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Stuart L Cantor et al.
Drug development and industrial pharmacy, 41(7), 1156-1164 (2014-07-08)
The purpose of this research was to develop an orally disintegrating tablet (ODT) dosage form containing taste-masked beads of clindamycin HCl. Several formulation strategies were evaluated and a taste-masked ODT of clindamycin HCl was prepared without the use of a
Sabine Neuberger et al.
Journal of pharmaceutical and biomedical analysis, 112, 70-78 (2015-05-10)
In the last decade, counterfeit pharmaceutical products have become a widespread issue for public health. Raman spectroscopy which is easy, non-destructive and information-rich is particularly suitable as screening method for fast characterization of chemicals and pharmaceuticals. Combined with chemometric techniques
Li Qu et al.
Drug development and industrial pharmacy, 41(5), 825-837 (2014-04-18)
Intensive dry powder coating (mechanofusion) with tablet lubricants has previously been shown to give substantial powder flow improvement. This study explores whether the mechanofusion of magnesium stearate (MgSt), on a fine drug powder can substantially improve flow, without preventing the
Uroš Klančar et al.
AAPS PharmSciTech, 16(2), 398-406 (2014-10-22)
It is challenging to achieve mechanically robust drug-release profiles from hydrophilic matrices containing a high dose of a drug with good solubility. However, a mechanically robust drug release over prolonged period of time can be achieved, especially if the viscosity
Bibi F Choonara et al.
AAPS PharmSciTech, 16(4), 771-786 (2015-01-01)
A menthol-based solid dispersion was designed to improve the intrinsic solubility of the poorly soluble sulfamethoxazole- a class II drug molecule of Biopharmaceutics Classification System (BCS) displaying widespread antibacterial activity. Solid dispersions of menthol and sulfamethoxazole were compressed with hydroxypropyl
Formulation and evaluation of different floating tablets containing metronidazole to target stomach.
Zhiao C Loh et al.
Current drug delivery, 12(4), 425-443 (2015-05-01)
The purpose of this study is to formulate and develop tablets dosage form containing Metronidazole which has swelling and floating properties as a gastroretentive controlled-release drug delivery system to improve drug bioavailability. Fifteen different formulations of effervescence-forming floating systems were
Rebekah L Scheuerle et al.
International journal of pharmaceutics, 486(1-2), 136-143 (2015-03-21)
Tablet disintegration characterisation is used in pharmaceutical research, development, and quality control. Standard methods used to characterise tablet disintegration are often dependent on visual observation in measurement of disintegration times. This presents a challenge for disintegration studies of tablets in
Akhtar Siddiqui et al.
International journal of pharmaceutics, 493(1-2), 1-6 (2015-07-26)
The objective of this study was to develop and validate XRPD analytical method for the estimation of percent crystalline warfarin sodium present in drug products. Warfarin sodium (WS) is a clathrate containing Isopropyl alcohol entrapped in the crystalline structure. Four
Marie Guhmann et al.
Drug development and industrial pharmacy, 41(4), 540-551 (2014-02-06)
Fast onset of action is prerequisite for acute pain medication. A palatable orodispersible medicine of diclofenac providing rapid analgesic effect should improve patient compliance and treatment. In the present study, diclofenac taste-masked orodispersible tablets (ODTs) with fast release characteristics were
A Kluk et al.
International journal of pharmaceutics, 485(1-2), 1-6 (2015-03-05)
Minitablets are a novel, multi-compartment solid drug formulation, particularly intended for children between 1 and 6 years of age. Available literature shows that even infants are capable of swallowing a single minitablet. In this study, we have explored the level
Eva Woltmann et al.
Analytical and bioanalytical chemistry, 406(25), 6347-6362 (2014-08-12)
High production output of solid pharmaceutical formulations requires fast methods to ensure their quality. Likewise, fast analytical procedures are required in forensic sciences, for example at customs, to substantiate an initial suspicion. We here present the design and the optimization
Nisrina Ramadhani et al.
International journal of pharmaceutics, 475(1-2), 514-522 (2014-09-15)
The oral route of administration is the most common and preferred route of drug delivery due to its ease of administration, cost-effectiveness and flexibility in design. However, limited aqueous solubility of the active pharmaceutical ingredient can result in poor bioavailability
R Wulff et al.
European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences, 77, 246-253 (2015-06-21)
The objective of this study was to investigate the suitability of "Eudragit® RL/Eudragit® L55" (RL/L55) blend coatings for a pH-independent release of acidic drugs. A coating for ketoprofen and naproxen mini tablets was developed showing constant drug release rate under
Yunzhou Fan et al.
Drug development and industrial pharmacy, 41(5), 801-811 (2014-04-04)
JFD (N-isoleucyl-4-methyl-1,1-cyclopropyl-1-(4-chlorine)phenyl-2-amylamine·HCl) is a novel investigational anti-obesity drug without obvious cardiotoxicity. The objective of this study was to characterize the key physicochemical properties of JFD, including solution-state characterization (ionization constant, partition coefficient, aqueous and pH-solubility profile), solid-state characterization (particle size
Jumpei Uchiyama et al.
Chemical & pharmaceutical bulletin, 63(3), 164-179 (2015-03-12)
The principles of thermal effusivity are applied to an understanding of the detailed mechanisms of the lubrication process in a rotating mixer. The relationships and impact of the lubrication process by the pattern of powder flow, the filling level, and
Mutasem Rawas-Qalaji et al.
The Journal of pharmacy and pharmacology, 67(1), 20-25 (2014-09-27)
For anaphylaxis treatment in community settings, adrenaline (epinephrine) administration using an auto-injector in the thigh is universally recommended. Despite this, many people at risk of anaphylaxis in community settings do not carry their prescribed auto-injectors consistently and hesitate to use
Julian Quodbach et al.
Journal of pharmaceutical sciences, 103(11), 3657-3665 (2014-09-17)
The aim of this study is the introduction of a novel apparatus that is capable of continuously measuring the particle size reduction of disintegrating tablets and analysis of the obtained results. The apparatus is constructed such that no particles pass
Mingda Bi et al.
Journal of pharmaceutical sciences, 103(7), 2062-2071 (2014-05-21)
The purpose of this study is to investigate if Johanson's rolling theory can correctly predict the maximum roll surface pressure during the roll compaction. Three model pharmaceutical formulations were roller compacted using the Gerteis Mini Pactor at multiple combinations of
Song Guo et al.
Brain : a journal of neurology, 137(Pt 11), 2951-2959 (2014-08-28)
The initiating mechanisms of migraine attacks are very complex but may involve the cyclic AMP signalling pathway. It is unknown whether intracellular cyclic AMP accumulation induces migraine attacks. We investigated whether administration of cilostazol, which causes cyclic AMP accumulation, may
Mireille Hassoun et al.
International journal of pharmaceutics, 490(1-2), 360-367 (2015-05-20)
Using salmeterol xinafoate (SX) as an active pharmaceutical ingredient, the effects of carrier lactose particle type, total lactose fines content and device resistance on dry powder inhaler performance were investigated in vitro. To mimic drug levels in commercial preparations, interactive
Nataša Djordjević Filijović et al.
Drug development and industrial pharmacy, 41(3), 502-514 (2014-03-13)
Stress stability testing represents an important part of the drug development process. It is used as an important tool for the identification of degradation products and degradation pathways, as well as for the assessment of changes in physical form of
Momoh A Mumuni et al.
Drug delivery, 21(4), 315-319 (2013-11-07)
To develop a novel PEGylated ibuprofen tablet formulations and evaluate its anti-inflammatory activity and pharmacokinetics profile in an animal model. Six batches of PEGylated ibuprofen tablets were prepared by direct compression using Avicel® and lactose as the binder diluents. In
Clara S Baffoe et al.
The Journal of pharmacy and pharmacology, 67(2), 189-198 (2014-12-17)
To develop and manufacture both immediate and sustained release vaginal tablets containing the anticancer drug disulfiram, which has the potential to be used as a non-invasive treatment for cervical cancer. Disulfiram-loaded vaginal tablets were manufactured at pilot scale using the
Douglas Fernandes Barbin et al.
Materials science & engineering. C, Materials for biological applications, 56, 274-279 (2015-08-08)
There is an increasing interest in the use of polysaccharides and proteins for the production of biodegradable films. Visible and near-infrared (VIS-NIR) spectroscopy is a reliable analytical tool for objective analyses of biological sample attributes. The objective is to investigate
Hana N Abduljabbar et al.
Current drug delivery, 12(5), 578-590 (2015-06-09)
Ranitidine HCl is an H2-antagonist that suffers from low oral bioavailability of 50%. The site-specific absorption from the upper part of the small intestine and the colonic metabolism of the drug could partially contribute to its reduced bioavailability. To surmount
Philip Carsten Christophersen et al.
European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences, 57, 232-239 (2013-09-24)
The present study aims at evaluating the ability of a gastro-intestinal in vitro lipolysis model to predict the performance of two lipid formulations and a conventional tablet containing a poorly soluble drug, cinnarizine, in dogs, both in the fasted and
Benoît Igne et al.
International journal of pharmaceutics, 473(1-2), 219-231 (2014-07-09)
The implementation of a blend monitoring and control method based on a process analytical technology such as near infrared spectroscopy requires the selection and optimization of numerous criteria that will affect the monitoring outputs and expected blend end-point. Using a
Xingchu Gong et al.
International journal of pharmaceutics, 493(1-2), 208-213 (2015-08-01)
An analysis of data collected from 25 sets of diverse pharmaceutical powders has identified that an exponential growth function satisfactorily describes the relationship between tablet brittleness and tablet porosity while a power law function well describes the relationship between tablet
Justin M Keen et al.
International journal of pharmaceutics, 487(1-2), 72-80 (2015-04-04)
Interest in granulation processes using twin screw extrusion machines is rapidly growing. The primary objectives of this study were to develop a continuous granulation process for direct production of granules using this technique with glyceryl behenate as a binder, evaluate
Harshal Ashok Pawar et al.
International journal of biological macromolecules, 72, 1228-1236 (2014-12-03)
The objective of the present research work was to isolate, purify and characterize Cordia dichotoma gum and investigate its disintegration property in oral tablets. The isolated gum was tested for physicochemical characteristics such as solubility, pH (1% w/w in water)
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