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Cory A Massey et al.
Journal of neurophysiology, 113(7), 2879-2888 (2015-02-20)
Serotonin (5-hydroxytryptamine, 5-HT) neurons from the mouse and rat rostral medulla are stimulated by increased CO2 when studied in culture or brain slices. However, the response of 5-HT neurons has been variable when animals are exposed to hypercapnia in vivo.
Yabin Lu et al.
Brain research bulletin, 118, 17-24 (2015-09-01)
Culture of human oligodendrocyte precursor cells (OPCs) can help understand the regulatory mechanism of differentiation and myelination of oligodendrocytes. However, existing culture methods have limitations, particularly the lack of a source of human donor tissue and high cost. We sorted
Irina Drachuk et al.
ACS nano, 9(2), 1219-1235 (2015-01-15)
This study introduces double-brush designs of functionalized silk polyelectrolytes based upon regenerated silk fibroin (SF), which is modified with poly-L-lysine (SF-PLL), poly-L-glutamic acid (SF-PGA), and poly(ethylene glycol) (PEG) side chains with different grafting architecture and variable amino acid-PEG graft composition
Jennifer L L Morgan et al.
Analytical chemistry, 83(18), 6956-6962 (2011-07-12)
We describe a new chemical separation method to isolate Ca from other matrix elements in biological samples, developed with the long-term goal of making high-precision measurement of natural stable Ca isotope variations a clinically applicable tool to assess bone mineral
Charalambos Sigalas et al.
The Journal of neuroscience : the official journal of the Society for Neuroscience, 35(32), 11196-11208 (2015-08-14)
Nicotinic acetylcholine receptors (nAChRs) play an important role in the modulation of many cognitive functions but their role in integrated network activity remains unclear. This is at least partly because of the complexity of the cholinergic circuitry and the difficulty
Chi-Kun Tong et al.
The Journal of neuroscience : the official journal of the Society for Neuroscience, 34(33), 10808-10820 (2014-08-15)
NMDA receptors are important elements in pain signaling in the spinal cord dorsal horn. They are heterotetramers, typically composed of two GluN1 and two of four GluN2 subunits: GluN2A-2D. Mice lacking some of the GluN2 subunits show deficits in pain
Hans Henrik Jeppesen et al.
Journal of analytical toxicology, 39(6), 451-459 (2015-04-15)
Crack cocaine (free-base cocaine) smokers belong to a subgroup of marginalized drug users exposed to severe health risks and great social harm. Detection of the urinary, pyrolytic biomarker methylecgonidine (MED) and its metabolite ecgonidine (ED) secures an unambiguous confirmation of
A Grzeczkowicz et al.
Journal of nanoscience and nanotechnology, 15(12), 9531-9538 (2015-12-19)
Carious is the most frequent disease of mineralized dental tissues which might result in dental pulp inflammation and mortality. In such cases an endodontic treatment is the only option to prolong tooth functioning in the oral cavity; however, in the
Joung-Woo Choi et al.
Biomaterials, 65, 163-174 (2015-07-15)
Adenovirus (Ad) is a widely used vector for cancer gene therapy but its therapeutic efficacy is limited by low coxsackievirus and adenovirus receptor (CAR) expression in tumors and non-specifically targeted infection. Ad infectivity and specificity can be markedly improved by
Yifeng Shen et al.
PloS one, 10(6), e0129689-e0129689 (2015-06-10)
A novel europium ligand 2,2',2'',2'''-(4,7-diphenyl-1,10-phenanthroline-2,9-diyl) bis (methylene) bis (azanetriyl) tetra acetic acid (BC-EDTA) was synthesized and characterized. It shows an emission spectrum peak at 610 nm when it is excited at 360 nm, with a large Stock shift (250 nm).
Taro Yamaguchi et al.
Journal of pharmacological sciences, 129(2), 127-134 (2015-10-27)
The endocochlear potential in the inner ear is essential for hearing ability, and maintained by various K(+) transport apparatuses including Na(+), K(+)-ATPase and gap junction-mediated intercellular communication (GJ-IC) in the lateral wall structures of the cochlea. Noise-induced hearing loss is
D Lindenbach et al.
British journal of pharmacology, 172(1), 119-130 (2014-09-02)
Treatment of Parkinson's disease (PD) with L-DOPA eventually causes abnormal involuntary movements known as dyskinesias in most patients. Dyskinesia can be reduced using compounds that act as direct or indirect agonists of the 5-HT1 A receptor, but these drugs have
Mihaela A Stavarache et al.
Neurobiology of disease, 82, 487-494 (2015-08-02)
Phosphatase and Tensin homolog deleted on chromosome 10 (PTEN) is a dual lipid-protein phosphatase known primarily as a growth preventing tumor suppressor. PTEN is also expressed in neurons, and pathways modulated by PTEN can influence neuronal function. Here we report
Pawel Tabakow et al.
Cell transplantation, 23(12), 1631-1655 (2014-10-24)
Treatment of patients sustaining a complete spinal cord injury remains an unsolved clinical problem because of the lack of spontaneous regeneration of injured central axons. A 38-year-old man sustained traumatic transection of the thoracic spinal cord at upper vertebral level
Wen-Zhe Jin et al.
Pharmacology, 96(5-6), 271-277 (2015-10-22)
Propofol is a global central nervous system depressant that affects information processing in the central nervous system. However, the effects of propofol on sensory information processing in the cerebellar cortical molecular layer are unknown. In this study, we examined the
Md Humayun Kabir et al.
The journal of physical chemistry. A, 114(42), 11109-11116 (2010-06-04)
Rotational relaxation rates for HBr(v = 1) colliding with helium atoms at room temperature have been measured using a time-resolved optical-optical double resonance technique. Rotational state selective excitation of v = 1 for rotational levels in the range J =
Shigeo Hayashi et al.
Journal of enzyme inhibition and medicinal chemistry, 29(6), 846-867 (2014-02-13)
Because of the pivotal role of cyclooxygenase (COX) in the inflammatory processes, non-steroidal anti-inflammatory drugs (NSAIDs) that suppress COX activities have been used clinically for the treatment of inflammatory diseases/syndromes; however, traditional NSAIDs exhibit serious side-effects such as gastrointestinal damage
Gajraj Singh Kushwaha et al.
Biochimica et biophysica acta, 1824(4), 679-691 (2012-03-01)
The ribosome inactivating proteins (RIPs) of type 1 are plant toxins that eliminate adenine base selectively from the single stranded loop of rRNA. We report six crystal structures, type 1 RIP from Momordica balsamina (A), three in complexed states with
Mathieu Rajalu et al.
Neuropharmacology, 88, 145-154 (2014-09-10)
GABAB receptors (GABABRs) are considered promising drug targets for the treatment of mental health disorders. GABABRs are obligate heteromers of principal GABAB1 and GABAB2 subunits. GABABRs can additionally associate with auxiliary KCTD8, 12, 12b and 16 subunits, which also bind
Ruirui Xing et al.
ACS applied materials & interfaces, 7(44), 24733-24740 (2015-10-20)
The biogenic synthesis of biomolecule-gold nanoconjugates is of key importance for a broad range of biomedical applications. In this work, a one-step, green, and condition-gentle strategy is presented to synthesize stable colloidal gold-collagen core-shell nanoconjugates in an aqueous solution at
Xuesheng Zhang et al.
Chemosphere, 134, 84-90 (2015-04-29)
In the present study, twenty-six types of polymethoxylated diphenyl ethers (PMeODEs), twenty types of polyhydroxylated diphenyl ethers (PHODEs), seven types of methoxylated-polychlorinated diphenyl ethers (MeO-PCDEs) and seven types of hydroxylated-polychlorinated diphenyl ethers (HO-PCDEs) were synthesized. The logKow and logKoc values
Bing Xue et al.
Journal of neuroscience research, 93(10), 1592-1599 (2015-07-15)
Dopamine and acetylcholine are two principal transmitters in the striatum and are usually balanced to modulate local neural activity and to maintain striatal homeostasis. This study investigates the role of dopamine and muscarinic acetylcholine receptors in the regulation of a
Akira Takaguri et al.
Cell biology international, 39(9), 1053-1060 (2015-04-11)
Doxorubicin is an anthracycline antibiotic widely used in cancer treatment. Although its antitumor efficacy appears to be dose dependent, its clinical use is greatly restricted by the development of cardiotoxicity associated with apoptosis. Although caveolin-1, the major structural protein in
S N Eustis et al.
The journal of physical chemistry. A, 114(3), 1357-1363 (2010-01-22)
The ammonia-hydrogen bromide and ammonia-hydrogen iodide, anionic heterodimers were studied by anion photoelectron spectroscopy. In complementary studies, these anions and their neutral counterparts were also investigated via ab initio theory at the coupled cluster level. In both systems, neutral NH(3)...HX
Rui Kimura et al.
The Journal of neuroscience : the official journal of the Society for Neuroscience, 34(30), 10122-10133 (2014-07-25)
Visual responsiveness of cortical neurons changes depending on the brain state. Neural circuit mechanism underlying this change is unclear. By applying the method of in vivo two-photon functional calcium imaging to transgenic rats in which GABAergic neurons express fluorescent protein
Caroline L Parworth et al.
The journal of physical chemistry. A, 115(45), 13133-13138 (2011-10-05)
The 1,2-HX elimination reaction (where X = F, Cl, Br, OH) has been established as an important reaction in the degradation of compounds introduced into the upper atmosphere, including common CFC replacement compounds. By analyzing the electron densities of the
Vladimir S Naumenko et al.
Behavioural brain research, 274, 1-9 (2014-08-08)
The effect of glial cell line-derived neurotrophic factor (GDNF) on behavior and brain dopamine system in predisposed to depressive-like behavior ASC (Antidepressant Sensitive Cataleptics) mice in comparison with the parental "nondepressive" CBA mice was studied. In 7days after administration (800ng
Saji Thomas et al.
The Analyst, 137(15), 3571-3582 (2012-06-27)
The present study describes the identification and characterization of two process impurities and major stress degradants in darifenacin hydrobromide using high performance liquid chromatography (HPLC) analysis. Forced degradation studies confirmed that the drug substance was stable under acidic, alkaline, aqueous
Leen Moens et al.
Infection and immunity, 83(7), 2889-2896 (2015-05-06)
The role of CD19(+) CD5(+) and CD19(+) CD5(-) B cell subpopulations in the antibody response to pneumococcal capsular polysaccharides (caps-PSs) is controversial. In the present study, we evaluated the role of human CD19(+) CD5(+) and CD19(+) CD5(-) cell populations in
Elena Dragicevic et al.
Brain : a journal of neurology, 137(Pt 8), 2287-2302 (2014-06-18)
Dopamine midbrain neurons within the substantia nigra are particularly prone to degeneration in Parkinson's disease. Their selective loss causes the major motor symptoms of Parkinson's disease, but the causes for the high vulnerability of SN DA neurons, compared to neighbouring
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