223-425-5

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Length polymorphism in heme oxygenase-1 is associated with arteriovenous fistula patency in hemodialysis patients.

C-C Lin et al.

Kidney international, 69(1), 165-172 (2005-12-24)

Heme oxygenase-1 (HO-1) is a rate-limiting enzyme in heme degradation, producing carbon monoxide (CO), which carries potent antiproliferative and anti-inflammatory effects in the vascular walls. Transcription of the HO-1 gene is regulated by the length polymorphism of dinucleotide guanosine thymine

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