21953

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Cell-penetrating antimicrobial peptides - prospectives for targeting intracellular infections.

Jesper S Bahnsen et al.

Pharmaceutical research, 32(5), 1546-1556 (2015-03-18)

To investigate the suitability of three antimicrobial peptides (AMPs) as cell-penetrating antimicrobial peptides. Cellular uptake of three AMPs (PK-12-KKP, SA-3 and TPk) and a cell-penetrating peptide (penetratin), all 5(6)-carboxytetramethylrhodamine-labeled, were tested in HeLa WT cells and analyzed by flow cytometry

In vitro and in vivo evaluation of a water-in-oil microemulsion system for enhanced peptide intestinal delivery.

Dongyun Liu et al.

The AAPS journal, 15(1), 288-298 (2012-12-01)

Peptide and protein drugs have become the new generation of therapeutics, yet most of them are only available as injections, and reports on oral local intestinal delivery of peptides and proteins are quite limited. The aim of this work was

Topological stability and self-association of a completely hydrophobic model transmembrane helix in lipid bilayers.

Yoshiaki Yano et al.

Biochemistry, 41(9), 3073-3080 (2002-02-28)

Investigation of interactions between hydrophobic model peptides and lipid bilayers is perhaps the only way to elucidate the principles of the folding and stability of membrane proteins (White, S. H., and Wimley, W. C. (1998) Biochim. Biophys. Acta 1367, 339-352).

Upconversion nanoparticle based LRET system for sensitive detection of MRSA DNA sequence.

Jinliang Liu et al.

Biosensors & bioelectronics, 43, 252-256 (2013-01-16)

In this short communication we report an efficient and versatile method for the detection of methicillin-resistant staphylococcus aureus (MRSA) DNA sequence with high sensitivity and specificity. This method is based on upconversion nanoparticles (UCNs) and luminescence resonance energy transfer (LRET)

Two-dimensional fluorescence intensity distribution analysis: theory and applications.

P Kask et al.

Biophysical journal, 78(4), 1703-1713 (2000-03-29)

A method of sample analysis is presented which is based on fitting a joint distribution of photon count numbers. In experiments, fluorescence from a microscopic volume containing a fluctuating number of molecules is monitored by two detectors, using a confocal

Non-covalent photo-patterning of gelatin matrices using caged collagen mimetic peptides.

Yang Li et al.

Macromolecular bioscience, 15(1), 52-62 (2014-12-06)

To address the downside of conventional photo-patterning which can alter the chemical composition of protein scaffolds, we developed a non-covalent photo-patterning strategy for gelatin (denatured collagen) hydrogels that utilizes UV activated triple helical hybridization of caged collagen mimetic peptide (caged

A FRET-based screening assay for nucleic acid ligands.

Daniel Renčiuk et al.

Methods (San Diego, Calif.), 57(1), 122-128 (2012-04-03)

Some of the most serious diseases are characterized by the presence of a specific secondary structure within DNA or RNA, often in the promoter or the coding region of the responsible gene, that enhances or disrupts expression of the protein.

Biochemical investigations of the mechanism of action of small molecules ZL006 and IC87201 as potential inhibitors of the nNOS-PDZ/PSD-95-PDZ interactions.

Anders Bach et al.

Scientific reports, 5, 12157-12157 (2015-07-17)

ZL006 and IC87201 have been presented as efficient inhibitors of the nNOS/PSD-95 protein-protein interaction and shown great promise in cellular experiments and animal models of ischemic stroke and pain. Here, we investigate the proposed mechanism of action of ZL006 and

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