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Debra D Bloom et al.
Cytotherapy, 17(2), 140-151 (2014-12-03)
The T-cell suppressive property of bone marrow-derived mesenchymal stromal cells (MSCs) has been considered a major mode of action and basis for their utilization in a number of human clinical trials. However, there is no well-established reproducible assay to measure
Nele Van den Eede et al.
Toxicology in vitro : an international journal published in association with BIBRA, 29(8), 2045-2054 (2015-09-01)
Since the publication of REACH guidelines, the need for in vitro tools for toxicity testing has increased. We present here the development of a hepatotoxicity testing tool using human HepaRG cell cultures and metabolomics. HepaRG cells were exposed to either
Maribel Reyes et al.
Xenobiotica; the fate of foreign compounds in biological systems, 45(2), 139-149 (2014-09-05)
1. Ponesimod [(R)-5-[3-chloro-4-(-2,3-dihydroxy-propoxy)-benzylidene]-2-propylimino-3-o-tolyl-thiazolidin-4-one] is an orally administered, selective S1P1 receptor modulator that blocks the egress of lymphocytes from lymphoid organs and reduces the availability of circulating effector T/B-cells. 2. The mass balance, pharmacokinetics and metabolism of 40 mg (14)C-ponesimod were investigated in six
A W Jones et al.
Journal of analytical toxicology, 13(4), 199-203 (1989-07-01)
In the course of analyzing blood samples from drunk drivers, several low molecular weight volatiles were occasionally identified in addition to ethanol on the gas chromatograms. Among 21, 153 blood specimens analyzed during 1986, 77 contained ethanol as well as
Chunxiu Huang et al.
Biosensors & bioelectronics, 63, 478-482 (2014-08-19)
The electrogenerated chemiluminescence (ECL) behavior of the bioinspired peptide nanovesicles (PNVs) was reported for the first time. The PNVs modified glassy carbon electrodes have shown a stable and efficient cathodic ECL signal with K2S2O8 as coreactant in aqueous solution. The
V Matvejev et al.
The journal of physical chemistry. B, 116(48), 14071-14077 (2012-11-17)
Solvation in water requires minimizing the perturbations in its hydrogen bonded network. Hence solutes distort water molecular motions in a surrounding domain, forming a molecule-specific hydration shell. The properties of those hydration shells impact the structure and function of the
Cosima Damiana Calvano et al.
Analytical and bioanalytical chemistry, 407(3), 1015-1022 (2014-12-01)
Direct on-target plate processing of small (ca. 100 μg) fragments of paint samples for MALDI-MS identification of lipid- and protein-based binders is described. Fragments were fixed on a conventional stainless steel target plate by colloidal graphite followed by in situ fast
U Kogel et al.
Toxicology in vitro : an international journal published in association with BIBRA, 29(8), 2102-2115 (2015-08-19)
Cigarette smoking causes serious and fatal diseases. The best way for smokers to avoid health risks is to quit smoking. Using modified risk tobacco products (MRTPs) may be an alternative to reduce the harm caused for those who are unwilling
Michaella J Levy et al.
Analytical and bioanalytical chemistry, 406(26), 6559-6567 (2013-11-23)
The FDA has approved more than 100 protein and peptide drugs with hundreds more in the pipeline (Lanthier et al. in Nat Rev Drug Discov 7(9):733-737, 2008). Many of these originator biologic products are now coming off patent and are
Alexandra Toma et al.
Journal of chromatographic science, 52(10), 1302-1307 (2014-01-28)
The retention behavior for a series of new polyheterocyclic compounds containing azolic rings (1,3-thiazole, 1,2,4-triazole, 1,3,4-oxadiazole, 1,3,4-thiadiazole) has been investigated using reversed-phase thin-layer chromatography. Different approaches and computational methods were employed to evaluate their lipophilicity indices derived from chromatographic parameters.
Rachel Y Barnett et al.
Journal of analytical toxicology, 38(8), 589-591 (2014-09-14)
Designer drugs appear to be increasing in popularity because of the ease of obtaining these constituents, the lack of ability to identify the substance(s) in routine drug screening, the appeal of the drug(s) being 'safe' due to them being marketed
Lin Li et al.
Journal of chromatography. A, 1381, 140-148 (2015-01-24)
Glycerophospholipids and sphingolipids are important signaling molecules which are involved in many physiological and pathological processes. Here we reported an effective method for accurate analysis of these lipids by liquid chromatography electrospray ionization tandem mass spectrometry (LC-ESI-MS/MS). The methanol method
Gera Goverse et al.
European journal of immunology, 45(1), 89-100 (2014-10-15)
The vitamin A metabolite retinoic acid (RA) has been reported to suppress Th1 responses and enhance Th2 responses. Here, we investigated whether differences in vitamin A metabolism could underlie the differences between C57BL/6 and BALB/c mice, which are reportedly seen
Jatinderpal K Sandhu et al.
Biomedical chromatography : BMC, 28(6), 913-917 (2014-05-28)
The accurate and specific measurement of vitamin D is increasingly important for determining the role of vitamin D in the pathogenesis of disease. Liquid chromatography coupled to tandem mass spectrometry (LC/MS/MS) has increasingly become the analytical modality of choice for
Chung-Hsin Tsai et al.
Molecular medicine reports, 12(5), 7326-7334 (2015-10-16)
Due to the fact that the treatment of breast cancer depends significantly on the molecular markers present in the cancer, including estrogen receptor (+), progesterone receptor (+) or erbB2 receptor (+), further investigation targeting triple‑negative breast cancer (TNBC) subtypes may
Daniele Tedesco et al.
Chirality, 27(12), 914-918 (2015-10-09)
Caffeic acid-derived polyethers are a class of natural products isolated from the root extracts of comfrey and bugloss, which are endowed with intriguing pharmacological properties as anticancer agents. The synthesis of new polyether derivatives is achieved through ring-opening polymerization of
Nataša Obermajer et al.
Journal of immunology (Baltimore, Md. : 1950), 193(10), 4988-4999 (2014-10-12)
The ultimate goal in transplantation medicine is the promotion of operational tolerance. Although Th cells of the Th17 type have been predominantly associated with rejection of allogeneic solid organ grafts, regulatory T (T(reg)) cells appear to foster operational tolerance. Induced
Candice N Baker et al.
American journal of physiology. Endocrinology and metabolism, 308(5), E402-E413 (2014-12-18)
As development proceeds from the embryonic to fetal stages, cardiac energy demands increase substantially, and oxidative phosphorylation of ADP to ATP in mitochondria becomes vital. Relatively little, however, is known about the signaling mechanisms regulating the transition from anaerobic to
Jiahao Guo et al.
Physical chemistry chemical physics : PCCP, 17(43), 28985-28992 (2015-10-13)
Exploiting an alternative of the Pt-based counter-electrode materials for the triiodide reduction reaction has become a major interest in the fundamental research of dye-sensitized solar cells. Transition-metal selenides have recently been demonstrated as promising non-precious metal electrocatalysts for the triiodide
Tewarit Sarachana et al.
Transfusion, 55(11), 2672-2683 (2015-07-16)
While biomarkers of storage lesions (SLs) for red blood cells (RBCs) abound, the physiologic consequences of SLs and associated important events are poorly understood. Previously we have identified differentially expressed regulatory small noncoding RNAs (ncRNAs) in stored RBCs, suggesting their
Randy W Purves et al.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences, 980, 1-7 (2015-01-02)
Acyl coenzyme A (acyl-CoA) thioesters are important intermediates in cellular metabolism and being able to distinguish among them is critical to fully understanding metabolic pathways in plants. Although significant advances have been made in the identification and quantification of acyl-CoAs
Pradipta Tokdar et al.
Indian journal of microbiology, 55(2), 184-193 (2015-03-26)
Coenzyme Q10 (CoQ10) is a blockbuster nutraceutical molecule which is often used as an oral supplement in the supportive therapy for cardiovascular diseases, cancer and neurodegenerative diseases. It is commercially produced by fermentation process, hence constructing the high yielding CoQ10
Franziska Janusch et al.
Environmental toxicology and pharmacology, 38(3), 792-799 (2014-10-13)
The application of antibiotics including fluoroquinolones to farming animals is widespread and may lead to the development of antibiotic resistance and other environmental effects. To calculate environmental loads and for a proper risk assessment it is necessary to determine the
Syed Ghulam Musharraf et al.
Scientific reports, 5, 8607-8607 (2015-02-26)
Lung cancer has been the most common death causing cancer in the world for several decades. This study is focused on the metabolite profiling of plasma from lung cancer (LC) patients with three control groups including healthy non-smoker (NS), smokers
Kelly Yoshizaki et al.
Respiratory research, 16, 18-18 (2015-04-08)
Diesel exhaust particles (DEPs) are deposited into the respiratory tract and are thought to be a risk factor for the development of diseases of the respiratory system. In healthy individuals, the timing and mechanisms of respiratory tract injuries caused by
Cristina Vilanova et al.
Scientific reports, 5, 17163-17163 (2015-11-26)
Microbial communities are ubiquitous in both natural and artificial environments. However, microbial diversity is usually reduced under strong selection pressures, such as those present in habitats rich in recalcitrant or toxic compounds displaying antimicrobial properties. Caffeine is a natural alkaloid
Silvia Falcinelli et al.
Scientific reports, 5, 9336-9336 (2015-03-31)
The microbiome plays an important role in lipid metabolism but how the introduction of probiotic communities affects host lipid metabolism is poorly understood. Using a multidisciplinary approach we addressed this knowledge gap using the zebrafish model by coupling high-throughput sequencing
Rounak Nassirpour et al.
Toxicological sciences : an official journal of the Society of Toxicology, 148(1), 35-47 (2015-08-09)
MicroRNAs (miRNAs) are small, noncoding RNAs that regulate protein levels posttranscriptionally. miRNAs play important regulatory roles in many cellular processes and have been implicated in several diseases. Recent studies have reported significant levels of miRNAs in a variety of body
Sajjad Karim et al.
CNS & neurological disorders drug targets, 13(8), 1334-1345 (2014-10-28)
Non-communicable chronic diseases have been apparently established as threat to human health, and are currently the world's main killer. Cardiovascular diseases (CVD), cancer, diabetes and neurodegenerative diseases are collectively amounting to more than 60% of non-communicable disease burden across world.
Thilak K Mudalige et al.
Journal of chromatography. A, 1420, 92-97 (2015-10-13)
Engineered nanoparticles are available in large numbers of commercial products claiming various health benefits. Nanoparticle absorption, distribution, metabolism, excretion, and toxicity in a biological system are dependent on particle size, thus the determination of size and size distribution is essential
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