27109

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Comparison of two FFPE preparation methods using label-free shotgun proteomics: Application to tissues of diverticulitis patients.

Florence Quesada-Calvo et al.

Journal of proteomics, 112, 250-261 (2014-09-15)

Formalin-fixed paraffin-embedded (FFPE) specimens of patients are useful sources of materials for clinical research and have recently gained interest for use in the discovery of clinical proteomic biomarkers. However, the critical step in this field is the ability to obtain

Protons are one of the limiting factors in determining sensitivity of nano surface-assisted (+)-mode LDI MS analyses.

Eunji Cho et al.

Journal of the American Society for Mass Spectrometry, 24(10), 1489-1492 (2013-08-21)

A proton source employing a nanostructured gold surface for use in (+)-mode laser desorption ionization mass spectrometry (LDI-MS) was evaluated. Analysis of perdeuterated polyaromatic hydrocarbon compound dissolved in regular toluene, perdeuterated toluene, and deuterated methanol all showed that protonated ions

Simultaneous high performance liquid chromatographic separation of purines, pyrimidines, N-acetylated amino acids, and dicarboxylic acids for the chemical diagnosis of inborn errors of metabolism.

Barbara Tavazzi et al.

Clinical biochemistry, 38(11), 997-1008 (2005-09-06)

To set up a novel simple, sensitive, and reliable ion-pairing HPLC method for the synchronous separation of several purines, pyrimidines, N-acetylated amino acids, and dicarboxylic acids for the chemical diagnosis and screening of inborn errors of metabolism (IEM). The separation

[Citric acid as an adjunct to periodontal surgery].

E Grossman et al.

Nederlands tijdschrift voor tandheelkunde, 100(1), 11-15 (1993-01-01)

This review focuses on the effect of acid demineralisation of the root surface as an adjunct to periodontal surgery in order to obtain new attachment. Several animal studies have shown that the treatment facilitates attachment of connective tissue to the

Evaluation of nanohydroxyapatite-containing toothpaste for occluding dentin tubules.

Bennett T Amaechi et al.

American journal of dentistry, 28(1), 33-39 (2015-04-14)

To compare dentin tubule occlusion by dentifrices containing either nanohydroxyapatite (10%nHAP and 15%nHAP), sodium monofluorophosphate (Na-MFP) or NovaMin (NovaMin). All 80 participants wore four intraoral appliances bearing dentin blocks while using one of the four test dentifrices (n = 20/dentifrice)

Is mechanical bowel preparation in laparoscopic radical prostatectomy beneficial? An analysis of a Japanese national database.

Toru Sugihara et al.

BJU international, 112(2), E76-E81 (2013-06-26)

WHAT'S KNOWN ON THE SUBJECT? AND WHAT DOES THE STUDY ADD?: Recently, the ineffectiveness of bowel mechanical preparation prior to colorectal surgery was focused on. Although its effectiveness was widely accepted in laparoscopic prostatectomy, the data were limited. This retrospective

Transformations of citrate and Tween coated silver nanoparticles reacted with Na₂S.

M Baalousha et al.

The Science of the total environment, 502, 344-353 (2014-09-30)

Silver nanoparticles (Ag NPs) are susceptible to transformations in environmental and biological media such as aggregation, oxidation, dissolution, chlorination, sulfidation, formation/replacement of surface coatings following interaction with natural organic matter (NOM). This paper investigates the impact of surface coating and

In vivo and in vitro properties of STX2484: a novel non-steroidal anti-cancer compound active in taxane-resistant breast cancer.

C Stengel et al.

British journal of cancer, 111(2), 300-308 (2014-06-25)

STX2484 is a novel non-steroidal compound with potent anti-proliferative activity. These studies aimed to identify STX2484's mechanism of action, in vivo efficacy and activity in taxane-resistant breast cancer models. Effects of STX2484 and paclitaxel on proliferation, cell cycle and apoptosis

Identification of the effective constituents for anti-inflammatory activity of Ju-Zhi-Jiang-Tang, an ancient traditional Chinese medicine formula.

Shufang Wang et al.

Journal of chromatography. A, 1348, 105-124 (2014-05-13)

The anti-inflammatory constituents of Ju-Zhi-Jiang-Tang (JZJT), a formula used for thousands of years in China, were identified by LC-MS and pharmacological activity evaluation. In this study, the whole extract of formula was separated into multiple components to facilitate the analytical

Highly magneto-responsive multilayer microcapsules for controlled release of insulin.

Chunli Zheng et al.

International journal of pharmaceutics, 475(1-2), 17-24 (2014-08-28)

In this study, magneto-responsive polyelectrolyte multilayer microcapsules were successfully prepared by the formation of shell with biocompatible iron oxide nanoparticles (Fe₃O₄ NPs) and polyallylamine hydrochloride (PAH) by layer-by-layer (LbL) self-assembly technique. The self-assembled microcapsules were characterized by SEM, TEM and

The cough reflex is upregulated by lisinopril microinjected into the caudal nucleus tractus solitarii of the rabbit.

Elenia Cinelli et al.

Respiratory physiology & neurobiology, 219, 9-17 (2015-08-04)

We have previously shown that cough potentiation induced by intravenous administration of the AT1 receptor antagonist losartan is lower than that induced by the ACE inhibitor lisinopril in anesthetized and awake rabbits. Since losartan and lisinopril cross the blood-brain barrier

Effect of memantine on cough reflex sensitivity: translational studies in guinea pigs and humans.

Peter V Dicpinigaitis et al.

The Journal of pharmacology and experimental therapeutics, 352(3), 448-454 (2014-12-20)

Cough is the most common complaint for which outpatients in the United States seek medical attention, and yet available therapeutic options for cough lack proven efficacy and are further limited by safety and abuse liabilities. Thus, safe and effective cough

Simplagrin, a platelet aggregation inhibitor from Simulium nigrimanum salivary glands specifically binds to the Von Willebrand factor receptor in collagen and inhibits carotid thrombus formation in vivo.

Andrezza C Chagas et al.

PLoS neglected tropical diseases, 8(6), e2947-e2947 (2014-06-13)

Among the several challenges faced by bloodsucking arthropods, the vertebrate hemostatic response against blood loss represents an important barrier to efficient blood feeding. Here we report the first inhibitor of collagen-induced platelet aggregation derived from the salivary glands of a

Polymorphism and DNA methylation in the promoter modulate KISS1 gene expression and are associated with litter size in goats.

X P An et al.

Animal reproduction science, 155, 36-41 (2015-02-28)

Polymorphisms in the promoter region are likely to impact KISS1 gene transcription and reproductive traits. In this study, Guanzhong (GZ, n=350) and Boer (BE, n=196) goats were used to detect polymorphism in the promoter of the goat KISS1 gene by

Citrate and mineral metabolism: kidney stones and bone disease.

Renata Caudarella et al.

Frontiers in bioscience : a journal and virtual library, 8, s1084-s1106 (2003-09-06)

Citrate is a weak acid that is formed in the tricarboxylic acid cycle or that may be introduced with diet. In the present paper all the mechanisms involved in intestinal absorption, renal handling and modulation of citrate will be reviewed.

Hepatocellular heme oxygenase-1: a potential mechanism of erythropoietin-mediated protection after liver ischemia-reperfusion injury.

Kimberly J Riehle et al.

Shock (Augusta, Ga.), 42(5), 424-431 (2014-07-09)

Hepatic ischemia-reperfusion (IR) results in progressive injury; initiated by oxidative stress during ischemia and compounded by cytokine-mediated inflammation during reperfusion. Recovery requires strict regulation of these events. Recombinant human erythropoietin (rhEPO) is thought to mitigate hepatocellular IR injury by altering

Protein enrichment of an Opuntia ficus-indica cladode hydrolysate by cultivation of Candida utilis and Kluyveromyces marxianus.

Gabriel B Akanni et al.

Journal of the science of food and agriculture, 95(5), 1094-1102 (2014-11-06)

The cladodes of Opuntia ficus-indica (prickly pear cactus) have a low protein content; for use as a balanced feed, supplementation with other protein sources is therefore desirable. We investigated protein enrichment by cultivation of the yeasts Candida utilis and Kluyveromyces

Fragment ion diagnostic strategies for the comprehensive identification of chemical profile of Gui-Zhi-Tang by integrating high-resolution MS, multiple-stage MS and UV information.

Shufang Wang et al.

Journal of pharmaceutical and biomedical analysis, 98, 22-35 (2014-06-01)

Gui-Zhi-Tang was considered to be the most famous formula in Shang-Han-Lun, treating 32 symptoms of disease after adding up or cutting down crude drugs. The chemical constituents in Gui-Zhi-Tang were comprehensively studied by rapid resolution liquid chromatography quadrupole time-of-flight mass

Enhancing perception of contaminated food through acid-mediated modulation of taste neuron responses.

Yan Chen et al.

Current biology : CB, 24(17), 1969-1977 (2014-08-19)

Natural foods contain not only nutrients, but also nonnutritious and potentially harmful chemicals. Thus, animals need to evaluate food content in order to make adequate feeding decisions. Here, we investigate the effects of acids on the taste neuron responses and

3-O-galloylated procyanidins from Rumex acetosa L. inhibit the attachment of influenza A virus.

Andrea Derksen et al.

PloS one, 9(10), e110089-e110089 (2014-10-11)

Infections by influenza A viruses (IAV) are a major health burden to mankind. The current antiviral arsenal against IAV is limited and novel drugs are urgently required. Medicinal plants are known as an abundant source for bioactive compounds, including antiviral

Preventing blockage of long-term indwelling catheters in adults: are citric acid solutions effective?

Jane Mayes et al.

British journal of community nursing, 8(4), 172-175 (2003-05-07)

Community health practitioners are frequently faced with the problem of indwelling catheters failing to drain. This mini-review examines the evidence regarding the effectiveness of citric acid-based bladder washout solutions (solution G, solution R), compared with saline for preventing blockage of

Intra-individual comparison of magnesium citrate and sodium phosphate for bowel preparation at CT colonography: automated volumetric analysis of residual fluid for quality assessment.

P Bannas et al.

Clinical radiology, 69(11), 1171-1177 (2014-09-23)

To perform an objective, intra-individual comparison of residual colonic fluid volume and attenuation associated with the current front-line laxative magnesium citrate (MgC) versus the former front-line laxative sodium phosphate (NaP) at CT colonography (CTC). This retrospective Health Insurance and Portability

Characterization of antibiotic and disinfectant susceptibility profiles among Pseudomonas aeruginosa veterinary isolates recovered during 1994-2003.

R C Beier et al.

Journal of applied microbiology, 118(2), 326-342 (2014-11-29)

To evaluate susceptibility of Pseudomonas aeruginosa veterinary isolates to antibiotics and disinfectants. Pseudomonas aeruginosa isolates collected from dogs (n = 155) and other animals (n = 20) from sixteen states during 1994-2003 were tested for susceptibility. Most isolates were resistant

Accurate analysis of ginkgolides and their hydrolyzed metabolites by analytical supercritical fluid chromatography hybrid tandem mass spectrometry.

Xin-Guang Liu et al.

Journal of chromatography. A, 1388, 251-258 (2015-03-03)

Hydrolysis plays an important role in the metabolic transformations of lactones. Analysis of lactones and their hydrolyzed metabolites in biological samples is challenging, because unexpected hydrolysis or reversed dehydration may occur depending on the test environments. In this work, a

Application of gas chromatography/flame ionization detector-based metabolite fingerprinting for authentication of Asian palm civet coffee (Kopi Luwak).

Udi Jumhawan et al.

Journal of bioscience and bioengineering, 120(5), 555-561 (2015-04-29)

Development of authenticity screening for Asian palm civet coffee, the world-renowned priciest coffee, was previously reported using metabolite profiling through gas chromatography/mass spectrometry (GC/MS). However, a major drawback of this approach is the high cost of the instrument and maintenance.

Electrochemical detection of nanomolar dopamine in the presence of neurophysiological concentration of ascorbic acid and uric acid using charge-coated carbon nanotubes via facile and green preparation.

Jeong-Wook Oh et al.

Talanta, 147, 453-459 (2015-11-26)

Negatively charged multi-walled carbon nanotubes (MWCNTs) were prepared using simple sonication technique with non-toxic citric acid (CA) for the electrochemical detection of dopamine (DA). CA/MWCNTs were placed on glassy carbon (GC) electrodes by drop-casting method and then electrochemical determinations of

[Citric acid].

G Isshiki et al.

Nihon rinsho. Japanese journal of clinical medicine, 53 Su Pt 1, 597-599 (1995-02-01)

Cold-inducible RNA-binding protein mediates neuroinflammation in cerebral ischemia.

Mian Zhou et al.

Biochimica et biophysica acta, 1840(7), 2253-2261 (2014-03-13)

Neuroinflammation is a key cascade after cerebral ischemia. Excessive production of proinflammatory mediators in ischemia exacerbates brain injury. Cold-inducible RNA-binding protein (CIRP) is a newly discovered proinflammatory mediator that can be released into the circulation during hemorrhage or septic shock.

Enhanced spectrophotometric determination of Losartan potassium based on its physicochemical interaction with cationic surfactant.

Laila Abdel-Fattah et al.

Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy, 136 Pt B, 178-184 (2014-10-16)

In this study, a simple and sensitive spectrophotometric method was developed for determination of Losartan potassium (LST K), an angiotensin-II receptor (type AT1) antagonist, in presence of cationic surfactant cetyltrimethylammonium bromide (CTAB). The physicochemical interaction of LST K with CTAB

Binding mechanisms for histamine and agmatine ligands in plasmid deoxyribonucleic acid purifications.

Ângela Sousa et al.

Journal of chromatography. A, 1366, 110-119 (2014-09-30)

Histamine and agmatine amino acid derivatives were immobilized into monolithic disks, in order to combine the specificity and selectivity of the ligand with the high mass transfer and binding capacity offered by monolithic supports, to purify potential plasmid DNA biopharmaceuticals.

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