233781

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Hydrogel formation by short D-peptide for cell-culture scaffolds.

Witta Kartika Restu et al.

Materials science & engineering. C, Materials for biological applications, 111, 110746-110746 (2020-04-14)

The present study reports that a short oligopeptide D-P1, consisting of only five D-amino acids, self-assembled into entangled nanofibers to form a hydrogel that functioned as a scaffold for cell cultures. D-P1 (Ac-D-Phe-D-Phe-D-Phe-Gly-D-Lys) gelated aqueous buffer solution and water at

Semi-synthesis of biologically active nisin hybrids composed of the native lanthionine ABC-fragment and a cross-stapled synthetic DE-fragment.

Jack C Slootweg et al.

Bioorganic & medicinal chemistry, 22(19), 5345-5353 (2014-09-10)

The antimicrobial peptide nisin is a promising template for designing novel peptide-based antibiotics to improve its drug-like properties. First steps in that direction represent the synthesis of hybrid nisin derivatives that contain a native nisin ABC-part and synthesized cross-stapled DE-ring

Deuterohemin-AlaHisLys mitigates the symptoms of rats with non-insulin dependent diabetes mellitus by scavenging reactive oxygen species and activating the PI3-K/AKT signal transduction pathway.

Liyan Lei et al.

Chemico-biological interactions, 220, 64-74 (2014-06-20)

Damage to pancreatic β-cells plays an important role in the development of type 2 diabetes, and oxidative stress is a likely contributor. In the present study, we investigated the effect of deuterohemin-AlaHisLys (DhHP-3), a microperoxidase-11 mimic, on rats with non-insulin

Multifunctional peptide-based fluorescent chemosensor for detection of Hg2+ , Cu2+ and S2- ions.

Xuliang Pang et al.

Luminescence : the journal of biological and chemical luminescence, 34(6), 585-594 (2019-05-11)

A novel multifunctional fluorescent peptide sensor based on pentapeptide dansyl-Gly-His-Gly-Gly-Trp-COOH (D-P5) was designed and synthesized efficiently using Fmoc solid-phase peptide synthesis (SPPS). This fluorescent peptide sensor shows selective and sensitive responses to Hg2+ and Cu2+ among 17 metal ions and

New Targeted Gold Nanorods for the Treatment of Glioblastoma by Photodynamic Therapy.

Zahraa Youssef et al.

Journal of clinical medicine, 8(12) (2019-12-19)

This study describes the employment of gold nanorods (AuNRs), known for their good reputation in hyperthermia-based cancer therapy, in a hybrid combination of photosensitizers (PS) and peptides (PP). We report here, the design and the synthesis of this nanosystem and

Effective In Vivo Topical Delivery of siRNA and Gene Silencing in Intact Corneal Epithelium Using a Modified Cell-Penetrating Peptide.

Davide Schiroli et al.

Molecular therapy. Nucleic acids, 17, 891-906 (2019-09-03)

Autosomal dominantly inherited genetic disorders such as corneal dystrophies are amenable to allele-specific gene silencing with small interfering RNA (siRNA). siRNA delivered to the cornea by injection, although effective, is not suitable for a frequent long-term treatment regimen, whereas topical

Specific Acetylation Patterns of H2A.Z Form Transient Interactions with the BPTF Bromodomain.

Gabriella T Perell et al.

Biochemistry, 56(35), 4607-4615 (2017-08-05)

Post-translational lysine acetylation of histone tails affects both chromatin accessibility and recruitment of multifunctional bromodomain-containing proteins for modulating transcription. The bromodomain- and PHD finger-containing transcription factor (BPTF) regulates transcription but has also been implicated in high gene expression levels in

Attractors in Sequence Space: Peptide Morphing by Directed Simulated Evolution.

Jan A Hiss et al.

Molecular informatics, 34(11-12), 709-714 (2016-01-19)

The native structure of annexin A2 peptides in hydrophilic environment determines their anti-angiogenic effects.

Aase M Raddum et al.

Biochemical pharmacology, 95(1), 1-15 (2015-03-17)

The progression of aggressive cancer occurs via angiogenesis and metastasis makes these processes important targets for the development of anti-cancer agents. However, recent studies have raised the concern that selective inhibition of angiogenesis results in a switch towards increased tumour

Exploring the prime site in caspases as a novel chemical strategy for understanding the mechanisms of cell death: a proof of concept study on necroptosis in cancer cells.

Katarzyna Groborz et al.

Cell death and differentiation, 27(2), 451-465 (2019-06-19)

Caspases participate in regulated cell death mechanisms and are divided into apoptotic and proinflammatory caspases. The main problem in identifying the unique role of a particular caspase in the mechanisms of regulated cell death is their overlapping substrate specificity; caspases

Structure-Activity Relationship of HER2 Receptor Targeting Peptide and Its Derivatives in Targeted Tumor Therapy.

Beáta Biri-Kovács et al.

Biomolecules, 10(2) (2020-01-30)

Human epidermal growth factor (HER2) is a transmembrane tyrosine kinase receptor that is frequently overexpressed in breast cancer. Its increased level prognoses a poor patient outcome and a high mortality rate. Despite the widening spectrum of therapies that are becoming

Ultrashort self-assembling Fmoc-peptide gelators for anti-infective biomaterial applications.

Alice P McCloskey et al.

Journal of peptide science : an official publication of the European Peptide Society, 23(2), 131-140 (2017-01-10)

Biomaterial-related infections have a significant impact on society and are a major contributor to the growing threat of antimicrobial resistance. Current licensed antibiotic classes struggle to breakdown or penetrate the exopolysaccharide biofilm barrier, resulting in sub-therapeutic concentrations of antibiotic at

Supramolecular self assembly of nanodrill-like structures for intracellular delivery.

N Ashwanikumar et al.

Journal of controlled release : official journal of the Controlled Release Society, 282, 76-89 (2018-03-05)

Despite recent advances in the supramolecular assembly of cell-penetrating peptide (CPP) nanostructures, the tuning of size, shape, morphology and packaging of drugs in these materials still remain unexplored. Herein, through sequential ligation of peptide building blocks, we create cell-penetrating self-assembling

Design rules for encapsulating proteins into complex coacervates.

Whitney C Blocher McTigue et al.

Soft matter, 15(15), 3089-3103 (2019-03-28)

We investigated the encapsulation of the model proteins bovine serum albumin (BSA), human hemoglobin (Hb), and hen egg white lysozyme (HEWL) into two-polymer complex coacervates as a function of polymer and solution conditions. Electrostatic parameters such as pH, protein net

Effects of Cyclization on Activity and Stability of α-Conotoxin TxIB.

Xincan Li et al.

Marine drugs, 18(4) (2020-04-03)

α-Conotoxin TxIB specifically blocked α6/α3β2β3 acetylcholine receptors (nAChRs), and it could be a potential probe for studying addiction and other diseases related to α6/α3β2β3 nAChRs. However, as a peptide, TxIB may suffer from low stability, short half-life, and poor bioavailability.

Insights into cell penetrating peptide conjugated gold nanoparticles for internalization into bacterial cells.

Munish Kumar et al.

Biophysical chemistry, 237, 38-46 (2018-04-16)

Gold nanoparticles (AuNPs) functionalized with different biomolecules find extensive application in therapy, clinical diagnosis and biomedical imaging. Herein, two derivatives of TAT peptide with sequences YGRKKRRQRRR and YGRKKRRQRRR-(β-ala)3-Cys-amide were conjugated with tannic acid capped gold nanoparticles which acted as a

Selective and Sensitive Sensing of Flame Retardant Chemicals Through Phage Display Discovered Recognition Peptide.

Hyo-Eon Jin et al.

Nano letters, 15(11), 7697-7703 (2015-10-13)

We report a highly selective and sensitive biosensor for the detection of an environmentally toxic molecule, decabrominated diphenyl ether (DBDE), one of the most common congeners of the polybrominated frame retardants (polybrominated diphenyl ether (PBDE)), using newly discovered DBDE peptide

Towards Developing Bioresponsive, Self-Assembled Peptide Materials: Dynamic Morphology and Fractal Nature of Nanostructured Matrices.

Kyle M Koss et al.

Materials (Basel, Switzerland), 11(9) (2018-08-29)

(Arginine-alanine-aspartic acid-alanine)₄ ((RADA)₄) nanoscaffolds are excellent candidates for use as peptide delivery vehicles: they are relatively easy to synthesize with custom bio-functionality, and assemble in situ to allow a focal point of release. This enables (RADA)₄ to be utilized in

Optimized Solid-Phase-Assisted Synthesis of Oleic Acid Containing siRNA Nanocarriers.

Sören Reinhard et al.

ChemMedChem, 12(17), 1464-1470 (2017-07-18)

Cationic lipo-oligomers containing unsaturated oleic acid are potent siRNA carriers based on electrostatic and hydrophobic lipo-polyplex formation and endosomal membrane destabilization. Lipo-oligomers can be produced by solid-phase-supported synthesis in sequence-defined form. However, the trifluoroacetic acid (TFA)-mediated removal of acid-labile protecting

Copper mediated amyloid-β binding to Transthyretin.

Lidia Ciccone et al.

Scientific reports, 8(1), 13744-13744 (2018-09-15)

Transthyretin (TTR), a homotetrameric protein that transports thyroxine and retinol both in plasma and in cerebrospinal (CSF) fluid provides a natural protective response against Alzheimer's disease (AD), modulates amyloid-β (Aβ) deposition by direct interaction and co-localizes with Aβ in plaques.

Biocompatible Inhibitor Based on Chitosan and Amphiphilic Peptide against Mutant Huntingtin Toxicity.

Devi Wahyuningtyas et al.

Chembiochem : a European journal of chemical biology, 20(16), 2133-2140 (2019-06-06)

Huntington's disease (HD) is classified as a protein-misfolding disease correlated with the mutant Huntingtin (mHtt) protein with abnormally expanded polyglutamine (polyQ) domains. Because no effective drugs have yet been reported, attempts to develop better therapy to delay the age of

A sequential and reversibility fluorescent pentapeptide probe for Cu(II) ions and hydrogen sulfide detections and its application in two different living cells imaging.

Yong An et al.

Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy, 216, 319-327 (2019-03-26)

In this study, we report a sequential and reversibility fluorescent probe (DP5) based on pentapeptide conjugated with dansyl groups using the solid phase peptide synthesis (SPPS) technology. DP5 showed immediate "turn off" response toward Cu2+ ions at an excitation wavelength

Using Small Peptide Segments of Amyloid-β and Humanin to Examine their Physical Interactions.

Deborah L Heyl et al.

Protein and peptide letters, 26(7), 502-511 (2019-04-06)

Amyloid fibrils in Alzheimer's disease are composed of amyloid-β (Aβ) peptides of variant lengths. Humanin (HN), a 24 amino acid residue neuroprotective peptide, is known to interact with the predominant Aβ isoform in the brain, Aβ (1-40). Here, we constructed

Elucidation of the Binding Mode of the Carboxyterminal Region of Peptide YY to the Human Y2 Receptor.

Bo Xu et al.

Molecular pharmacology, 93(4), 323-334 (2018-01-26)

Understanding the agonist-receptor interactions in the neuropeptide Y (NPY)/peptide YY (PYY) signaling system is fundamental for the design of novel modulators of appetite regulation. We report here the results of a multidisciplinary approach to elucidate the binding mode of the

Gomesin inhibits melanoma growth by manipulating key signaling cascades that control cell death and proliferation.

Maria P Ikonomopoulou et al.

Scientific reports, 8(1), 11519-11519 (2018-08-03)

Consistent with their diverse pharmacology, peptides derived from venomous animals have been developed as drugs to treat disorders as diverse as hypertension, diabetes and chronic pain. Melanoma has a poor prognosis due in part to its metastatic capacity, warranting further

Sequential Ligand Exchange of Coordination Polymers Hybridized with In Situ Grown and Aligned Au Nanowires for Rapid and Selective Gas Sensing.

Pingping Li et al.

ACS applied materials & interfaces, 11(14), 13624-13631 (2019-03-20)

Combining polymeric materials and conductive one-dimensional metal nanostructures is able to achieve enhanced chemical and electrical properties, but the control over their morphology and spatial arrangement remains a big challenge. Herein, by replacing benzenedicarboxylate (BDC) in ZnBDC nanoplates with oleylamine

Control of thiol-maleimide reaction kinetics in PEG hydrogel networks.

Lauren E Jansen et al.

Acta biomaterialia, 70, 120-128 (2018-02-17)

Michael-type addition reactions are widely used to polymerize biocompatible hydrogels. The thiol-maleimide modality achieves the highest macromer coupling efficiency of the reported Michael-type pairs, but the resulting hydrogel networks are heterogeneous because polymerization is faster than the individual components can

Targeted capture of Chinese hamster ovary host cell proteins: Peptide ligand binding by proteomic analysis.

R Ashton Lavoie et al.

Biotechnology and bioengineering, 117(2), 438-452 (2019-10-28)

The clearance of host cell proteins (HCPs) is of crucial importance in biomanufacturing, given their diversity in composition, structure, abundance, and occasional structural homology with the product. The current approach to HCP clearance in the manufacturing of monoclonal antibodies (mAbs)

Polymer conjugates of doxorubicin bound through an amide and hydrazone bond: Impact of the carrier structure onto synergistic action in the treatment of solid tumours.

Tomáš Etrych et al.

European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences, 58, 1-12 (2014-03-19)

In this study, we describe the synthesis, physico-chemical characterisation and results of the in vitro and in vivo evaluation of the biological behaviour of N-(2-hydroxypropyl)methacrylamide-based (HPMA) copolymer conjugates bearing doxorubicin (DOX) partly bound via a pH-sensitive hydrazone and partly via

Novel two-chain fatty acid-based lipids for development of vancomycin pH-responsive liposomes against Staphylococcus aureus and methicillin-resistant Staphylococcus aureus (MRSA).

Sifiso S Makhathini et al.

Journal of drug targeting, 27(10), 1094-1107 (2019-03-23)

The development of bacterial resistance against antibiotics is attributed to poor localisation of lethal antibiotic dose at the infection site. This study reports on the synthesis and use of novel two-chain fatty acid-based lipids (FAL) containing amino acid head groups

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