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Jesper Dyrendom Svalgaard et al.
Immunologic research, 58(1), 40-50 (2014-01-05)
p-Phenylenediamine (PPD) and Diphenylcyclopropenone (DPCP) are two potent haptens. Both haptens are known to cause delayed-type hypersensitivity, involving a cytokine response and local infiltration of T-cell subpopulations, resulting in contact dermatitis. We investigated the systemic immune effects of PPD and
Shigeki Inui et al.
The Journal of dermatology, 37(10), 888-893 (2010-09-24)
Pigmentary complication by contact immunotherapy (CI) for alopecia areata (AA) has been reported but its pathophysiology remains unknown. To characterize pigmentary complication by CI and its pathophysiology, we examined the incidence of hyperpigmentation in 186 consecutive patients treated with CI
N Bangsgaard et al.
Clinical and experimental immunology, 165(3), 310-317 (2011-06-15)
An inverse relation between contact allergy and autoimmune diseases is suggested from epidemiological studies. The aim of this study was to investigate susceptibility and reactivity in patients with psoriasis, patients with diabetes and healthy controls in an experimental sensitization study.
A Ahangari et al.
Internal medicine journal, 45(7), 725-731 (2015-04-15)
Acute intermittent porphyria (AIP), a life-threatening form of the disease, is accompanied by several pain, mental and physical symptoms. In this study, we evaluated the cyclicity of AIP and premenstrual syndrome (PMS) symptoms in 32 women with DNA-diagnosed AIP during
Narrow-band ultraviolet B treatment for diphenylcyclopropenone-induced vitiliginous lesions.
Yu-Jin Oh et al.
Acta dermato-venereologica, 92(1), 102-103 (2012-01-05)
Morihiko Hirota et al.
The Journal of toxicological sciences, 35(6), 871-879 (2010-12-09)
Changes of cell-surface thiols induced by chemical treatment may affect the conformations of membrane proteins and intracellular signaling mechanisms. In our previous study, we found that a non-toxic dose of diphenylcyclopropene (DPCP), which is a potent skin sensitizer, induced an
Atsuhiko Murata et al.
International journal of clinical pharmacy, 37(1), 139-147 (2014-12-18)
There have been no studies comparing the effects of antithrombin (AT-III) and recombinant human soluble thrombomodulin (rhs-TM) on outcomes in patients with disseminated intravascular coagulation (DIC) associated with infectious diseases. The aim of this observational study is to compare AT-III
Antonio Fortunato et al.
Clinica chimica acta; international journal of clinical chemistry, 444, 106-112 (2015-02-11)
Two new immunoassay methods for aldosterone assay using automated platforms recently became available into market. The main aim of the present study is to evaluate the analytical performance of these automated direct immunoassay methods, and also to compare their analytical
Abdullah Alkhalifah et al.
Journal of the American Academy of Dermatology, 62(2), 191-202 (2010-02-02)
Various therapeutic agents have been described for the treatment of alopecia areata (AA), but none are curative or preventive. The aim of AA treatment is to suppress the activity of the disease. The high rate of spontaneous remission and the
Bakr Mohamed El-Zawahry et al.
Gene, 523(2), 147-151 (2013-04-11)
PTPN22 1858C>T gene polymorphism has been associated with several autoimmune disorders including alopecia areata. The aim of the current study was to investigate the effect of the inherited genetic polymorphism 1858C>T of PTPN22 gene on the predisposition to severe forms
Hong-Mei Guo et al.
Proceedings of the National Academy of Sciences of the United States of America, 112(14), 4435-4440 (2015-04-02)
The airway epithelia initiate and modulate the inflammatory responses to various pathogens. The cystic fibrosis transmembrane conductance regulator-mediated Cl(-) secretion system plays a key role in mucociliary clearance of inhaled pathogens. We have explored the effects of Toxoplasma gondii, an
J Schrader et al.
Experimental and clinical endocrinology & diabetes : official journal, German Society of Endocrinology [and] German Diabetes Association, 123(2), 118-125 (2014-11-14)
Class 1A phosphoinositide 3-kinase (PI3K) is essential for beta-cell growth and survival. Although PI3K has been studied extensively in diabetes the effect of alternatively spliced isoforms of the catalytic subunit p85α on beta cell proliferation and survival remains to be
Frank Martiniuk et al.
Journal of drugs in dermatology : JDD, 9(11), 1368-1372 (2010-11-11)
The authors provide an update on a previously reported patient with in-transit metastatic melanoma of the scalp treated with topical diphencyprone (DPCP). Molecular studies implicate the thymus-derived TH17 lymphocyte subset in a remarkable immunotherapeutic regression. The authors performed RT-PCR of
Stamatis Gregoriou et al.
Mediators of inflammation, 2010, 928030-928030 (2010-03-20)
Alopecia areata, a disease of the hair follicles with multifactorial etiology and a strong component of autoimmune origin, has been extensively studied as far as the role of several cytokines is concerned. So far, IFN-gamma, interleukins, TNF-alpha, are cytokines that
Ronald T Acton et al.
Metabolic syndrome and related disorders, 13(2), 57-63 (2014-11-26)
In some reports, serum ferritin (SF) has been associated with insulin resistance and metabolic syndrome. We studied non-Hispanic whites without diabetes mellitus in a postscreening examination. Participants included cases [HFE C282Y homozygosity; and transferrin saturation (TS) >50% and SF >300 μg/L
Jose Luis Ortega-Roldan et al.
FEBS letters, 589(5), 659-665 (2015-02-04)
The sigma-1 receptor (S1R) is a ligand-regulated membrane chaperone protein associated with endoplasmic reticulum stress response, and modulation of ion channel activities at the plasma membrane. We report here a solution NMR study of a S1R construct (S1R(Δ35)) in which
Axel C Carlsson et al.
Blood purification, 39(4), 259-265 (2015-05-01)
Although both endostatin and cathepsins S have been associated with higher mortality, data in patients with end-stage renal disease (ESRD) are scarce. A longitudinal cohort study of 207 prevalent patients undergoing hemodialysis. Cathepsins S and L were associated with soluble
Nahla Hunter et al.
The Journal of dermatological treatment, 22(1), 2-10 (2010-06-08)
To evaluate the efficacy of two topically applied immunomodulative agents through the detection of lymphocyte subsets using monoclonal antibodies against CD4, CD8 and MHC II. Fifty patients from the Departments of Medical Biochemistry, Dermatology and Pathology at Cairo University with
Julius Popp et al.
Neurobiology of aging, 36(2), 601-607 (2014-12-02)
Increased peripheral and central nervous system cortisol levels have been reported in Alzheimer's disease (AD) and may reflect dysfunction of cerebral components of the hypothalamic-pituitary-adrenal (HPA) axis. However, brain exposure to high cortisol concentrations may also accelerate disease progression and
Nannie Bangsgaard et al.
Contact dermatitis, 63(1), 10-14 (2010-07-06)
It is uncertain whether polysensitized patients acquire multiple allergies only because of a high degree of exposure to environmental allergens, or because of being highly susceptible to developing contact allergy. The aim of this study was to investigate and compare
Tao Tong et al.
PloS one, 10(6), e0129578-e0129578 (2015-06-11)
Oleuropein promoted cultured human follicle dermal papilla cell proliferation and induced LEF1 and Cyc-D1 mRNA expression and β-catenin protein expression in dermal papilla cells. Nuclear accumulation of β-catenin in dermal papilla cells was observed after oleuropein treatment. Topical application of
Yu-Ching Chen et al.
Cancer biology & therapy, 16(8), 1172-1183 (2015-07-07)
The antimicrobial and anticancer activities of an antimicrobial peptide (AMP) KL15 obtained through in silico modification on the sequences of 2 previously identified bacteriocins m2163 and m2386 from Lactobacillus casei ATCC 334 by us have been studied. While significant bactericidal
Aírton J Rombaldi et al.
PloS one, 10(5), e0125984-e0125984 (2015-05-12)
There is conflicting evidence about the association between physical activity and inflammatory markers. Few prospective studies are available, particularly from low and middle-income countries. This study was aimed at assessing the cross-sectional and prospective associations between physical activity and C-reactive
G Ganzetti et al.
International journal of immunopathology and pharmacology, 24(4), 1087-1091 (2012-01-11)
Alopecia areata (AA) is an inflammatory skin disease the most effective therapy for which is diphenylcyclopropenone (DPCP). Videodermatoscopy and intra-vital capillaroscopy (IVCP) are two non-invasive techniques that help in the differential diagnosis of alopecias. It is known that, after DPCP
Stefanie Meister et al.
Rheumatology international, 35(8), 1311-1318 (2015-01-30)
The inhibitory FcγRIIB plays an important role for the peripheral B cell tolerance and plasma cell homeostasis, and any malfunctioning is predicted to result in humoral autoimmunity. An association between rheumatoid arthritis (RA) and FCGR2B promoter and TM region variant
Robby Engelmann et al.
Rheumatology (Oxford, England), 54(3), 545-553 (2014-09-07)
The prevention of bone resorption and subsequent joint destruction is one of the main challenges in the treatment of patients suffering from RA. Various mechanisms have previously been described that contribute to bone resorption in tightly defined cohorts. Here we
MicroRNA 150 in humans and murine contact sensitivity.
Joel Wolf et al.
Journal of drugs in dermatology : JDD, 11(10), 1152-1152 (2013-01-05)
Valerio Tabacchini et al.
Physics in medicine and biology, 60(14), 5513-5525 (2015-07-03)
Gamma-ray detectors based on bright monolithic scintillation crystals coupled to pixelated photodetectors are currently being considered for several applications in the medical imaging field. In a typical monolithic detector, both the light intensity and the time of arrival of the
Oriana Del Rocío Cruz-Guzmán et al.
BioMed research international, 2015, 891972-891972 (2015-09-18)
Inflammation described in patients with Duchenne muscular dystrophy (DMD) may be related to loss of muscle function or to obesity. It is unknown if circulating proinflammatory cytokines (IL-6, IL-1, and TNF-α) levels are associated with muscle function. The purpose was
Wojciech Zygner et al.
Veterinary parasitology, 211(1-2), 23-27 (2015-05-16)
Low triiodothyronine (T3) syndrome, also named euthyroid sick syndrome or non-thyroidal illness syndrome, has been recognized in canine babesiosis caused by Babesia rossi, where it manifested by lowering of the serum thyrotropin (TSH), total thyroxin (TT4) and free thyroxin (FT4)
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