2019-32-6

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关键词:'2019-32-6'

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Management of retinitis pigmentosa by Wharton's jelly derived mesenchymal stem cells: preliminary clinical results.

Emin Özmert et al.

Stem cell research & therapy, 11(1), 25-25 (2020-01-15)

The aim of this study is to determine if umbilical cord Wharton's jelly derived mesenchymal stem cells implanted in sub-tenon space have beneficial effects on visual functions in retinitis pigmentosa patients by reactivating the degenerated photoreceptors in dormant phase. This

Preservation of Denonvilliers' fascia for nerve-sparing laparoscopic total mesorectal excision: A neuro-histological study.

Jianpei Liu et al.

Clinical anatomy (New York, N.Y.), 32(3), 439-445 (2019-01-22)

Urogenital complications due to pelvic autonomic nerve damage frequently occur following rectal surgery. We investigated whether total mesorectal excision (TME) with preservation of the Denonvilliers' fascia (DVF) can effectively prevent the removal of pelvic autonomic nerves through microscopy. Twenty consecutive

Long COVID in a prospective cohort of home-isolated patients.

Bjørn Blomberg et al.

Nature medicine, 27(9), 1607-1613 (2021-06-25)

Long-term complications after coronavirus disease 2019 (COVID-19) are common in hospitalized patients, but the spectrum of symptoms in milder cases needs further investigation. We conducted a long-term follow-up in a prospective cohort study of 312 patients-247 home-isolated and 65 hospitalized-comprising

The European delicacy Tuber melanosporum forms mycorrhizae with some indigenous Chinese Quercus species and promotes growth of the oak seedlings.

Ran Wang et al.

Mycorrhiza, 29(6), 649-661 (2019-11-25)

We aimed to test whether Tuber melanosporum and native Chinese oak species could form stable mycorrhizal symbioses. Six oak species were all either inoculated or not, with spores of the Périgord black truffle in the greenhouse. Ectomycorrhizal development was monitored

Distribution and antimicrobial resistance profiles of bacterial species in stray dogs, hospital-admitted dogs, and veterinary staff in South Korea.

Woo Kyung Jung et al.

Preventive veterinary medicine, 184, 105151-105151 (2020-10-05)

Transferring antimicrobial-resistant bacteria from companion animals to human hosts has become increasingly common. Data regarding antimicrobial susceptibility could help veterinarians to select the most appropriate antibiotic treatment. However, standardized and ongoing surveys regarding antimicrobial resistance remain limited. In this study

Hybrid repair of extensive thoracic aortic aneurysms.

Gabriele Piffaretti et al.

European journal of cardio-thoracic surgery : official journal of the European Association for Cardio-thoracic Surgery, 58(5), 940-948 (2020-07-31)

Our goal was to report the midterm results of hybrid treatment of extensive thoracic aortic aneurysm (ETAA) with the completion of thoracic endovascular aortic repair after proximal ascending-arch graft replacement. This was a multicentre, observational study. Data were collected prospectively

Are immune checkpoint inhibitors a valid option for papillary renal cell carcinoma? A multicentre retrospective study.

Manon de Vries-Brilland et al.

European journal of cancer (Oxford, England : 1990), 136, 76-83 (2020-07-13)

Papillary renal cell carcinoma (pRCC) is the most common non-clear cell RCC (nccRCC). Pivotal studies evaluating immune checkpoint inhibitors mostly excluded nccRCC. The aim of this retrospective and multicentre study was to evaluate the activity of programmed death-1 (PD-1)/ programmed

Diffusive Gradients in Thin Films Can Predict the Toxicity of Metal Mixtures to Two Microalgae: Validation for Environmental Monitoring in Antarctic Marine Conditions.

Darren J Koppel et al.

Environmental toxicology and chemistry, 38(6), 1323-1333 (2019-02-23)

Anthropogenic contamination in the Antarctic near-shore marine environment is a challenge for environmental managers because of its isolation, high costs associated with monitoring and remediation activities, and the current lack of Antarctic-specific ecotoxicological data. The present study investigated the application

Tardive dyskinesia is associated with altered putamen Akt/GSK-3β signaling in nonhuman primates.

Giovanni Hernandez et al.

Movement disorders : official journal of the Movement Disorder Society, 34(5), 717-726 (2019-01-25)

Tardive dyskinesia is a delayed and potentially irreversible motor complication arising from chronic exposure to antipsychotic drugs. Interaction of antipsychotic drugs with G protein-coupled receptors triggers multiple intracellular events. Nevertheless, signaling pathways that might be associated with chronic unwanted effects

SARS-CoV-2 Subgenomic RNA Kinetics in Longitudinal Clinical Samples.

Renu Verma et al.

Open forum infectious diseases, 8(7), ofab310-ofab310 (2021-07-24)

Given the persistence of viral RNA in clinically recovered coronavirus disease 2019 (COVID-19) patients, subgenomic RNAs (sgRNAs) have been reported as potential molecular viability markers for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). However, few data are available on their

The INTUIT Study: Investigating Neuroinflammation Underlying Postoperative Cognitive Dysfunction.

Miles Berger et al.

Journal of the American Geriatrics Society, 67(4), 794-798 (2019-01-24)

Every year, up to 40% of the more than 16 million older Americans who undergo anesthesia/surgery develop postoperative cognitive dysfunction (POCD) or delirium. Each of these distinct syndromes is associated with decreased quality of life, increased mortality, and a possible

Tardive dyskinesia is associated with altered putamen Akt/GSK-3β signaling in nonhuman primates.

Giovanni Hernandez et al.

Movement disorders : official journal of the Movement Disorder Society, 34(5), 717-726 (2019-01-25)

Clinical and diagnostic imaging findings in 37 rescued dogs with heartworm disease in Germany.

Imke Maerz

Veterinary parasitology, 283, 109156-109156 (2020-06-12)

Canine dirofilariasis is currently uncommon in Germany, but its prevalence appears to be increasing due to rehoming of dogs from endemic areas. As part of staging of the disease, this case series describes clinical, radiological and echocardiographic findings in 37

Activity and safety of the multi-target tyrosine kinase inhibitor cabozantinib in patients with metastatic gastrointestinal stromal tumour after treatment with imatinib and sunitinib: European Organisation for Research and Treatment of Cancer phase II trial 1317 'CaboGIST'.

Patrick Schöffski et al.

European journal of cancer (Oxford, England : 1990), 134, 62-74 (2020-05-30)

Gastrointestinal stromal tumour (GIST) is commonly treated with tyrosine kinase inhibitors (TKIs), but most patients ultimately develop secondary resistance. Cabozantinib, a multi-targeted TKI inhibitor, has activity in patient-derived GIST mouse xenograft models and can overcome compensatory MET signalling occurring on

Acute effects of dapagliflozin on renal oxygenation and perfusion in type 1 diabetes with albuminuria: A randomised, double-blind, placebo-controlled crossover trial.

Jens Christian Laursen et al.

EClinicalMedicine, 37, 100895-100895 (2021-08-14)

Inhibitors of the sodium-glucose cotransporter 2 (SGLT2) slow the progression of diabetic kidney disease, possibly by reducing the proximal tubule transport workload with subsequent improvement of renal oxygenation. We aimed to test this hypothesis in individuals with type 1 diabetes

Pathogen flows from on-site sanitation systems in low-income urban neighborhoods, Dhaka: A quantitative environmental assessment.

Nuhu Amin et al.

International journal of hygiene and environmental health, 230, 113619-113619 (2020-09-18)

Despite wide usage of on-site sanitation, there is limited field-based evidence on the removal or release of pathogens from septic tanks and other primary treatment systems, such as anaerobic baffled reactors (ABR). In two low-income areas in Dhaka, we conducted

Prenatal brain imaging for predicting need for postnatal hydrocephalus treatment in fetuses that had neural tube defect repair in utero.

A Zarutskie et al.

Ultrasound in obstetrics & gynecology : the official journal of the International Society of Ultrasound in Obstetrics and Gynecology, 53(3), 324-334 (2019-01-09)

To determine if brain imaging in fetuses that underwent prenatal repair of neural tube defect (NTD) can predict the need for postnatal hydrocephalus treatment (HT) in the first year postpartum. This was a retrospective study of fetuses diagnosed with open

Effects of Candesartan vs Lisinopril on Neurocognitive Function in Older Adults With Executive Mild Cognitive Impairment: A Randomized Clinical Trial.

Ihab Hajjar et al.

JAMA network open, 3(8), e2012252-e2012252 (2020-08-08)

Observational studies have suggested that angiotensin receptor blockers are associated with a unique cognitive protection. It is unclear if this is due to reduced blood pressure (BP) or angiotensin receptors type 1 blockade. To determine neurocognitive effects of candesartan vs

Early versus deferred standard androgen suppression therapy for advanced hormone-sensitive prostate cancer.

Frank Kunath et al.

The Cochrane database of systematic reviews, 6, CD003506-CD003506 (2019-06-14)

Standard androgen suppression therapy (AST) using surgical or medical castration is considered a mainstay of advanced hormone-sensitive prostate cancer treatment. AST can be initiated early when disease is asymptomatic or deferred when patients suffer symptoms of disseminated prostate cancer. To

Newly characterized decidual Tim-3+ Treg cells are abundant during early pregnancy and driven by IL-27 coordinately with Gal-9 from trophoblasts.

Xiaohui Hu et al.

Human reproduction (Oxford, England), 35(11), 2454-2466 (2020-10-28)

What is the mechanism of Tim-3+ regulatory T (Treg)-cell accumulation in the decidua during early pregnancy and is its disruption associated with recurrent pregnancy loss (RPL)? IL-27 and Gal-9 secreted by trophoblasts activate the Tim-3 signaling pathway in CD4+ T

The euploid blastocysts obtained after luteal phase stimulation show the same clinical, obstetric and perinatal outcomes as follicular phase stimulation-derived ones: a multicenter study.

Alberto Vaiarelli et al.

Human reproduction (Oxford, England), 35(11), 2598-2608 (2020-09-21)

Are the reproductive outcomes (clinical, obstetric and perinatal) different between follicular phase stimulation (FPS)- and luteal phase stimulation (LPS)-derived euploid blastocysts? No difference was observed between FPS- and LPS-derived euploid blastocysts after vitrified-warmed single embryo transfer (SET). Technical improvements in

Treatment regimens for administration of anti-vascular endothelial growth factor agents for neovascular age-related macular degeneration.

Emily Li et al.

The Cochrane database of systematic reviews, 5, CD012208-CD012208 (2020-05-07)

Age-related macular degeneration (AMD) is one of the leading causes of permanent blindness worldwide. The current mainstay of treatment for neovascular AMD (nAMD) is intravitreal injection of anti-vascular endothelial growth factor (anti-VEGF) agents: aflibercept, ranibizumab, and off-label bevacizumab. Injections can

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