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Mario Tumbarello et al.
Antimicrobial agents and chemotherapy, 51(6), 1987-1994 (2007-03-28)
Bloodstream infections (BSI) caused by extended-spectrum beta-lactamase (ESBL)-producing organisms markedly increase the rates of treatment failure and death. We conducted a retrospective cohort analysis to identify risk factors for mortality in adult in-patients with BSI caused by ESBL-producing Enterobacteriaceae (ESBL-BSI).
Qiang Guo et al.
European journal of medicinal chemistry, 45(11), 5498-5506 (2010-09-14)
A series of novel 7-[3-(N'-alkoxycarbamimidoyl)-4-(alkoxyimino)pyrrolidin-1-yl] fluoroquinolone derivatives were designed, synthesized and characterized by (1)H NMR, MS and HRMS. These fluoroquinolones were screened for their in vitro antibacterial activity. Most of them exhibit good potency in inhibiting the growth of Staphylococcus
George G Zhanel et al.
Drugs, 62(1), 13-59 (2002-01-16)
The new fluoroquinolones (clinafloxacin, gatifloxacin, gemifloxacin, grepafloxacin, levofloxacin, moxifloxacin, sitafloxacin, sparfloxacin and trovafloxacin) offer excellent activity against Gram-negative bacilli and improved Gram-positive activity (e.g. against Streptococcus pneumoniae and Staphylococcus aureus) over ciprofloxacin. Ciprofloxacin still maintains the best in vitro activity
Kunikazu Yamane et al.
Antimicrobial agents and chemotherapy, 52(4), 1564-1566 (2008-02-21)
Seven hundred fifty-one Escherichia coli clinical isolates collected from 140 Japanese hospitals between 2002 and 2006 were screened for the qepA and qnr genes. Two E. coli isolates (0.3%) harbored qepA, but no qnr was identified. The results suggested a
Michelle Nelson et al.
Antimicrobial agents and chemotherapy, 54(9), 3922-3926 (2010-07-14)
Pharmacokinetic and efficacy studies with levofloxacin were performed in the common marmoset (Callithrix jacchus) model of inhalational tularemia. Plasma levofloxacin pharmacokinetics were determined in six animals in separate single-dose and multidose studies. Plasma drug concentrations were analyzed using liquid chromatography-tandem
Saira Furqan et al.
JPMA. The Journal of the Pakistan Medical Association, 64(4), 399-402 (2014-05-29)
To determine the frequency of Streptococcus pneumoniae and Haemophilus influenzae in acute exacerbation of chronic obstructive pulmonary disease and their sensitivity to levofloxacin. The cross-sectional study was conducted at the Department of Medicine, AbbasiShaheed Hospital, Karachi, between July 2009 and
J M Rodríguez-Martínez et al.
Antimicrobial agents and chemotherapy, 51(6), 2236-2239 (2007-04-04)
The influence of qnrA1 on the development of quinolone resistance in Enterobacteriaceae was evaluated by using the mutant prevention concentration parameter. The expression of qnrA1 considerably increased the mutant prevention concentration compared to strains without this gene. In the presence
Thomas P Lodise et al.
Antimicrobial agents and chemotherapy, 51(11), 3977-3982 (2007-08-22)
Data comparing the treatment outcomes of the two most frequently recommended empirical antibiotic regimens for community-acquired pneumonia (CAP)--combination therapy with an extended-spectrum beta-lactam and a macrolide (BL+M) or fluoroquinolone (F) monotherapy--for patients with severe CAP are sparse. The purpose of
Manli Liu et al.
Cornea, 34(4), 392-397 (2015-03-06)
To evaluate decentration from pupil center and corneal vertex normal following femtosecond laser small incision lenticule extraction (SMILE) for the treatment of myopia and myopic astigmatism. This study evaluated 101 eyes of 101 patients with a spherical equivalent (SE) of
Masayuki Ohtsuka et al.
Antimicrobial agents and chemotherapy, 53(7), 3147-3149 (2009-05-06)
Six Bordetella pertussis strains isolated from children in Japan from 2004 to 2006 showed high-level resistance to nalidixic acid (NAL; MIC, >256 microg/ml) and decreased susceptibilities to fluoroquinolones. All of the NAL-resistant strains had the same D87G mutation in gyrA.
Katie Saxton et al.
Antimicrobial agents and chemotherapy, 53(2), 412-420 (2008-08-20)
The incidence of Clostridium difficile infection is increasing, with reports implicating fluoroquinolone use. A three-stage chemostat gut model was used to study the effects of three fluoroquinolones (ciprofloxacin, levofloxacin, and moxifloxacin) on the gut microbiota and two epidemic C. difficile
Takeshi Amemiya et al.
PloS one, 10(4), e0125391-e0125391 (2015-04-29)
The human amniotic membrane (AM) is a thin intrauterine placental membrane that is highly biocompatible and possesses anti-inflammatory and anti-scarring properties. Using AM, we developed a novel method for cultivating oral mucosal epithelial cell sheets. We investigated the autologous transplantation
N Almeida et al.
Clinical microbiology and infection : the official publication of the European Society of Clinical Microbiology and Infectious Diseases, 20(11), 1127-1133 (2014-06-04)
Helicobacter pylori resistance to antimicrobial agents is steadily increasing. It is extremely important to be aware of the local prevalence of antibiotic resistance so as to adjust treatment strategies. During this single-centre, prospective study, we aimed to determine primary and
Céline Vidaillac et al.
Antimicrobial agents and chemotherapy, 53(6), 2360-2366 (2009-04-08)
Ceftaroline is a novel broad-spectrum cephalosporin that exhibits bactericidal activity against many gram-positive and -negative pathogens. However, the activity of ceftaroline cannot be solely relied upon for eradication of multidrug-resistant gram-negative isolates, such as Pseudomonas aeruginosa and extended-spectrum beta-lactamase (ESBL)-producing
Stephen P Hawser et al.
Antimicrobial agents and chemotherapy, 54(7), 3043-3046 (2010-04-28)
From 2002 to 2008, there was a significant increase in extended-spectrum beta-lactamase (ESBL)-positive Escherichia coli isolates in European intra-abdominal infections, from 4.3% in 2002 to 11.8% in 2008 (P < 0.001), but not for ESBL-positive Klebsiella pneumoniae isolates (16.4% to
Dougal H Adamson et al.
The Journal of antimicrobial chemotherapy, 70(8), 2271-2278 (2015-04-30)
The objectives of this study were to compare the antibiotic susceptibility of Pseudomonas aeruginosa strains with increased efflux pump expression in vitro and in vivo and to use these same strains to evaluate the efficacy of combinations of antibiotics with
Detection of the pandemic O25-ST131 human virulent Escherichia coli CTX-M-15-producing clone harboring the qnrB2 and aac(6')-Ib-cr genes in a dog.
Constança Pomba et al.
Antimicrobial agents and chemotherapy, 53(1), 327-328 (2008-11-13)
Laura Lawrence et al.
Antimicrobial agents and chemotherapy, 52(5), 1653-1662 (2008-03-05)
Rx-01_423 and Rx-01_667 are two members of the family of oxazolidinones that were designed using a combination of computational and medicinal chemistry and conventional biological techniques. The compounds have a two- to eightfold-improved potency over linezolid against serious gram-positive pathogens
Deborah C Draghi et al.
Antimicrobial agents and chemotherapy, 52(7), 2383-2388 (2008-04-30)
Telavancin is an investigational, rapidly bactericidal lipoglycopeptide antibiotic that is being developed to treat serious infections caused by gram-positive bacteria. A baseline prospective surveillance study was conducted to assess telavancin activity, in comparison with other agents, against contemporary clinical isolates
Kathleen M Giacomini et al.
Nature reviews. Drug discovery, 9(3), 215-236 (2010-03-02)
Membrane transporters can be major determinants of the pharmacokinetic, safety and efficacy profiles of drugs. This presents several key questions for drug development, including which transporters are clinically important in drug absorption and disposition, and which in vitro methods are
Rationalizing use of fluoroquinolones and pyrazinamide in the battle against multidrug-resistant tuberculosis.
Kwok-Chiu Chang et al.
American journal of respiratory and critical care medicine, 188(1), 10-11 (2013-07-03)
Carolyn V Gould et al.
Antimicrobial agents and chemotherapy, 51(9), 3225-3229 (2007-08-01)
The occurrence of mutator phenotypes among laboratory-generated and clinical levofloxacin-resistant strains of Streptococcus pneumoniae was determined using fluctuation analysis. The in vitro selection for levofloxacin-resistant mutants of strain D39, each with point mutations in both gyrA and parC or parE
Juan Liu et al.
Journal of natural products, 74(8), 1826-1829 (2011-07-13)
Four new polyketides (1-4) were isolated from the fungus Paecilomyces variotii, which was derived from the jellyfish Nemopilema nomurai. The planar structures and relative configurations of these polyketides were elucidated on the basis of spectroscopic analyses, including 2D NMR experiments.
Somay Yamagata Murayama et al.
Antimicrobial agents and chemotherapy, 53(6), 2650-2653 (2009-04-01)
Streptococcus agalactiae isolates (n = 189) from patients with invasive infections were analyzed for capsular type by PCR, for antimicrobial susceptibility, and for the presence of resistance genes. In contrast to the predominance of capsular type III in children, types
Yun Chai et al.
Bioorganic & medicinal chemistry letters, 21(11), 3377-3380 (2011-04-26)
We report herein the design and synthesis of novel 7-(4-alkoxyimino-3-aminomethylpiperidin-1-yl) fluoroquinolone derivatives. The antibacterial activity of the newly synthesized compounds was evaluated and compared with gemifloxacin, levofloxacin and ciprofloxacin. Results reveal that compounds 10, 16, and 17 have good activity
Inna Chmelnitsky et al.
Antimicrobial agents and chemotherapy, 52(8), 2962-2965 (2008-06-04)
Fourteen out of 16 carbapenem-resistant quinolone-susceptible Enterobacter cloacae isolates were found to carry qnrB2 and bla(KPC-2) genes encoded on the same plasmid. One isolate also carried the aac(6')-Ib-cr gene. Coexistence of quinolone resistance determinants and bla(KPC-2) on the same plasmid
Patrizia Spigaglia et al.
Antimicrobial agents and chemotherapy, 53(6), 2463-2468 (2009-04-15)
Recent studies have suggested that exposure to fluoroquinolones represents a risk factor for the development of Clostridium difficile infections and that the acquisition of resistance to the newer fluoroquinolones is the major reason facilitating wide dissemination. In particular, moxifloxacin (MX)
Yu-Chia Hsieh et al.
Antimicrobial agents and chemotherapy, 52(6), 2266-2269 (2008-04-17)
This study aimed to evaluate the antimicrobial susceptibility profiles of 364 Streptococcus pneumoniae isolates and studied the genotypes of S. pneumoniae with high level beta-lactam resistance in Taiwan. Clonal complexes related to Spain(23F)-1, Taiwan(19F)-14, and Taiwan(23F)-15 were responsible for the
Manthena V S Varma et al.
Journal of medicinal chemistry, 53(3), 1098-1108 (2010-01-15)
Oral bioavailability (F) is a product of fraction absorbed (Fa), fraction escaping gut-wall elimination (Fg), and fraction escaping hepatic elimination (Fh). In this study, using a database comprised of Fa, Fg, Fh, and F values for 309 drugs in humans
Kenichiro Shimizu et al.
Antimicrobial agents and chemotherapy, 52(10), 3823-3825 (2008-07-23)
A new chromosome-carried quinolone resistance gene from Stenotrophomonas maltophilia, Smqnr, was characterized. The gene was present in type strain CCUG 5866 and was also detected in 24 clinical isolates and showed some allelic diversity. The expression of Smqnr in Escherichia
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