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Richard J Delle Bovi et al.
Biochimica et biophysica acta. Biomembranes, 1861(4), 819-826 (2019-01-27)
The plasma membrane is a dynamic environment with a complex composition of lipids, proteins, and cholesterol. Areas enriched in cholesterol and sphingolipids are believed to form lipid rafts, domains of highly ordered lipids. The unique physical properties of these domains
H S Lin et al.
Steroids, 63(4), 202-207 (1998-05-20)
4 alpha-(2-Propenyl)-5 alpha-cholestan-3 alpha-ol (LY295427) was previously identified from a CHO cell-based assay to be a potent LDL receptor up-regulator and had demonstrated to be an effective agent in lowering plasma cholesterol levels in hypercholesterolemic hamsters. In order to investigate
K Hayashi et al.
Journal of atherosclerosis and thrombosis, 2(2), 117-121 (1996-01-01)
We developed a simple, sensitive and accurate method for assaying cellular free and total cholesterol by monitoring 4-cholesten-3-one, a conversion product of the cholesterol oxidase-catalyzed oxidation of the free cholesterol that has a strong chromophoric alpha, beta-unsaturated ketone at 240
Hui Li et al.
Applied biochemistry and biotechnology, 187(4), 1238-1254 (2018-09-14)
3-Ketosteroid-9α-hydroxylase (KSH) consists of two protein systems, KshA and KshB, and is a key enzyme in microbial degradation pathway of natural sterols. 9α-Hydroxy-4-androstene-3,17-dione (9α-OH-AD) is a valuable steroid pharmaceutical intermediate. The expression of a 3-ketosteroid-9α-hydroxylase oxygenase (KshA1) with a broad
Satoshi Yamaguchi et al.
Scientific reports, 7, 41007-41007 (2017-01-25)
A chemically-activatable alkynyl steroid analogue probe has been synthesized for visualizing the lipid raft membrane domains by Raman microscopy. The Raman probe, in which ring A of its steroid backbone is replaced with an alkynyl group, was designed to enable
An-Shen Lin et al.
Bioorganic & medicinal chemistry, 18(23), 8264-8269 (2010-11-03)
Bioactivity-guided fractionation of the extract from a Fijian red alga Peyssonnelia sp. led to the isolation of two novel sterol glycosides 19-O-β-d-glucopyranosyl-19-hydroxy-cholest-4-en-3-one (1) and 19-O-β-d-N-acetyl-2-aminoglucopyranosyl-19-hydroxy-cholest-4-en-3-one (2), and two known alkaloids indole-3-carboxaldehyde (3) and 3-(hydroxyacetyl)indole (4). Their structures were characterized by
Hui Lei et al.
Zhong yao cai = Zhongyaocai = Journal of Chinese medicinal materials, 34(2), 180-183 (2011-08-10)
To study the sterol constituents of Bugula neritina from the South China Sea. The alcohol extract of Bugula neritina was purified by silica gel column and Sephadex LH-20 column chromatography, and structures of the isolated compounds were identified by spectroscopic
K Suzuki et al.
Bioorganic & medicinal chemistry letters, 8(16), 2133-2138 (1999-01-05)
Based on the findings that cholest-4-en-3-one, an intestinal metabolite of cholesterol, has an anti-obesity effect on animals, the structure-effect relationship of its 3-oxo derivatives and related compounds were investigated. Cholesten-3-ones, which possesses an enone structure with a carbonyl group at
K Suzuki
Journal of nutritional science and vitaminology, 39(5), 537-543 (1993-10-01)
An anti-obesity effect was observed for cholest-4-en-3-one (cholestenone) which is an intestinal catabolite of cholesterol. Body weight gain and body fat accumulation of CDF1 mice were inhibited by 0.5% dietary exposure to this chemical. Dose response for the effect of
J-F Rontani et al.
Rapid communications in mass spectrometry : RCM, 18(9), 955-959 (2004-04-30)
The electron ionization (EI) mass spectral fragmentation of derivatized 4,5- and 5,6-epoxysterols was investigated. Interesting fragmentation processes involving a transannular cleavage of the epoxide ring after transfer of the trimethylsilyl group are significant in the case of 4,5-epoxysterol trimethylsilyl ethers
Jenna K Capyk et al.
The Journal of biological chemistry, 284(51), 35534-35542 (2009-10-23)
Cyp125 (Rv3545c), a cytochrome P450, is encoded as part of the cholesterol degradation gene cluster conserved among members of the Mycobacterium tuberculosis complex. This enzyme has been implicated in mycobacterial pathogenesis, and a homologue initiates cholesterol catabolism in the soil
J A Weststrate et al.
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association, 37(11), 1063-1071 (1999-11-24)
A study was conducted in 12 healthy males and 12 females (mean age 36 years) to assess the impact of a margarine enriched with phytosterol esters on faecal concentrations of bile acids and sterols. During the run-in period, volunteers consumed
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