242543

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Trace Amine-Associated Receptor 1 Agonists as Narcolepsy Therapeutics.

Sarah W Black et al.

Biological psychiatry, 82(9), 623-633 (2016-12-07)

Narcolepsy, a disorder of rapid eye movement (REM) sleep, is characterized by excessive daytime sleepiness and cataplexy, a loss of muscle tone triggered by emotional stimulation. Current narcolepsy pharmacotherapeutics include controlled substances with abuse potential or drugs with undesirable side

High-performance liquid chromatographic behaviour of some pharmaceutically important thiazide, loop and potassium-sparing diuretics.

F De Croo et al.

Journal of chromatography, 325(2), 395-411 (1985-06-07)

This paper deals with the specific identification of several thiazide, potassium-sparing and loop diuretics. The liquid chromatographic behaviour of these compounds is studied. Different organic modifiers (methanol, acetonitrile and tetrahydrofuran) are compared in terms of selectivity for the thiazide diuretics.

Evaluation of the neuroprotective and antidiabetic potential of phenol-rich extracts from virgin olive oils by in vitro assays.

M Figueiredo-González et al.

Food research international (Ottawa, Ont.), 106, 558-567 (2018-03-28)

In this work, phenol-rich extracts from 'Cornicabra' and 'Picual' virgin-olive oils (EVOOs) were examined, for the first time, to establish their capacity to inhibit key enzymes involved in Alzheimer's disease (AD) (acetylcholinesterase (AChE), butyrylcholinesterase (BuChE) and 5-lipoxygenase (LOX)), major depressive

Changes in intensity of serotonin syndrome caused by adverse interaction between monoamine oxidase inhibitors and serotonin reuptake blockers.

Rui Tao et al.

Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology, 39(8), 1996-2007 (2014-03-01)

Drug interaction between inhibitors of monoamine oxidase (MAOIs) and selective serotonin (5-hydroxytryptamine, 5-HT) reuptake (SSRIs) induces serotonin syndrome, which is usually mild but occasionally severe in intensity. However, little is known about neural mechanisms responsible for the syndrome induction and

Effects of the Hydrophilic-Lipophilic Balance of Alternating Peptides on Self-Assembly and Thermo-Responsive Behaviors.

Abu Bin Ihsan et al.

International journal of molecular sciences, 20(18) (2019-09-20)

A series of N-substituted poly(Gly-alter-Val) peptides were successfully synthesized for the systematic evaluation of the micellization behavior of alternating peptides. Three-component polymerization employing an aldehyde, a primary ammonium chloride, and potassium isocyanoacetate afforded four alternating peptides in excellent yields. We

Quantification of short chain amines in aqueous matrices using liquid chromatography electrospray ionization tandem mass spectrometry.

Jyrki Viidanoja

Journal of chromatography. A, 1480, 106-111 (2016-12-21)

A new liquid chromatography-electrospray ionization-tandem Mass Spectrometry (LC-ESI-MS/MS) method was developed for the determination of more than 20 C1-C6 alkyl and alkanolamines in aqueous matrices. The method employs Hydrophilic Interaction Liquid Chromatography Multiple Reaction Monitoring (HILIC-MRM) with a ZIC-pHILIC column

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