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Nie Tian et al.
Biochemical and biophysical research communications, 450(1), 746-749 (2014-06-21)
Accumulating evidence has pointed to the direct inhibitory action of lithium, an anti-depressant, on GSK-3β. The present study investigated further insight into lithium signaling pathways. In the cell-free assay Li2CO3 significantly inhibited phosphoinositide 3-kinase (PI3K)-mediated phosphorylation of Akt1 at Ser473
A Halboos et al.
Deutsche medizinische Wochenschrift (1946), 137(49), 2583-2585 (2012-11-29)
A 69-year-old man came to the emergency unit because of vertigo and presyncope. A bipolar disorder - known since an age of 15 years - has been treated with 2 × 450 mg lithium and 100 mg perazine per day for several
D C Clark et al.
Recent developments in alcoholism : an official publication of the American Medical Society on Alcoholism, the Research Society on Alcoholism, and the National Council on Alcoholism, 7, 315-328 (1989-01-01)
In order to test the efficacy of lithium therapy for alcoholism, to test whether lithium therapy reduces depressive symptoms among alcoholics, and to test whether any positive lithium treatment effects are associated with an antidepressant action, we undertook a double-blind
[Lithium carbonate].
S Higuchi et al.
Nihon rinsho. Japanese journal of clinical medicine, 53 Su Pt 1, 942-944 (1995-02-01)
Claudia Del Grande et al.
Rivista di psichiatria, 47(6), 515-526 (2012-11-20)
Despite the great quantity of evidence supporting the efficacy of lithium in the maintenance treatment of bipolar disorder (BD), its use has often been limited because of issues about the management of this compound. W aimed to evaluate the use
Vanadium modified LiFePO4 cathode for Li-ion batteries.
Hong J, et al
Electrochemical and Solid-State Letters, 12(2), A33-A38 (2009)
Ashwati Raghunath
BMJ case reports, 2013, doi:10-doi:10 (2013-01-04)
The patient is a 52-year-old man with schizophrenia who developed severe, unremitting gingival pain after his ziprasidone dosage was increased from 80 to 120 mg. His physical examination and laboratory findings were unremarkable. He did not have any extra-pyramidal side
Andrew A Nierenberg et al.
The American journal of psychiatry, 170(1), 102-110 (2013-01-05)
Lithium salts, once the mainstay of therapy for bipolar disorder, have tolerability issues at a higher dosage that often limit adherence. The authors investigated the comparative effectiveness of more tolerable dosages of lithium as part of optimized personalized treatment (OPT).
Carl Redshaw et al.
Dalton transactions (Cambridge, England : 2003), 42(6), 1983-1986 (2013-01-03)
The structures of three novel compounds prepared from the reaction of the lower-rim 1,3-diacid calix[4]arene (LH(2)) with lithium carbonate (1), t-butyl-lithium (2) and zinc acetate (3) are reported.
A simple question answered: adding moderate-dosage lithium does not help patients with bipolar disorder.
Boadie W Dunlop et al.
The American journal of psychiatry, 170(1), 9-11 (2013-01-05)
R Yassa et al.
International pharmacopsychiatry, 15(5), 301-308 (1980-01-01)
In this paper, the efficacy of lithium therapy in the treatment of tardive dyskinesia is reviewed. It is noted that most of the published papers on this topic are anecdotal and single case reports with contradictory results. The well-designed studies
Samah Kalakh et al.
Neuropathology and applied neurobiology, 41(7), 964-982 (2015-03-20)
Experimental evidence has shown that the adrenal steroid hormone, androstenediol, dampens the symptoms of demyelination. However, the cellular and molecular effects of androstenediol are not yet known. In the present study, we investigated the cellular and subcellular effects of this
Towards homonuclear J solid-state NMR correlation experiments for half-integer quadrupolar nuclei: experimental and simulated 11B MAS spin-echo dephasing and calculated 2JBB coupling constants for lithium diborate.
Barrow NS, et al.
Physical Chemistry Chemical Physics, 13(13), 5778-5789 (2011)
Psychopharmacology column: the use of lithium carbonate with pediatric populations.
Geraldine S Pearson et al.
Journal of child and adolescent psychiatric nursing : official publication of the Association of Child and Adolescent Psychiatric Nurses, Inc, 25(4), 232-234 (2012-11-06)
Stefan J Kempf et al.
Journal of proteome research, 14(11), 4674-4686 (2015-10-01)
Recent epidemiological data indicate that radiation doses as low as those used in computer tomography may result in long-term neurocognitive side effects. The aim of this study was to elucidate long-term molecular alterations related to memory formation in the brain
Methodologies to avoid the enrollment of ineligible patients in clinical trials.
Mauricio Tohen
The Journal of clinical psychiatry, 73(11), 1426-1427 (2012-12-12)
Celen Zerouni et al.
Recent patents on endocrine, metabolic & immune drug discovery, 7(1), 77-79 (2012-12-04)
A 40-year-old female patient with bipolar disorder and premenstrual dysphoric disorder did not present any physical evidence of virilization, treated with quetiapine and lithium carbonate. Laboratory testing showed evidence of hyperandrogenism (Testosterone levels 88.5ng/dL). After control, testosterone levels were normal
[Lithium carbonate].
Shun Higuchi
Nihon rinsho. Japanese journal of clinical medicine, 62 Suppl 12, 385-387 (2005-01-22)
M Simard et al.
Archives of internal medicine, 149(1), 36-46 (1989-01-01)
Lithium carbonate is a widely used and invaluable drug in the treatment and prevention of manic-depressive illness. However, this medication has a low therapeutic index and, therefore, many attendant side effects. Acute lithium carbonate intoxication affects predominantly the central nervous
Janusz Rybakowski et al.
Psychiatria polska, 46(4), 627-636 (2012-12-12)
In 1963 it was first demonstrated that long-term lithium administration exerts a "mood-stabilising" effect, preventing recurrences of mania and depression in bipolar affective disorder. Despite the introduction of many other drugs having mood-stabilising effect, lithium still remains the first choice
Andrea Contestabile et al.
The Journal of clinical investigation, 123(1), 348-361 (2012-12-04)
Down syndrome (DS) patients exhibit abnormalities of hippocampal-dependent explicit memory, a feature that is replicated in relevant mouse models of the disease. Adult hippocampal neurogenesis, which is impaired in DS and other neuropsychiatric diseases, plays a key role in hippocampal
Tom Bschor et al.
Journal of clinical psychopharmacology, 33(1), 38-44 (2013-01-02)
Studies of the 1970s and 1980s showed lithium monotherapy to be an effective treatment of acute unipolar major depressive disorder (MDD) and hence as a potential alternative to monoaminergic antidepressants.The objective was to conduct the first comparison of a lithium
Kazumasu Sasaki et al.
British journal of pharmacology, 172(2), 654-667 (2014-06-11)
μ Opioid receptor knockout (MOP-KO) mice display several behavioural differences from wild-type (WT) littermates including differential responses to nociceptive stimuli. Brain structural changes have been tied to behavioural alterations noted in transgenic mice with targeting of different genes. Hence, we
[Lithium carbonate].
S Higuchi et al.
Nihon rinsho. Japanese journal of clinical medicine, 57 Suppl, 383-384 (1999-10-30)
Single daily dosage of lithium carbonate.
C M Hammond
The Annals of pharmacotherapy, 28(4), 472-474 (1994-04-01)
Gary S Sachs et al.
The Journal of clinical psychiatry, 73(11), 1420-1425 (2012-12-12)
High failure rates of randomized controlled trials (RCTs) are well recognized but poorly understood. We report exploratory analyses from an adjunctive ziprasidone double-blind RCT in adults with bipolar I disorder (reported in part 1 of this article). Data collected by
Harm-Pieter Spaans et al.
The Journal of clinical psychiatry, 74(11), e1029-e1036 (2013-12-18)
To compare the efficacy and cognitive side effects of high-dose unilateral brief pulse electroconvulsive therapy (ECT) with those of high-dose unilateral ultrabrief pulse ECT in the treatment of major depression. From April 2007 until March 2011, we conducted a prospective
Wen-Yu Chen et al.
Acta neurologica Taiwanica, 22(1), 32-35 (2013-03-13)
To report the first case of Taiwanese with lithium intoxication presenting as oro-lingual dyskinesia. A 68-year-old man had bipolar disorder with chronic lithium treatment. He had acute conscious disturbance, atrial flutter, myoclunus of limbs, and oro-lingual dyskinesia. Biochemistry study revealed
M Leon et al.
American journal of kidney diseases : the official journal of the National Kidney Foundation, 23(2), 313-316 (1994-02-01)
Ethylene glycol poisoning is accompanied by a high anion gap metabolic acidosis. We describe a case of severe ethylene glycol poisoning in which severe acidosis was not present. This appears to be due to a beneficial effect exerted by simultaneous
Nicoletta Croce et al.
Journal of psychopharmacology (Oxford, England), 28(10), 964-972 (2014-04-05)
One of the common effects of lithium (Li) and valproic acid (VPA) is their ability to protect against excitotoxic insults. Neurodegenerative and neuropsychiatric diseases may be also associated with altered trophic support of brain-derived neurotrophic factor (BDNF), the most widely
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