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Keyata N Thompson et al.
Oncotarget, 6(34), 35231-35246 (2015-10-27)
A high proportion of human tumors maintain activation of both the PI3K and Ras/MAPK pathways. In basal-like breast cancer (BBC), PTEN expression is decreased/lost in over 50% of cases, leading to aberrant activation of the PI3K pathway. Additionally, BBC cell
W T Beher et al.
Life sciences, 32(26), 2933-2937 (1983-06-27)
Daily excretion of fecal total bile acids and neutral steroids were compared in five controls and two patients with extremely low concentrations of plasma high density lipoprotein (3 to 11 mg/dl) and severe atherosclerosis. There was no significant difference in
Oliver Bloch et al.
Medical science monitor : international medical journal of experimental and clinical research, 18(12), BR487-BR492 (2012-12-05)
Only limited information is available regarding the influence of decellularization on the extracellular matrix in heart valves. Within the extracellular matrix proteoglycans (PG) play a central role in the structural organization and physical functioning of valves and in their capability
Vedagopuram Sreekanth et al.
The journal of physical chemistry. B, 117(7), 2123-2133 (2013-02-07)
We have studied the interactions of three bile acid-tamoxifen conjugates, lithocholic acid-tamoxifen (LA-Tam(1)-Am), deoxycholic acid-tamoxifen (DCA-Tam(2)-Am), and cholic acid-tamoxifen (CA-Tam(3)-Am), possessing 1-3 tamoxifen molecules having an amine headgroup with model DPPC membranes and compared with N-desmethylated tamoxifen (TamNHMe) using DPH
Zheng Li et al.
Biological & pharmaceutical bulletin, 37(11), 1766-1775 (2014-09-10)
Our previous studies showed that berberine (BBR) increases liver low-density lipoprotein (LDL) receptor expression in an extracellular signal-regulated kinase (ERK)-dependent manner. This study was designed to explore the upstream cellular signaling molecules recruited by BBR to activate the ERK mitogen-activated
Brian J Pepe-Mooney et al.
Cell stem cell, 25(1), 23-38 (2019-05-14)
The liver can substantially regenerate after injury, with both main epithelial cell types, hepatocytes and biliary epithelial cells (BECs), playing important roles in parenchymal regeneration. Beyond metabolic functions, BECs exhibit substantial plasticity and in some contexts can drive hepatic repopulation.
Huiyong Wang et al.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences, 980, 72-78 (2015-01-16)
Bile acids (BAs) have recently gained more attention because of their diverse roles from digestion to signaling. Simultaneous analyses of various BAs in biological samples are challenging due to their structural similarity, relatively low concentrations, and the presence of isomeric
Alejandro J Krolewiecki et al.
The American journal of tropical medicine and hygiene, 88(3), 578-582 (2013-01-23)
Cutaneous leishmaniasis is endemic in Salta, the northwestern province of Argentina. We describe an outbreak involving five recreational hunters whose exposure was limited to several hours in a residual patch of primary forest. All patients presented with typical cutaneous lesions
F Stellaard et al.
Journal of lipid research, 27(11), 1222-1225 (1986-11-01)
We have developed an isotope dilution method for determination of deoxycholic acid pool size and input rate which employs oral administration of 50 mg of [24-13C]deoxycholic acid and serum sampling. The method has been validated by classical isotope dilution technique
Dong Jin Lee et al.
International journal of pharmaceutics, 471(1-2), 127-134 (2014-05-27)
In this study, polypeptide-based nanoparticles [constituted using poly(L-lysine) coupled with deoxycholic acid (DOCA) and conjugated with 2,3-dimethylmaleic acid (DMA)] have high tumor selectivity once electrostatically switched by the acidic milieu of solid tumors. These nanoparticles exhibited a significantly increased in
Katkam N Gangadhar et al.
International journal of pharmaceutics, 471(1-2), 430-438 (2014-06-08)
Amphotericin B (AmB) is still used as the gold standard for therapy against invasive fungal diseases. However, the use of AmB through oral administration is restricted due to its low solubility and stability in aqueous solution, which is the cause
Adam C Kaufman et al.
Annals of neurology, 77(6), 953-971 (2015-02-25)
Currently no effective disease-modifying agents exist for the treatment of Alzheimer disease (AD). The Fyn tyrosine kinase is implicated in AD pathology triggered by amyloid-ß oligomers (Aßo) and propagated by Tau. Thus, Fyn inhibition may prevent or delay disease progression.
Michael A Trembley et al.
Development (Cambridge, England), 142(1), 21-30 (2014-12-18)
An important pool of cardiovascular progenitor cells arises from the epicardium, a single layer of mesothelium lining the heart. Epicardium-derived progenitor cell (EPDC) formation requires epithelial-to-mesenchymal transition (EMT) and the subsequent migration of these cells into the sub-epicardial space. Although
Marine Baptissart et al.
Hepatology (Baltimore, Md.), 60(3), 1054-1065 (2014-05-07)
Bile acids (BAs) are signaling molecules that are involved in many physiological functions, such as glucose and energy metabolism. These effects are mediated through activation of the nuclear and membrane receptors, farnesoid X receptor (FXR-α) and TGR5 (G-protein-coupled bile acid
J Stadler et al.
Cancer letters, 38(3), 315-320 (1988-01-01)
Rectal biopsies and fecal collections were obtained from a consecutive series of 34 outpatients prior to colonoscopy at a gastroenterology clinic. Subsequently, 14 were found to have no colonic pathology, 13 had adenomatous polyps, (3 of those had a previous
Sze Ue Iris Luk et al.
Oncotarget, 5(16), 6896-6908 (2014-07-30)
Treatment resistance, the major challenge in the management of advanced prostate cancer, is in part based on resistance to apoptosis. The Inhibitor of Apoptosis (IAP) family is thought to play key roles in survival and drug resistance of cancer via
J Rudi et al.
Zeitschrift fur Gastroenterologie, 34(3), 188-191 (1996-03-01)
Pregnancy is very uncommon in patients with primary biliary cirrhosis (PBC) and only few reports exist about pregnancy and PBC. However, no data are available on therapy and potential risks of treatment with ursodeoxycholic acid (UDCA) in PBC, especially in
Mohammed Ihsan et al.
American journal of physiology. Regulatory, integrative and comparative physiology, 309(3), R286-R294 (2015-06-05)
This study investigated the effect of regular postexercise cold water immersion (CWI) on muscle aerobic adaptations to endurance training. Eight males performed 3 sessions/wk of endurance training for 4 wk. Following each session, subjects immersed one leg in a cold
A Matsui et al.
Journal of clinical pathology, 35(9), 1011-1017 (1982-09-01)
Serum glycocholic acid (SGC) was measured by radioimmunoassay in 277 samples from 122 children with hepatobiliary disorders and from 23 healthy age-matched controls. In patients with hepatobiliary disease the SGC was more frequently abnormal (83%) than values for serum albumin
Yunjing Zhang et al.
British journal of pharmacology, 176(16), 2848-2863 (2019-05-12)
Ursodeoxycholic acid (UDCA) is the first-line treatment for primary biliary cholangitis, but its effects on the enterohepatic circulation of bile acid (BA) have been under-investigated. Therefore, we studied the influence of UDCA on BA enterohepatic circulation in vivo and the
Seiji Okada et al.
Journal of oral pathology & medicine : official publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology, 44(2), 115-125 (2014-07-26)
Hematopoietic pre-B-cell leukemia transcription factor-interacting protein (HPIP) is a corepressor of pre-B-cell leukemia homeobox (PBX) 1 and is known to play a role in hematopoiesis. Recently, HPIP was demonstrated to promote breast cancer cell proliferation and hepatocellular carcinoma growth. Moreover
Peng Cheng et al.
Molecular medicine reports, 12(3), 3257-3264 (2015-05-23)
The pathophysiological mechanisms of the irritable bowel syndrome (IBS), one of the most prevalent gastrointestinal disorders, are complex and have not been fully elucidated. The present study aimed to investigate the molecular and cellular mechanisms of tight junction (TJ) dysfunction
X L Jin et al.
Reproduction (Cambridge, England), 148(2), 147-157 (2014-06-26)
The co-expression of the CREB and ATF1 transcription factors is required for the development of preimplantation embryos. Embryotropin-mediated, calcium/calmodulin-dependent signalling activates CREB-induced transcription in the two-cell embryo, but the regulation of ATF1 in the embryo is not known. This study
Amphotericin B in severe fungal infections: a critical reappraisal of the evidence.
Pedro Póvoa et al.
American journal of respiratory and critical care medicine, 188(8), 1032-1032 (2013-10-17)
Ke Li et al.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences, 1001, 27-34 (2015-08-09)
Many fishes are hypothesized to use bile acids (BAs) as chemical cues, yet quantification of BAs in biological samples and the required methods remain limited. Here, we present an UHPLC-MS/MS method for simultaneous, sensitive, and rapid quantification of 15 BAs
Tomoaki Tadano et al.
Rinsho byori. The Japanese journal of clinical pathology, 54(2), 103-110 (2006-03-22)
Both radioimmunoassay (RIA) and enzyme-linked immunosorbent assay (ELISA) methods are utilized in the clinical laboratory to measure bile acids in human body fluids. For a more detailed analysis, we attempted simultaneous analysis of serum and feces bile acids using gas
Florence Teulé et al.
Nature protocols, 4(3), 341-355 (2009-02-21)
The extreme strength and elasticity of spider silks originate from the modular nature of their repetitive proteins. To exploit such materials and mimic spider silks, comprehensive strategies to produce and spin recombinant fibrous proteins are necessary. This protocol describes silk
Leann Buhrow et al.
Biochemistry, 52(40), 6995-7006 (2013-10-01)
A conserved bile acid site has been crystallographically defined in the membrane domain of mammalian and Rhodobacter sphaeroides cytochrome c oxidase (RsCcO). Diverse amphipathic ligands were shown previously to bind to this site and affect the electron transfer equilibrium between
Weixuan Ning et al.
Biological & pharmaceutical bulletin, 38(11), 1700-1706 (2015-09-09)
Vitiligo is an inflammatory skin disorder in which activated T cells play an important role in its onset and progression. Epigallocatechin-3-gallate (EGCG), the major chemical constituent of green tea, exhibits remarkable anti-oxidative and anti-inflammatory properties. EGCG administration has been confirmed
N F LaRusso et al.
Gastroenterology, 72(1), 132-140 (1977-01-01)
The effect of deoxycholate ingestion, 750 mg per day, on bile acid kinetics, biliary bile acid composition, and biliary lipid secretion was studied in 7 healthy volunteers. Bile acid kinetics were measured by isotope dilution, and hourly outputs of bile
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