1607007

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Role of cannabinoid CB2 receptor in the reinforcing actions of ethanol.

Antonio Ortega-Álvaro et al.

Addiction biology, 20(1), 43-55 (2013-07-17)

This study examines the role of the cannabinoid CB2 receptor (CB2 r) on the vulnerability to ethanol consumption. The time-related and dose-response effects of ethanol on rectal temperature, handling-induced convulsions (HIC) and blood ethanol concentrations were evaluated in CB2 KO

A novel strategy for pharmaceutical cocrystal generation without knowledge of stoichiometric ratio: myricetin cocrystals and a ternary phase diagram.

Chao Hong et al.

Pharmaceutical research, 32(1), 47-60 (2014-06-19)

To develop a streamlined strategy for pharmaceutical cocrystal preparation without knowledge of the stoichiometric ratio by preparing and characterizing the cocrystals of myricetin (MYR) with four cocrystal coformers (CCF). An approach based on the phase solubility diagram (PSD) was used

[Sweetening agents: saccharin--cyclamate and its metabolites--aspartame].

J Lederer

Revue medicale de la Suisse romande, 100(1), 87-100 (1980-01-01)

Multi-well microelectrode array recordings detect neuroactivity of ToxCast compounds.

Pablo Valdivia et al.

Neurotoxicology, 44, 204-217 (2014-07-06)

Spontaneous activity in neuronal cultures on microelectrode arrays (MEAs) is sensitive to effects of drugs, chemicals, and particles. Multi-well MEA (mwMEA) systems have increased throughput of MEAs, enabling their use for chemical screening. The present experiments examined a subset of

Determination of eight artificial sweeteners and common Stevia rebaudiana glycosides in non-alcoholic and alcoholic beverages by reversed-phase liquid chromatography coupled with tandem mass spectrometry.

Paweł Kubica et al.

Analytical and bioanalytical chemistry, 407(5), 1505-1512 (2014-12-05)

The method for the determination of acesulfame-K, saccharine, cyclamate, aspartame, sucralose, alitame, neohesperidin dihydrochalcone, neotame and five common steviol glycosides (rebaudioside A, rebaudioside C, steviol, steviolbioside and stevioside) in soft and alcoholic beverages was developed using high-performance liquid chromatography and

Toxicology of saccharin.

D L Arnold

Fundamental and applied toxicology : official journal of the Society of Toxicology, 4(5), 674-685 (1984-10-01)

Saccharin, like most of the artificial sweeteners, was discovered quite by accident. The controversy regarding its use as a food additive is reflected by the number of chronic/carcinogenic studies conducted to assess its safety. Two chronic studies were conducted prior

Administration of saccharin to neonatal mice influences body composition of adult males and reduces body weight of females.

Sebastian D Parlee et al.

Endocrinology, 155(4), 1313-1326 (2014-01-25)

Nutritional or pharmacological perturbations during perinatal growth can cause persistent effects on the function of white adipose tissue, altering susceptibility to obesity later in life. Previous studies have established that saccharin, a nonnutritive sweetener, inhibits lipolysis in mature adipocytes and

Promotion: is saccharin a promoter in the urinary bladder?

R M Hicks

Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association, 22(9), 755-760 (1984-09-01)

A review of various in vivo and in vitro studies indicates that saccharin has second-stage promoting activity in the rat bladder. In vitro, its effect on the human bladder is comparable to that on the rat bladder, and it produces

Dopamine D1 and opioid receptor antagonist-induced reductions of fructose and saccharin intake in BALB/c and SWR inbred mice.

Tamar T Kraft et al.

Pharmacology, biochemistry, and behavior, 131, 13-18 (2015-01-28)

Sugar and fat intake in rodents are mediated in part by brain dopamine (DA) and opioid neurotransmitter systems although important strain differences exist. Thus, whereas sucrose intake of BALB/c and SWR mice was reduced by DA D1 (SCH23390: SCH) receptor

Novel 5-HT6 receptor antagonists/D2 receptor partial agonists targeting behavioral and psychological symptoms of dementia.

Marcin Kołaczkowski et al.

European journal of medicinal chemistry, 92, 221-235 (2015-01-06)

We describe a novel class of designed multiple ligands (DMLs) combining serotonin 5-HT6 receptor (5-HT6R) antagonism with dopamine D2 receptor (D2R) partial agonism. Prototype hybrid molecules were designed using docking to receptor homology models. Diverse pharmacophore moieties yielded 3 series

Effects of coformers on phase transformation and release profiles of carbamazepine cocrystals in hydroxypropyl methylcellulose based matrix tablets.

Shi Qiu et al.

International journal of pharmaceutics, 479(1), 118-128 (2014-12-30)

The aim of this study was to investigate the effects of coformers on phase transformation and release profiles of carbamazepine (CBZ) cocrystals in hydroxypropyl methylcellulose (HPMC) based matrix tablets. It has been found that selection of different coformers of saccharin

A review and biological risk assessment of sodium saccharin.

C I Chappel

Regulatory toxicology and pharmacology : RTP, 15(3), 253-270 (1992-06-01)

Dietary sodium saccharin is associated with bladder tumors when fed at high levels to the male rat. Under these conditions urinary pH, sodium concentration, and volume are elevated and proliferative changes are present in the urothelium. Extensive epidemiological studies have

Sucrose consumption test reveals pharmacoresistant depression-associated behavior in two mouse models of temporal lobe epilepsy.

Sabine Klein et al.

Experimental neurology, 263, 263-271 (2014-09-16)

Among the comorbidities observed in epilepsy patients depression is the most frequent one. Likewise, depression by itself is accompanied by an increased risk to develop epilepsy. Both epilepsy and depression are characterized by a high incidence of pharmacoresistance, which might

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