177377

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Unstable Foxp3+ regulatory T cells and altered dendritic cells are associated with lipopolysaccharide-induced fetal loss in pregnant interleukin 10-deficient mice.

Jelmer R Prins et al.

Biology of reproduction, 93(4), 95-95 (2015-08-01)

Maternal interleukin (IL) 10 deficiency elevates susceptibility to fetal loss induced by the model Toll-like receptor agonist lipopolysaccharide, but the mechanisms are not well elucidated. Here, we show that Il10 null mutant (Il10(-/-)) mice exhibit altered local T cell responses

Squalene-containing nanostructured lipid carriers promote percutaneous absorption and hair follicle targeting of diphencyprone for treating alopecia areata.

Yin-Ku Lin et al.

Pharmaceutical research, 30(2), 435-446 (2012-10-17)

Diphencyprone (DPCP) is a therapeutic agent for treating alopecia areata. To improve skin absorption and follicular targeting nanostructured lipid carriers (NLCs) were developed. Nanoparticles were characterized by size, zeta potential, molecular environment, differential scanning calorimetry (DSC), and nuclear magnetic resonance

A fluorescence high throughput screening method for the detection of reactive electrophiles as potential skin sensitizers.

Cristina Avonto et al.

Toxicology and applied pharmacology, 289(2), 177-184 (2015-10-13)

Skin sensitization is an important toxicological end-point in the risk assessment of chemical allergens. Because of the complexity of the biological mechanisms associated with skin sensitization, integrated approaches combining different chemical, biological and in silico methods are recommended to replace

Characterisation of the antibacterial properties of a bacterial derived peptidoglycan hydrolase (LysCs4), active against C. sakazakii and other Gram-negative food-related pathogens.

Lorraine Endersen et al.

International journal of food microbiology, 215, 79-85 (2015-09-08)

Illness caused by the consumption of contaminated food products continues to represent one of the main challenges facing food manufacturers worldwide. Even with current intervention technologies and increased hygiene measures, foodborne illness remains a significant threat to public health. This

Inhibition of gastric H+,K+-ATPase by 4-(2-butyl-6,7-dichloro-2-cyclopentylindan-1-on-5-yl)oxybutyric acid (DCPIB), an inhibitor of volume-regulated anion channel.

Takuto Fujii et al.

European journal of pharmacology, 765, 34-41 (2015-08-19)

4-(2-Butyl-6,7-dichloro-2-cyclopentylindan-1-on-5-yl)oxybutyric acid (DCPIB) has been used as an inhibitor of volume-regulated anion channel (VRAC), which is expressed in almost all cells (IC50 is around 4 µM). Here, we found that DCPIB significantly inhibited the activities of gastric proton pump (H+,K+-ATPase)

Plasma endothelin-1 levels during exacerbation of atopic dermatitis.

Namjil N Tsybikov et al.

Allergy and asthma proceedings, 36(4), 320-324 (2015-06-25)

Endothelin (ET) -1 was found to participate in the pathogenesis of bronchial asthma. At present, there is no information regarding the role of ET-1 in the pathophysiology of atopic dermatitis (AD). We assessed blood ET-1 levels during the exacerbation of

Secondary structure and membrane topology of dengue virus NS4B N-terminal 125 amino acids.

Yan Li et al.

Biochimica et biophysica acta, 1848(12), 3150-3157 (2015-09-26)

The transmembrane NS4B protein of dengue virus (DENV) is a validated antiviral target that plays important roles in viral replication and invasion of innate immune response. The first 125 amino acids of DENV NS4B are sufficient for inhibition of alpha/beta

Structuration in the interface of direct and reversed micelles of sucrose esters, studied by fluorescent techniques.

Catalina Sandoval et al.

PloS one, 10(4), e0123669-e0123669 (2015-04-24)

Reactors found in nature can be described as micro-heterogeneous systems, where media involved in each micro-environment can behave in a markedly different way compared with the properties of the bulk solution. The presence of water molecules in micro-organized assemblies is

Solution structure of the transmembrane domain of the mouse erythropoietin receptor in detergent micelles.

Qingxin Li et al.

Scientific reports, 5, 13586-13586 (2015-09-01)

Erythropoiesis is regulated by the erythropoietin receptor (EpoR) binding to its ligand. The transmembrane domain (TMD) and the juxtamembrane (JM) regions of the EpoR are important for signal transduction across the cell membrane. We report a solution NMR study of

The effects of hypokalaemia on the hormone exocytosis in adenohypophysis and prolactinoma cell culture model systems.

Z Molnár et al.

Experimental and clinical endocrinology & diabetes : official journal, German Society of Endocrinology [and] German Diabetes Association, 122(10), 575-581 (2014-07-24)

The extracellular ion milieu determines the exocytosis mechanism that is coupled to spontaneous electrical activity. The K(+) ion plays crucial role in this mechanism: as the potassium current is associated with membrane hyperpolarization and hormone release through protein cascade activation.

Ethnic disparity in central arterial stiffness and its determinants among Asians with type 2 diabetes.

Xiao Zhang et al.

Atherosclerosis, 242(1), 22-28 (2015-07-15)

We previously reported ethnic disparity in adverse outcomes among Asians with type 2 diabetes (T2DM) in Singapore. Central arterial stiffness can aggravate systemic vasculopathy by propagating elevated systolic and pulse pressures forward, thereby accentuating global vascular injury. We aim to

Dietary factors and luteal phase deficiency in healthy eumenorrheic women.

Mary A Andrews et al.

Human reproduction (Oxford, England), 30(8), 1942-1951 (2015-06-18)

Are prospectively assessed dietary factors, including overall diet quality, macronutrients and micronutrients, associated with luteal phase deficiency (LPD) in healthy reproductive aged women with regular menstrual cycles? Mediterranean Diet Score (MDS), fiber and isoflavone intake were positively associated with LPD

Flipping in the pore: discovery of dual inhibitors that bind in different orientations to the wild-type versus the amantadine-resistant S31N mutant of the influenza A virus M2 proton channel.

Yibing Wu et al.

Journal of the American Chemical Society, 136(52), 17987-17995 (2014-12-04)

Influenza virus infections lead to numerous deaths and millions of hospitalizations each year. One challenge facing anti-influenza drug development is the heterogeneity of the circulating influenza viruses, which comprise several strains with variable susceptibility to antiviral drugs. For example, the

Dramatic regression of cutaneous, nodal, and visceral melanoma metastases.

Diona L Damian et al.

Journal of the American Academy of Dermatology, 65(3), 665-666 (2011-08-16)

The periovulatory endocrine milieu affects the uterine redox environment in beef cows.

Roney S Ramos et al.

Reproductive biology and endocrinology : RB&E, 13, 39-39 (2015-05-11)

In cattle, recent studies have shown positive associations between pre-ovulatory concentrations of estradiol (E2), progesterone (P4) at early diestrus and fertility. However, information on cellular and molecular mechanisms through which sex steroids regulate uterine function to support early pregnancy is

A potential role for miRNAs in topical drug development.

Joshua W Hagen et al.

Journal of drugs in dermatology : JDD, 12(2), 152-152 (2013-02-05)

MicroRNAs (miRNAs) are small, noncoding regulatory RNAs demonstrated to play a role in regulating diverse physiologic and pathologic processes in humans. The understanding of their role in dermatologic disorders has been rapidly expanding, and technological advances in the field of

Release of erythropoietin and neuron-specific enolase after breath holding in competing free divers.

T Kjeld et al.

Scandinavian journal of medicine & science in sports, 25(3), e253-e257 (2014-08-22)

Free diving is associated with extreme hypoxia. This study evaluated the combined effect of maximal static breath holding and underwater swimming on plasma biomarkers of tissue hypoxemia: erythropoietin, neuron-specific enolase and S100B, C-reactive protein, pro-atrial natriuretic peptide, and troponin T.

Topical immunotherapy with diphenylcyclopropenone is effective and preferred in the treatment of periungual warts.

Yunseok Choi et al.

Annals of dermatology, 25(4), 434-439 (2013-12-29)

There exists a treatment challenge with periungual warts. Topical immunotherapy with diphenylcyclopropenone (DPCP) has recently been reported to be an effective treatment for recalcitrant warts, including periungual types. We aimed to evaluate the effectiveness and preference of topical immunotherapy with

Topical immunotherapy with diphenylcyclopropenone of patients with alopecia areata--a large retrospective study on 142 patients with a self-controlled design.

M C Ohlmeier et al.

Journal of the European Academy of Dermatology and Venereology : JEADV, 26(4), 503-507 (2011-05-17)

Although diphenylcyclopropenone (DCP) is frequently used for the treatment of alopecia areata (AA), large studies with more than 100 patients are still scarce. To determine the efficacy of DCP immunotherapy in a large cohort of patients with AA who had

Myelin basic protein is a glial microtubule-associated protein -- characterization of binding domains, kinetics of polymerization, and regulation by phosphorylation and a lipidic environment.

Agata Zienowicz et al.

Biochemical and biophysical research communications, 461(1), 136-141 (2015-04-12)

The 18.5-kDa splice isoform of myelin basic protein (MBP) predominates in the adult brain, adhering the cytoplasmic leaflets of the oligodendrocyte membrane together, but also assembling the cytoskeleton at leading edges of membrane processes. Here, we characterized MBP's role as

Comparison of cure rates and durations of treatment with diphenylcyclopropenone immunotherapy for warts in children/adolescents and adults.

Ho Song Kang et al.

International journal of dermatology, 53(10), 1293-1298 (2014-04-05)

Immunotherapy has been used for many years in the treatment of warts. Diphenylcyclopropenone is frequently used as an immunotherapeutic agent. A total of 143 patients with 180 cases of warts were included in this study. We divided the patients into

Effect of pre- and postnatal growth and post-weaning activity on glucose metabolism in the offspring.

Neele S Dellschaft et al.

The Journal of endocrinology, 224(2), 171-182 (2014-11-25)

Maternal caloric restriction during late gestation reduces birth weight, but whether long-term adverse metabolic outcomes of intra-uterine growth retardation (IUGR) are dependent on either accelerated postnatal growth or exposure to an obesogenic environment after weaning is not established. We induced

Physical Activity, Fitness, and Cardiometabolic Risk Factors in Adult Survivors of Childhood Cancer with a History of Hematopoietic Cell Transplantation.

Megan E Slater et al.

Biology of blood and marrow transplantation : journal of the American Society for Blood and Marrow Transplantation, 21(7), 1278-1283 (2015-04-14)

Along with other childhood cancer survivors (CCS), hematopoietic cell transplantation (HCT) survivors are at high risk of treatment-related late effects, including cardiovascular disease and diabetes. Cardiometabolic risk factor abnormalities may be exacerbated by inadequate physical activity (PA). Relationships between PA

Solute-solvent hydrogen-bonding in room temperature ionic liquids studied by Raman spectroscopy.

Akira Kobayashi et al.

Physical chemistry chemical physics : PCCP, 14(39), 13676-13683 (2012-09-13)

The vibrational frequencies of the C=O + C=C band of diphenylcyclopropenone and the NH(2) stretching band of p-aminobenzonitrile were determined in various room temperature ionic liquids (RTILs). The vibrational frequency shifts of the C=O + C=C stretching mode were compared

Effects of intranasal oxytocin on steroid hormones in men and women.

Michelle M Wirth et al.

Neuropsychobiology, 71(4), 202-211 (2015-06-06)

Recent interest in the social and cognitive effects of intranasal oxytocin prompts a need for understanding its physiological effects in humans. Few studies have examined the effects of intranasal oxytocin on steroid hormones. Filling this gap is especially important given

Phototherapy as a useful therapeutic option in the treatment of diphenylcyclopropenone-induced vitiligo.

Giulia Ganzetti et al.

Acta dermato-venereologica, 90(6), 642-643 (2010-11-09)

Topical diphencyprone immunotherapy for a large primary melanoma on an elderly leg.

Diona L Damian et al.

American journal of clinical dermatology, 12(6), 403-404 (2011-10-05)

Structural study of caveolin-1 intramembrane domain by circular dichroism and nuclear magnetic resonance.

Guanhua Yang et al.

Biopolymers, 104(1), 11-20 (2014-12-05)

Caveolin-1 is a main structural component of caveolae and essential for the invagination of caveolae by forming a hairpin-shaped structure in the membrane-inserting domain (residues, 102-122). In this article, we determined the tertiary structures of the peptides comprising residues 93-126

Allergic contact dermatitis induces upregulation of identical microRNAs in humans and mice.

Marie T Vennegaard et al.

Contact dermatitis, 67(5), 298-305 (2012-05-19)

MicroRNAs are short, endogenous RNA molecules that can bind to parts of target mRNAs, thus inhibiting their translation and causing accelerated turnover or degradation of transcripts, thereby regulating gene expression. Several microRNAs have been found to be upregulated in atopic

Exercise-induced stress inhibits both the induction and elicitation phases of in vivo T-cell-mediated immune responses in humans.

Adam D Harper Smith et al.

Brain, behavior, and immunity, 25(6), 1136-1142 (2011-03-03)

Little is known about the influence of exercise on induction and elicitation phases of in vivo immunity in humans. We used experimental contact-hypersensitivity, a clinically relevant in vivo measure of T cell-mediated immunity, to investigate the effects of exercise on

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