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Haishan Lin et al.
Frontiers in oncology, 10, 535449-535449 (2020-10-13)
KDM5c is a histone demethylase that specifically demethylates trimethylated and dimethylated H3 Lys-4 to play a central role in transcriptional repression. C-Jun is a proto-oncogene and promotes cell proliferation when ectopically accumulated, but can be ubiquitinated by SCF (FBXW7), leading
Preethi Vijayaraj et al.
Cell reports, 29(11), 3488-3505 (2019-12-12)
Progressive organ fibrosis accounts for one-third of all deaths worldwide, yet preclinical models that mimic the complex, progressive nature of the disease are lacking, and hence, there are no curative therapies. Progressive fibrosis across organs shares common cellular and molecular
Hsiu-Fen Lin et al.
Journal of investigative medicine : the official publication of the American Federation for Clinical Research, 65(4), 794-799 (2017-02-15)
Matrix metalloproteinase-2 (MMP-2) is involved in the pathophysiology of stroke. Previous studies have shown that MMP-2 activity is increased in stroke; however, evidence of epigenetic regulation of the MMP-2 in stroke is still limited. We examined methylation of the MMP-2
Ragu Ramanathan et al.
Bioanalysis, 9(22), 1787-1806 (2017-10-06)
Coproporphyrin-I (CP-I) and coproporphyrin-III (CP-III) in plasma and urine have been proposed as biomarkers for assessing drug-drug interactions involving hepatic drug transporters such as organic anion-transporting peptides (OATP), 1B1 and 1B3. Materials & methods: Plasma and urine extracts were analyzed for CP-I/CP-III
Masaki Moriyama et al.
Advanced healthcare materials, 4(4), 569-575 (2014-09-13)
Antioxidant micelles capable of scavenging reactive oxygen species (ROS) are prepared from poly(ethylene glycol)-b-poly(dopamine) block copolymers. The micelles inhibit tube formation of human umbilical vein endothelial cells (HUVECs) by scavenging endogenous ROS. Furthermore, the micelles inhibit angiogenesis in the chicken
Maja Turinek et al.
Journal of the science of food and agriculture, 97(8), 2647-2656 (2016-10-16)
Organic production is widely assumed to affect quality and nutritional parameters of arable crops. A field experiment was started in 2009 following integrated (INT), organic (ORG) and biodynamic (BD) production standards for wheat, maize and rapeseed production. With resort to
Kangmei Chen et al.
Theranostics, 8(2), 423-436 (2018-01-02)
Human growth factor receptor-bound protein-7 (GRB7) is a pivotal mediator involved in receptor tyrosine kinase signaling and governing diverse cellular processes. Aberrant upregulation of GRB7 is frequently associated with the progression of human cancers. However, the molecular mechanisms leading to
Fabrication of self-ordered porous alumina via anodizing in sulfate solutions
Kondo R, et al.
Materials Letters, 183, 285-289 (2016)
Min-Jie Cao et al.
The Plant journal : for cell and molecular biology, 73(4), 607-616 (2012-10-26)
Plants play a prominent role as sulfur reducers in the global sulfur cycle. Sulfate, the major form of inorganic sulfur utilized by plants, is absorbed and transported by specific sulfate transporters into plastids, especially chloroplasts, where it is reduced and
Fernanda L Souza et al.
Chemosphere, 109, 187-194 (2014-03-13)
The electrooxidation of the dimethyl phthalate (DMP) ester was galvanostatically carried out in a filter-press reactor using a fluoride-doped lead dioxide (β-PbO2,F) film electrodeposited on a Ti substrate. The variables investigated were the nature of the supporting electrolyte (NaCl and
Anissa El Arfani et al.
Neurochemistry international, 88, 88-96 (2015-07-15)
Parkinson's disease (PD) is hallmarked by progressive degeneration of the substantia nigra pars compacta (SNc) neurons and is associated with aberrant glutamatergic activity. However, studies on the glutamatergic system in the motor cortex and striatum, two motor loop-related areas, are
Brian Cunniff et al.
PloS one, 10(5), e0127310-e0127310 (2015-05-27)
Dysregulation of signaling pathways and energy metabolism in cancer cells enhances production of mitochondrial hydrogen peroxide that supports tumorigenesis through multiple mechanisms. To counteract the adverse effects of mitochondrial peroxide many solid tumor types up-regulate the mitochondrial thioredoxin reductase 2--thioredoxin
Kuo-Tung Huang et al.
PloS one, 15(2), e0228958-e0228958 (2020-02-19)
Obstructive sleep apnea (OSA) is a syndrome leading to chronic intermittent hypoxia, and the up-regulation of toll-like receptors (TLR) 2 and 6 on peripheral blood cells has been reported. We hypothesized that DNA methylation in TLR2 and TLR6 genes may
Guangjie Li et al.
Journal of cellular physiology, 234(12), 23485-23494 (2019-06-18)
MicroRNAs (miRs) involve in osteogenic differentiation and osteogenic potential of mesenchymal stem cells (MSCs). Accordingly, the present study aimed to further uncover role miR-149 plays in osteogenic differentiation of MSCs with the involvement of the stromal cell-derived factor-1 (SDF-1)/CXC chemokine
Chunyan Yang et al.
Protein science : a publication of the Protein Society, 22(3), 314-326 (2013-01-03)
The hepatitis E virus (HEV) capsid protein has been demonstrated to be able to assemble into particles in vitro. However, this process and the mechanism of protein-protein interactions during particle assembly remain unclear. In this study, we investigated the assembly
Mingtian Deng et al.
Cellular reprogramming, 19(3), 199-207 (2017-03-30)
In mammals, the imprinted genes play vital roles in development and are generally controlled by DNA methylation at imprinting control regions (ICRs). Recently, it was discovered that 5-hydroxymethylcytosine (5-hmC) is a stable epigenetic modification; however, its functions in cloned animal
Yoshihiko Nakatani et al.
European journal of pharmacology, 815, 381-390 (2017-10-04)
Glycyrrhiza (the roots and rhizomes of licorice) has been used worldwide as both an herbal nutraceutical and herbal medicine. In addition, it is well known that Glycyrrhiza contains various compounds with biological effects, such as anti-viral, anti-inflammatory, immunoregulatory, anti-tumor and
Gunyoung Lee et al.
Food additives & contaminants. Part A, Chemistry, analysis, control, exposure & risk assessment, 36(6), 876-883 (2019-04-16)
Food additives such as antioxidants and color fixatives are substances used in food intentionally for technical effect, such as decolorizing or intensifying the color of food. Based on the necessity of re-evaluating food additives for safety and to improve consumer
Tanoy Dutta et al.
Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy, 191, 217-220 (2017-10-19)
A "naked-eye" detection of health hazardous bisulfite (HSO
P Mehdipour et al.
Molecular neurobiology, 52(1), 293-302 (2014-08-28)
Ataxia telangiectasia mutated (ATM) is a key gene in DNA double-strand break (DSB), and therefore, most of its disabling genetic alterations play an important initiative role in many types of cancer. However, the exact role of ATM gene and its
S E Cloft et al.
Poultry science, 98(10), 4878-4888 (2019-05-08)
An experiment was conducted to evaluate broilers vaccinated against coccidiosis fed combinations of pre-starter and starter diets varying in digestible amino acid (dAA) density from 1 to 19 d of age on subsequent growth performance and meat yield. A total
Tatiane Lima Amorim et al.
Journal of agricultural and food chemistry, 68(39), 10893-10901 (2020-09-02)
This work aimed to predict C18:1 TFA isomers as well as other groups of fatty acids (saturated, monounsaturated, polyunsaturated, and total TFA) in chocolates by ATR-FTIR and partial least square regression. The quantification of fatty acids in representative samples (white
K J Nagarajan et al.
Carbohydrate polymers, 235, 115997-115997 (2020-03-04)
The Used Disposal Paper Cups (UDPCs) have become a concern to the solid waste management sector as scientists triggered the problems in recent years, to proceed forward in developing the process for this issue. Based on this concern, the present
Shanshan Li et al.
Life sciences, 231, 116576-116576 (2019-06-19)
Studies suggest that cardiovascular function in offspring can be epigenetically programmed by environmental changes during pregnancy. CaV1.2 channel plays a major role in the regulation of the vascular tone. This study investigated the effects and underlying mechanisms of exercise during
Amanda J Foss et al.
Toxicon : official journal of the International Society on Toxinology, 140, 45-59 (2017-11-07)
In 2013 and 2015, the Pennsylvania Department of Environmental Protection conducted a survey of lotic habitats within the Susquehanna, Delaware, and Ohio River basins in Pennsylvania, USA, to screen for microcystins/nodularins (MCs/NODs) in algae communities and smallmouth bass (Micropterus dolomieu).
Thomas Canam et al.
Plant science : an international journal of experimental plant biology, 198, 17-26 (2012-12-04)
Brassica carinata (Ethiopian mustard) has previously been identified as a potential crop species suitable for marginal land in the North American prairies due to its relatively high salt tolerance. Two genetically related B. carinata lines with brown-seeded (BS) and yellow-seeded
Lucas M S G A Applegarth et al.
Applied spectroscopy, 69(8), 972-983 (2015-07-15)
This paper reports methods for obtaining time-dependent reduced isotropic Raman spectra of aqueous species in quartz capillary high-pressure optical cells under hydrothermal conditions, as a means of determining quantitative speciation in hydrothermal fluids. The methods have been used to determine
Jiao Deng et al.
Plant & cell physiology, 56(8), 1546-1555 (2015-05-29)
Lotus is a vital aquatic ornamental plant with different flower colors. To explore the flower coloration mechanism in lotus, the constituents and contents of pigments in two lotus cultivars with red and white flowers were analyzed. Although flavones and flavonols
Sergio G Nebauer et al.
Plant physiology and biochemistry : PPB, 63, 61-69 (2012-12-13)
Previous works into photosynthesis regulation under salt stress have focused on the effect of NaCl, although other salts may significantly contribute to the toxicity of saline soils. In this paper, the effects of different salt sources (NaCl, Na(2)SO(4), MgCl(2) and
Hong Wang et al.
Clinical epigenetics, 7, 119-119 (2015-11-10)
The Response Evaluation Criteria in Solid Tumors (RECIST) guideline and Common Terminology Criteria for Adverse Events (CTCAE) criteria are used to assess chemotherapy efficiency and toxicity in patients with advanced lung cancer. However, no real-time, synchronous indicators that can evaluate
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