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Jean-Paul Lemaître et al.
Applied and environmental microbiology, 81(6), 2117-2124 (2015-01-18)
The detection of Listeria monocytogenes from food is currently carried out using a double enrichment. For the ISO methodology, this double enrichment is performed using half-Fraser and Fraser broths, in which the overgrowth of L. innocua can occur in samples
Tina Horbach et al.
PloS one, 9(9), e107914-e107914 (2014-09-23)
The upstream stimulatory factor 2 (USF2) is a regulator of important cellular processes and is supposed to have also a role during tumor development. However, the knowledge about the mechanisms that control the function of USF2 is limited. The data
Madeline Hayes et al.
Nature communications, 5, 4777-4777 (2014-09-04)
Scoliosis is a complex genetic disorder of the musculoskeletal system, characterized by three-dimensional rotation of the spine. Curvatures caused by malformed vertebrae (congenital scoliosis (CS)) are apparent at birth. Spinal curvatures with no underlying vertebral abnormality (idiopathic scoliosis (IS)) most
Vitali Alexeev et al.
Molecular cancer therapeutics, 13(12), 2968-2977 (2014-11-16)
Normal tissue toxicity markedly reduces the therapeutic index of genotoxic anticancer agents, including ionizing radiation. Countermeasures against tissue damage caused by radiation are limited by their potential to also protect malignant cells and tissues. Here, we tested a panel of
Akiva N Rappaport et al.
The Journal of neuroscience : the official journal of the Society for Neuroscience, 35(47), 15568-15581 (2015-11-27)
Learning of novel information, including novel taste, requires activation of neuromodulatory transmission mediated, for example, by the muscarinic acetylcholine receptors (mAChRs) in relevant brain structures. In addition, drugs enhancing the function of mAChRs are used to treat memory impairment and
Yanbing Zhu et al.
Journal of basic microbiology, 55(10), 1219-1231 (2015-07-16)
A new lipolytic enzyme gene was cloned from a thermophile Geobacillus sp. JM6. The gene contained 750 bp and encoded a 249-amino acid protein. The recombinant enzyme was expressed and purified from Escherichia coli BL21 (DE3) with a molecular mass
Meltem Weger et al.
Developmental biology, 380(2), 259-273 (2013-05-15)
The circadian clock co-ordinates physiology and behavior with the day/night cycle. It consists of a transcriptional-translational feedback loop that generates self-sustained oscillations in transcriptional activity with a roughly 24h period via E-box enhancer elements. Numerous in vivo aspects of core
Erin M Rock et al.
Psychopharmacology, 231(16), 3207-3215 (2014-03-07)
The effectiveness of cannabidiolic acid (CBDA) was compared with other potential treatments for anticipatory nausea (AN), using a rat model of contextually elicited conditioned gaping reactions. The potential of ondansetron (OND), Δ(9)-tetrahydrocannabinol (THC), chlordiazepoxide (CDP), CBDA, and co-administration of CBDA
Carlee R White et al.
Scientific reports, 5, 17311-17311 (2015-12-03)
Assisted reproductive technologies (ARTs) represent the best chance for infertile couples to conceive, although increased risks for morbidities exist, including imprinting disorders. This increased risk could arise from ARTs disrupting genomic imprints during gametogenesis or preimplantation. The few studies examining
L M Harrison et al.
Neuroscience, 236, 21-30 (2013-02-06)
G protein-coupled receptors (GPCR) signal not only through heterotrimeric G proteins, but also through alternate pathways. Thus, dopamine D2 receptors in the striatum signal through Gαi/o and also by promoting formation of a multi-protein complex containing β-arrestin2, protein phosphatase 2A
Lucie Kalferstova et al.
Journal of clinical microbiology, 53(5), 1515-1522 (2015-02-20)
Cepacia syndrome (CS) is a fatal septic condition that develops in approximately 20% of cystic fibrosis (CF) patients chronically infected with the Burkholderia cepacia complex (Bcc). The most common causative agent is Burkholderia cenocepacia, a clinically dominant Bcc species that
H Kubová et al.
Neuroscience, 235, 232-249 (2013-01-12)
The present study examined whether status epilepticus (SE) induced by LiCl-pilocarpine in immature rats (postnatal day [P]12) interferes with normal development; leads to progressive epileptogenesis, or cognitive decline and to pathology similar to that seen in human temporal lobe epilepsy.
Jiansheng Liu et al.
Biomaterials, 74, 64-76 (2015-10-09)
Despite optimal therapeutic regimen with currently available antiepileptic drugs (AEDs), approximately a third of epilepsy patients remain drug refractory. Region-specific overexpression of multidrug efflux transporters at the blood-brain barrier, such as P-glycoprotein (P-gp), might contribute to multidrug resistance (MDR) by
Catherine M Cowan et al.
Scientific reports, 5, 17191-17191 (2015-11-27)
Aggregation of highly phosphorylated tau is a hallmark of Alzheimer's disease and other tauopathies. Nevertheless, animal models demonstrate that tau-mediated dysfunction/toxicity may not require large tau aggregates but instead may be caused by soluble hyper-phosphorylated tau or by small tau
Michela Boi et al.
Clinical cancer research : an official journal of the American Association for Cancer Research, 21(7), 1628-1638 (2015-01-28)
In cancer cells, the epigenome is often deregulated, and inhibition of the bromodomain and extra-terminal (BET) family of bromodomain-containing proteins is a novel epigenetic therapeutic approach. Preliminary results of an ongoing phase I trial have reported promising activity and tolerability
Aiping Lan et al.
PloS one, 9(8), e105451-e105451 (2014-08-26)
Obstructive nephropathy is an aggressive form of chronic kidney disease (CKD), which is characterized by an epithelial-to-mesenchymal transition (EMT) and interstitial fibrosis. However, the molecular mechanisms of EMT and fibrosis are complex and not fully understood. In this study, we
Morten B Ley et al.
Dalton transactions (Cambridge, England : 2003), 43(35), 13333-13342 (2014-07-26)
Rare earth metal borohydrides have been proposed as materials for solid-state hydrogen storage because of their reasonably low temperature of decomposition. New synthesis methods, which provide halide-free yttrium and gadolinium borohydride, are presented using dimethyl sulfide and new solvates as
Mina Heidarian Höckerfelt et al.
International journal of pharmaceutics, 477(1-2), 326-333 (2014-12-03)
The purpose of the research was to investigate the effect of moisture content of cellulose on the degradation of a drug in binary mixtures with cellulose. Physical mixtures of acetylsalicylic acid and two forms of cellulose, either microcrystalline cellulose or
Hyun Jin Kwun et al.
Journal of virology, 89(8), 4191-4200 (2015-01-30)
Merkel cell polyomavirus (MCV) is a newly discovered human cancer virus encoding a small T (sT) oncoprotein. We performed MCV sT FLAG-affinity purification followed by mass spectroscopy (MS) analysis, which identified several protein phosphatases (PP), including PP2A A and C
Bei Liu et al.
Molecular neurobiology, 50(2), 327-338 (2014-01-28)
Efflux of monocaroxylates like lactate, pyruvate, and ketone bodies from astrocytes through monocarboxylate transporter 4 (MCT4) supplies the local neuron population with metabolic intermediates to meet energy requirements under conditions of increased demand. Disruption of this astroglial-neuron metabolic coupling pathway
Horner-wadsworth-emmons reaction: Use of lithium chloride and an amine for base-sensitive compounds.
Blanchette MA, et al.
Tetrahedron Letters, 25(21), 2183-2186 (1984)
Francesca Mateo et al.
Molecular cancer, 13, 237-237 (2014-10-22)
Tumor cell subpopulations can either compete with each other for nutrients and physical space within the tumor niche, or co-operate for enhanced survival, or replicative or metastatic capacities. Recently, we have described co-operative interactions between two clonal subpopulations derived from
Alex R Hill et al.
European journal of mass spectrometry (Chichester, England), 21(3), 265-274 (2015-08-27)
The complexation of triacetone triperoxide (TATP) with a range of alkali metals has been studied by electrospray ionisation-mass spectrometry yield [M+Cat](+) ions for all of the alkali metals. The formation of [2TATP+Li+LiX](+) (X = Br, Cl) sandwich complexes was also
Sule Ayla et al.
Journal of pediatric hematology/oncology, 36(1), 37-44 (2012-11-07)
Neuroblastoma is a severe pediatric tumor characterized by poor prognosis. Identification of novel molecular targets and diversion of investigations on new drug trials is mandatory for cancer therapy. In this study, vinorelbine tartrate, lithium chloride, clomipramine, and medroxyprogesterone acetate are
Ming Zheng et al.
PLoS medicine, 12(2), e1001782-e1001782 (2015-02-04)
We know very little about the genetic factors affecting susceptibility to drug-induced central nervous system (CNS) toxicities, and this has limited our ability to optimally utilize existing drugs or to develop new drugs for CNS disorders. For example, haloperidol is
Alessandro Di Maio et al.
EvoDevo, 6, 17-17 (2015-07-15)
Wnt signaling is one of the earliest and most highly conserved regulatory pathways for the establishment of the body axes during regeneration and early development. In regeneration, body axes determination occurs independently of tissue rearrangement and early developmental cues. Modulation
Maria Teresa Esposito et al.
Nature medicine, 21(12), 1481-1490 (2015-11-26)
Acute myeloid leukemia (AML) is mostly driven by oncogenic transcription factors, which have been classically viewed as intractable targets using small-molecule inhibitor approaches. Here we demonstrate that AML driven by repressive transcription factors, including AML1-ETO (encoded by the fusion oncogene
Naveed Asghar et al.
PloS one, 9(7), e103264-e103264 (2014-07-25)
The increased distribution of the tick-borne encephalitis virus (TBEV) in Scandinavia highlights the importance of characterizing novel sequences within the natural foci. In this study, two TBEV strains: the Norwegian Mandal 2009 (questing nymphs pool) and the Swedish Saringe 2009
Xi Chen et al.
Neurosciences (Riyadh, Saudi Arabia), 18(4), 356-362 (2013-10-22)
To investigate whether lithium modifies open-field and elevated plus maze behavior, and brain phospho-glycogen synthase kinase 3 (P-GSK3beta) expression in Fmr1 knockout mice. One hundred and eighty FVB mice, including knockout and wild type, with an age of 30 days
Linda A Parker et al.
Psychopharmacology, 232(3), 583-593 (2014-08-03)
To determine the role of the endocannabinoid, 2-arachodonyl glycerol (2-AG), in the regulation of nausea and vomiting. We evaluated the effectiveness of the potent selective monoacylglycerol lipase (MAGL) inhibitor, MJN110, which selectively elevates the endocannabinoid 2-AG, to suppress acute nausea
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