Antibiotics, 1, Gottlieb, D., and Shaw, P.
D., eds., Springer-Verlag (New York, NY: 1967), p.
651-665.
3. Ryan, in Antibiotics, 5-pt. 1, Hahn, F. E., ed.,
Springer-Verlag (New York, NY: 1979)
detected upon cleavage of a DNA
Probe, which yields a fluorescent DNA
product measured at
Ex = 651 nm/Em = 681 nm. The limit of
quantification is 178 fmoles of DNA probe
cleaved per minute per mL
R5145 6195 RPS6KA1 P NP_001006666.1 y y y
654 S6 Kinase S4047 6198 RPS6KB1 P NP_003152.1 y y y
651 S-100 (a-Subunit) S2407 6271 S100A1 M NP_006262.1 y n/d n/d
652 S-100 (?-Subunit) S2532 6285 S100B
R5145 6195 RPS6KA1 P NP_001006666.1 y y y
654 S6 Kinase S4047 6198 RPS6KB1 P NP_003152.1 y y y
651 S-100 (a-Subunit) S2407 6271 S100A1 M NP_006262.1 y n/d n/d
652 S-100 (?-Subunit) S2532 6285 S100B
R5145 6195 RPS6KA1 P NP_001006666.1 y y y
654 S6 Kinase S4047 6198 RPS6KB1 P NP_003152.1 y y y
651 S-100 (a-Subunit) S2407 6271 S100A1 M NP_006262.1 y n/d n/d
652 S-100 (?-Subunit) S2532 6285 S100B
I (Ki = 190 nM), calpain II (Ki = 220 nM), cathepsin
B (Ki = 150 nM), and cathepsin L (Ki = 500 pM). Inhibits neutral cysteine proteases and
the proteasome (Ki = 6 µM). Modulates the processing of the
RPS6KA1 NP_112369.1,NP_033123.2,NP_002944.2 P y y y
650 S-100 S2644 81778 S100a10 NP_112376.1 P y n/d y
651 S-100 (α-Subunit) S2407 6271 S100A1 NP_006262.1 M y n/d n/d
652 S-100 (β-Subunit) S2532 6285, 25742
RPS6KA1 NP_112369.1,NP_033123.2,NP_002944.2 P y y y
650 S-100 S2644 81778 S100a10 NP_112376.1 P y n/d y
651 S-100 (α-Subunit) S2407 6271 S100A1 NP_006262.1 M y n/d n/d
652 S-100 (β-Subunit) S2532 6285, 25742