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T Kubo et al.
Brain research, 616(1-2), 311-314 (1993-07-09)
Neonatal Wistar rats were subcutaneously injected with 0.1, 1, or 2 mg/g b.wt. of monosodium glutamate (MSG) at 1, 3, 5, 7, and 9 days after birth. The animals were observed for degeneration of pyramidal cells in the hippocampus. The
Rapid regioselective oligomerization of L-glutamic acid diethyl ester catalyzed by papain
Li G, et al.
Macromolecules, 39(23), 7915-7921 (2006)
Manoel Jorge Nobre et al.
Life sciences, 71(25), 2961-2972 (2002-10-18)
Gradual increases in the electrical stimulation of the inferior colliculus produces progressive aversive responses from vigilance, through freezing, until escape. These responses are probably mediated by excitatory amino acids (EAA) mechanisms as microinjection of glutamate into the inferior colliculus can
Inhibition of cocaine intoxication by excitatory amino acid receptor antagonists.
R W Rockhold et al.
Annals of the New York Academy of Sciences, 648, 335-337 (1992-05-11)
M Sasa et al.
Uchu Seibutsu Kagaku, 15(4), 371-374 (2002-07-09)
This review article focused on the primary neurotransmitters involved in transmission from the otolith to the vestibular nucleus (VN), especially in relation to the neurotransmission to the VN neurons (gravity-sensitive neurons) activated by tilt stimulation. The medial vestibular nucleus (MVN)
Niyasha P Wijedasa et al.
Materials science & engineering. C, Materials for biological applications, 109, 110540-110540 (2020-04-02)
New peptide based hybrid scaffolds were prepared by blending two different fish scale derived hydroxyapatite with functionalized peptide nanofibers for potential applications in periodontal tissue regeneration. The nanofibers were prepared by self-assembly of the newly designed peptide bolaamphiphile Bis (N-α-amido-glutamic
Yan Meng et al.
Nanoscale, 9(21), 7199-7206 (2017-05-18)
A bolaamphiphile with diacteylene mesogen unit and l-glutamic acid as the terminal group was newly designed and its self-assembly was investigated. The compound formed hydrogels with water upon heating and cooling. The as-formed gel could be switched to a dispersion
G I Kovalev et al.
Eksperimental'naia i klinicheskaia farmakologiia, 65(6), 6-9 (2003-02-25)
Participation of the non-NMDA glutamate receptor subtype in the formation of the EEG frequency spectrum was studied in wakeful rats upon a long-term (10 x 0.2 mg/kg, s.c.) administration of the nootropic dipeptide GVS-111 (noopept or N-phenylacetyl-L-prolyglycine ethylate). The EEGs
M G Matheus et al.
Psychopharmacology, 132(1), 14-18 (1997-07-01)
Microinjections of glutamate into the dorsal periaqueductal grey (DPAG) of rats induce flight behavior, and blockade of glutamate NMDA receptors in the same region increases exploratory behavior of rats tested on the elevated plus maze. To investigate a possible role
Paola Corona et al.
European journal of medicinal chemistry, 43(1), 189-203 (2007-05-29)
Several diamino quinoxalines were designed, synthesized and evaluated as anti-tumor agents. Two compounds showed the most potent cytotoxic activities against the leukemia CCRF-CEM cell line (GI(50)<0.01microM) and the ovarian cancer cell line OVCAR-4 (GI(50)=0.03microM), respectively, with comparable/better activities than Methotrexate
J Folbergrová
Experimental neurology, 130(2), 344-350 (1994-12-01)
Homocysteine induces seizures in adult, as well as in immature, experimental animals, but the mechanism of its action is still unknown. The aim of the present study was to examine whether homocysteine in immature animals may act via excitatory amino
B W Peeters et al.
Brain research bulletin, 33(6), 709-713 (1994-01-01)
The involvement of AMPA and kainate receptors in nonconvulsive epilepsy was studied by intracerebroventricular injections of AMPA, GDEE, kainic acid and kynurenic acid in WAG/Rij rats. The WAG/Rij rat strain is recognized as an animal model for human absence epilepsy.
Hiroshi Uyama et al.
Biomacromolecules, 3(2), 318-323 (2002-03-13)
Protease-catalyzed polymerization and copolymerization of L-glutamic acid diethyl ester hydrochloride (1) have been performed in a buffer of high concentration. Papain and bromelain showed high catalytic activity toward the polymerization. H-H COSY NMR analysis of the product showed the exclusive
Asako Narai-Kanayama et al.
Biochimica et biophysica acta, 1780(6), 881-891 (2008-04-15)
Papain polymerizes L-glutamic acid diethyl ester (Glu-di-OEt) regioselectively, resulting in the formation of poly (gamma-ethyl alpha-L-glutamic acid) with various degrees of polymerization of less than 13. Reaction temperatures below 20 degrees C were appropriate for the reaction in terms of
J Folbergrová
Experimental neurology, 145(2 Pt 1), 442-450 (1997-06-01)
Seizures were induced in immature 18-day-old rats by i.p. administration of homocysteine (11 mmol/kg) and the effects of selected antagonists of NMDA receptors [MK-801 (0.5 mg/kg), AP7 (0.33 mmol/kg), CGP 40116 (10 mg/kg)] and non-NMDA receptors [GDEE (4 mmol/kg), NBQX
Ultrasound induced formation of organogel from a glutamic dendron
Li Y, et al.
Tetrahedron, 63(31), 7468-7473 (2007)
W C Wu et al.
Journal of the autonomic nervous system, 67(3), 145-155 (1998-02-28)
The present study is designed to determine and characterize two neurobiological events. Firstly, we investigated whether increases of systemic arterial pressure (SAP) and sympathetic vertebral nerve activity (VNA) produced by microinjection of glycine (Gly) in the dorsomedial (DM) or rostral
O Nanka
Sbornik lekarsky, 100(1), 53-56 (2000-06-22)
Changes of evoked potentials under the influence of NBQX (a non-NMDA receptor antagonist), MK-801 (a NMDA receptor antagonist) and GDEE (a nonselective antagonist of glutamate receptor) were studied. GDEE augmented potentiation and was marked progression of potentiation with increasing number
G I Kovalev et al.
Eksperimental'naia i klinicheskaia farmakologiia, 63(1), 3-6 (2000-04-14)
The glutamatergic component of the piracetam effect upon the EEG frequency spectrum was studied in wakeful rats with electrodes implanted into somatosensory cortex and hippocampus and a cannula in the lateral ventricle. Piracetam at a dose of 400 mg/kg enhanced
S Takeshita et al.
Brain research, 840(1-2), 99-105 (1999-10-13)
The responses of the medial vestibular nucleus (MVN) neurons to lateral tilt and the neurotransmitters mediating otolith information to MVN neurons were investigated using rats. A computer-operated goniometer was tilted 20 degrees clockwise and counterclockwise at an angular speed of
F Barnabi et al.
American journal of physiology. Regulatory, integrative and comparative physiology, 281(5), R1665-R1674 (2001-10-20)
Neurotransmitters relaying ascending visceral information were examined by comparing the response of neurons in the insular cortex to vagal stimulation (0.8 Hz, 2 mA) before and after neurotransmitter antagonist injections (200 nl) in the ventroposterior parvocellular nucleus of the thalamus
V I Petrov et al.
Biulleten' eksperimental'noi biologii i meditsiny, 113(6), 617-619 (1992-06-01)
A comparative study was performed to assess effects of different antagonists of glutamate receptors on spatial discrimination of rats in 8-arm radial and water mazes. Noncompetitive NMDA receptor blocker MK-801 in the dose 0.10 mg/kg and higher impaired the accuracy
P D Evans et al.
The Journal of experimental biology, 173, 229-249 (1992-12-01)
L-Glutamate application can produce three different responses in the membrane potential of the Schwann cell of the tropical squid, Sepioteuthis sepioidea, which appear to be mediated by three pharmacologically distinct classes of receptor. A class of non-NMDA-type receptors, with some
K Horie et al.
Life sciences, 57(8), 735-741 (1995-01-01)
Novel vasoconstrictor peptides, endothelin-1 (ET-1) and endothelin-3 (ET-3), are also known as neuropeptides or neuromodulators. When either ET-1 or ET-3 was administered to the rat striatum via a microinjection needle, the dopamine release from the striatum dose-dependently increased. Pretreatment with
Effects of L-glutamate, substance P and substance P(1-7) on cardiovascular regulation in the nucleus tractus solitarius.
M E Hall et al.
Regulatory peptides, 46(1-2), 102-109 (1993-07-02)
R Lalonde et al.
Pharmacology, biochemistry, and behavior, 44(3), 539-545 (1993-03-01)
An NMDA antagonist, ketamine, at the highest dose tested (15 mg/kg), impaired the acquisition of a hole-board spatial learning task but not the acquisition of a left-right alternation task. A non-NMDA (quisqualate) antagonist, L-glutamic acid diethyl ester (LGDE), did not
N F Suvorov et al.
Fiziologicheskii zhurnal imeni I.M. Sechenova, 81(12), 1-12 (1995-12-01)
Experiments in dogs, cats and monkeys revealed that, along with the diffuse principle of afferent terminal arrangement within the striatum, there exist some features of terminal organisation by the anterior-posterior and medio-lateral gradients. The data obtained suggest that the prefrontal
Chao Tian et al.
Beijing da xue xue bao. Yi xue ban = Journal of Peking University. Health sciences, 40(4), 443-445 (2008-08-05)
To find a best synthesis method of diethyl N-[p-(methylamino)benzoyl]-L-glutamate(1). Using diethyl N-(p- aminobenzoyl)-L-glutamate (2) as a starting material via a one-pot process of benzylation and methylation, the diethyl N-[p-(methylamino)benzoyl ]-L-glutamate (3) is prepared in high yield. Then compound 1 was
B W Peeters et al.
Brain research bulletin, 33(6), 715-718 (1994-01-01)
The interaction between NMDA and nonNMDA receptors was studied in nonconvulsive epilepsy in WAG/Rij rats. Compounds acting on NMDA (NMDA, APH) and nonNMDA (AMPA, GDEE, kainic acid, kynurenic acid) receptors were coinjected intracerebroventricularly. The WAG/Rij rat strain may be an
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