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Activity of Tigecycline against Coryneform Bacteria of Clinical Interest and Listeria monocytogenes.
Carlos Salas et al.
Antimicrobial agents and chemotherapy, 52(4), 1503-1505 (2008-01-30)
The activities of tigecycline and eight other agents were evaluated against 220 coryneform bacteria and 42 Listeria monocytogenes isolates. All strains were inhibited by tigecycline at 0.5 mug/ml, except for 11 Corynebacterium striatum strains that were inhibited at 1 mug/ml.
John S Bradley et al.
Pediatrics, 134(1), e146-e153 (2014-06-12)
Safety concerns for fluoroquinolones exist from animal studies demonstrating cartilage injury in weight-bearing joints, dependent on dose and duration of therapy. For children treated with levofloxacin or comparator in randomized, prospective, comparative studies for acute otitis media and community-acquired pneumonia
Jessica Krezdorn et al.
Journal of medical microbiology, 63(Pt 7), 945-955 (2014-06-15)
The aim of this study was to compare the inhibitory effect of antibiotic combinations in vitro with efficacy in Galleria mellonella larvae in vivo to identify efficacious combinations that target Pseudomonas aeruginosa. P. aeruginosa NCTC 13437, a multidrug-resistant strain resistant
Linda K McDougal et al.
Antimicrobial agents and chemotherapy, 54(9), 3804-3811 (2010-06-30)
USA300 methicillin-resistant Staphylococcus aureus (MRSA) isolates are usually resistant only to oxacillin, erythromycin, and, increasingly, levofloxacin. Of these, oxacillin and levofloxacin resistances are chromosomally encoded. Plasmid-mediated clindamycin, mupirocin, and/or tetracycline resistance has been observed among USA300 isolates, but these descriptions
Antoni Torres et al.
Expert opinion on pharmacotherapy, 13(8), 1203-1212 (2012-05-19)
Fluoroquinolone use has dramatically increased since the introduction of the first respiratory fluoroquinolone in the late 1990s. Levofloxacin , like other fluoquinolones, is a potent antibiotic, due to high levels of susceptibility among Gram-negative, Gram-positive (including penicillin-resistant strains of Streptococcus
Catherine Clark et al.
Antimicrobial agents and chemotherapy, 52(1), 77-84 (2007-10-17)
DC-159a yielded MICs of <or=1 mug/ml against 316 strains of both quinolone-susceptible and -resistant pneumococci (resistance was defined as a levofloxacin MIC >or=4 microg/ml). Although the MICs for DC-159a against quinolone-susceptible pneumococci were a few dilutions higher than those of
Xiaodan Jiang et al.
Drug design, development and therapy, 9, 3043-3050 (2015-06-26)
Dry eye is a chronic inflammatory ocular surface disease with high prevalence. The current therapies for dry eye remain to be unspecific and notcomprehensive. This study aims to explore safety and efficacy of a novel treatment - subconjunctival injection of
Lei Jia et al.
Bioorganic & medicinal chemistry, 16(11), 6252-6260 (2008-05-02)
Drug-induced long QT syndrome (LQTS) can cause critical cardiovascular side effects and has accounted for the withdrawal of several drugs from the market. Blockade of the potassium ion channel encoded by the human ether-a-go-go-related gene (hERG) has been identified as
Stéphanie Matrat et al.
Antimicrobial agents and chemotherapy, 51(5), 1643-1648 (2007-02-28)
Mycobacterium leprae, the causative agent of leprosy, is noncultivable in vitro; therefore, evaluation of antibiotic activity against M. leprae relies mainly upon the mouse footpad system, which requires at least 12 months before the results become available. We have developed
Motoi Tobita et al.
Bioorganic & medicinal chemistry letters, 15(11), 2886-2890 (2005-05-25)
HERG attracts attention as a risk factor for arrhythmia, which might trigger torsade de pointes. A highly accurate classifier of chemical compounds for inhibition of the HERG potassium channel is constructed using support vector machine. For two test sets, our
A Safarika et al.
European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology, 34(2), 317-323 (2014-09-07)
In the present study, we challenged the concept that levofloxacin should not be used for the management of ventilator-associated pneumonia (VAP) when minimum inhibitory concentrations (MICs) exceed 2 μg/ml. Multidrug-resistant (MDR) and genetically distinct isolates of Pseudomonas aeruginosa (n = 49) and
H J Choi et al.
American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons, 15(3), 628-641 (2015-02-14)
The porcine cornea may be a good solution for the shortage of human donor corneas because its size and refractive properties are comparable to those of the human cornea. However, antigenic differences need to be overcome to apply xenocorneal transplantation
[Present aspects and prospects of levofloxacin use in therapy of nosocomial pneumonia].
E L Riabkova et al.
Antibiotiki i khimioterapiia = Antibiotics and chemoterapy [sic], 53(9-10), 6-11 (2008-01-01)
Mohan N Patel et al.
Bioorganic & medicinal chemistry, 17(15), 5648-5655 (2009-07-08)
Here in we tried to increase an antibacterial activity of ciprofloxacin drug due to formation of mixed-ligand complexes. Synthesized compounds were found to be more potent compare to drugs, ligands and metal salt against selective gram((+ve)) and gram((-ve)) organisms. Interaction
Moira Madeo et al.
Journal of chemotherapy (Florence, Italy), 27(4), 201-206 (2014-04-12)
Susceptibility of 96 Listeria monocytogenes human isolates collected in northern Italy between 2008 and 2010, to 15 antimicrobials, was investigated. Minimum inhibitory concentration (MIC) was evaluated by means of the standardized broth microdilution method, according to the European Committee on
Andrea Endimiani et al.
Antimicrobial agents and chemotherapy, 51(6), 2211-2214 (2007-04-04)
Clinical isolates of Acinetobacter baumannii (n = 470) were collected during a 7-year period and investigated for the genetic determinants of resistance to expanded-spectrum beta-lactams. Thirty-one isolates produced the TEM-92 extended-spectrum beta-lactamase (ESBL) and were clonally related. This is the
Roseanne A Ressner et al.
Antimicrobial agents and chemotherapy, 52(3), 1147-1149 (2008-01-09)
Broth microdilution was used to determine the MICs of AR-709 and comparator antimicrobial agents for 224 invasive multidrug-resistant isolates of Streptococcus pneumoniae. AR-709 was highly active, with a MIC 50 of 0.25 microg/ml, a MIC 90 of 0.5 microg/ml, and
Kunikazu Yamane et al.
Antimicrobial agents and chemotherapy, 51(9), 3354-3360 (2007-06-06)
Plasmid-mediated Qnr and AAC(6')-Ib-cr have been recognized as new molecular mechanisms affecting fluoroquinolone (FQ) resistance. C316, an Escherichia coli strain demonstrating resistance to various FQs, was isolated in Japan. Resistance to FQs was augmented in an E. coli CSH2 transconjugant
C Esteve et al.
European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology, 34(1), 137-145 (2014-08-02)
Aeromonas infections are rare in Europe and often related to traveller's diarrhoea. A total of 185 Aeromonas isolates from river water, fish and clinical sources, recovered during a 1-year period, were used to investigate the disease spectrum and impact of
Yang Liu et al.
Antimicrobial agents and chemotherapy, 53(5), 2160-2162 (2009-03-11)
Fifty-three Mycoplasma pneumoniae strains were isolated from pediatric patients in Shanghai, China, from October 2005 to February 2008. Of 53 clinical isolates, 44 (83%) were resistant to erythromycin (MICs of >128 microg/ml for all 44 strains), azithromycin, and clarithromycin. All
Shivani Singh et al.
Antimicrobial agents and chemotherapy, 58(8), 4657-4665 (2014-06-04)
Tuberculosis is characterized by extensive destruction and remodelling of the pulmonary extracellular matrix. Stromal cell-derived matrix metalloproteinases (MMPs) are implicated in this process and may be a target for adjunctive immunotherapy. We hypothesized that MMPs are elevated in bronchoalveolar lavage
Achilles tendon rupture associated with combination therapy of levofloxacin and steroid in four patients and a review of the literature.
Chetan Parmar et al.
Foot & ankle international, 28(12), 1287-1289 (2008-01-05)
Molly Mombeshora et al.
BMC complementary and alternative medicine, 19(1), 315-315 (2019-11-21)
Pseudomonas aeruginosa has become a main cause of Gram-negative infection, particularly in patients with compromised immunity. High rates of resistance to antibiotics are associated with nosocomial infections caused by P. aeruginosa strains. The search for novel antimicrobials has been necessitated
Somvadee Laohavaleeson et al.
Antimicrobial agents and chemotherapy, 52(7), 2389-2394 (2008-04-16)
Ceftobiprole (BPR) is an investigational cephalosporin with activity against Staphylococcus aureus, including methicillin-resistant S. aureus (MRSA) strains. The pharmacodynamic (PD) profile of BPR against S. aureus strains with a variety of susceptibility phenotypes in an immunocompromised murine pneumonia model was
Stefanie Schuster et al.
Praxis, 102(14), 873-876 (2013-07-05)
We report the case of a 73 year old patient with a COPD. A severe exazerbation was treated with glucocorticoids and Quinolones. A few days later both ankles were tender and painful. Ultrasound examination showed bilateral Achilles tendon ruptures. Diagnostics
R Scott Obach et al.
Drug metabolism and disposition: the biological fate of chemicals, 36(7), 1385-1405 (2008-04-23)
We present herein a compilation and trend analysis of human i.v. pharmacokinetic data on 670 drugs representing, to our knowledge, the largest publicly available set of human clinical pharmacokinetic data. This data set provides the drug metabolism scientist with a
Faina Nakonechny et al.
International journal of molecular sciences, 20(13) (2019-07-03)
The global spread of bacterial resistance to antibiotics promotes a search for alternative approaches to eradication of pathogenic bacteria. One alternative is using photosensitizers for inhibition of Gram-positive and Gram-negative bacteria under illumination. Due to low penetration of visible light
Muhammad Iqbal Nasiri et al.
Pakistan journal of pharmaceutical sciences, 26(2), 415-419 (2013-03-05)
The aim of this study is to evaluate the susceptibility and resistance pattern of clinical isolates causing different types of infections and to compare the efficacy of antibiotics namely levofloxacin and cefepime. The in-vitro antibacterial activity and resistance patterns of
Motoki Bito et al.
Biological & pharmaceutical bulletin, 36(1), 31-35 (2013-01-11)
Fluoroquinolones reportedly induce hypoglycemia through stimulation of insulin secretion from pancreatic β-cells via inhibition of K(ATP) channels and activation of L-type voltage-dependent Ca(2+) channels. In physiological condition, the cytosolic Ca(2+) concentration ([Ca(2+)](c)) is also regulated by release of Ca(2+) from
Yun Chai et al.
European journal of medicinal chemistry, 44(10), 4063-4069 (2009-06-02)
A series of novel 7-(4-alkoxyimino-3-amino-3-methylpiperidin-1-yl)fluoroquinolone derivatives were designed, synthesized and characterized by (1)H NMR, MS and HRMS. These fluoroquinolones were evaluated for in vitro antibacterial activity against representative Gram-positive and Gram-negative strains. All of the title compounds have considerable activity
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