et al.
The Journal of surgical research, 197(2), 247-255 (2015-05-23)
Rhodiola crenulata is a perennial plant that grows in the high altitudes of Eastern Europe and Asia. R crenulata has been used for many years in Eastern traditional medicine for a variety of medicinal purposes and it has been shown
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