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Wenjing Zhang et al.
PloS one, 9(10), e110973-e110973 (2014-10-21)
Epigenetic changes frequently occur during tumorigenesis and DNA hypermethylation may account for the inactivation of tumor suppressor genes in cancer cells. Studies in Multiple Myeloma (MM) have shown variable DNA methylation patterns with focal hypermethylation changes in clinically aggressive subtypes.
Dong Gu Lee et al.
Chemical & pharmaceutical bulletin, 63(11), 927-934 (2015-11-03)
Four phytochemical constituents were isolated from Panax ginseng root by repeated column chromatography (CC), medium pressure liquid chromatography (MPLC), high-speed counter current chromatography (HSCCC), and semi-preparative HPLC. Their structures were elucidated as the dammarane-type triterpene saponins ginsenoside-Rg18 (1), 6-acetyl ginsenoside-Rg3
Z T Williams et al.
Poultry science, 91(9), 2083-2088 (2012-08-23)
Controlling Salmonella populations on commercial broiler grow out farms is a crucial step in reducing Salmonella contamination in processing plants. Broiler litter harbors many species of pathogenic bacteria including Salmonella. Sodium bisulfate has been shown to reduce concentration of bacteria
Guangjie Li et al.
Journal of cellular physiology, 234(12), 23485-23494 (2019-06-18)
MicroRNAs (miRs) involve in osteogenic differentiation and osteogenic potential of mesenchymal stem cells (MSCs). Accordingly, the present study aimed to further uncover role miR-149 plays in osteogenic differentiation of MSCs with the involvement of the stromal cell-derived factor-1 (SDF-1)/CXC chemokine
S E Cloft et al.
Poultry science, 98(10), 4878-4888 (2019-05-08)
An experiment was conducted to evaluate broilers vaccinated against coccidiosis fed combinations of pre-starter and starter diets varying in digestible amino acid (dAA) density from 1 to 19 d of age on subsequent growth performance and meat yield. A total
Yoshihiko Nakatani et al.
European journal of pharmacology, 815, 381-390 (2017-10-04)
Glycyrrhiza (the roots and rhizomes of licorice) has been used worldwide as both an herbal nutraceutical and herbal medicine. In addition, it is well known that Glycyrrhiza contains various compounds with biological effects, such as anti-viral, anti-inflammatory, immunoregulatory, anti-tumor and
Mingtian Deng et al.
Cellular reprogramming, 19(3), 199-207 (2017-03-30)
In mammals, the imprinted genes play vital roles in development and are generally controlled by DNA methylation at imprinting control regions (ICRs). Recently, it was discovered that 5-hydroxymethylcytosine (5-hmC) is a stable epigenetic modification; however, its functions in cloned animal
Mara Schiro et al.
Physical review letters, 109(26), 265503-265503 (2013-02-02)
Pressure exerted by crystallization of salts within porous materials contributes to damage in historic and modern construction. By unequivocally identifying the precipitating phase(s) while simultaneously determining solution supersaturation and associated crystallization pressure in subsurface pores, we show that the formation
Ho-Sun Lee et al.
Clinical epigenetics, 12(1), 148-148 (2020-10-17)
Considering that DNA methylation (DNAm) profiles are, in large part, modifiable by lifestyle and environmental influences, it has been proposed that epigenetic clocks provide a better estimate of biological age than chronological age, as associated with current health status. Even
Haishan Lin et al.
Frontiers in oncology, 10, 535449-535449 (2020-10-13)
KDM5c is a histone demethylase that specifically demethylates trimethylated and dimethylated H3 Lys-4 to play a central role in transcriptional repression. C-Jun is a proto-oncogene and promotes cell proliferation when ectopically accumulated, but can be ubiquitinated by SCF (FBXW7), leading
Ragu Ramanathan et al.
Bioanalysis, 9(22), 1787-1806 (2017-10-06)
Coproporphyrin-I (CP-I) and coproporphyrin-III (CP-III) in plasma and urine have been proposed as biomarkers for assessing drug-drug interactions involving hepatic drug transporters such as organic anion-transporting peptides (OATP), 1B1 and 1B3. Materials & methods: Plasma and urine extracts were analyzed for CP-I/CP-III
Masaki Moriyama et al.
Advanced healthcare materials, 4(4), 569-575 (2014-09-13)
Antioxidant micelles capable of scavenging reactive oxygen species (ROS) are prepared from poly(ethylene glycol)-b-poly(dopamine) block copolymers. The micelles inhibit tube formation of human umbilical vein endothelial cells (HUVECs) by scavenging endogenous ROS. Furthermore, the micelles inhibit angiogenesis in the chicken
Maja Turinek et al.
Journal of the science of food and agriculture, 97(8), 2647-2656 (2016-10-16)
Organic production is widely assumed to affect quality and nutritional parameters of arable crops. A field experiment was started in 2009 following integrated (INT), organic (ORG) and biodynamic (BD) production standards for wheat, maize and rapeseed production. With resort to
Hsiu-Fen Lin et al.
Journal of investigative medicine : the official publication of the American Federation for Clinical Research, 65(4), 794-799 (2017-02-15)
Matrix metalloproteinase-2 (MMP-2) is involved in the pathophysiology of stroke. Previous studies have shown that MMP-2 activity is increased in stroke; however, evidence of epigenetic regulation of the MMP-2 in stroke is still limited. We examined methylation of the MMP-2
Yanfeng Liu et al.
Toxicology in vitro : an international journal published in association with BIBRA, 52, 321-331 (2018-07-22)
The purpose of present study was to investigate the applicability of reconstructed human epidermis model to identify skin corrosive UN GHS Categories 1A, 1B/1C and non-corrosive chemicals in China. By using a commercialized reconstructed human epidermis model, China EpiSkin™ which
Fabrication of self-ordered porous alumina via anodizing in sulfate solutions
Kondo R, et al.
Materials Letters, 183, 285-289 (2016)
Min-Jie Cao et al.
The Plant journal : for cell and molecular biology, 73(4), 607-616 (2012-10-26)
Plants play a prominent role as sulfur reducers in the global sulfur cycle. Sulfate, the major form of inorganic sulfur utilized by plants, is absorbed and transported by specific sulfate transporters into plastids, especially chloroplasts, where it is reduced and
Anissa El Arfani et al.
Neurochemistry international, 88, 88-96 (2015-07-15)
Parkinson's disease (PD) is hallmarked by progressive degeneration of the substantia nigra pars compacta (SNc) neurons and is associated with aberrant glutamatergic activity. However, studies on the glutamatergic system in the motor cortex and striatum, two motor loop-related areas, are
Brian Cunniff et al.
PloS one, 10(5), e0127310-e0127310 (2015-05-27)
Dysregulation of signaling pathways and energy metabolism in cancer cells enhances production of mitochondrial hydrogen peroxide that supports tumorigenesis through multiple mechanisms. To counteract the adverse effects of mitochondrial peroxide many solid tumor types up-regulate the mitochondrial thioredoxin reductase 2--thioredoxin
Kangmei Chen et al.
Theranostics, 8(2), 423-436 (2018-01-02)
Human growth factor receptor-bound protein-7 (GRB7) is a pivotal mediator involved in receptor tyrosine kinase signaling and governing diverse cellular processes. Aberrant upregulation of GRB7 is frequently associated with the progression of human cancers. However, the molecular mechanisms leading to
Gunyoung Lee et al.
Food additives & contaminants. Part A, Chemistry, analysis, control, exposure & risk assessment, 36(6), 876-883 (2019-04-16)
Food additives such as antioxidants and color fixatives are substances used in food intentionally for technical effect, such as decolorizing or intensifying the color of food. Based on the necessity of re-evaluating food additives for safety and to improve consumer
Tanoy Dutta et al.
Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy, 191, 217-220 (2017-10-19)
A "naked-eye" detection of health hazardous bisulfite (HSO
P Mehdipour et al.
Molecular neurobiology, 52(1), 293-302 (2014-08-28)
Ataxia telangiectasia mutated (ATM) is a key gene in DNA double-strand break (DSB), and therefore, most of its disabling genetic alterations play an important initiative role in many types of cancer. However, the exact role of ATM gene and its
Fernanda L Souza et al.
Chemosphere, 109, 187-194 (2014-03-13)
The electrooxidation of the dimethyl phthalate (DMP) ester was galvanostatically carried out in a filter-press reactor using a fluoride-doped lead dioxide (β-PbO2,F) film electrodeposited on a Ti substrate. The variables investigated were the nature of the supporting electrolyte (NaCl and
Chunyan Yang et al.
Protein science : a publication of the Protein Society, 22(3), 314-326 (2013-01-03)
The hepatitis E virus (HEV) capsid protein has been demonstrated to be able to assemble into particles in vitro. However, this process and the mechanism of protein-protein interactions during particle assembly remain unclear. In this study, we investigated the assembly
Kuo-Tung Huang et al.
PloS one, 15(2), e0228958-e0228958 (2020-02-19)
Obstructive sleep apnea (OSA) is a syndrome leading to chronic intermittent hypoxia, and the up-regulation of toll-like receptors (TLR) 2 and 6 on peripheral blood cells has been reported. We hypothesized that DNA methylation in TLR2 and TLR6 genes may
L Rossi et al.
Physical review. E, Statistical, nonlinear, and soft matter physics, 86(2 Pt 2), 026313-026313 (2012-09-26)
This article pursues the idea that the degree of striations, called lamination, could be engineered to complement stretching and to design new sequential mixers. It explores lamination and mixing in three new mixing sequences experimentally driven by electromagnetic body forces.
Yanyan Zhang et al.
Hypertension research : official journal of the Japanese Society of Hypertension, 41(2), 96-103 (2017-11-03)
Promoter methylation is a key mechanism in the epigenetic reprogramming of gene expression patterns. Here, we investigated the contribution of DNA methylation and the associated expression and function of large-conductance Ca
K J Nagarajan et al.
Carbohydrate polymers, 235, 115997-115997 (2020-03-04)
The Used Disposal Paper Cups (UDPCs) have become a concern to the solid waste management sector as scientists triggered the problems in recent years, to proceed forward in developing the process for this issue. Based on this concern, the present
Sylwia Baluta et al.
Sensors (Basel, Switzerland), 20(5) (2020-03-11)
A novel fluorescence-sensing pathway for epinephrine (EP) detection was investigated. The ceramic-based miniature biosensor was developed through the immobilization of an enzyme (laccase, tyrosinase) on a polymer-poly-(2,6-di([2,2'-bithiophen]-5-yl)-4-(5-hexylthiophen-2-yl)pyridine), based on low temperature cofired ceramics technology (LTCC). The detection procedure was based
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