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Natacha Leroi et al.
Oncotarget, 6(34), 36825-36837 (2015-10-07)
Neoadjuvant radiotherapy (neoRT) used in cancer treatments aims at improving local tumor control and patient overall survival. The neoRT schedule and the timing of the surgical treatment (ST) are empirically based and influenced by the clinician's experience. The current study
Savannah E Howe et al.
PloS one, 9(12), e114601-e114601 (2014-12-10)
The female reproductive tract (FRT) includes the oviducts (fallopian tubes), uterus, cervix and vagina. A layer of columnar epithelium separates the endocervix and uterus from the outside environment, while the vagina is lined with stratified squamous epithelium. The mucosa of
Yuan Liu et al.
PloS one, 10(7), e0133068-e0133068 (2015-07-21)
Sex-biased genes are considered to account for most of phenotypic differences between males and females. In order to explore the sex-biased gene expression in crab, we performed the whole-body transcriptome analysis in male and female juveniles of the Chinese mitten
Linda K Banbury et al.
Journal of ethnopharmacology, 163, 251-255 (2015-02-07)
Australian Aboriginal people used crushed leaves of Geijera parviflora Lindl. both internally and externally for pain relief, including for toothache (Cribb and Cribb, 1981). This study tested the hypothesis that this traditional use might be at least in part explained
Raziye Akcılar et al.
International journal of clinical and experimental medicine, 8(8), 12783-12791 (2015-11-10)
Hypertension is a risk factor for the cardiovascular diseases. Ozone as a therapeutic agent for the treatment of several disorders. We aimed to observe the effects of ozone on the blood pressure in DOCA-salt hypertensive rats. Twenty three young Sprague
Iwona Ziemecka et al.
Lab on a chip, 15(2), 504-511 (2014-11-20)
Pervaporation in a microfluidic device is performed on liquid ternary solutions of hydrogen peroxide-water-methanol in order to concentrate hydrogen peroxide (H2O2) by removing methanol. The quantitative analysis of the pervaporation of solutions with different initial compositions is performed, varying the
Andrew T Lucas et al.
PloS one, 9(11), e112823-e112823 (2014-11-15)
The translationally-controlled tumor protein (TCTP) is a highly conserved, ubiquitously expressed, abundant protein that is broadly distributed among eukaryotes. Its biological function spans numerous cellular processes ranging from regulation of the cell cycle and microtubule stabilization to cell growth, transformation
Roger R Beerli et al.
mAbs, 6(6), 1608-1620 (2014-12-09)
Anti-cytokine autoantibodies have been widely reported to be present in human plasma, both in healthy subjects and in patients with underlying autoimmune conditions, such as autoimmune polyendocrinopathy candidiasis ectodermal dystrophy (APECED) or thymic epithelial neoplasms. While often asymptomatic, they can
Marlene Kaposi et al.
Dalton transactions (Cambridge, England : 2003), 44(36), 15976-15983 (2015-08-19)
Amino-functionalised metal-organic frameworks UiO-66 and -67 were post-synthetically modified with salicylaldehyde. A molybdenum complex was immobilised on the resulting materials. They were characterised by (13)C-MAS-NMR, XPS and PXRD to confirm immobilisation and stability. The immobilised complex is an active and
Guillaume Povie et al.
Chimia, 67(4), 250-252 (2013-08-24)
Water or low molecular weight alcohols are, due to their availability, low price and low toxicity ideal reagents for organic synthesis. Recently, it was reported that, despite the very strong BDE of the O-H bond, they can be used as
Yunqing Tang et al.
Scientific reports, 5, 11073-11073 (2015-06-23)
Single molecule localization based super-resolution fluorescence microscopy offers significantly higher spatial resolution than predicted by Abbe's resolution limit for far field optical microscopy. Such super-resolution images are reconstructed from wide-field or total internal reflection single molecule fluorescence recordings. Discrimination between
Mary A Rodgers et al.
The Journal of experimental medicine, 211(7), 1333-1347 (2014-06-25)
Linear ubiquitination is a newly discovered posttranslational modification that is currently restricted to a small number of known protein substrates. The linear ubiquitination assembly complex (LUBAC), consisting of HOIL-1L, HOIP, and Sharpin, has been reported to activate NF-κB-mediated transcription in
Agriculture: State-of-the-art soil.
Rachel Cernansky
Nature, 517(7534), 258-260 (2015-01-17)
Manuela Urbischek et al.
Planta, 242(3), 733-746 (2015-06-25)
The extreme Alb3 C terminus is important for Alb3 stability in a light dependent manner, but is dispensable for LHCP insertion or D1 synthesis. YidC/Oxa1/Alb3 dependent insertion of membrane proteins is evolutionary conserved among bacteria, mitochondria and chloroplasts. Chloroplasts are
Daniel Garcia-Seco et al.
PloS one, 10(11), e0142639-e0142639 (2015-11-13)
Application of a plant growth promoting rhizobacterium (PGPR), Pseudomonas fluorescens N21.4, to roots of blackberries (Rubus sp.) is part of an optimised cultivation practice to improve yields and quality of fruit throughout the year in this important fruit crop. Blackberries
Claudia Stäubert et al.
Oncotarget, 6(23), 19706-19720 (2015-04-04)
Cancer cells exhibit characteristic changes in their metabolism with efforts being made to address them therapeutically. However, targeting metabolic enzymes as such is a major challenge due to their essentiality for normal proliferating cells. The most successful pharmaceutical targets are
Lena Neufeld et al.
International journal of pharmaceutics, 491(1-2), 170-179 (2015-06-28)
A new design for nanocomposite hydrogels based on cross-linked chitosan for the delivery of mesalamine is presented. To enhance drug loading in chitosan, the mineral montmorillonite was incorporated into the matrix. The exfoliated silica montmorillonite nanosheets form interactions with both
Poulami Basu et al.
Molecular and cellular biology, 35(15), 2641-2657 (2015-05-20)
Phosphatidylethanolamine (PE) is the most abundant inner membrane phospholipid. PE synthesis from ethanolamine and diacylglycerol is regulated primarily by CTP:phosphoethanolamine cytidylyltransferase (Pcyt2). Pcyt2(+/-) mice have reduced PE synthesis and, as a consequence, perturbed glucose and fatty acid metabolism, which gradually
Stephan Blüml et al.
Arthritis research & therapy, 17, 230-230 (2015-08-27)
Autoreactive T cells are a central element in many systemic autoimmune diseases. The generation of these pathogenic T cells is instructed by antigen-presenting cells (APCs). However, signaling pathways in APCs that drive autoimmune diseases, such as rheumatoid arthritis, are not
Mohammad Namavari et al.
Molecular imaging and biology : MIB : the official publication of the Academy of Molecular Imaging, 17(2), 168-176 (2014-10-04)
To develop novel positron emission tomography (PET) agents for visualization and therapy monitoring of bacterial infections. It is known that maltose and maltodextrins are energy sources for bacteria. Hence, (18)F-labelled maltose derivatives could be a valuable tool for imaging bacterial
Chaker Attaoua et al.
Fundamental & clinical pharmacology, 29(1), 62-71 (2014-10-07)
On account of its extreme intrinsic resistance to apoptosis and of its strong ability to become chemoresistant after a primary response to drugs, malignant melanoma (MM) is still a therapeutic challenge. We previously showed that glutathione S-transferase mu 1 (GSTM1)
The HO-1/CO system regulates mitochondrial-capillary density relationships in human skeletal muscle.
Shelly R H Pecorella et al.
American journal of physiology. Lung cellular and molecular physiology, 309(8), L857-L871 (2015-07-19)
The heme oxygenase-1 (HO-1)/carbon monoxide (CO) system induces mitochondrial biogenesis, but its biological impact in human skeletal muscle is uncertain. The enzyme system generates CO, which stimulates mitochondrial proliferation in normal muscle. Here we examined whether CO breathing can be
Stefan Wagner et al.
Bioorganic & medicinal chemistry, 23(12), 2839-2847 (2015-04-25)
Phosphopeptide mimetics containing the 4-phosphonocarbonyl phenylalanine (pcF) as a photo-active phosphotyrosine isoster are developed as potent, light-switchable inhibitors of the protein tyrosine phosphatase PTP1B. The photo-active inhibitors 6-10 are derived from phosphopeptide substrates and are prepared from the suitably protected
Rebecca Klar et al.
The Journal of neuroscience : the official journal of the Society for Neuroscience, 35(19), 7600-7615 (2015-05-15)
Of the eight metabotropic glutamate (mGlu) receptor subtypes, only mGlu7 is expressed presynaptically at the Schaffer collateral (SC)-CA1 synapse in the hippocampus in adult animals. Coupled with the inhibitory effects of Group III mGlu receptor agonists on transmission at this
Egor V Verbitskiy et al.
Journal of fluorescence, 25(3), 763-775 (2015-03-31)
Novel donor-π-acceptor dyes bearing the pyrimidine unit as an electron-withdrawing group have been synthesized by using combination of two processes, based on the microwave-assisted Suzuki cross-coupling reaction and nucleophilic aromatic substitution of hydrogen. Spectral properties of the obtained dyes in
Karsten Geletneky et al.
Comparative medicine, 65(1), 23-35 (2015-03-03)
Parvovirus H1 (H1PV) is an autonomous parvovirus that is transmitted in rodent populations. Its natural host is rats. H1PV infection is nonpathogenic except in rat and hamster fetuses and newborns. H1PV infection of human cancer cells caused strong oncolytic effects
Kirsi Jussila et al.
Prehospital and disaster medicine, 29(6), 580-588 (2014-11-02)
Prehospital maritime transportation in northern areas sets high demands on hypothermia prevention. To prevent body cooling and hypothermia of seriously-ill or injured casualties during transportation, casualty coverings must provide adequate thermal insulation and protection against cold, wind, moisture, and water
Temperance and Genevieve.
Lauren Mingus
Midwifery today with international midwife, (110)(110), 43-44 (2014-08-13)
Diana Zhang et al.
Nucleic acids research, 42(21), 13422-13429 (2014-11-13)
We have determined the 1.50 Å crystal structure of the DNA decamer, d(CCA(CNV)KGCGTGG) ((CNV)K, 3-cyanovinylcarbazole), which forms a G-quadruplex structure in the presence of Ba(2+). The structure contains several unique features including a bulged nucleotide and the first crystal structure
Distinct Characteristics of Indole-3-Acetic Acid and Phenylacetic Acid, Two Common Auxins in Plants.
Satoko Sugawara et al.
Plant & cell physiology, 56(8), 1641-1654 (2015-06-17)
The phytohormone auxin plays a central role in many aspects of plant growth and development. IAA is the most studied natural auxin that possesses the property of polar transport in plants. Phenylacetic acid (PAA) has also been recognized as a
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