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显示 1-30 共 170 条结果 关于 "17-10085" 范围 论文
Yuzhu Hou et al.
Immunity, 49(3), 490-503 (2018-09-02)
The NF-κB pathway plays a crucial role in supporting tumor initiation, progression, and radioresistance of tumor cells. However, the role of the NF-κB pathway in radiation-induced anti-tumor host immunity remains unclear. Here we demonstrated that inhibiting the canonical NF-κB pathway
mTORC1 Promotes T-bet Phosphorylation To Regulate Th1 Differentiation.
Chornoguz, O; Hagan, RS; Haile, A; Arwood, ML; Gamper, CJ; Banerjee, A; Powell, JD
Journal of immunology (Baltimore, Md. : 1950) null
Rola Dali et al.
Molecular oncology, 12(6), 775-787 (2018-01-10)
Glioblastoma (GBM) is the most common and deadly malignant brain cancer of glial cell origin, with a median patient survival of less than 20 months. Transcription factors FOXG1 and TLE1 promote GBM propagation by supporting maintenance of brain tumour-initiating cells (BTICs)
Genome-wide DNA methylation profiles in hematopoietic stem and progenitor cells reveal overrepresentation of ETS transcription factor binding sites.
Hogart, A; Lichtenberg, J; Ajay, SS; Anderson, S; , ; Margulies, EH; Bodine, DM
Genome Research null
Arpana Verma et al.
Journal of cellular biochemistry, 116(5), 743-753 (2014-12-17)
In this study genome-wide di-methylated H3K4 (H3K4me2) and tri-methylated H3K27 (H3K27me3) modification profiles were analyzed in spermatozoa of buffalo bulls having wide fertility differences. The custom designed 4 × 180 K buffalo (Bubalus bubalis) ChIP-on-chip array was fabricated by employing array-based sequential hybridization
Xiangqi Meng et al.
Oncogene, 41(36), 4231-4243 (2022-07-30)
Altered expression of Urea Cycle (UC) enzymes occurs in many tumors, resulting a metabolic hallmark termed as UC dysregulation. Polyamines are synthesized from ornithine, and polyamine synthetic genes are elevated in various tumors. However, the underlying deregulations of UC/ polyamine
Sen Wang et al.
Redox biology, 28, 101319-101319 (2019-09-20)
Helicobacter pylori (H. pylori) infection is the main risk factor for gastric cancer. The role of antioxidant enzyme peroxiredoxin 2 (PRDX2) in gastric tumorigenesis remains unknown. In vitro (AGS and SNU-1 cell lines) and in vivo mouse models were utilized
B Zhang et al.
Current molecular medicine, 16(4), 404-411 (2016-03-17)
MBD1 (Methyl-CpG Binding Domain Protein 1) is highly expressed in pancreatic cancer. Nrf2 (NF-E2 p45-related factor 2) and the 'antioxidant response element' (ARE)-driven genes that NRF2 controls are frequently upregulated in pancreatic cancer and correlate with poor survival. Keap1 (Kelch-like
MiR-212/132 is epigenetically downregulated by SOX4/EZH2-H3K27me3 feedback loop in ovarian cancer cells.
Lin, L; Wang, Z; Jin, H; Shi, H; Lu, Z; Qi, Z
Tumour Biology : the Journal of the International Society For Oncodevelopmental Biology and Medicine null
Xin Lin et al.
The Journal of biological chemistry, 298(2), 101524-101524 (2021-12-27)
RNA-binding protein RBM28 (RBM28), as a nucleolar component of spliceosomal small nuclear ribonucleoproteins, is involved in the nucleolar stress response. Whether and how RBM28 regulates tumor progression remains unclear. Here, we report that RBM28 is frequently overexpressed in various types
Sandra Varum et al.
Cell stem cell, 24(4), 637-653 (2019-04-06)
Increasing evidence suggests that cancer cells highjack developmental programs for disease initiation and progression. Melanoma arises from melanocytes that originate during development from neural crest stem cells (NCSCs). Here, we identified the transcription factor Yin Yang 1 (Yy1) as an
Xuanrong Chen et al.
Journal of Cancer, 12(24), 7349-7357 (2022-01-11)
The role of lysyl oxidase (LOX) in prostate cancer remains controversial. Studies have shown that LOX may inhibit the progression of prostate cancer (PCa), whereas other studies demonstrate that LOX may act as a tumor activator in PCa. Here, we
ARF6, induced by mutant Kras, promotes proliferation and Warburg effect in pancreatic cancer.
Liang, C; Qin, Y; Zhang, B; Ji, S; Shi, S; Xu, W; Liu, J; Xiang, J; Liang, D; Hu, Q; Ni et al.
Cancer letters null
Chiara Cencioni et al.
Nature communications, 9(1), 1281-1281 (2018-03-31)
Nitric oxide (NO) synthesis is a late event during differentiation of mouse embryonic stem cells (mESC) and occurs after release from serum and leukemia inhibitory factor (LIF). Here we show that after release from pluripotency, a subpopulation of mESC, kept
Yanyan Gao et al.
Scientific reports, 6, 19874-19874 (2016-01-28)
Although the involvement of protein arginine methyltransferase 1 (PRMT1) in tumorigenesis has been reported, its roles in breast cancer progression and metastasis has not been elucidated. Here we identified PRMT1 as a key regulator of the epithelial-mesenchymal transition (EMT) in
Arunava Bandyopadhaya et al.
Nature microbiology, 1, 16174-16174 (2016-10-04)
The mechanisms by which pathogens evade elimination without affecting host fitness are not well understood. For the pathogen Pseudomonas aeruginosa, this evasion appears to be triggered by excretion of the quorum-sensing molecule 2-aminoacetophenone, which dampens host immune responses and modulates
Kevin M Tharp et al.
Cell metabolism, 27(3), 602-615 (2018-03-08)
The activation of brown/beige adipose tissue (BAT) metabolism and the induction of uncoupling protein 1 (UCP1) expression are essential for BAT-based strategies to improve metabolic homeostasis. Here, we demonstrate that BAT utilizes actomyosin machinery to generate tensional responses following adrenergic
Can Xu et al.
Frontiers in oncology, 12, 888922-888922 (2022-05-17)
Glioblastoma (GBM) is the most common and lethal type of primary malignant central nervous system (CNS) tumor with an extremely poor prognosis, and the mesenchymal subtype of GBM has the worst prognosis. Here, we found that lncRNA PRADX was overexpressed
MiR-129-5p is downregulated in breast cancer cells partly due to promoter H3K27m3 modification and regulates epithelial-mesenchymal transition and multi-drug resistance.
Luan, QX; Zhang, BG; Li, XJ; Guo, MY
European Review for Medical and Pharmacological Sciences null
Gang Yu et al.
Analytical cellular pathology (Amsterdam), 2022, 5374262-5374262 (2022-03-05)
The association between collagen type I alpha (COL1A) and chemoresistance has been verified in cancers. However, the specific role of COL1A2 in gastric cancer (GC) cell resistance to apatinib, a highly selective small-molecule inhibitor of vascular endothelial growth factor receptor
Xiaoyuan Tao et al.
Plant physiology, 186(4), 2152-2168 (2021-04-20)
The genomic shock of whole-genome duplication (WGD) and hybridization introduces great variation into transcriptomes, for both coding and noncoding genes. An altered transcriptome provides a molecular basis for improving adaptation during the evolution of new species. The allotetraploid cotton, together
Mingcai Zhang et al.
The international journal of biochemistry & cell biology, 72, 125-134 (2016-01-26)
While the developmental role of the SOX9 transcription factor in chondrocyte differentiation and cartilage formation is well documented, age-dependent SOX9 expression in articular chondrocytes (ACs) and its regulatory mechanisms remain unclear. This study aimed to explore epigenetic regulatory mechanisms for
Yi-Chuan Cheng et al.
Neural development, 10, 28-28 (2015-12-31)
Notch signaling has been conserved throughout evolution and plays a fundamental role in various neural developmental processes and the pathogenesis of several human cancers and genetic disorders. However, how Notch signaling regulates various cellular processes remains unclear. Although Deltex proteins
The role of SMAD3 in the genetic predisposition to papillary thyroid carcinoma.
Wang, Y; He, H; Liyanarachchi, S; Genutis, LK; Li, W; Yu, L; Phay, JE; Shen, R; Brock et al.
Genetics in Medicine : Official Journal of the American College of Medical Genetics null
Arctigenin, a dietary phytoestrogen, induces apoptosis of estrogen receptor-negative breast cancer cells through the ROS/p38 MAPK pathway and epigenetic regulation.
Hsieh, CJ; Kuo, PL; Hsu, YC; Huang, YF; Tsai, EM; Hsu, YL
Free radical biology & medicine null
Yu Chen et al.
Molecular and cellular biochemistry, 415(1-2), 103-109 (2016-03-14)
The T-box transcription factor TBX2 is known for its role as a critical regulator of melanoma cell proliferation, but its role in regulating melanogenesis has not been widely studied. Here we use a series of experiments to show in primary
Rushita A Bagchi et al.
JCI insight, 3(15) (2018-08-10)
Little is known about the biological function of histone deacetylase 11 (HDAC11), which is the lone class IV HDAC. Here, we demonstrate that deletion of HDAC11 in mice stimulates brown adipose tissue (BAT) formation and beiging of white adipose tissue
Y Qiao et al.
Oncogene, 35(20), 2664-2674 (2015-09-15)
Runt-related transcription factor 3 (RUNX3) is a well-documented tumour suppressor that is frequently inactivated in gastric cancer. Here, we define a novel mechanism by which RUNX3 exerts its tumour suppressor activity involving the TEAD-YAP complex, a potent positive regulator of
Satya P Singh et al.
Journal of immunology (Baltimore, Md. : 1950), 194(9), 4350-4361 (2015-04-03)
Th17 cells, which express the chemokine receptor CCR6, are implicated in many immune-mediated disorders, such as psoriasis and multiple sclerosis. We found that expression levels of CCR6 on human effector/memory CD4(+) T cells reflect a continuum of Th17 differentiation. By
TCF7L2 positively regulates aerobic glycolysis via the EGLN2/HIF-1? axis and indicates prognosis in pancreatic cancer.
Xiang, J; Hu, Q; Qin, Y; Ji, S; Xu, W; Liu, W; Shi, S; Liang, C; Liu, J; Meng, Q; Liang et al.
Cell Death & Disease null
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