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A F Vanin et al.
Biofizika, 58(1), 126-136 (2013-05-09)
Current notions and new experimental data of the authors on physico-chemical features of dinitrosyl iron complexes with natural thiol-containing ligands (glutathione or cysteine), underlying the ability of the complexes to act as NO molecule and nitrosonium ion donors, are considered.
Christopher M Jenkins et al.
Biochemistry, 52(24), 4250-4263 (2013-05-25)
The multifaceted roles of calcium-independent phospholipase A2β (iPLA2β) in numerous cellular processes have been extensively examined through utilization of the iPLA2-selective inhibitor (E)-6-(bromomethylene)-3-(1-naphthalenyl)-2H-tetrahydropyran-2-one (BEL). Herein, we employed accurate mass/high resolution mass spectrometry to demonstrate that the active site serine (S465)
N A Strutyns'ka et al.
Fiziolohichnyi zhurnal (Kiev, Ukraine : 1994), 59(1), 3-10 (2013-05-30)
In experiments in vivo and in vitro on the mitochondria isolated from the control and spontaneously hypertensive rats (SHR) hearts, we studied the effects of a donor of hydrogen sulfide (H2S), NaHS, and H2S biosynthesis substrate, L-cysteine, on the sensitivity
Zrinka Karačić et al.
Biological chemistry, 393(12), 1523-1532 (2013-05-15)
Human dipeptidyl peptidase III (DPP III) is a member of the metallopeptidase family M49, involved in protein metabolism and oxidative stress response. DPPIII crystal structure shows the two lobe-like domains separated by a wide cleft. The human enzyme has a
Mingdeng Liu et al.
Water science and technology : a journal of the International Association on Water Pollution Research, 67(11), 2444-2450 (2013-06-12)
In the present work, cysteine-modified orange peel (COP) for the removal of Cu(II) from aqueous solutions has been developed and comparatively studied with diethylenetriamine-modified orange peel (DOP). Both COP and DOP were systematically evaluated via their capabilities for adsorbing Cu(II)
Jiahua Li et al.
American journal of physiology. Cell physiology, 305(2), C190-C196 (2013-05-17)
Claudins constitute a family of tight junction transmembrane proteins whose first extracellular loop (ECL1) determines the paracellular permeability and ion selectivity in epithelia. There are two cysteines in the ECL1 that are conserved among all claudins. We hypothesized that these
Pramod Kumar Yadav et al.
The Journal of biological chemistry, 288(27), 20002-20013 (2013-05-24)
Mercaptopyruvate sulfurtransferase (MST) is a source of endogenous H2S, a gaseous signaling molecule implicated in a wide range of physiological processes. The contribution of MST versus the other two H2S generators, cystathionine β-synthase and γ-cystathionase, has been difficult to evaluate
T L Stepuro et al.
Rossiiskii fiziologicheskii zhurnal imeni I.M. Sechenova, 99(1), 111-119 (2013-05-11)
The aim of the present study was to investigate the role of nitric oxide (NO) in the regulation of hemoglobin oxygen affinity (HOA) in the presence of different oxygen partial pressure. In this research the effect of NO donors on
D J Powell et al.
Poultry science, 92(8), 2163-2173 (2013-07-23)
Early posthatch satellite cell (SC) mitotic activity is a critical component of muscle development and growth. Satellite cells are stem cells that can be induced by nutrition to follow other cellular developmental pathways. The objective of the current study was
Gustavo H C Varca et al.
Drug development and industrial pharmacy, 41(3), 430-435 (2014-01-15)
The performance of the standardized extrusion-spheronization technique, operational conditions, formulation parameters and storage of the final product over the bioactivity of papain containing pellets has been evaluated to obtain an insight into the potential of the technique for the manufacture
Nitric oxide quenches the fire in heart mitochondria.
Paul T Schumacker
Nature medicine, 19(6), 666-667 (2013-06-08)
Laurine Legroux et al.
Journal of neuroscience methods, 247, 23-31 (2015-03-31)
Flow cytometry is an efficient and powerful technique to characterize and quantify numerous cells. However, the strengths of this technique have not been widely harnessed in neurosciences due to the critical step of CNS tissue preparation into a single cell
Rana Barakat et al.
MicrobiologyOpen, 3(1), 1-14 (2013-12-07)
The blue-green phenazine, Pyocyanin (PYO), is a well-known virulence factor produced by Pseudomonas aeruginosa, notably during cystic fibrosis lung infections. It is toxic to both eukaryotic and bacterial cells and several mechanisms, including the induction of oxidative stress, have been
[Targeted effect profile - proven effectiveness].
MMW Fortschritte der Medizin, 155(5), 70-71 (2013-05-10)
Michael Hellwig et al.
Journal of agricultural and food chemistry, 63(30), 6723-6730 (2015-07-18)
Maillard reaction products (MRPs) are taken up in substantial amounts with the daily diet, but the majority are not transported across the intestinal epithelium. The aim of this study was to obtain first insights into the stability of dietary MRPs
Borna Ghosh et al.
The Journal of biological chemistry, 288(24), 17420-17431 (2013-05-04)
General anesthetics exert many of their CNS actions by binding to and modulating membrane-embedded pentameric ligand-gated ion channels (pLGICs). The structural mechanisms underlying how anesthetics modulate pLGIC function remain largely unknown. GLIC, a prokaryotic pLGIC homologue, is inhibited by general
Biochemistry: Oxidation controls the DUB step.
Michael J Clague
Nature, 497(7447), 49-50 (2013-05-03)
Charles Ansong et al.
Proceedings of the National Academy of Sciences of the United States of America, 110(25), 10153-10158 (2013-05-31)
Characterization of the mature protein complement in cells is crucial for a better understanding of cellular processes on a systems-wide scale. Toward this end, we used single-dimension ultra-high-pressure liquid chromatography mass spectrometry to investigate the comprehensive "intact" proteome of the
Joshua D Chandler et al.
The Journal of biological chemistry, 288(25), 18421-18428 (2013-05-01)
The endogenously produced oxidant hypothiocyanous acid (HOSCN) inhibits and kills pathogens but paradoxically is well tolerated by mammalian host tissue. Mammalian high molecular weight thioredoxin reductase (H-TrxR) is evolutionarily divergent from bacterial low molecular weight thioredoxin reductase (L-TrxR). Notably, mammalian
Tania Gómez-Sierra et al.
The Journal of pharmacy and pharmacology, 66(9), 1271-1281 (2014-05-02)
Cisplatin (CP) is an antineoplastic agent that induces nephrotoxicity and oxidative stress. S-allylcysteine (SAC) is a garlic-derived antioxidant. This study aims to explore whether SAC protects against CP-induced nephrotoxicity in rats. In the first stage, the SAC protective dose was
Sebastián Carballal et al.
Biochemistry, 52(26), 4553-4562 (2013-06-25)
Cystathionine β-synthase (CBS) catalyzes the condensation of homocysteine with serine or cysteine to form cystathionine and water or hydrogen sulfide (H2S), respectively. In addition to pyridoxal phosphate, human CBS has a heme cofactor with cysteine and histidine as ligands. While
K B Shumaev et al.
Biofizika, 58(2), 239-245 (2013-06-13)
It has been shown that interaction of cysteine dinitrosyl iron complexes with methylglyoxal leads to the formation of a new type of dinitrosyl iron complexes., EPR spectrum of these complexes essentially differs from spectra of dinitrosyl iron complexes containing unmodified
Tal Ilani et al.
Science (New York, N.Y.), 341(6141), 74-76 (2013-05-25)
Disulfide bond formation in secretory proteins occurs primarily in the endoplasmic reticulum (ER), where multiple enzyme families catalyze cysteine cross-linking. Quiescin sulfhydryl oxidase 1 (QSOX1) is an atypical disulfide catalyst, localized to the Golgi apparatus or secreted from cells. We
Piero Pingitore et al.
Biochimica et biophysica acta, 1828(9), 2238-2246 (2013-06-13)
The human glutamine/neutral amino acid transporter ASCT2 (hASCT2) was over-expressed in Pichia pastoris and purified by Ni(2+)-chelating and gel filtration chromatography. The purified protein was reconstituted in liposomes by detergent removal with a batch-wise procedure. Time dependent [(3)H]glutamine/glutamine antiport was
Shinichiro Oku et al.
The Journal of biological chemistry, 288(27), 19816-19829 (2013-05-21)
Protein palmitoylation, a common post-translational lipid modification, plays an important role in protein trafficking and functions. Recently developed palmitoyl-proteomic methods identified many novel substrates. However, the whole picture of palmitoyl substrates has not been clarified. Here, we performed global in
Qinjian Zhao et al.
Human vaccines & immunotherapeutics, 10(3), 734-739 (2013-12-05)
Cryo-transmission electron microscopy (cryoTEM) is a powerful characterization method for assessing the structural properties of biopharmaceutical nanoparticles, including Virus Like Particle-based vaccines. We demonstrate the method using the Human Papilloma Virus (HPV) VLPs in GARDASIL®. CryoTEM, coupled to automated data
Arne Trettin et al.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences, 966, 171-178 (2013-12-25)
Paracetamol (acetaminophen, APAP) is a commonly used analgesic drug. Known paracetamol metabolites include the glucuronide, sulfate and mercapturate. N-Acetyl-benzoquinonimine (NAPQI) is considered the toxic intermediate metabolite of paracetamol. In vitro and in vivo studies indicate that paracetamol is also metabolized
(Bio)synthesis, extraction and purification of garlic derivatives showing therapeutic properties.
B Dethier et al.
Communications in agricultural and applied biological sciences, 78(1), 149-155 (2013-07-24)
Lars Bräutigam et al.
Biochemical and biophysical research communications, 436(3), 491-496 (2013-06-13)
Glutaredoxins that contain a Cys-X-X-Cys active site motif are glutathione-dependent thiol-disulfide oxidoreductases. Vertebrate glutaredoxin 2 is characterized by two extra cysteines that form an intra-molecular disulfide bridge. Zebrafish glutaredoxin 2 contains four additional cysteines that are conserved within the infraclass
Indira Wu et al.
Biochimica et biophysica acta, 1834(8), 1539-1544 (2013-05-17)
Numerous protein engineering studies have focused on increasing the thermostability of fungal cellulases to improve production of fuels and chemicals from lignocellulosic feedstocks. However, the engineered enzymes still undergo thermal inactivation at temperatures well below the inactivation temperatures of hyperthermophilic
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