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Gina M Story et al.
Cell, 112(6), 819-829 (2003-03-26)
Mammals detect temperature with specialized neurons in the peripheral nervous system. Four TRPV-class channels have been implicated in sensing heat, and one TRPM-class channel in sensing cold. The combined range of temperatures that activate these channels covers a majority of
R V Olsen et al.
European journal of pain (London, England), 18(9), 1333-1342 (2014-03-26)
Activation of TRPM8 and TRPA1 receptors generates cold and cold pain sensations, respectively, and is presumably important in clinical pain manifestations, such as cold hyperalgesia. This study investigated the interaction between TRPM8 and TRPA1 receptors through stimulation of glabrous human
Thomas Voets et al.
Nature chemical biology, 1(2), 85-92 (2006-01-13)
Drosophila melanogaster flies carrying the trp (transient receptor potential) mutation are rapidly blinded by bright light, because of the absence of a Ca2+-permeable ion channel in their photoreceptors. The identification of the trp gene and the search for homologs in
Gaurav Mukerji et al.
BMC urology, 6, 6-6 (2006-03-08)
The recent identification of the cold-menthol sensory receptor (TRPM8; CMR1), provides us with an opportunity to advance our understanding of its role in the pathophysiology of bladder dysfunction, and its potential mediation of the bladder cooling reflex. In this study
Antonio Celso Saragossa Ramos-Filho et al.
PloS one, 9(11), e111616-e111616 (2014-11-07)
Agonists such as icilin and menthol can activate the cool temperature-sensitive ion channel TRPM8. However, biological responses to menthol may occur independently of TRPM8 activation. In the rodent urinary bladder, menthol facilitates the micturition reflex but inhibits muscarinic contractions of
Alexander Klimovich et al.
Proceedings of the National Academy of Sciences of the United States of America, 117(30), 17854-17863 (2020-07-11)
Pacemaker neurons exert control over neuronal circuit function by their intrinsic ability to generate rhythmic bursts of action potential. Recent work has identified rhythmic gut contractions in human, mice, and hydra to be dependent on both neurons and the resident
Debra Martin et al.
Journal of clinical pharmacology, 44(10), 1151-1157 (2004-09-03)
Camphor, menthol, and methyl salicylate occur in numerous over-the-counter products. Although extensively used, there have been no estimates of human exposure following administration via dermal application. Furthermore, there is little information about the pharmacokinetics of those compounds. The authors report
Peter J McNamara et al.
Antimicrobial agents and chemotherapy, 53(5), 1898-1906 (2009-02-19)
Menstrual toxic shock syndrome is a rare but potentially life-threatening illness manifest through the actions of Staphylococcus aureus toxic shock syndrome toxin 1 (TSST-1). Previous studies have shown that tampon additives can influence staphylococcal TSST-1 production. We report here on
A Gelal et al.
Clinical pharmacology and therapeutics, 66(2), 128-135 (1999-08-25)
Menthol is widely used in a variety of commercial products and foods, but its clinical pharmacology is not well studied. To determine the disposition kinetics and to examine subjective and cardiovascular effects of menthol, we conducted a crossover placebo-controlled study
Tibor Rohács et al.
Nature neuroscience, 8(5), 626-634 (2005-04-27)
The subjective feeling of cold is mediated by the activation of TRPM8 channels in thermoreceptive neurons by cold or by cooling agents such as menthol. Here, we demonstrate a central role for phosphatidylinositol 4,5-bisphosphate (PI(4,5)P(2)) in the activation of recombinant
Oxindole alkaloids. A novel non-biomimetic entry to (-)-Horsfiline.
Palmisano G, et al.
Tetrahedron Asymmetry, 7(1), 1-4 (1996)
Marei GI, et al.
Pesticide Biochemistry and Physiology, 103(1), 56-61 (2012)
Anne-Mette Haahr et al.
Physiology & behavior, 82(2-3), 531-540 (2004-07-28)
During chewing, the oral cavity functions like a bellow, forcing volatile flavour compounds into the exhaling air to the nasal compartment. Accordingly, we hypothesised that flavour release from chewing gum is predominantly governed by chewing frequency (CF), although other oral
G Haeseler et al.
European journal of anaesthesiology, 19(8), 571-579 (2002-08-31)
Thymol is a naturally occurring phenol derivative used in anaesthetic practice as a stabilizer and preservative of halothane, usually at a concentration of 0.01%. Although analgesic effects have long been described for thymol and its structural homologue menthol, a molecular
Guide to Receptors and Channels (GRAC), 4th Edition.
British journal of pharmacology, 158 Suppl 1, S1-254 (2009-11-04)
Hjalte H Andersen et al.
Pain, 156(5), 880-889 (2015-02-27)
Topical high-concentration L-menthol is the only established human experimental pain model to study mechanisms underlying cold hyperalgesia. We aimed at investigating the combinatorial effect of cold stimuli and topical L-menthol on cold pain and secondary mechanical hyperalgesia. Analogue to the
An asymmetric approach to coumarin anticoagulants via hetero-Diels-Alder cycloaddition.
Cravotto G, et al.
Tetrahedron Asymmetry, 12(5), 707-709 (2001)
Lynn Ren et al.
Molecular pain, 11, 37-37 (2015-06-27)
Genome-wide association studies have identified TRPM8 (transient receptor potential melastatin 8) as one of the susceptibility genes for common migraine. Here, we investigated the postnatal changes of TRPM8-expressing dural afferent fibers as well as the function of dural TRPM8 channels
A new 31P NMR method for the enantiomeric excess determination of diols and secondary diamines with C 2 symmetry.
Tetrahedron Asymmetry, 6(9), 2353-2356 (1995)
Transient receptor potential ankyrin 1 (TRPA1) channel as emerging target for novel analgesics and anti-inflammatory agents.
Pier Giovanni Baraldi et al.
Journal of medicinal chemistry, 53(14), 5085-5107 (2010-04-02)
Novel 2-(hydroxyalkyl) pyridines derived from the chiral pool.
Adolfsson H, et al.
Tetrahedron Asymmetry, 7(7), 1967-1972 (1996)
Josefin Larsson et al.
Journal of natural products, 68(7), 985-991 (2005-07-26)
Recently various attempts have been made to increase the efficacy and precision of chemical libraries used in high-throughput screening (HTS) drug discovery approaches. One such approach is ChemGPS, which provides a defined chemical space for prescreening evaluation of chemical compound
Y-L Hsieh et al.
Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer, 24(1), 233-242 (2015-05-27)
Cold and mechanical allodynia caused by oxaliplatin-induced acute peripheral neuropathy frequently occur after drug infusion. Low-level laser therapy (LLLT) has been used to improve pain symptoms associated with various conditions and may have potential as a therapy for oxaliplatin-induced allodynia.
Shakir D Alsharari et al.
PloS one, 10(9), e0137070-e0137070 (2015-09-12)
Although menthol, a common flavoring additive to cigarettes, has been found to impact the addictive properties of nicotine cigarettes in smokers little is known about its pharmacological and molecular actions in the brain. Studies were undertaken to examine whether the
Thomas Voets et al.
Nature chemical biology, 3(3), 174-182 (2007-02-13)
TRPM8, a member of the transient receptor potential (TRP) channel superfamily, is expressed in thermosensitive neurons, in which it functions as a cold and menthol sensor. TRPM8 and most other temperature-sensitive TRP channels (thermoTRPs) are voltage gated; temperature and ligands
Joshua E Muscat et al.
Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology, 18(1), 35-41 (2009-01-07)
Menthol is a controversial cigarette additive because its physiologic or pharmacologic effects may possibly increase the risk for cancer and its targeted market is the Black community. In a community-based cross-sectional study on 525 Black and White volunteers, we compared
R Eccles
The Journal of pharmacy and pharmacology, 46(8), 618-630 (1994-08-01)
Menthol and related cooling compounds such as 'coolant agent 10', are widely used in products ranging from common cold medications to toothpastes, confectionery, cosmetics and pesticides. The review brings together a range of information on production and chemistry of menthol
Catarina L Silva et al.
Talanta, 89, 360-368 (2012-01-31)
A sensitive assay to identify volatile organic metabolites (VOMs) as biomarkers that can accurately diagnose the onset of breast cancer using non-invasively collected clinical specimens is ideal for early detection. Therefore the aim of this study was to establish the
H G Grigoleit et al.
Phytomedicine : international journal of phytotherapy and phytopharmacology, 12(8), 612-616 (2005-08-27)
The principal pharmacodynamic effect of peppermint oil relevant to the gastrointestinal tract is a dose-related antispasmodic effect on the smooth musculature due to the interference of menthol with the movement of calcium across the cell membrane. The choleretic and antifoaming
H F Stich et al.
Cancer letters, 15(3), 193-202 (1982-03-01)
Saliva of volunteers chewing betel quid, cured betel nut (Areca catechu), betel leaves (Piper betle), a mixture of quid ingredients (dried betel nut flakes, catechu, cardamon, lime, copra and menthol) and Indian tobacco was collected and examined for its genotoxic
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