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17-10085
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Jatin Mehta et al.
PloS one, 10(3), e0120622-e0120622 (2015-03-18)
Androgen Receptor (AR) is an essential transcription factor for the development of secondary sex characteristics, spermatogenesis and carcinogenesis. Recently AR has been implicated in the development and progression of breast and prostate cancers. Although some of the functions of the
Cold atmospheric plasma as a potential tool for multiple myeloma treatment.
Xu, D; Xu, Y; Cui, Q; Liu, D; Liu, Z; Wang, X; Yang, Y; Feng, M; Liang, R; Chen, H; Ye, K; Kong, MG
Oncotarget null
Pinglei Liu et al.
Cell death and differentiation, 24(10), 1672-1680 (2017-06-18)
Although much is known about transcriptional networks that control embryonic stem cell (ESC) self-renewal and differentiation, the metabolic regulation of ESC is less clear. Autophagy is a catabolic process that is activated under both stress and normal conditions to degrade
Julie R Secor McVoy et al.
Journal of neuroinflammation, 12, 27-27 (2015-04-19)
The nuclear receptor liver X receptor (LXR) exerts transcriptional control over lipid metabolism and inflammatory response in cells of the myeloid lineage, suggesting that LXR may be a potential target in a number of chronic neuroinflammatory and neurodegenerative diseases where
Cuiping Zhang et al.
Oncotarget, 9(51), 29665-29679 (2018-07-25)
High-risk B-cell acute lymphoblastic leukemia (B-ALL) remains a therapeutic challenge despite advances in the use of tyrosine kinase inhibitors and chimeric-antigen-receptor engineered T cells. Lymphoblastic-leukemia precursors are highly sensitive to oxidative stress. KLF5 is a member of the Krüppel-like family
Suppressor of sable [Su(s)] and Wdr82 down-regulate RNA from heat-shock-inducible repetitive elements by a mechanism that involves transcription termination.
Brewer-Jensen, P; Wilson, CB; Abernethy, J; Mollison, L; Card, S; Searles, LL
RNA null
Lei Qiang et al.
Autophagy, 13(12), 2086-2103 (2017-09-22)
Macroautophagy (hereafter autophagy) is a cellular "self-eating" process that is implicated in many human cancers, where it can act to either promote or suppress tumorigenesis. However, the role of autophagy in regulation of inflammation during tumorigenesis remains unclear. Here we
Daxx inhibits hypoxia-induced lung cancer cell metastasis by suppressing the HIF-1α/HDAC1/Slug axis.
Ching-Wen Lin et al.
Nature communications, 7, 13867-13867 (2016-12-23)
Hypoxia is a major driving force of cancer invasion and metastasis. Here we show that death domain-associated protein (Daxx) acts to negatively regulate hypoxia-induced cell dissemination and invasion by inhibiting the HIF-1α/HDAC1/Slug pathway. Daxx directly binds to the DNA-binding domain
Oncogenic KRAS Targets MUC16/CA125 in Pancreatic Ductal Adenocarcinoma.
Liang, C; Qin, Y; Zhang, B; Ji, S; Shi, S; Xu, W; Liu, J; Xiang, J; Liang, D; Hu, Q; Ni et al.
Molecular Cancer Research null
Ya Gao et al.
Communications biology, 2, 359-359 (2019-10-12)
Biomechanical force and pathological angiogenesis are dominant features in fibro-proliferative disorders. Understanding the role and regulation of the mechanical microenvironment in which pathological angiogenesis occurs is an important challenge when investigating numerous angiogenesis-related diseases. In skin fibrosis, dermal fibroblasts and
Hongyu Zhao et al.
Clinical and translational medicine, 9(1), 10-10 (2020-01-30)
The EGFR-vIII mutation is the most common malignant event in GBM. Epigenetic reprogramming in EGFR-activated GBM has recently been suggested to downregulate the expression of tumour suppressor genes. Histone acetylation is important for chromatin structure and function. However, the role
Jin-Fei Lin et al.
Signal transduction and targeted therapy, 7(1), 54-54 (2022-03-01)
Metabolic enzymes have an indispensable role in metabolic reprogramming, and their aberrant expression or activity has been associated with chemosensitivity. Hence, targeting metabolic enzymes remains an attractive approach for treating tumors. However, the influence and regulation of cysteine desulfurase (NFS1)
Epigenetically mediated spontaneous reduction of NFAT1 expression causes imbalanced metabolic activities of articular chondrocytes in aged mice.
Zhang, M; Lu, Q; Egan, B; Zhong, XB; Brandt, K; Wang, J
Osteoarthritis and Cartilage / OARS, Osteoarthritis Research Society null
Temozolomide down-regulates P-glycoprotein in human blood-brain barrier cells by disrupting Wnt3 signaling.
Riganti, C; Salaroglio, IC; Pinzon-Daza, ML; Caldera, V; Campia, I; Kopecka, J; Mellai et al.
Cellular and Molecular Life Sciences null
Wencheng Zhang et al.
Diabetes, 62(7), 2347-2358 (2013-02-12)
White adipose tissue (WAT) is not only a lipogenic and fat storage tissue but also an important endocrine organ that regulates energy homeostasis, lipid metabolism, appetite, fertility, and immune and stress responses. Liver kinase B1 (LKB1), a tumor suppressor, is
The ubiquitin ligase CHIP prevents SirT6 degradation through noncanonical ubiquitination.
Ronnebaum, SM; Wu, Y; McDonough, H; Patterson, C
Molecular and cellular biology null
Chih-Chieh Tao et al.
Cell death and differentiation, 27(1), 192-209 (2019-05-28)
Amyloid-β (Aβ) oligomers largely initiate the cascade underlying the pathology of Alzheimer's disease (AD). Galectin-3 (Gal-3), which is a member of the galectin protein family, promotes inflammatory responses and enhances the homotypic aggregation of cancer cells. Here, we examined the
C/EBP? drives interactions between human MAIT cells and endothelial cells that are important for extravasation.
Lee, CH; Zhang, HH; Singh, SP; Koo, L; Kabat, J; Tsang, H; Singh, TP; Farber, JM
eLife null
Rui Zhang et al.
Journal of immunology (Baltimore, Md. : 1950), 207(2), 613-625 (2021-07-18)
Alphaherpesviruses are large dsDNA viruses with an ability to establish persistent infection in hosts, which rely partly on their ability to evade host innate immune responses, notably the type I IFN response. However, the relevant molecular mechanisms are not well
Kuo-Ting Sun et al.
Bone, 73, 145-153 (2014-12-09)
Autophagy and autophagy-related proteins (ATGs) play decisive roles in osteoclast differentiation. Emerging lines of evidence show the deregulation of miRNA in autophagic responses. However, the role of hypoxia and involvement of miRNA in osteoclast differentiation are unclear. In the present
Ryoma Yoneda et al.
The Journal of biological chemistry, 295(17), 5626-5639 (2020-03-14)
pncRNA-D is an irradiation-induced 602-nt long noncoding RNA transcribed from the promoter region of the cyclin D1 (CCND1) gene. CCND1 expression is predicted to be inhibited through an interplay between pncRNA-D and RNA-binding protein TLS/FUS. Because the pncRNA-D-TLS interaction is
Weishen Chen et al.
Biochimica et biophysica acta, 1863(12), 2881-2891 (2016-11-05)
Histone acetylation regulated by class I histone deacetylases (HDACs) plays a pivotal role in matrix-specific gene transcription and cartilage development. While we previously demonstrated that microRNA (miR)-455-3p is upregulated during chondrogenesis and can enhance early chondrogenesis, the mechanism underlying this
A novel HIV-1-encoded microRNA enhances its viral replication by targeting the TATA box region.
Zhang, Y; Fan, M; Geng, G; Liu, B; Huang, Z; Luo, H; Zhou, J; Guo, X; Cai, W; Zhang, H
Retrovirology null
MYH9 binds to lncRNA gene PTCSC2 and regulates FOXE1 in the 9q22 thyroid cancer risk locus.
Wang, Y; He, H; Li, W; Phay, J; Shen, R; Yu, L; Hancioglu, B; de la Chapelle, A
Proceedings of the National Academy of Sciences of the USA null
Rachel Hood Edwards et al.
mBio, 6(2) (2015-04-16)
The Epstein-Barr virus protein latent membrane protein 1 (LMP1) has two NF-κB activating domains within its intracellular carboxy terminus (carboxy-terminal activating region 1 [CTAR1] and CTAR2). LMP1-CTAR1 is required for B-lymphocyte transformation, is capable of transforming rodent fibroblasts, and uniquely
MPC1, a key gene in cancer metabolism, is regulated by COUPTFII in human prostate cancer.
Wang, L; Xu, M; Qin, J; Lin, SC; Lee, HJ; Tsai, SY; Tsai, MJ
Oncotarget null
Li-Wen Fang et al.
BMB reports, 52(9), 548-553 (2019-05-11)
Ets-1 is a prototype of the ETS protein family. Members of the ETS protein family contain a unique ETS domain. Ets-1 is associated with cancer progression and metastasis in many types of cancer. Many studies have shown a link between
Benedetta Pignoloni et al.
Journal of immunology (Baltimore, Md. : 1950), 197(10), 4066-4078 (2016-10-14)
Elimination of virus-infected cells by cytotoxic lymphocytes is triggered by activating receptors, among which NKG2D and DNAM-1/CD226 play an important role. Their ligands, that is, MHC class I-related chain (MIC) A/B and UL16-binding proteins (ULBP)1-6 (NKG2D ligand), Nectin-2/CD112, and poliovirus
The oncogene ATF3 is potentiated by cyclosporine A and ultraviolet light A.
Dziunycz, PJ; Lefort, K; Wu, X; Freiberger, SN; Neu, J; Djerbi, N; Iotzowa-Weiss et al.
The Journal of Investigative Dermatology null
Acute hyperglycemia impairs functional improvement after spinal cord injury in mice and humans.
Kobayakawa, K; Kumamaru, H; Saiwai, H; Kubota, K; Ohkawa, Y; Kishimoto, J; Yokota et al.
Science Translational Medicine null
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