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关键词:'276685'
显示 1-30 共 367 条结果 关于 "276685" 范围 论文
Sanika Suvarnapathaki et al.
Macromolecular bioscience, 20(10), e2000176-e2000176 (2020-08-06)
Reinforcing polymeric scaffolds with micro/nanoparticles improve their mechanical properties and render them bioactive. In this study, hydroxyapatite (HA) is incorporated into 5% (w/v) gelatin methacrylate (GelMA) hydrogels at 1, 5, and 20 mg mL-1 concentrations. The material properties of these
Weiwei Zhao et al.
ACS applied materials & interfaces, 12(46), 51236-51248 (2020-11-10)
Osteoarthritis (OA) is a chronic joint disease and its progression and pathogenesis are highly associated with the significant increase of joint friction and overproduction of reactive oxygen species (ROS) in inflammation. Combination of ROS elimination and lubrication enhancement may provide
Mi Y Kwon et al.
Advanced healthcare materials, 7(9), e1701199-e1701199 (2018-01-24)
The transmembrane glycoprotein N-cadherin (NCad) mediates cell-cell interactions found during mesenchymal condensation and chondrogenesis. Here, NCad-derived peptides (i.e., HAV) are incorporated into hyaluronic acid (HA) hydrogels with encapsulated mesenchymal stem cells (MSCs). Since the dose and timing of NCad signaling
Calogero Fiorica et al.
Materials science & engineering. C, Materials for biological applications, 76, 794-801 (2017-05-10)
With the aim to produce, by a simple and reproducible technique, porous scaffolds potentially employable for tissue engineering purposes, in this work, we have synthesized a methacrylate (MA) copolymer of α,β-poly(N-2-hydroxyethyl)-dl-aspartamide (PHEA) and polylactic acid (PLA). PHEA-PLA-MA has been dissolved
Wonseop Lim et al.
Polymers, 12(10) (2020-10-21)
Bioink based 3D bioprinting is a promising new technology that enables fabrication of complex tissue structures with living cells. The printability of the bioink depends on the physical properties such as viscosity. However, the high viscosity bioink puts shear stress
Jasper Van Hoorick et al.
Advanced healthcare materials, 9(16), e2000760-e2000760 (2020-07-01)
Corneal blindness is the fourth leading cause of visual impairment. Of specific interest is blindness due to a dysfunctional corneal endothelium which can only be treated by transplanting healthy tissue from a deceased donor. Unfortunately, corneal supply does not meet
Lin Gong et al.
Acta biomaterialia, 117, 246-260 (2020-10-03)
Multilayer scaffolds fabricated by 3D printing or other techniques have been used to repair osteochondral defects. However, it remains a challenge to regenerate the articular cartilage and subchondral bone simultaneously with higher performance. In the present study, we enhanced the
Minwook Kim et al.
Proceedings of the National Academy of Sciences of the United States of America, 116(5), 1569-1578 (2019-01-17)
Several recent studies have demonstrated that coculture of chondrocytes (CHs) with bone marrow-derived mesenchymal stem cells (MSCs) improves their chondrogenesis. This implies that intercellular communication dictates fate decisions in recipient cells and/or reprograms their metabolic state to support a differentiated
Hyunbum Kim et al.
International journal of molecular sciences, 22(5) (2021-04-04)
The cell-cell/cell-matrix interactions between myoblasts and their extracellular microenvironment have been shown to play a crucial role in the regulation of in vitro myogenic differentiation and in vivo skeletal muscle regeneration. In this study, by harnessing the heparin-mimicking polymer, poly(sodium-4-styrenesulfonate)
Jonathan R Soucy et al.
Tissue engineering. Part A, 24(17-18), 1393-1405 (2018-03-28)
Suturing peripheral nerve transections is the predominant therapeutic strategy for nerve repair. However, the use of sutures leads to scar tissue formation, hinders nerve regeneration, and prevents functional recovery. Fibrin-based adhesives have been widely used for nerve reconstruction, but their
Jingyi Liu et al.
Bioactive materials, 6(1), 219-229 (2020-09-12)
Nerve conduits have been identified as one of the most promising treatments for peripheral nerve injuries, yet it remains unsolved how to develop ideal nerve conduits with both appropriate biological and mechanical properties. Existing nerve conduits must make trade-offs between
Bogdan M Beca et al.
Tissue engineering. Part C, Methods, 25(10), 581-592 (2019-07-25)
Biomechanical stimulation is a common strategy to improve the growth, maturation, and function of a variety of engineered tissues. However, identifying optimized biomechanical conditioning protocols is challenging, as cell responses to mechanical stimuli are modulated by other multifactorial microenvironmental cues
Wenqian Xiao et al.
Materials science & engineering. C, Materials for biological applications, 116, 111143-111143 (2020-08-19)
Surface tension-driven assembly is a simple routine used in modular tissue engineering to create three-dimensional (3D) biomimetic tissues with desired structural and biological characteristics. A major bottleneck for this technology is the lack of suitable hydrogel materials to meet the
Xi He et al.
Carbohydrate polymers, 247, 116689-116689 (2020-08-25)
Natural polymeric hydrogel featuring multifunctional properties is more attractive as wound dressing. Herein, Tannic acid (TA)-reinforced methacrylated chitosan (CSMA)/methacrylated silk fibroin (SFMA) hydrogels were fabricated by two-step method of photopolymerization and TA solution incubating treatment. The TA in hydrogels not
Cemile Kilic Bektas et al.
Biomaterials science, 8(1), 438-449 (2019-11-21)
Tissue engineering aims to replace missing or damaged tissues and restore their functions. Three-dimensional (3D) printing has been gaining more attention because it enables the researchers to design and produce cell loaded constructs with predetermined shapes, sizes, and interior architecture.
Trevor R Ham et al.
Acta biomaterialia, 53, 140-151 (2017-02-06)
Tethered growth factors offer exciting new possibilities for guiding stem cell behavior. However, many of the current methods present substantial drawbacks which can limit their application and confound results. In this work, we developed a new method for the site-specific
Yohann Catel et al.
Dental materials : official publication of the Academy of Dental Materials, 37(2), 351-358 (2020-12-29)
To evaluate high refractive index methacrylates as diluents for the formulation of radiopaque esthetic bulk-fill composites. 2-(4-Cumylphenoxy)ethyl methacrylate 1, 2-(2-phenylphenoxy)ethyl methacrylate 2 and 2-[2-(2-phenylphenoxy)ethoxy]ethyl methacrylate 3 were synthesized and characterized by 1H NMR spectroscopy. The reactivity of each monomer was
Zhanpeng Zhang et al.
Advanced functional materials, 25(3), 350-360 (2015-06-13)
Injectable microspheres are attractive stem cell carriers for minimally invasive procedures. For tissue regeneration, the microspheres need to present the critical cues to properly direct stem cell differentiation. In natural extracellular matrix (ECM), growth factors (GFs) and collagen nanofibers provide
Lei Wang et al.
Acta biomaterialia, 122, 160-171 (2020-12-22)
Pulp-capping materials are commonly adopted in the clinic to form reparative dentin and thus protect dental pulp tissues from cases of deep caries, accidentally exposed pulps or partial pulpotomy. Some traditional pulp capping materials used in the clinic include calcium
Seyedsina Moeinzadeh et al.
Tissue engineering. Part A, 25(3-4), 234-247 (2018-08-28)
The higher regenerative capacity of fetal articular cartilage compared with the adult is rooted in differences in cell density and matrix composition. We hypothesized that the zonal organization of articular cartilage can be engineered by encapsulation of mesenchymal stem cells
Xuemin Liu et al.
Advanced healthcare materials, e2000076-e2000076 (2020-04-28)
There is a great challenge in regenerating osteochondral defects because they involve lesions of both cartilage and subchondral bone, which have remarkable differences in their chemical compositions and biological lineages. Thus, considering the complicated requirements in osteochondral reconstruction, a biomimetic
Raphaël F Canadas et al.
Biomaterials, 181, 402-414 (2018-08-24)
Organized networks are common in nature showing specific tissue micro-architecture, where cells can be found isotropically or anisotropically distributed in characteristic arrangements and tissue stiffness. However, when addressing an in vitro tissue model, it is challenging to grant control over
Xifang Chen et al.
Biomaterials science, 7(8), 3497-3509 (2019-07-11)
An array of biological properties is demonstrated in the category of extracts broadly known as ulvans, including antibacterial, anti-inflammatory and anti-coagulant activities. However, the development of this category in biomedical applications is limited due to high structural variability across species
Artur Chabros et al.
Materials (Basel, Switzerland), 13(1) (2019-12-28)
The paper investigates the properties of unsaturated polyester resins and microcrystalline cellulose (MCC) composites. The influence of MCC modification on mechanical, thermomechanical, and thermal properties of obtained materials was discussed. In order to reduce the hydrophilic character of the MCC
Matthew B Fisher et al.
Cartilage, 7(2), 174-184 (2016-04-06)
We have recently shown that mesenchymal stem cells (MSCs) embedded in a hyaluronic acid (HA) hydrogel and exposed to chondrogenic factors (transforming growth factor-β3 [TGF-β3]) produce a cartilage-like tissue in vitro. The current objective was to determine if these same
Antonelle Pardo et al.
Journal of chromatography. A, 1364, 128-139 (2014-09-10)
Molecularly imprinted polymers (MIPs) based on quercetin and synthesized by either bulk, precipitation or suspension polymerization were characterized in terms of size and shape by scanning electron microscopy (SEM) and transmission electron microscopy (TEM). After a study of rebinding protocols
S Sharareh Mahdavi et al.
Annals of biomedical engineering, 48(7), 1955-1970 (2020-06-07)
3D bioprinting technology is a promising approach for corneal stromal tissue regeneration. In this study, gelatin methacrylate (GelMA) mixed with corneal stromal cells was used as a bioink. The visible light-based stereolithography (SLA) 3D bioprinting method was utilized to print
Dong Hwa Kim et al.
Acta biomaterialia, 12, 21-29 (2014-12-03)
Degradation of the nucleus pulposus (NP) is an early hallmark of intervertebral disc degeneration. The capacity for endogenous regeneration in the NP is limited due to the low cellularity and poor nutrient and vascular supply. Towards restoring the NP, a
Wanjun Liu et al.
Biofabrication, 10(2), 024102-024102 (2017-11-28)
Bioinks with shear-thinning/rapid solidification properties and strong mechanics are usually needed for the bioprinting of three-dimensional (3D) cell-laden constructs. As such, it remains challenging to generate soft constructs from bioinks at low concentrations that are favorable for cellular activities. Herein
Xuanang Gong et al.
Carbohydrate polymers, 250, 116846-116846 (2020-10-15)
In this work, reversible addition-fragmentation chain transfer (RAFT) polymerization and Schiff base chemistry was combined to fabricate self-healing adhesives. An esterification reaction was first performed to prepare ethyl cellulose based macroinitiators. Then, a "grafting from" RAFT of vanillin methacrylate and
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