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Vedagopuram Sreekanth et al.
The journal of physical chemistry. B, 117(7), 2123-2133 (2013-02-07)
We have studied the interactions of three bile acid-tamoxifen conjugates, lithocholic acid-tamoxifen (LA-Tam(1)-Am), deoxycholic acid-tamoxifen (DCA-Tam(2)-Am), and cholic acid-tamoxifen (CA-Tam(3)-Am), possessing 1-3 tamoxifen molecules having an amine headgroup with model DPPC membranes and compared with N-desmethylated tamoxifen (TamNHMe) using DPH
Oliver Bloch et al.
Medical science monitor : international medical journal of experimental and clinical research, 18(12), BR487-BR492 (2012-12-05)
Only limited information is available regarding the influence of decellularization on the extracellular matrix in heart valves. Within the extracellular matrix proteoglycans (PG) play a central role in the structural organization and physical functioning of valves and in their capability
Michael A Trembley et al.
Development (Cambridge, England), 142(1), 21-30 (2014-12-18)
An important pool of cardiovascular progenitor cells arises from the epicardium, a single layer of mesothelium lining the heart. Epicardium-derived progenitor cell (EPDC) formation requires epithelial-to-mesenchymal transition (EMT) and the subsequent migration of these cells into the sub-epicardial space. Although
Adam C Kaufman et al.
Annals of neurology, 77(6), 953-971 (2015-02-25)
Currently no effective disease-modifying agents exist for the treatment of Alzheimer disease (AD). The Fyn tyrosine kinase is implicated in AD pathology triggered by amyloid-ß oligomers (Aßo) and propagated by Tau. Thus, Fyn inhibition may prevent or delay disease progression.
Dong Jin Lee et al.
International journal of pharmaceutics, 471(1-2), 127-134 (2014-05-27)
In this study, polypeptide-based nanoparticles [constituted using poly(L-lysine) coupled with deoxycholic acid (DOCA) and conjugated with 2,3-dimethylmaleic acid (DMA)] have high tumor selectivity once electrostatically switched by the acidic milieu of solid tumors. These nanoparticles exhibited a significantly increased in
Keyata N Thompson et al.
Oncotarget, 6(34), 35231-35246 (2015-10-27)
A high proportion of human tumors maintain activation of both the PI3K and Ras/MAPK pathways. In basal-like breast cancer (BBC), PTEN expression is decreased/lost in over 50% of cases, leading to aberrant activation of the PI3K pathway. Additionally, BBC cell
Marine Baptissart et al.
Hepatology (Baltimore, Md.), 60(3), 1054-1065 (2014-05-07)
Bile acids (BAs) are signaling molecules that are involved in many physiological functions, such as glucose and energy metabolism. These effects are mediated through activation of the nuclear and membrane receptors, farnesoid X receptor (FXR-α) and TGR5 (G-protein-coupled bile acid
F Stellaard et al.
Journal of lipid research, 27(11), 1222-1225 (1986-11-01)
We have developed an isotope dilution method for determination of deoxycholic acid pool size and input rate which employs oral administration of 50 mg of [24-13C]deoxycholic acid and serum sampling. The method has been validated by classical isotope dilution technique
Mohammed Ihsan et al.
American journal of physiology. Regulatory, integrative and comparative physiology, 309(3), R286-R294 (2015-06-05)
This study investigated the effect of regular postexercise cold water immersion (CWI) on muscle aerobic adaptations to endurance training. Eight males performed 3 sessions/wk of endurance training for 4 wk. Following each session, subjects immersed one leg in a cold
A Matsui et al.
Journal of clinical pathology, 35(9), 1011-1017 (1982-09-01)
Serum glycocholic acid (SGC) was measured by radioimmunoassay in 277 samples from 122 children with hepatobiliary disorders and from 23 healthy age-matched controls. In patients with hepatobiliary disease the SGC was more frequently abnormal (83%) than values for serum albumin
Huiyong Wang et al.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences, 980, 72-78 (2015-01-16)
Bile acids (BAs) have recently gained more attention because of their diverse roles from digestion to signaling. Simultaneous analyses of various BAs in biological samples are challenging due to their structural similarity, relatively low concentrations, and the presence of isomeric
Zheng Li et al.
Biological & pharmaceutical bulletin, 37(11), 1766-1775 (2014-09-10)
Our previous studies showed that berberine (BBR) increases liver low-density lipoprotein (LDL) receptor expression in an extracellular signal-regulated kinase (ERK)-dependent manner. This study was designed to explore the upstream cellular signaling molecules recruited by BBR to activate the ERK mitogen-activated
Brian J Pepe-Mooney et al.
Cell stem cell, 25(1), 23-38 (2019-05-14)
The liver can substantially regenerate after injury, with both main epithelial cell types, hepatocytes and biliary epithelial cells (BECs), playing important roles in parenchymal regeneration. Beyond metabolic functions, BECs exhibit substantial plasticity and in some contexts can drive hepatic repopulation.
Katkam N Gangadhar et al.
International journal of pharmaceutics, 471(1-2), 430-438 (2014-06-08)
Amphotericin B (AmB) is still used as the gold standard for therapy against invasive fungal diseases. However, the use of AmB through oral administration is restricted due to its low solubility and stability in aqueous solution, which is the cause
Sze Ue Iris Luk et al.
Oncotarget, 5(16), 6896-6908 (2014-07-30)
Treatment resistance, the major challenge in the management of advanced prostate cancer, is in part based on resistance to apoptosis. The Inhibitor of Apoptosis (IAP) family is thought to play key roles in survival and drug resistance of cancer via
J Rudi et al.
Zeitschrift fur Gastroenterologie, 34(3), 188-191 (1996-03-01)
Pregnancy is very uncommon in patients with primary biliary cirrhosis (PBC) and only few reports exist about pregnancy and PBC. However, no data are available on therapy and potential risks of treatment with ursodeoxycholic acid (UDCA) in PBC, especially in
Alejandro J Krolewiecki et al.
The American journal of tropical medicine and hygiene, 88(3), 578-582 (2013-01-23)
Cutaneous leishmaniasis is endemic in Salta, the northwestern province of Argentina. We describe an outbreak involving five recreational hunters whose exposure was limited to several hours in a residual patch of primary forest. All patients presented with typical cutaneous lesions
Jun Qin et al.
Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy, 102, 425-431 (2012-12-25)
The Flow Inject Drop Luminescence Sensor (FIDLS) is featured by advantages such as high precision and work simplification over typical luminescent spectrometers. With the FIDLS system, this study is the first to examine the sodium deoxycholate (NaDC) inducing room temperature
Emily J Poulin et al.
Stem cell research, 13(3 Pt A), 422-430 (2014-12-03)
Lrig1 is an intestinal stem cell marker important for epithelial homeostasis. However, the position of the Lrig1(+) population in the intestinal crypt has been debated, largely due to discrepant staining patterns using two Lrig1 antibodies. Here, we set out to
João Mello-Vieira et al.
Biochimica et biophysica acta, 1828(9), 2152-2163 (2013-06-12)
Submillimolar concentrations of cytotoxic bile acids (BAs) induce cell death via apoptosis. On the other hand, several cytoprotective BAs were shown to prevent apoptosis in the same concentration range. Still, the mechanisms by which BAs trigger these opposite signaling effects
J Stadler et al.
Cancer letters, 38(3), 315-320 (1988-01-01)
Rectal biopsies and fecal collections were obtained from a consecutive series of 34 outpatients prior to colonoscopy at a gastroenterology clinic. Subsequently, 14 were found to have no colonic pathology, 13 had adenomatous polyps, (3 of those had a previous
X L Jin et al.
Reproduction (Cambridge, England), 148(2), 147-157 (2014-06-26)
The co-expression of the CREB and ATF1 transcription factors is required for the development of preimplantation embryos. Embryotropin-mediated, calcium/calmodulin-dependent signalling activates CREB-induced transcription in the two-cell embryo, but the regulation of ATF1 in the embryo is not known. This study
Sweety Mathew et al.
Journal of translational medicine, 12, 161-161 (2014-06-08)
High-throughput screening techniques that analyze the metabolic endpoints of biological processes can identify the contributions of genetic predisposition and environmental factors to the development of common diseases. Studies applying controlled physiological challenges can reveal dysregulation in metabolic responses that may
Nicholas E Dickenson et al.
Biochemistry, 52(49), 8790-8799 (2013-11-19)
The type III secretion system (T3SS) is an essential virulence factor for Shigella flexneri , providing a conduit through which host-altering effectors are injected directly into a host cell to promote uptake. The type III secretion apparatus (T3SA) is composed
Xiaowen Wu et al.
International journal of pharmaceutics, 454(1), 453-461 (2013-07-04)
A method has been developed for the synthesis of intercalated layered double hydroxide (LDH) nanohybrids of the charge-neutral and poorly water-soluble anticancer drug camptothecin (CPT) using a coassembly route. For this route, CPT molecules were initially incorporated into the micelles
Ana Gutiérrez-Fernández et al.
The EMBO journal, 34(14), 1875-1888 (2015-05-21)
MT1-MMP (MMP14) is a collagenolytic enzyme located at the cell surface and implicated in extracellular matrix (ECM) remodeling. Mmp14(-/-) mice present dwarfism, bone abnormalities, and premature death. We demonstrate herein that the loss of MT1-MMP also causes cardiac defects and
Carrie Hiser et al.
Biochemistry, 52(8), 1385-1396 (2013-01-29)
A conserved, crystallographically defined bile acid binding site was originally identified in the membrane domain of mammalian and bacterial cytochrome c oxidase (CcO). Current studies show other amphipathic molecules including detergents, fatty acids, steroids, and porphyrins bind to this site
Leann Buhrow et al.
Biochemistry, 52(40), 6995-7006 (2013-10-01)
A conserved bile acid site has been crystallographically defined in the membrane domain of mammalian and Rhodobacter sphaeroides cytochrome c oxidase (RsCcO). Diverse amphipathic ligands were shown previously to bind to this site and affect the electron transfer equilibrium between
Weixuan Ning et al.
Biological & pharmaceutical bulletin, 38(11), 1700-1706 (2015-09-09)
Vitiligo is an inflammatory skin disorder in which activated T cells play an important role in its onset and progression. Epigallocatechin-3-gallate (EGCG), the major chemical constituent of green tea, exhibits remarkable anti-oxidative and anti-inflammatory properties. EGCG administration has been confirmed
Su Jin Chung et al.
Life sciences, 108(2), 88-93 (2014-06-01)
Phosphatidylcholine with deoxycholic acid (PC/DA) is widely used to reduce localized fat deposits with mild adverse effects. We previously demonstrated that PC induces lipolysis with mild PMN infiltration, while DA induces adipose tissue damage. Therefore, the aim of this study
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