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显示 1-30 共 250 条结果 关于 "217-217-3" 范围 论文
Zun-Hong Liang et al.
Regenerative therapy, 15, 202-209 (2021-01-12)
The process of wound healing is complex. Increasing evidences have shown that lncRNA MALAT1 is abundant in fibroblasts and may be engaged in wound healing process. Therefore, we explored the mechanism of MALAT1 affecting wound healing. The expression levels of
Lihong Zhu et al.
International journal of molecular medicine, 44(5), 1824-1832 (2019-09-06)
MicroRNA (miR)‑217 serves a pivotal role in the progression of colorectal cancer, renal cell carcinoma and glioma, however, the role of miR‑217 in cervical cancer (CC) remains unclear. In the present study, the mechanism of miR‑217 in cervical cancer was
Mao Zhang et al.
Oncology reports, 37(3), 1772-1778 (2017-02-12)
Hepatocellular carcinoma (HCC) has frequent incidence and the third highest mortality rate among cancers in the world. This study aimed to clarify the roles of miR-217 and metadherin (MTDH) in HCC. First, we identified that miR-217 expression was downregulated and
Ai-Na Liu et al.
Journal of cellular and molecular medicine, 22(9), 4034-4044 (2018-06-24)
We tried to identify the function of LINC01614 in lung adenocarcinoma (LUAD) and reveal its underlying mechanisms. qRT-PCR was applied to assess the expression of LINC016014 in LUAD tissues, noncancerous tissues and cells. Through colony formation assay, MTT assay and
Cheng-Liang Yang et al.
Journal of cellular physiology, 234(4), 3410-3424 (2018-11-13)
Liver injury is an important cause of serious liver disease. This study aims to explore the effects of miR-217 targeting NAT2 on hepatocyte proliferation, apoptosis, and autophagy following carbon tetrachloride (CCL4)-induced liver injury. Rat models of CCL4-induced liver injury were
Yumei Lv et al.
Journal of clinical laboratory analysis, 36(4), e24236-e24236 (2022-03-12)
Mounting evidence summarizes that circRNA is closely implicated in the development of numerous cancers. Our study aimed to investigate the role of circ_0119412 whose function was not explored in cervical cancer. RT-qPCR analysis was utilized for the expression analysis of
Yanfang Li et al.
Cardiovascular engineering and technology, 11(2), 219-227 (2020-01-10)
Recent studies have demonstrated that miRNAs play a vital role in regulating myocardial ischemia/reperfusion injury (MIRI). MiR-217 has been proven to be implicated in cardiac diseases such as chronic heart failure and cardiac myxoma. However, the role of miR-217 in
Joan D Beckman et al.
The Journal of biological chemistry, 286(5), 3194-3202 (2010-11-26)
Heme oxygenase-1 (HO-1) enzyme plays a critical role in metabolizing the excess heme generated during hemolysis. Our previous studies suggested that during intravascular hemolysis the expression of HO-1 protein is not sufficient to reduce the oxidative burden of free heme
L Yang et al.
European review for medical and pharmacological sciences, 23(3), 949-957 (2019-02-20)
This study aims to investigate whether circ-VANGL1 can promote the progression of osteoporosis (OP) by absorbing miRNA-217 to regulate RUNX2 expression. The serum levels of circ-VANGL1, miRNA-217 and RUNX2 in OP patients and non-OP patients were detected by quantitative Real
Rossella Menghini et al.
Circulation, 120(15), 1524-1532 (2009-09-30)
Aging is a major risk factor for the development of atherosclerosis and coronary artery disease. Through a microarray approach, we have identified a microRNA (miR-217) that is progressively expressed in endothelial cells with aging. miR-217 regulates the expression of silent
Marion Flum et al.
Journal of cell communication and signaling, 12(2), 451-466 (2017-09-15)
Apoptosis is a genetically directed process of programmed cell death. A variety of microRNAs (miRNAs), endogenous single-stranded non-coding RNAs of about 22 nucleotides in length have been shown to be involved in the regulation of the intrinsic or extrinsic apoptotic
Juan Sun et al.
Biochemical and biophysical research communications, 483(1), 318-324 (2016-12-27)
Podocyte damage is the initial hallmark of diabetic nephropathy (DN), leading to the increasing morbidity and mortality in diabetic patients. Recent researches have corroborated the critical roles of miRNAs in the pathological progression of DN. Here, elevation of miR-217 was
Yu-Long Zhu et al.
Molecular medicine reports, 15(5), 3271-3277 (2017-03-25)
The elucidation of the underlying molecular mechanisms regulating the osteogenic differentiation of bone marrow‑derived mesenchymal stem cells (BMSCs) is of great importance in improving the treatment of bone‑associated diseases. MicroRNAs (miRNAs) have been proven to regulate the osteogenic differentiation of
Hong-Sheng Zhang et al.
Biochimica et biophysica acta, 1823(5), 1017-1023 (2012-03-13)
MicroRNAs (miRNAs) are small non-coding RNAs that regulate gene expression and may contribute to the development and progression of many infective diseases including human immunodeficiency virus 1 (HIV-1) infection. The Tat protein is fundamental to viral gene expression. In this
Jianying Wang et al.
Toxicologic pathology, 45(2), 321-334 (2016-12-27)
Detecting and monitoring exocrine pancreatic damage during nonclinical and clinical testing is challenging because classical biomarkers amylase and lipase have limited sensitivity and specificity. Novel biomarkers for drug-induced pancreatic injury are needed to improve safety assessment and reduce late-stage attrition
Li-Chao Zhang et al.
World journal of gastroenterology, 27(46), 7982-7994 (2022-01-21)
Inflammatory bowel disease (IBD) affects millions of people worldwide and has emerged as a growing problem in industrialized nations. The lack of therapeutic targets has limited the treatment of IBD. Studies found that parasitic nematode infections can ameliorate clinical and
Vijaya M Lakshmi et al.
Drug metabolism and disposition: the biological fate of chemicals, 37(8), 1690-1697 (2009-05-20)
Metabolism of the heterocyclic amine carcinogen 2-amino-3-methylimidazo[4,5-f]quinoline (IQ) was evaluated in mice with and without 40 mg/kg beta-naphthoflavone (BNF). Following an oral dose of 40 mg/kg (14)C-IQ, a 24-h urine sample was collected. Metabolism was assessed by high-performance liquid chromatography
Guillermo J Ruiz-Delgado et al.
Hematology (Amsterdam, Netherlands), 17(3), 140-143 (2012-06-06)
Twenty-nine consecutive patients with hairy cell leukemia (HCL) were treated in two institutions with interferon (IFN, n = 18) or cladribine (n = 11), between July 1987 and May 2011. Median age was 62 (range 29-83) years; there were 21
Yanyan Zheng et al.
American journal of translational research, 12(8), 4204-4215 (2020-09-12)
LncRNA-LYPLAL1-2 (lysophospholipase-like 1-2) is expressed at a very low level in gliomas, which are some of the most aggressive tumors. However, the function and mechanism of LYPLAL1-2 are not clear. The purpose of this study was to explore the role
R L Yauch et al.
The Journal of biological chemistry, 275(13), 9230-9238 (2000-03-29)
Previously we established that the alpha(3)beta(1) integrin shows stable, specific, and stoichiometric association with the TM4SF (tetraspannin) protein CD151. Here we used a membrane impermeable cross-linking agent to show a direct association between extracellular domains of alpha(3)beta(1) and CD151. The
Bernal León et al.
Journal of equine veterinary science, 92, 103140-103140 (2020-08-17)
Eastern equine encephalitis and Venezuelan equine encephalitis are endemic neglected tropical diseases in the Americas, causing encephalitis in both horses and humans. In 2013, a cross-sectional study was performed in 243 horses located in the highlands and lowlands throughout Costa
H Riol et al.
Journal of neuroscience research, 32(1), 79-85 (1992-05-01)
During mouse brain maturation, GFAP-mRNA undergoes a two-step developmental expression. It increases between birth and day 15 (period of astrocytic proliferation) and then decreases until day 55 (period of astrocytic morphological differentiation). We have developed an in vitro transcription procedure
K S Kim et al.
Enzyme and microbial technology, 12(8), 564-570 (1990-08-01)
The effect of treatment with various intercalating dyes on the ability to produce antibiotics in Micromonospora rosaria and Micromonospora purpurea was studied. Treatment with acriflavine resulted in a high frequency loss of antibiotic productivity in both species. In M. rosaria
Nathalie Vigneron et al.
Journal of immunology (Baltimore, Md. : 1950), 201(7), 1875-1888 (2018-08-24)
Cancer immunotherapy has been flourishing in recent years with remarkable clinical success. But as more patients are treated, a shadow is emerging that has haunted other cancer therapies: tumors develop resistance. Resistance is often caused by defects in the MHC
R P Swenson et al.
The Journal of biological chemistry, 259(9), 5585-5590 (1984-05-10)
Incubation of D-amino acid oxidase with excess methyl-p-nitrobenzenesulfonate results in a pseudo-first order, irreversible loss of 95% of the assayable activity using D-phenylglycine as substrate. The rate of inactivation reaches a limiting value of 0.021 min-1 (pH 7.7, 22 degrees
S M Wu et al.
Blood, 89(11), 4058-4062 (1997-06-01)
The human gene for gamma-glutamyl carboxylase is 13 kb in length and contains 15 exons. Transcription starts at a cytosine 217 base pair upstream of the first codon. There are two major transcripts in all tissues examined. They are distinguished
Jonathan A Winger et al.
The Journal of biological chemistry, 282(2), 897-907 (2006-11-14)
Regulation of soluble guanylate cyclase (sGC), the primary NO receptor, is linked to NO binding to the prosthetic heme group. Recent studies have demonstrated that the degree and duration of sGC activation depend on the presence and ratio of purine
Angelica Giuliani et al.
Scientific reports, 10(1), 21782-21782 (2020-12-15)
Increasing evidence suggest that the glucose-lowering drug metformin exerts a valuable anti-senescence role. The ability of metformin to affect the biogenesis of selected microRNAs (miRNAs) was recently suggested. MicroRNA isoforms (isomiRs) are distinct variations of miRNA sequences, harboring addition or
Kayce Newbern et al.
Fertility and sterility, 99(7), 1831-1837 (2013-03-08)
To determine whether HESX1 mutations are present in patients with idiopathic hypogonadotropic hypogonadism (IHH)/Kallmann syndrome (KS). Polymerase chain reaction-based DNA sequencing was performed on 217 well-characterized IHH/KS patients. Putative missense mutations were analyzed by sorting intolerant from tolerant (SIFT) and
V Ionasescu et al.
Human molecular genetics, 3(2), 355-358 (1994-02-01)
Ten families with X-linked dominant CMT neuropathy (CMTX1) were screened for point mutations of the connexin32 (Cx32, GJB1) gene. Two families showed missense mutations, respectively an A-->G transition at amino acid 102 (glutamate to glycine) and a C-->T transition at
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