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James R Pinney et al.
Biomaterials, 35(31), 8820-8828 (2014-07-23)
Chronic fibrosis caused by acute myocardial infarction (MI) leads to increased morbidity and mortality due to cardiac dysfunction. We have developed a therapeutic materials strategy that aims to mitigate myocardial fibrosis by utilizing injectable polymeric microstructures to mechanically alter the
Anne Schwerk et al.
Cytotherapy, 17(2), 199-214 (2014-12-03)
In Parkinson's disease (PD), neurogenesis in the subventricular zone (SVZ)-olfactory bulb (OB) axis is affected as the result of the lack of dopaminergic innervations reaching the SVZ. This aberrant network has been related to the hyposmia of PD patients, which
Céline Devroye et al.
Neuropharmacology, 89, 375-381 (2014-12-03)
The serotonin(2C) receptor (5-HT(2C)R) is known to control dopamine (DA) neuron function by modulating DA neuronal firing and DA exocytosis at terminals. Recent studies assessing the influence of 5-HT(2C)Rs on cocaine-induced neurochemical and behavioral responses have shown that 5-HT2CRs can
Annelies Grimonprez et al.
Brain stimulation, 8(1), 13-20 (2014-12-03)
Depression is the most common psychiatric comorbidity in epilepsy patients. The lack of success with current pharmacological interventions for this patient population, highlights the importance of optimizing non-pharmacological neuromodulatory treatments such as vagus nerve stimulation (VNS). Studies on the antidepressant
2-Methylbutane (isopentane). CAS# 78-78-4.
J B Galvin et al.
Journal of toxicology and environmental health. Part A, 58(1-2), 23-33 (1999-10-28)
John G Swales et al.
Analytical chemistry, 86(16), 8473-8480 (2014-08-02)
Cassette dosing of compounds for preclinical drug plasma pharmacokinetic analysis has been shown to be a powerful strategy within the pharmaceutical industry for increasing throughput while decreasing the number of animals used. Presented here for the first time is data
Lauren M Reynolds et al.
Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology, 40(5), 1101-1112 (2014-10-23)
Initiation of drug use during adolescence is a strong predictor of both the incidence and severity of addiction throughout the lifetime. Intriguingly, adolescence is a period of dynamic refinement in the organization of neuronal connectivity, in particular medial prefrontal cortex
Melody P Lun et al.
The Journal of neuroscience : the official journal of the Society for Neuroscience, 35(12), 4903-4916 (2015-03-27)
A sheet of choroid plexus epithelial cells extends into each cerebral ventricle and secretes signaling factors into the CSF. To evaluate whether differences in the CSF proteome across ventricles arise, in part, from regional differences in choroid plexus gene expression
Corina Nagy et al.
Journal of neuropathology and experimental neurology, 74(5), 459-469 (2015-04-14)
Postmortem brain research is invaluable to the study of neurologic and neuropsychiatric disorders, including Alzheimer disease, schizophrenia, and major depression. A major confounder in molecular studies using human brain tissue is postmortem interval (i.e. the amount of time between a
Pierre Abramowski et al.
Journal of neuroimmunology, 274(1-2), 111-124 (2014-08-05)
The 2-lysophosphatidylcholine analog edelfosine induces apoptosis in highly proliferating cells, e.g. activated immune cells. We examined mechanisms of action of edelfosine on immune functions in experimental autoimmune encephalomyelitis, a well-accepted animal model for multiple sclerosis. We observed activated caspase-3 expression
Ian M Packham et al.
PloS one, 9(9), e107503-e107503 (2014-09-23)
We sought to determine a role for platelets in in vivo angiogenesis, quantified by changes in the capillary to fibre ratio (C:F) of mouse skeletal muscle, utilising two distinct forms of capillary growth to identify differential effects. Capillary sprouting was
Daria Guseva et al.
PloS one, 9(11), e112984-e112984 (2014-11-14)
L1 is among the few adhesion molecules that favors repair after trauma in the adult central nervous system of vertebrates by promoting neuritogenesis and neuronal survival, among other beneficial features. In the peripheral nervous system, L1 is up-regulated in Schwann
Anna K Kopec et al.
Toxicological sciences : an official journal of the Society of Toxicology, 141(2), 515-523 (2014-07-25)
Epidemiological studies suggest that exposure to environmental chemicals increases the risk of developing autoimmune liver disease. However, the identity of specific chemical perpetrators and the mechanisms whereby environmental chemicals modify liver disease is unclear. Previous studies link exposure to trichloroethylene
Manon M Roustit et al.
The Journal of endocrinology, 223(2), 143-154 (2014-08-15)
Insulin resistance (IR) in skeletal muscle is an important component of both type 2 diabetes and the syndrome of sarcopaenic obesity, for which there are no effective therapies. Urocortins (UCNs) are not only well established as neuropeptides but also have
Susanne Steu et al.
Virchows Archiv : an international journal of pathology, 452(3), 305-312 (2008-02-07)
Different methods for snap freezing surgical human tissue specimens exist. At pathology institutes with higher work loads, solid carbon dioxide, freezing sprays, and cryostat freezing are commonly used as coolants for diagnosing frozen tissue sections, whereas for tissue banking, liquid
U M Abdel-Motal et al.
Gene therapy, 21(9), 802-810 (2014-06-27)
Topical microbicides are a leading strategy for prevention of HIV mucosal infection to women; however, numerous pharmacokinetic limitations associated with coitally related dosing strategy have contributed to their limited success. Here we test the hypothesis that adeno-associated virus (AAV) mediated
Brandon M Fritz et al.
Behavioural brain research, 273, 8-15 (2014-07-22)
Extrasynaptic GABAA receptors, often identified as those containing both α4 and δ subunits, demonstrate super-sensitivity to GABA and are involved in tonic inhibitory processes regulating activity within mesolimbocortical circuitry. Rodent studies testing the effects of the δ-subunit selective agonist Gaboxadol
Verena C Wimmer et al.
The Journal of comparative neurology, 523(5), 814-830 (2014-11-26)
The β1 subunit of voltage-gated sodium channels, Nav β1, plays multiple roles in neurons spanning electrophysiological modulation of sodium channel α subunits to cell adhesion and neurite outgrowth. This study used immunohistochemistry to investigate Nav β1 subneuronal and regional expression.
Mark E Koina et al.
Investigative ophthalmology & visual science, 56(2), 1310-1327 (2015-01-15)
Lymphatics subserve many important functions in the human body including maintenance of fluid homeostasis, immune surveillance, and tumor metastasis. Our aim was to provide structural and phenotypic evidence of lymphatic-like structures in the human choroid, including details of its development.
Kun Liu et al.
Autophagy, 11(2), 271-284 (2015-02-05)
Recent evidence that excessive lipid accumulation can decrease cellular levels of autophagy and that autophagy regulates immune responsiveness suggested that impaired macrophage autophagy may promote the increased innate immune activation that underlies obesity. Primary bone marrow-derived macrophages (BMDM) and peritoneal
Takayoshi Kinoshita et al.
Molecular and cellular biochemistry, 356(1-2), 97-105 (2011-07-08)
The detailed understanding of the molecular features of a ligand binding to a target protein, facilitates the successful design of potent and selective inhibitors. We present a case study of ATP-competitive kinase inhibitors that include a pyradine moiety. These compounds
Chary Marquez Batista et al.
Neural plasticity, 2014, 451639-451639 (2014-08-12)
Pigment epithelium derived factor (PEDF) exerts trophic actions to motoneurons and modulates nonneuronal restorative events, but its effects on neuroplasticity responses after spinal cord (SC) injury are unknown. Rats received a low thoracic SC photothrombotic ischemia and local injection of
Gary L Bratthauer
Methods in molecular biology (Clifton, N.J.), 588, 67-73 (2009-12-17)
The analysis of frozen tissue by antibodies can be accomplished by the quick freezing of a small tissue sample in liquid nitrogen. Super-cooled isopentane can also be used to further the preservation process. Freezing preserves the available proteins in a
Andrea Matteucci et al.
Experimental eye research, 125, 20-29 (2014-06-01)
Müller cell activation is an early finding in diabetic retinopathy (DR), but its physiopathologic role in the disease is still unclear, especially in the early phases. We investigated on Müller glial activation in primary rat retinal cultures, exposed to High
Bandana Shrestha et al.
Journal of neuropathology and experimental neurology, 73(11), 1047-1061 (2014-10-08)
The choroid plexus (CP) is considered to be a point of leukocyte entry into the CNS during normal immune surveillance and in neuroinflammatory diseases. The structural and functional alterations within the CP that support this migration are not understood. We
Eun-Joo Lee et al.
Pathology international, 64(8), 388-396 (2014-08-22)
Various attempts have been made to find treatments for Duchenne muscular dystrophy (DMD) patients. Exon skipping is one of the promising technologies for DMD treatment by restoring dystropin protein, which is one of the muscle components. It is well known
Formation of alkyl nitrates from the reaction of branched and cyclic alkyl peroxy radicals with NO.
Atkinson R, et al.
International Journal of Chemical Kinetics, 16(9), 1085-1101 (1984)
Clare Timbie et al.
The Journal of neuroscience : the official journal of the Society for Neuroscience, 34(24), 8106-8118 (2014-06-13)
The primate amygdala sends dense projections to posterior orbitofrontal cortex (pOFC) in pathways that are critical for processing emotional content, but the synaptic mechanisms are not understood. We addressed this issue by investigating pathways in rhesus monkeys (Macaca mulatta) from
William C W Chen et al.
Stem cells (Dayton, Ohio), 33(2), 557-573 (2014-10-23)
Perivascular mesenchymal precursor cells (i.e., pericytes) reside in skeletal muscle where they contribute to myofiber regeneration; however, the existence of similar microvessel-associated regenerative precursor cells in cardiac muscle has not yet been documented. We tested whether microvascular pericytes within human
Caroline G M de Theije et al.
Neuropharmacology, 90, 15-22 (2014-12-03)
Allergy is suggested to exacerbate impaired behaviour in children with neurodevelopmental disorders. We have previously shown that food allergy impaired social behaviour in mice. Dietary fatty acid composition may affect both the immune and nervous system. The aim of this
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