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Takao Matsubara et al.
Clinical orthopaedics and related research, 471(3), 792-802 (2012-09-26)
Wide-margin resections are an accepted method for treating soft tissue sarcoma. However, a wide-margin resection sometimes impairs function because of the lack of normal tissue. To preserve the normal tissue surrounding a tumor, we developed a less radical (ie, without
Sophia Karastogianni et al.
Journal of inorganic biochemistry, 118, 48-58 (2012-11-06)
The mononuclear complex [Mn(thiophenyl-2-carboxylate)(2)(H(3)tea)] (1), where H(3)tea=triethanolamine has been synthesized, characterized, while the DNA binding properties and the antioxidant activity were studied. The crystal structure of 1 is also reported. The interaction between 1 and calf thymus double stranded (ds)
Dan Gareau et al.
Journal of biomedical optics, 17(6), 066018-066018 (2012-06-28)
For rapid, intra-operative pathological margin assessment to guide staged cancer excisions, multimodal confocal mosaic scan image wide surgical margins (approximately 1 cm) with sub-cellular resolution and mimic the appearance of conventional hematoxylin and eosin histopathology (H&E). The goal of this
Jonathan Pratt et al.
Glycobiology, 22(9), 1245-1255 (2012-06-14)
Pre-clinical trials for cancer therapeutics support the anti-neoplastic properties of the lectin from Canavalia ensiformis (Concanavalin-A, ConA) in targeting apoptosis and autophagy in a variety of cancer cells. Given that membrane type-1 matrix metalloproteinase (MT1-MMP), a plasma membrane-anchored matrix metalloproteinase
Ruth Kläver et al.
Journal of assisted reproduction and genetics, 29(9), 943-950 (2012-06-14)
Assess short- and mid-term impact of cryopreservation on DNA methylation status of different genes in spermatozoa. Semen samples from 10 healthy normozoospermic men were collected at the Department of Clinical Andrology of the Centre of Reproductive Medicine and Andrology (Muenster
Rainara Moreno Sanches de Almeida et al.
Photodiagnosis and photodynamic therapy, 30, 101685-101685 (2020-02-13)
Gliosarcoma is a highly aggressive malignant neoplasm and a histopathological variant of wild-type glioblastoma multiforme isocitrate dehydrogenase (HDI). The current standard treatment consists of chemotherapy, radiotherapy and surgical resection, however, despite advances in these techniques, the patient's prognosis remains unfavorable.
Steve M Nelson et al.
Developmental biology, 328(1), 24-39 (2009-02-13)
Retinal homeobox (Rx/Rax) genes are essential for the organogenesis of the vertebrate eye. These genes are dynamically expressed in a tissue-specific manner during eye development, suggesting pleiotropic roles. We use a temporally-selective gene knockdown approach to identify endogenous functions for
Grace Emily Okuthe
Acta histochemica, 115(2), 178-184 (2012-07-17)
Oogenesis involves a sequence of cellular divisions and developmental changes leading to the formation of oocytes, whose role in development is to transfer genomic information to the next generation. During this process, the gene expression pattern changes considerably concomitant with
Leandro C Cerchietti et al.
Cancer research, 68(9), 3361-3369 (2008-05-03)
Transcription factors play a central role in malignant transformation by activating or repressing waves of downstream target genes. Therapeutic targeting of transcription factors can reprogram cancer cells to lose their advantages in growth and survival. The BCL6 transcriptional repressor plays
Demethylation of Acridine Orange by Arthrobacter globiformis
Itoh K
Bulletin of Environmental Contamination and Toxicology, 60, 781-785 (1998)
Chingju Lin et al.
International journal of oncology, 42(3), 993-1000 (2013-01-29)
Baicalin is one of the major compounds in the traditional Chinese medicinal herb from Scutellaria baicalensis Georgi. We investigated the molecular mechanisms of cell autophagy induced by baicalin in human bladder cancer T24 cells. Baicalin inhibited cell survival as shown
Daisuke Matsumaru et al.
PloS one, 6(1), e16260-e16260 (2011-02-02)
An omphalocele is one of the major ventral body wall malformations and is characterized by abnormally herniated viscera from the body trunk. It has been frequently found to be associated with other structural malformations, such as genitourinary malformations and digit
Yasuko Fukushi et al.
Biochemical and biophysical research communications, 447(1), 38-43 (2014-04-01)
Secretion from the gastric gland involves the activation of various types of cells in a coordinated manner. In order to elucidate the mechanisms underlying the coordination of secretion, we studied live fluorescence images of guinea pig gastric glands stained with
Hong-xiang Wang et al.
Zhonghua yi xue za zhi, 92(26), 1828-1831 (2012-09-05)
To ascertain the epididymal sperm nuclear maturity in obstructive azoospermia (OA) patients. A total of 81 infertile males from andriatry clinic of Renji hospital were selected, including 32 OA patients (OA group) and 49 asthenospermia patients (asthenospermia group). Another 32
Zsuzsanna Grózer et al.
Virulence, 6(1), 85-92 (2015-02-06)
Prostaglandins are C20 fatty acid metabolites with diverse biological functions. In mammalian cells, prostaglandins are produced from arachidonic acid (AA) via cyclooxygenases (COX1 and COX2). Although fungi do not possess cyclooxygenase homologues, several pathogenic species are able to produce prostaglandins from
Basudev Maity et al.
European journal of medicinal chemistry, 57, 250-258 (2012-10-16)
Polypyridyl platinum(II) complexes (1-5), viz., [Pt(pyphen)Cl]Cl (1), [Pt(pyphen)(C≡CFc)]Cl (2), [Pt(pydppz)Cl]Cl (3), [Pt(pydppz)(C≡CPh)]Cl (4) and [Pt(pydppz)(C≡CFc)]Cl (5), where pyphen is 6-(2-pyridyl)-1,10-phenanthroline, pydppz is 6-(2-pyridyl)-dipyrido-[3,2-a:2',3'-c]-phenazine, FcC≡CH is ferrocenyl acetylene and PhC≡CH is phenyl acetylene, were synthesized, characterized and their DNA binding and
Asuman Demiroglu-Zergeroglu et al.
Cell biology international, 44(9), 1934-1944 (2020-05-22)
Malignant mesothelioma is a rare but aggressive form of malignancy, which is difficult to diagnose and is resistant to current chemotherapeutic treatment options. Molecular techniques have been used to investigate the mechanisms of action and the beneficial therapeutic effects of
Shufang Zhang et al.
Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy, 97, 521-525 (2012-07-31)
The interaction of luteolin with calf thymus deoxyribonucleic acid (ctDNA) under physiological conditions (Tris-HCl buffer solutions, pH 7.4) was studied by UV-Vis spectroscopy, fluorescence spectroscopy and viscosity measurement method, respectively. The results indicated that a complex of luteolin with ctDNA
Magdalena Pilz et al.
Journal of orthopaedic research : official publication of the Orthopaedic Research Society, 30(12), 2046-2051 (2012-06-08)
Although combination of surgery with chemotherapy has noticeably improved the survival rate of osteosarcoma patients, the application of anticancer drugs is still associated with significant adverse reactions, for instance acquisition of drug-resistant phenotypes, necessitating the development of new chemotherapeutical agents.
M F Shishova et al.
Ontogenez, 43(6), 413-424 (2013-02-14)
Comparative analysis of the transport activity of proton pumps (plasmalemma H+-ATPase, vacuolar H+-ATPase, and vacuolar H+-pyrophosphatase) in the membrane preparations obtained from coleoptile cells ofetiolated maize seedlings (Zea mays L.) was carried out. The highest level ofvacuolar pyrophosphatase activity was
Ilgım Göktürk et al.
Artificial cells, nanomedicine, and biotechnology, 41(2), 78-84 (2013-01-12)
The aim of this study is to label the cells with polymeric nanoparticles properly and efficiently. For this purpose, acridine orange (AO)-loaded poly(2-hydroxyethyl methacrylate) (PHEMA) nanoparticles were synthesized by miniemulsion polymerization. PHEMA nanoparticles were characterized by zeta sizer, zeta potential
Sayeed Ur Rehman et al.
Archives of biochemistry and biophysics, 566, 7-14 (2014-12-22)
Non-covalent interactions of chlorambucil with calf thymus DNA was investigated using multi-spectroscopic techniques and molecular docking study. Binding constant calculated was found to be 1.54×10(4)M(-1) at 290K, significantly lower than various known intercalators. Quenching process was found to be static
A Magge et al.
Journal of applied microbiology, 106(3), 814-824 (2009-02-04)
To determine roles of coats in staining Bacillus subtilis spores, and whether spores have membrane potential. Staining by four dyes and autofluorescence of B. subtilis spores that lack some (cotE, gerE) or most (cotE gerE) coat protein was measured. Wild-type
Q L Chen et al.
Talanta, 97, 48-54 (2012-07-31)
We have utilized various valving scheme to leverage purely rotation-regulated flow control to enable comprehensive cell-based bioassays (CBBs) on centrifuge-based lab-on-a-disc (LOAD). A LOAD has been developed to examine allergic degranulation from live basophils for allergens screening for the first
Muthukumar Abinaya et al.
Journal of photochemistry and photobiology. B, Biology, 192, 55-67 (2019-01-28)
Arboviral diseases and microbial pathogens resistant to commercially available drugs are on the rise. Herein, a facile microbial-based approach was developed to synthesize selenium nanowires (Se NWs) using microbial exopolymer (MEP) extracted from the Bacillus licheniformis (probiotic bacteria). MEP-Se NWs
Kseniya V Shishova et al.
Developmental biology, 397(2), 267-281 (2014-12-08)
It is well known that fully-grown mammalian oocytes, rather than typical nucleoli, contain prominent but structurally homogenous bodies called "nucleolus-like bodies" (NLBs). NLBs accumulate a vast amount of material, but their biochemical composition and functions remain uncertain. To clarify the
No Soo Kim et al.
Journal of ethnopharmacology, 241, 112025-112025 (2019-06-13)
A rhizome of Phragmites communis Trinius has been used in traditional medicine to remove a heat, relieve vomiting and fever, nourish body fluids, and treat diseases like cancers. However, the safety of Phragmitis rhizoma has not yet been fully assessed.
Shagun Arora et al.
International journal of medicinal mushrooms, 15(3), 301-314 (2013-05-15)
Cancer is one of the most prevalent chronic diseases of the world. Certain edible mushroom species are rich in antioxidants, which perform a vital role in preventing this risk in manifesting itself. Initial screening was followed by qualitative phytochemical analysis;
Cheng Zeng et al.
Aquatic toxicology (Amsterdam, Netherlands), 149, 25-32 (2014-02-22)
We previously demonstrated that cyanobacteria-derived microcystin-leucine-arginine (MCLR) is able to induce developing toxicity, such as malformation, growth delay and also decreased heart rates in zebrafish embryos. However, the molecular mechanisms by which MCLR induces its toxicity during the development of
Ravichandran Rekha et al.
Journal of trace elements in medicine and biology : organ of the Society for Minerals and Trace Elements (GMS), 51, 191-203 (2018-11-24)
Herein, we reported a method to synthesize selenium nanowires (Cr-SeNWs) relying to purified cysteine-rich antimicrobial peptide crustin in presence of ascorbic acid. Cr-SeNWs were characterized by UV-vis, XRD, FTIR and Raman spectroscopy, as well as SEM, HR-TEM and EDAX. The
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