Antonios G. Mikos†�
†Department of Bioengineering, Rice University, MS-142, P.O. Box 1892, Houston, TX 77251-1892; §School of Chemical, Biological, and Materials
Engineering, University of Oklahoma, 100
similar to those shown on the platinum/
cobalt scale.
This method was developed by Allen Hazen in 1892 and was originally based on a visual comparison of the
color of the sample solution with a defined
scaffold.
Systems using direct mechanical strain
Since the German anatomist Julius Wolff in 1892 postu-
lated that bone remodeling depends on mechanical load,
numerous scientists have focused on