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Solubilizing and hydrotropic properties of isosorbide monoalkyl-and dimethyl-ethers.
Durand M, et al.
Journal of Surfactants and Detergents, 12(4), 371-378 (2009)
E Squillante et al.
European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V, 46(3), 265-271 (1999-01-14)
The in vitro percutaneous fluxes of propylene glycol (PG), cis-oleic acid (OA) and dimethyl isosorbide (DI) were determined and their effect on nifedipine (N) flux and lag time evaluated. PG, OA and DI flux through hairless mouse (HM) skin was
Amin Swed et al.
International journal of pharmaceutics, 493(1-2), 357-365 (2015-07-26)
The aim of this work was to encapsulate transforming growth factor β1 (TGF-β1) into PLGA microparticles for regenerative medicine applications. TGF-β1 was firstly precipitated to ensure its stability during subsequent encapsulation within microparticles. A novel emulsification/extraction process in CO2 medium
Capping carious exposed pulps with potassium nitrate, dimethyl isosorbide, polycarboxylate cement.
Milton Hodosh et al.
Dentistry today, 22(1), 46-51 (2003-03-06)
Green synthesis of dimethyl isosorbide.
Pietro Tundo et al.
ChemSusChem, 3(5), 566-570 (2010-04-20)
Greener solvents for solid-phase synthesis.
Lawrenson S, et al.
Green Chemistry, 19(4), 952-962 (2017)
Adrian P Funke et al.
Pharmaceutical research, 19(5), 661-668 (2002-06-19)
Highly lipophilic basic drugs, the antiestrogens AE 1 (log P = 5.82) and AE 2 (log P = 7.8) shall be delivered transdermally. Transdermal permeation of drugs, enhancers, and solvents from various fluid formulations were characterized by in-vitro permeation studies
Carlos van Hemelrijck et al.
International journal of pharmaceutics, 420(2), 297-303 (2011-09-20)
A poloxamer 407 (POX) gel containing dimethyl isosorbide (DMIS), isopropyl alcohol (IPA), propylene glycol dicaprylocaprate (MIG) and water has been suggested in a previous study for permeation enhancement of 5-aminolevulinic acid (ALA) across isolated human stratum corneum. The purpose of
Carlos van Hemelrijck et al.
International journal of pharmaceutics, 437(1-2), 120-129 (2012-08-18)
Topical application of 5-aminolevulinic acid (ALA) in photodynamic therapy is of great interest because of avoiding systemic side effects with such an easy way of application. However, due to ALA's high polarity its dermal bioavailability is rather limited and thus
Isosorbide mono-and di-alkyl ethers, a new class of sustainable coalescents for water-borne paints.
Durand M, et al.
Progress in Organic Coatings, 69(4), 344-351 (2010)
B W Barry et al.
The Journal of investigative dermatology, 82(1), 49-52 (1984-01-01)
The occluded vasoconstrictor assay was used to assess the effect of penetration enhancers on the topical bioavailability of a representative steroid, betamethasone 17-benzoate, with dimethylisosorbide (DMI) as a reference solvent. In the initial test, only N-methyl-2-pyrrolidone (NMP) increased the steroid
My-Kien Tran et al.
European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V, 82(3), 498-507 (2012-09-11)
The aim of this work was to elaborate formulation strategies to encapsulate a protein into biodegradable polymeric particles for sustained release purpose. In this paper, two encapsulation methods will be presented, one dealing with a phase separation phenomenon while the
A Otto et al.
Skin pharmacology and physiology, 21(6), 326-334 (2008-10-04)
In this study the effect of 2 penetration modifiers, dimethyl isosorbide (DMI) and diethylene glycol monoethyl ether (DGME) on the skin delivery of hydroquinone (HQ), salicylic acid (SA) and octadecenedioic acid (DIOIC) was investigated. Ten percent DMI and DGME were
H Zia et al.
Pharmaceutical research, 8(4), 502-504 (1991-04-01)
Dimethyl isosorbide (DMI), which is currently under investigation for its potential use as a pharmaceutical vehicle and drug permeation enhancer, is a water-miscible liquid with relatively low viscosity. The solubilization behavior of DMI as a cosolvent for nonpolar drugs was
Bshaer M Jameel et al.
International journal of pharmaceutics, 569, 118549-118549 (2019-08-09)
Trial-and-error approach to formulation development is long and costly. With growing time and cost pressures in the pharmaceutical industry, the need for computer-based formulation design is greater than ever. In this project, emulgels were designed and optimized using Formulating for
M Brisaert et al.
Pharmacy world & science : PWS, 18(5), 182-186 (1996-10-01)
Erythromycin, an antibiotic commonly used topically in the treatment of acne, is unstable in solution. The stability is influenced by the pH and by the presence of water. The influence of the pH on the stability of erythromycin was investigated
Y Zhang et al.
International journal of cosmetic science, 41(5), 479-488 (2019-08-06)
Phenylethyl resorcinol (PR) has been used widely in the personal care industry as a novel skin lightening ingredient. Surprisingly, there is only limited information describing the physicochemical properties of this active. Therefore, the primary objective of this study was to
Piyush Jain et al.
Journal of cosmetic dermatology, 11(2), 101-110 (2012-06-08)
Skin-lightening preparations are used by people all over the world for a diverse range of dermatologic indications. The gold standard treatment for skin lightening is with hydroquinone but has been controversial because of the presence of several side effects. Therefore
Eco-friendly solvents and amphiphilic catalytic polyoxometalate nanoparticles: a winning combination for olefin epoxidation.
Mouret A, et al.
Green Chemistry, 16(1), 269-278 (2014)
HMF derivatives as platform molecules: aqueous Baylis-Hillman reaction of glucosyloxymethyl-furfural towards new biobased acrylates.
Tan JN, et al.
Royal Society of Chemistry Advances, 3(39), 17649-17653 (2013)
Bola D Majekodunmi et al.
Pharmaceutical development and technology, 12(6), 609-620 (2007-12-29)
The chemical stability of benzoyl peroxide (BPO) was studied in solutions and gels. The solutions (1% w/v) were prepared in single solvents (alcohol USP, isopropyl alcohol USP, ethyl benzoate, C12-15 alkyl benzoate, dimethyl isosorbide, propylene carbonate, and acetone) and in
Milton Hodosh et al.
Quintessence international (Berlin, Germany : 1985), 35(2), 137-141 (2004-03-06)
Concentrated potassium nitrate has been used to lessen the pain caused by aphthous stomatitis. The problem with this approach is that it can have difficulty penetrating into the deeper layers of mucosae or skin, and for this reason, its beneficial
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