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Sean E Low et al.
Journal of neurophysiology, 108(1), 148-159 (2012-04-12)
The molecular and physiological basis of the touch-unresponsive zebrafish mutant fakir has remained elusive. Here we report that the fakir phenotype is caused by a missense mutation in the gene encoding voltage-gated calcium channel 2.1b (CACNA1Ab). Injection of RNA encoding
Ruina Gao et al.
Drug metabolism and disposition: the biological fate of chemicals, 40(3), 556-567 (2011-12-21)
Morinidazole [R,S-1-(2-methyl-5-nitro-1H-imidazol-1-yl)-3-morpholinopropan-2-ol] is a new 5-nitroimidazole class antimicrobial agent. The present study aimed to determine the metabolism and pharmacokinetics of morinidazole in humans and to identify the enzymes responsible for the formation of the major metabolites. Plasma and urine samples
Anantha-Barathi Muthukrishnan et al.
PloS one, 9(9), e109005-e109005 (2014-10-01)
The fast adaptation of Escherichia coli to stressful environments includes the regulation of gene expression rates, mainly of transcription, by specific and global stress-response mechanisms. To study the effects of mechanisms acting on a global level, we observed with single
Factors influencing the rate of formation of nitrosomorpholine from morpholine and nitrite: acceleration by thiocyanate and other anions.
T Y Fan et al.
Journal of agricultural and food chemistry, 21(2), 237-240 (1973-03-01)
Claire L Jarvis et al.
Organic letters, 16(13), 3556-3559 (2014-06-14)
Secondary amines react with thiosalicylaldehydes in the presence of catalytic amounts of acetic acid to generate ring-fused N,S-acetals in redox-neutral fashion. A broad range of amines undergo α-sulfenylation, including challenging substrates such morpholine, thiomorpholine, and piperazines. Computational studies employing density
Su-Juan Li et al.
ACS nano, 4(11), 6417-6424 (2010-10-21)
A strategy for label-free oligonucleotide (DNA) analysis has been proposed by measuring the DNA-morpholino hybridization hindered diffusion flux of probe ions Fe(CN)(6)(3-) through nanochannels of a porous anodic alumina (PAA) membrane. The flux of Fe(CN)(6)(3-) passing through the PAA nanochannels
Ryan C Middleton et al.
Experimental cell research, 319(6), 860-874 (2013-01-15)
The small heat shock protein HspB1 (Hsp27) is abundantly expressed in embryonic muscle tissues of a wide variety of vertebrate species. However, the functional significance of this expression pattern is not well established. In the present study, we observed specific
Bruno Bard et al.
Journal of medicinal chemistry, 52(10), 3416-3419 (2009-04-29)
RPLC gains acceptance in pharmaceutical research for the rapid determination of lipophilicity but remains limited for the determination of partition coefficients of moderate to strong basic compounds under their neutral form because stationary phases are not compatible with high pH
Louis De Muynck et al.
Neurobiology of aging, 34(11), 2541-2547 (2013-05-28)
Progranulin (PGRN) is a growth factor involved in wound healing, inflammation, tumor growth, and neurodegeneration. Mutations in the gene encoding PGRN give rise to shortage of PGRN and cause familial frontotemporal lobar degeneration. PGRN exerts neurotrophic functions and binding of
Jinqiang Kuang et al.
Journal of the American Chemical Society, 132(6), 1786-1787 (2010-01-28)
ZnI(2) has been identified as the catalyst for the one-step synthesis of allenes from terminal alkynes and aldehydes with morpholine as the base in toluene. The reaction is believed to proceed via the intermediacy of propargylic amines, which was converted
Andrew J Tilley et al.
Bioorganic & medicinal chemistry, 20(7), 2353-2361 (2012-03-02)
Isoflavone consumption correlates with reduced rates of cardiovascular disease. Epidemiological studies and clinical data provide evidence that isoflavone metabolites, such as the isoflavan equol, contribute to these beneficial effects. In this study we developed a new route to isoflavans and
Vítor S Fernandes et al.
American journal of physiology. Cell physiology, 309(2), C107-C116 (2015-05-08)
Hydrogen sulfide (H2S) is a key signaling molecule regulating important physiological processes, including smooth muscle function. However, the mechanisms underlying H2S-induced detrusor smooth muscle (DSM) contractions are not well understood. This study investigates the cellular and tissue mechanisms by which
Andrea C Mislak et al.
Biochimica et biophysica acta, 1840(7), 2203-2211 (2014-04-15)
Non-nucleoside reverse transcriptase inhibitors (NNRTIs) are vital in treating HIV-1 infection by inhibiting reverse transcriptase (RT). Drug toxicity and resistance drive the need for effective new inhibitors with improved physiochemical properties and potent antiviral activity. Computer-aided and structure-based drug design
Synthesis of acylsilanes from morpholine amides. Synthesis of 1-(dimethyl(phenyl)silyl)propan-1-one
Lettan II RB, et al.
Organic Syntheses, 84, 22-22 (2007)
Morpholine.
IARC monographs on the evaluation of carcinogenic risks to humans, 47, 199-213 (1989-01-01)
Shi-Kai Xiang et al.
Chemical communications (Cambridge, England), 47(28), 8097-8099 (2011-06-21)
Organocatalytic direct C3 alkenylation of indoles has been developed. Simple and readily available morpholine trifluoroacetic acid salt is employed as an efficient catalyst in this oxidative dehydrogenative reaction. Simplicity and practicality constitute the most attractive advantages of this reaction.
Mohammednoor Altarawneh et al.
The journal of physical chemistry. A, 116(29), 7703-7711 (2012-07-04)
The combustion chemistry of morpholine (C(4)H(8)ONH) has been experimentally investigated recently as a representative model compound for O- and N-containing structural entities in biomass. Detailed profiles of species indicate the self-breakdown reactions prevailing over oxidative decomposition reactions. In this study
Benoît Pilmis et al.
The Journal of antimicrobial chemotherapy, 70(1), 14-22 (2014-09-11)
Antifungal prescription remains a challenge in pregnant women because of uncertainties regarding fetal toxicity and altered maternal pharmacokinetic parameters that may affect efficacy or increase maternal and fetal toxicity. We present updated data reviewing the available knowledge and current recommendations
R John Xavier et al.
Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy, 101, 148-155 (2012-10-27)
The 4-morpholine carbonitrile (4MC) was investigated by vibrational spectroscopy and quantum chemical methods. The solid phase FT-IR and FT-Raman spectra were recorded in the region 4000-400 cm(-1) and 3500-50 cm(-1), respectively. The molecular geometry and vibrational frequencies of 4MC have
Bachir Latli et al.
Current radiopharmaceuticals, 5(4), 314-317 (2012-06-26)
Morpholine-4-carboxylic acid {(S)-1-[4-cyano-1-(3-morpholin-4-yl-propyl)-piperidin-4-ylcarbamoyl]-4,4- dimethyl-hexyl}-amide, (1) is a potent reversible and selective cathepsin S inhibitor. Deuterium labeled (1) was prepared in four steps in 62% overall yield from [2H8]- morpholine and chiral acid (6). Carbon-14 labeled (1) was obtained in two
J Luong et al.
Journal of chromatography. A, 1229, 223-229 (2012-02-14)
Steam condensate water treatment is a vital and integral part of the overall cooling water treatment process. Steam condensate often contains varying levels of carbon dioxide and oxygen which acts as an oxidizer. Carbon dioxide forms corrosive carbonic acid when
Radosław Starosta et al.
Dalton transactions (Cambridge, England : 2003), 39(32), 7547-7555 (2010-07-10)
Chalcogenide derivatives of three aminomethylphosphines: P(CH2N(CH2CH2)2NCH3)3 (1), P(CH2N(CH2CH2)2NCH2CH3)3 (2) and P(CH2N(CH2CH2)2O)3 (3) were prepared: oxides--OP(CH2N(CH2CH2)2NCH3)3 (4), OP(CH2N(CH2CH2)2NCH2CH3)3 (5), OP(CH2N(CH2CH2)2O)3 (6), sulfides--SP(CH2N(CH2CH2)2NCH3)3 (7), SP(CH2N(CH2CH2)2NCH2CH3)3 (8), SP(CH2N(CH2CH2)2O)3 (9) and selenides--SeP(CH2N(CH2CH2)2NCH3)3 (10), SeP(CH2N(CH2CH2)2NCH2CH3)3 (11), SeP(CH2N(CH2CH2)2O)3 (12). The spectroscopic NMR analyses, DFT (B3LYP/6-31G**) calculations
Linda Z Holland et al.
Methods in molecular biology (Clifton, N.J.), 770, 423-438 (2011-08-02)
The invertebrate chordate amphioxus (Branchiostoma), which is the most basal living chordate, has become an accepted model for the vertebrate ancestor in studies of development and evolution. Amphioxus resembles vertebrates in regard to morphology, developmental gene expression, and gene function.
Xing Liu et al.
Biochemical pharmacology, 97(1), 111-121 (2015-07-28)
Gefitinib (GEF), an inhibitor of epidermal growth factor receptor (EGFR) tyrosine kinase, is widely used for the treatment of cancers, particularly non-small cell lung cancer. However, its clinical use is limited by multiple adverse effects associated with GEF, such as
Soojin Kwon et al.
Journal of the American Chemical Society, 127(48), 16796-16797 (2005-12-01)
An enantioselective synthesis of the natural antiproliferative agent quinocarcin was achieved by the directed condensation of optically active alpha-amino aldehyde intermediates. Condensation of the N-protected alpha-amino aldehyde 1, prepared in eight steps (19% yield) from (R,R)-pseudoephedrine glycinamide, with the C-protected
M F Kasakin et al.
Bioorganicheskaia khimiia, 37(6), 830-835 (2012-04-14)
A simple and effective method for the synthesis of 2'-aminomethylmorpholino-4'-carboxymethyl nucleoside analogues and Boc-modified derivatives as synthons for peptide synthesis was developed.
Copper-catalyzed electrophilic amination of diorganozinc reagents: 4-phenylmorpholine
Berman AM and Johnson JS
Organic Syntheses, 83, 31-31 (2006)
A Olma et al.
Amino acids, 42(6), 2525-2528 (2011-08-19)
The cyclization of N-Boc-α-alkylserines to corresponding β-lactones under Mitsunobu reaction conditions and the ring opening with heterocyclic amines (pyrrolidine, piperidine, morpholine and thiomorpholine) produced N-Boc-α-alkyl-β-(sec-amino)alanines. The removal of the Boc group gives di-hydrochlorides of non-protein amino acids.
Mark E Wood et al.
Organic & biomolecular chemistry, 11(16), 2712-2723 (2013-03-13)
Using C-3 di-deuterated morpholin-2-ones bearing N-2-iodobenzyl and N-3-bromobut-3-enyl radical generating groups, only products derived from the more stabilised C-3, rather than the less stabilised C-5 translocated radicals, were formed after intramolecular 1,5-hydrogen atom transfer, suggesting that any kinetic isotope effect
Amjad M Qandil et al.
Drug development and industrial pharmacy, 39(9), 1346-1356 (2012-09-22)
Six aminoethyl and aminobutyl esters of ketorolac containing 1-methylpiperazine (MPE and MPB), N-acetylpiperazine (APE and APB) or morpholine (ME and MB), were synthesized and their hydrolysis kinetics were studied. The hydrolysis was studied at pH 1 to 9 (for MPE
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