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Xiaobiao Zhu et al.
Biodegradation, 26(6), 465-474 (2015-10-30)
The bioaugmentation strains for phenol, pyridine, quinoline, carbazole, and naphthalene degradation were employed to treat coking wastewater in a membrane bioreactor (MBR). The results showed that the bioaugmented MBR was much better in pollutant removal than that of the control
Alexander P Gorka et al.
Journal of medicinal chemistry, 56(13), 5231-5246 (2013-04-17)
Historically, the most successful molecular target for antimalarial drugs has been heme biomineralization within the malarial parasite digestive vacuole. Heme released from catabolized host red blood cell hemoglobin is toxic, so malarial parasites crystallize heme to nontoxic hemozoin. For years
Nanotube composite carbon fibers
Andrews R, et al.
Applied Physics Letters, 75(9), 1329-1331 (1999)
Jin Hoon Kim et al.
Dalton transactions (Cambridge, England : 2003), 42(15), 5500-5507 (2013-02-22)
Zinc sensors based on 2,3-dipicolylamine (DPA) and quinoline have been synthesized. They fluoresced in the presence of Zn(2+) and remained fluorescent when other metal ions were present. Fluorescence enhancement of the sensors was not seen for most other metal ions.
The many roles for fluorine in medicinal chemistry.
William K Hagmann
Journal of medicinal chemistry, 51(15), 4359-4369 (2008-06-24)
Tiina J Kauppila et al.
Journal of the American Society for Mass Spectrometry, 25(11), 1870-1881 (2014-09-25)
A novel, gas-tight API interface for gas chromatography-mass spectrometry was used to study the ionization mechanism in direct and dopant-assisted atmospheric pressure photoionization (APPI) and atmospheric pressure laser ionization (APLI). Eight analytes (ethylbenzene, bromobenzene, naphthalene, anthracene, benzaldehyde, pyridine, quinolone, and
J R Manjunatha et al.
Food chemistry, 136(2), 650-658 (2012-11-06)
Tetrahydrocurcumin (THC, 1) and zingerone (2) are biologically active molecules originating from the important spices turmeric and ginger, respectively. Novel quinoline derivatives of THC and zingerone have been synthesised by an efficient protocol involving their reaction with substituted 2-aminobenzophenones and
Yuji Mikata et al.
Chemistry & biodiversity, 9(9), 2064-2075 (2012-09-15)
Quinoline-based tetradentate ligands with glucose pendants, N,N'-bis[2-(β-d-glucopyranosyloxy)ethyl]-N,N'-bis[(6-methoxyquinolin-2-yl)methyl]ethylenediamine (N,N'-6-MeOBQBGEN) and its N,N-counterpart, N,N-6-MeOBQBGEN, have been prepared, and their fluorescence-spectral changes upon Zn binding were investigated. Upon excitation at 336 nm, N,N'-6-MeOBQBGEN showed weak fluorescence (ϕ ≈ 0.016) in HEPES buffer (HEPES
Narendra Reddy Chereddy et al.
Dalton transactions (Cambridge, England : 2003), 41(38), 11753-11759 (2012-08-21)
Two new rhodamine based probes 1 and 2 for the detection of Fe(3+) were synthesized and their selectivity towards Fe(3+) ions in the presence of other competitive metal ions tested. The probe 1 formed a coloured complex with Fe(3+) as
Alfonso Pérez-Garrido et al.
Bioorganic & medicinal chemistry, 17(2), 896-904 (2008-12-06)
This paper reports a QSAR study for predicting the complexation of a large and heterogeneous variety of substances (233 organic compounds) with beta-cyclodextrins (beta-CDs). Several different theoretical molecular descriptors, calculated solely from the molecular structure of the compounds under investigation
David J Lewis et al.
Dalton transactions (Cambridge, England : 2003), 41(42), 13138-13146 (2012-09-26)
In order to evaluate quinoline as a remote sensitiser, we have prepared a DTPA based ligand, H3L, bearing quinoline bisamide arms for the complexation of a range of lanthanide(III) ions to give the neutral complexes LnLwhere Ln(3+) = Y(3+), Eu(3+)
Yanyan Zhang et al.
Natural product communications, 7(7), 963-968 (2012-08-23)
In recent years, a number of alkaloids have been discovered from endophytic fungi in plants, which exhibited excellent biological properties such as antimicrobial, insecticidal, cytotoxic, and anticancer activities. This review mainly deals with the research progress on endophytic fungi for
Fang-Fang Wang et al.
Organic & biomolecular chemistry, 10(43), 8605-8608 (2012-10-09)
A practical Brønsted acid promoted benzylic C-H functionalization of 2-methylazaarenes and nucleophilic addition to aldehydes was developed in good to excellent yields. A six-membered hydrogen-bonding transition state is proposed to be crucial for the reaction. Ready availability of the two
Chunrong Wang et al.
Bioscience, biotechnology, and biochemistry, 79(1), 164-170 (2014-09-02)
A novel quinoline-degrading strain, named K4, was isolated from activated sludge of a coking wastewater treatment plant and identified as Brevundimonas sp. on the basis of its 16s rDNA gene sequence analysis. Its optimum temperature and pH for quinoline degradation
Madishetti Shravani et al.
Chemphyschem : a European journal of chemical physics and physical chemistry, 13(15), 3526-3534 (2012-08-14)
We carried out a detailed computational investigation of an earlier experimentally observed, unusual, regioselective, electrophilic halogenation in helically folded quinoline oligoamides. In the experimental studies, halogenation occurred selectively at a given monomer of a foldamer substituted with electron-withdrawing groups at
Sergey Kapishnikov et al.
Proceedings of the National Academy of Sciences of the United States of America, 109(28), 11188-11193 (2012-06-30)
Heme detoxification is a critical step in the life cycle of malaria-causing parasites, achieved by crystallization into physiologically insoluble hemozoin. The mode of nucleation has profound implications for understanding the mechanism of action of antimalarial drugs that inhibit hemozoin growth.
John W Scott et al.
Biochemical and biophysical research communications, 443(2), 435-440 (2013-12-18)
The AMP-activated protein kinase (AMPK) regulates cellular and whole-body energy balance in response to changes in adenylate charge and hormonal signals. Activation of AMPK in tissues such as skeletal muscle and liver reverses many of the metabolic defects associated with
Michael T Rudd et al.
Bioorganic & medicinal chemistry letters, 22(23), 7201-7206 (2012-10-02)
A series of macrocyclic compounds containing 2-substituted-quinoline moieties have been discovered and shown to exhibit excellent HCV NS3/4a genotype 3a and genotype 1b R155K mutant activity while maintaining the high rat liver exposure. Cyclization of the 2-substituted quinoline substituent led
Peng Liao et al.
Journal of colloid and interface science, 382(1), 74-81 (2012-06-30)
Adsorption of three nitrogen-heterocyclic compounds (NHCs), pyridine, indole, and quinoline, on a new porous carbonaceous adsorbent, bamboo charcoal (BC), is investigated. Different structures and surface properties of BC are created by HNO(3) and NaOH treatment as well as by microwave
Jieying Jing et al.
Journal of hazardous materials, 237-238, 247-255 (2012-09-06)
Anatase TiO(2) nanoparticles with an average size of 16 nm were synthesized via a modified sol-gel method and were employed to degrade quinoline under UV irradiation (λ=365 nm). The influence of reaction parameters such as TiO(2) dosage, initial quinoline concentration
Marella A, et al.
Saudi Pharmaceutical Journal : SPJ : The Official Publication of the Saudi Pharmaceutical Society, 21(1), 1-2 (2013)
Oleg V Larionov et al.
Organic letters, 16(3), 864-867 (2014-01-15)
A one-step transformation of heterocyclic N-oxides to 2-alkyl-, aryl-, and alkenyl-substituted N-heterocycles is described. The success of this broad-scope methodology hinges on the combination of copper catalysis and activation by lithium fluoride or magnesium chloride. The utility of this method
Yu Zhang et al.
Dalton transactions (Cambridge, England : 2003), 41(38), 11776-11782 (2012-08-21)
A series of carboxamidoquinoline-based fluorescent sensors (the AQZ family) were synthesized and characterized. The AQZ family members were highly soluble in water and showed good selectivity for Zn(2+)via enhanced fluorescence in aqueous buffer solution. Fluorescence signals could be tuned from
Carol E Griffin et al.
Antimicrobial agents and chemotherapy, 56(10), 5356-5364 (2012-08-08)
The Cinchona alkaloids are quinoline aminoalcohols that occur as diastereomer pairs, typified by (-)-quinine and (+)-quinidine. The potency of (+)-isomers is greater than the (-)-isomers in vitro and in vivo against Plasmodium falciparum malaria parasites. They may act by the
Pascal Rouge et al.
Food chemistry, 141(3), 1888-1894 (2013-07-23)
The aim of this work was to characterise new UV-absorbing compounds (UAC) in cow milk in order to gain an overview of the molecular diversity of the minor bioactive constituents, that could be used to trace animal feed or that
M Kumru et al.
Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy, 113, 72-79 (2013-05-29)
The FT-IR (4000-50 cm(-1)), FT-Raman (4000-50 cm(-1)) and Dispersive-Raman (3500-50 cm(-1)) spectra of solid sample of quinoline-4-carbaldehyde (Q4C) have been recorded. The molecule structure, vibrational frequencies, IR intensities, Raman intensities and thermodynamic properties of the two possible aldehyde rotamers of
Jane Greeff et al.
Bioorganic & medicinal chemistry, 20(2), 809-818 (2011-12-27)
Neurodegenerative disorders are frequently associated with increased oxidative damage to the brain as a result of free radicals produced by cellular respiration. The onset and progression of neurodegeneration may therefore be curbed by exogenous hydrogen-donating antioxidant moieties such as the
Narsidas J Parmar et al.
Bioorganic & medicinal chemistry letters, 23(6), 1656-1661 (2013-02-19)
An improved domino/Knoevenagel-hetero-Diels-Alder reaction of two new aldehyde substrates; 7-olefinoxy-coumarin-8-carbaldehyde and 2-alkensulfanyl-quinoline-3-carbaldehyde, with pyrazolones was studied in ionic liquid triethylammonium acetate (TEAA), affording a series of pyrazolopyran annulated-pyrano-fused coumarins, and thiopyrano-fused quinolones. Besides acting as catalyst, since no additional catalyst
Yoshiaki Yasutake et al.
FEBS letters, 588(1), 105-110 (2013-11-26)
The cytochrome P450 RauA from Rhodococcus erythropolis JCM 6824 catalyzes the hydroxylation of a nitrogen atom in the quinolone ring of aurachin, thereby conferring strong antibiotic activity on the aurachin alkaloid. Here, we report the crystal structure of RauA in
Ikarastika Rahayu Abdul Wahab et al.
Planta medica, 78(14), 1597-1600 (2012-07-21)
One novel compound was isolated from the hexane extract of Choisya ternata Kunth. leaves, choisyaternatine (1), together with the known compounds tecleamaniensine A (2), lup-20(29)-en-3β-ol (lupeol) (3), lup-20(29)-en-3β,24-diol (4), β-sitosterol glucoside (5), and skimmianine (6), plus the following known compounds
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