202-214-1

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FTDP-17 missense mutations site-specifically inhibit as well as promote dephosphorylation of microtubule-associated protein tau by protein phosphatases of HEK-293 cell extract.

Dong Han et al.

Neurochemistry international, 54(1), 14-27 (2008-11-11)

FTDP-17 missense tau mutations: G272V, P301L, V337M and R406W promote tau phosphorylation in human and transgenic mice brains by interfering with the tau phosphorylation/dephosphorylation balance. The effect of FTDP-17 mutations on tau phosphorylation by different kinases has been studied previously.

Efficacy and safety of oxybutynin topical gel 3% in patients with urgency and/or mixed urinary incontinence: a randomized, double-blind, placebo-controlled study.

Evan R Goldfischer et al.

Neurourology and urodynamics, 34(1), 37-43 (2013-10-18)

To assess the efficacy and safety of oxybutynin transdermal gel 3% (OTG3%), with propylene glycol for enhanced skin permeation, in patients with urinary incontinence (UI). In this phase 3 study, 626 patients ≥18 years old with urgency and/or mixed UI

Stable bone density in adolescents with severe growth hormone deficiency after six months off rhGH.

Roland Schweizer et al.

Bone, 142, 115771-115771 (2020-11-28)

Severe growth hormone deficiency causes lean body mass loss in male adolescents and increased fat mass in both sexes. The changes appear after a 6 month GH pause. The aim was to examine bone density and structure changes in adolescents with

Neurodegeneration in heterozygous Niemann-Pick type C1 (NPC1) mouse: implication of heterozygous NPC1 mutations being a risk for tauopathy.

Wenxin Yu et al.

The Journal of biological chemistry, 280(29), 27296-27302 (2005-05-28)

Niemann-Pick type C1 (NPC1) disease is an autosomal recessive, fatal disorder characterized by a defect in cholesterol trafficking and progressive neurodegeneration. The disease is predominantly caused by mutations in the NPC1 gene; however, it has been assumed that heterozygous NPC1

Rootstock effects on bitter pit incidence in 'Honeycrisp' apples are associated with changes in fruit's cell wall chemical properties.

Md Tabibul Islam et al.

Frontiers in plant science, 13, 1034664-1034664 (2022-11-01)

Bitter pit (BP) is a physiological disorder of apples that often appears during or after cold storage. Despite being defined as a calcium deficiency disorder, BP is a complex process that is not only affected by the total Ca2+ content

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